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<ACCESSION-NUMBER>0001047469-05-012638
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<PERIOD>20050502
<ITEMS>8.01
<ITEMS>9.01
<FILING-DATE>20050502
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<CONFORMED-NAME>MYRIAD GENETICS INC
<CIK>0000899923
<ASSIGNED-SIC>2835
<IRS-NUMBER>870494517
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0630
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<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>000-26642
<FILM-NUMBER>05789458
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<BUSINESS-ADDRESS>
<STREET1>320 WAKARA WAY
<CITY>SALT LAKE CITY
<STATE>UT
<ZIP>84108
</BUSINESS-ADDRESS>
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<STREET1>320 WAKARA WAY
<CITY>SALT LAKE CITY
<STATE>UT
<ZIP>84108
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<TYPE>8-K
<SEQUENCE>1
<FILENAME>a2157330z8-k.htm
<DESCRIPTION>8-K
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<P ALIGN="CENTER"><FONT SIZE=5><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, D.C. 20549  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=5><B>FORM 8-K  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=3><B>CURRENT REPORT<BR>  </B></FONT><FONT SIZE=2><B>Pursuant to Section&nbsp;13 or 15(d)&nbsp;of the Securities Exchange Act of 1934  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>Date of Report (Date of earliest event reported): </FONT><FONT SIZE=2><B>May&nbsp;2, 2005</B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>MYRIAD GENETICS,&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Exact name of registrant as specified in its charter) </FONT></P>

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<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2><B>Delaware</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2><B>0-26642</B></FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2><B>87-0494517</B></FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2>(State or other jurisdiction<BR>
of incorporation)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2>(Commission<BR>
File Number)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="31%" ALIGN="CENTER"><FONT SIZE=2>(IRS Employer<BR>
Identification No.)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2><B>320 Wakara Way<BR>
Salt Lake City, Utah 84108<BR>  </B></FONT><FONT SIZE=2>(Address of principal executive offices) (Zip Code) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>Registrant's
telephone number, including area code: </FONT><FONT SIZE=2><B>(801)&nbsp;584-3600</B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>Not Applicable<BR>  </B></FONT><FONT SIZE=2>(Former name or former address, if changed since last report) </FONT></P>


<P><FONT SIZE=2>Check
the appropriate box below if the Form&nbsp;8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
(</FONT><FONT SIZE=2><I>see</I></FONT><FONT SIZE=2> General Instruction A.2. below): </FONT></P>

<DL compact>
<DT style='margin-bottom:-11pt;'><FONT SIZE=2><FONT FACE="WINGDINGS">&#111;</FONT></FONT></DT><DD><FONT SIZE=2>Written
communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR 230.425)
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2><FONT FACE="WINGDINGS">&#111;</FONT></FONT></DT><DD><FONT SIZE=2>Soliciting
material pursuant to Rule&nbsp;14a-12 under the Exchange Act (17 CFR 240.14a-12)
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2><FONT FACE="WINGDINGS">&#111;</FONT></FONT></DT><DD><FONT SIZE=2>Pre-commencement
communications pursuant to Rule&nbsp;14d-2(b) under the Exchange Act (17 CFR
240.14d-2(b))
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2><FONT FACE="WINGDINGS">&#111;</FONT></FONT></DT><DD><FONT SIZE=2>Pre-commencement
communications pursuant to Rule&nbsp;13e-4(c) under the Exchange Act (17 CFR
240.13e-4(c)) </FONT><P><FONT SIZE=2>
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<P><FONT SIZE=2><A
NAME="de1849_item_8.01_other_events"> </A>
<A NAME="toc_de1849_1"> </A>
<BR></FONT><FONT SIZE=2><B>ITEM 8.01 Other Events    <BR>    </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;On May&nbsp;2, 2005, Myriad Genetics,&nbsp;Inc. announced the preliminary results of its Phase 2 clinical trial of Flurizan&#153; for the treatment of
patients with mild to moderate Alzheimer's disease. The press release is attached hereto as an exhibit to this Current Report on Form&nbsp;8-K and is being filed pursuant to this Item
8.01 as Exhibit&nbsp;99.1 to this Current Report on Form&nbsp;8-K. </FONT></P>


<P><FONT SIZE=2><A
NAME="de1849_item_9.01_financial_statements_and_exhibits."> </A>
<A NAME="toc_de1849_2"> </A>
<BR></FONT><FONT SIZE=2><B>ITEM 9.01 Financial Statements and Exhibits.    <BR>    </B></FONT></P>

<UL>
<DL compact>
<DT style='margin-bottom:-11pt;'><FONT SIZE=2>(c)</FONT></DT><DD><FONT SIZE=2>The
following exhibit is filed with this report: </FONT></DD></DL>
</UL>
<BR>

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Number</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="85%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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<TR VALIGN="TOP">
<TD WIDTH="12%" ALIGN="RIGHT"><FONT SIZE=2>99.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="85%"><FONT SIZE=2>The Registrant's press release dated May&nbsp;2, 2005.</FONT></TD>
</TR>
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<P><FONT SIZE=2>
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<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>    </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned
hereunto duly authorized. </FONT></P>

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&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD COLSPAN=3><BR><FONT SIZE=2><B>MYRIAD GENETICS,&nbsp;INC.</B></FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="47%"><BR><FONT SIZE=2>Date: May&nbsp;2, 2005</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="45%"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>PETER D. MELDRUM</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Peter D. Meldrum<BR>
President and Chief Executive Officer</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ka1849_exhibit_index"> </A>
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<BR></FONT><FONT SIZE=2><B>EXHIBIT INDEX    <BR>    </B></FONT></P>

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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>99.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>The Registrant's press release dated May&nbsp;2, 2005.</FONT></TD>
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<UL>
<FONT SIZE=2><A HREF="#toc_de1849_1">ITEM 8.01 Other Events</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1849_2">ITEM 9.01 Financial Statements and Exhibits.</A></FONT><BR>
</UL>
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<FONT SIZE=2><A HREF="#toc_jc1849_1">SIGNATURES</A></FONT><BR>
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<TYPE>EX-99.1
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<P ALIGN="RIGHT"><FONT SIZE=2><B>Exhibit&nbsp;99.1  </B></FONT></P>

<P><FONT SIZE=2><B>Contact:<BR>  </B></FONT><FONT SIZE=2>William A. Hockett<BR>
Vice President of Corporate Communications<BR>
(801)&nbsp;584-3600<BR>
Email: bhockett@myriad.com<BR>
www.myriad.com </FONT></P>

<P><FONT SIZE=2><B>FOR IMMEDIATE RELEASE  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B> <A NAME="ma1849_myriad_genetics_reports_result__myr03898"> </A>
<A NAME="toc_ma1849_1"> </A>
<BR>    Myriad Genetics Reports Results of Phase 2 Trial of Flurizan&#153; in Patients with Alzheimer's Disease    <BR>    </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>&#151;Conference
Call Scheduled for 4:00&nbsp;p.m. Eastern Time Today&#151; </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><B>Salt Lake City, May&nbsp;2, 2005</B></FONT><FONT SIZE=2>&#151;Myriad Genetics,&nbsp;Inc. (Nasdaq: MYGN), announced that preliminary results of its
Phase 2 clinical trial of Flurizan did not achieve statistical significance in patients with mild to moderate Alzheimer's disease; however, a positive trend was observed on all three primary endpoints
in patients with mild Alzheimer's disease, on the 800 mg twice-daily dose. Additionally, mild Alzheimer's disease patients who achieved high plasma concentrations of Flurizan demonstrated a
statistically significant effect in two of the three primary endpoints. The initial findings also indicate that Flurizan was well tolerated in this 12-month, 207 patient clinical study. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
three primary endpoints of the Phase 2 study were the Alzheimer's Disease Cooperative Study&#151;Activities of Daily Living inventory (ADCS-ADL), Clinical
Dementia Rating&#151;Sum of Boxes (CDR-sb), and the Alzheimer's Disease Assessment Scale&#151;Cognitive function subscale (ADAS-cog). Patients with mild
Alzheimer's disease who were given the 800 mg twice-daily dose of Flurizan demonstrated a 44% slowing of decline in their performance of activities of daily living, as measured by the
ADCS-ADL. This assessment measures basic activities of daily living such as dressing and eating. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
800 mg twice-daily drug-treated group with mild disease at baseline demonstrated a 41% slowing of decline during the 12-month study period in global function
as measured by the CDR-sb. In this exam, the investigator performs a semi-structured interview with both the patient and the caregiver. The patient's performance is assessed in
memory, orientation, judgment, problem solving, community activities, home and hobbies and personal care. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A
positive trend was also seen in patients with mild disease on the 800 mg twice-daily dose for the primary cognitive endpoint, ADAS-cog. This group achieved a 29% slowing of
cognitive decline. The ADAS-cog measures a patient's performance in word recall, response to directions, ability to copy geometric forms, delayed word recall, ability to name objects,
memory and quality of speech. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A
further analysis of data from 128 mild Alzheimer's disease patients (68% of the patients eligible for analysis) indicates that those who achieved the greatest plasma concentrations of
Flurizan demonstrated a statistically significant 67% reduction in decline in activities of daily living (p=0.017, two-sided) as measured by ADCS-ADL, compared to patients in
the placebo group. This finding was confirmed by analyzing the same group of patients versus the control group for the global function assessment, which showed a 54% slower decline (p=0.034,
two-sided) as measured by CDR-sb. Finally, the high plasma concentration group demonstrated a 30% slowing in the rate of decline of cognitive function (not statistically
significant), as measured by ADAS-cog. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;"This
study has been very useful and indicates that this drug may well be helpful in early stages of Alzheimer's disease," said Gordon Wilcock, M.D., Professor in Care of the Elderly,
University of Bristol, United Kingdom. "It is in keeping with the evolving understanding of the relationship between amyloid deposition and Alzheimer's disease. The study has also shown a dose that is
most likely to be effective. We now need further studies to confirm these findings."
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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
addition to efficacy measures, the Phase 2 trial assessed the safety of Flurizan in the study population. The preliminary results showed that Flurizan was well tolerated in this
study. Review of the full safety data set is underway. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;"Even
though Flurizan did not achieve significance in the primary endpoints of the Phase 2 Alzheimer's study, we are encouraged by the statistically significant effect observed in the
mild Alzheimer's disease patients," said Peter Meldrum, President of Myriad Genetics,&nbsp;Inc. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Based
on the Phase 2 results, the Company intends to continue its Phase 3 trial, and believes that 800 mg twice daily is the preferred dose. The Company will review the protocol for the
Phase 3 study with the principal investigators to determine any modifications in treatment regimens. Subject to regulatory approval, the Company will also consider modifying the Phase 3 protocol to
focus future enrollment on mild Alzheimer's disease patients. Additionally, the Company will continue to analyze the data from the moderate Alzheimer's disease patients in order to better understand
the effect of Flurizan in this population. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Phase 2 trial was conducted at approximately 30 centers in the United Kingdom and Canada, with 189 patients who qualified for the intent-to-treat analysis. It
was designed to study the safety and efficacy of Flurizan in altering the progression of Alzheimer's disease. The format of the trial was double blind and placebo-controlled, with a
12-month study period. Patients were randomized into one of three groups upon enrollment in the trial, and given twice-daily doses of either 400mg or 800mg of drug or placebo. At the time
of enrollment, the patient group as a whole had an average Mini Mental State Exam (MMSE) score of 21 and the trial was composed of 50% men and 50% women. </FONT></P>

<P><FONT SIZE=2><B>About Flurizan  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Flurizan is a selective amyloid beta 42 lowering agent (SALA). Flurizan has been shown to be effective in lowering levels of Abeta42 in cellular assays and animal
models. Abeta42 is the primary constituent of senile plaques that accumulate in the brains of patients with Alzheimer's disease. It is thought to be the key initiator of Alzheimer's disease since this
peptide has the greatest tendency to aggregate, cause neuronal damage and initiate amyloid deposits in the brain. Most genetic mutations that cause early-onset Alzheimer's disease appear to do so by
increasing production of Abeta42. Myriad believes that Flurizan is the first well-tolerated drug that inhibits the production of Abeta42 to be evaluated in a clinical trial for the
treatment of Alzheimer's disease. </FONT></P>

<P><FONT SIZE=2><B>Conference Call and Audio Web Cast  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT SIZE=2><B>Myriad management will host a conference call at 4:00&nbsp;p.m. Eastern time today, May&nbsp;2, 2005, to discuss today's announcement.
The call-in number for the conference call will be (888)&nbsp;589-2820 or (706)&nbsp;634-2173. A replay of the conference call will be available for one week
following the call by dialing (800)&nbsp;642-1687 or (706)&nbsp;645-9291, and entering conference identification number 6051295. The call will also be available through a
link on Myriad's home page&nbsp;at www.myriad.com.</B></FONT></P>

<P><FONT SIZE=2><B>About Myriad  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Myriad Genetics,&nbsp;Inc. is a biopharmaceutical company focused on the development of novel healthcare products. The Company develops and markets predictive
medicine products, and is developing and intends to market therapeutic products. Myriad's news and other information are available on the Company's Web site at www.myriad.com. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
SIZE=2><I>This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These forward looking
statements include, the positive trend observed on all three primary end points in patients with mild Alzheimer's disease on the 800 mg twice daily dose; Flurizan's demonstrated statistically
significant effect in two of the three primary endpoints; the positive trend
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seen in patients with mild disease on the 800 mg twice daily dose for the primary cognitive endpoint, ADAS-cog; the statistically significant reduction of 67% in the decline in activities
of daily living (p=0.017, two sided) as measured by ADCS-ADL in patients who achieved the greatest plasma concentrations of Flurizan as compared to patients in the placebo group; the
encouragement of the Company with respect to the statistically significant effect observed in the mild Alzheimer's disease patients; the toleration of Flurizan by study patients; the continuation of
the Company's Phase 3 trial; the Company's belief that 800 mg twice daily is the preferred dose; the Company's review of the Phase 3 study to determine modifications of the treatment regimes; the
modification the Phase 3 protocol to focus future enrollment on mild Alzheimer's disease patients; the Company's continued study and analysis of the data from the moderate Alzheimer's disease
patients; and the ability of Flurizan to be helpful in early stages of Alzheimer's disease. The forward-looking statements are based on management's current expectation and are subject to certain
risks and uncertainties that could cause actual results to differ materially from those set forth or implied by forward-looking statements. These include, but are not limited to, uncertainties related
to the clinical development of drugs, including that results in earlier stage clinical trials will not be repeated or confirmed in larger, later stage studies; uncertainties as to the extent of future
government regulation of Myriad Genetics' business; uncertainties as to whether Myriad Genetics and its collaborators will be successful in developing, and obtaining regulatory approval for, and
commercial acceptance of, therapeutic compounds; the risk that markets will not exist for therapeutic compounds that Myriad Genetics develops or if such markets exist, that Myriad Genetics will not be
able to sell compounds, which it develops, at acceptable prices; and the risk that the Company will not be able to sustain revenue growth for its predictive medicine business and products. These and
other risks are identified in the Company's filings with the Securities and Exchange Commission, including the Company's Annual Report on Form&nbsp;10-K for the fiscal year ended
June&nbsp;30, 2004. All information in this press release is as of May&nbsp;2, 2005, and Myriad undertakes no duty to update this information unless required by law.</I></FONT></P>

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<FONT SIZE=2><A HREF="#toc_ma1849_1">Myriad Genetics Reports Results of Phase 2 Trial of Flurizan&#153; in Patients with Alzheimer's Disease</A></FONT><BR>

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