10-K 1 d736246d10k.htm 10-K

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K

(Mark One)

x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended June 30, 2014

¨ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission file number: 0-26642

MYRIAD GENETICS, INC.

(Exact name of registrant as specified in its charter)

Delaware |  | 87-0494517
(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)
320 Wakara Way, Salt Lake City, UT |  | 84108
(Address of principal executive offices) |  | (Zip Code)

Registrant’s telephone number, including area code: (801) 584-3600

Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class |  | Name of each exchange on which registered
Common Stock, $.01 Par Value Per Share |  | The NASDAQ Global Select Market

Securities registered pursuant to Section 12(g) of the Exchange Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes x No ¨

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act. Yes ¨ No x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes x No ¨

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of “large accelerated filer”, “accelerated filer”, and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer |  | x |  | Accelerated filer |  | ¨
Non-accelerated filer |  | ¨ (do not check if a smaller reporting company) |  | Smaller reporting company |  | ¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No x

The aggregate market value of the registrant’s common stock held by non-affiliates of the registrant (without admitting that any person whose shares are not included in such calculation is an affiliate), computed by reference to the price at which the common stock was last sold on December 31, 2013, the last business day of the registrant’s most recently completed second fiscal quarter, was $1,547,653,605.

As of August 1, 2014 the registrant had 72,795,117 shares of common stock outstanding.

DOCUMENTS INCORPORATED BY REFERENCE

The following documents (or parts thereof) are incorporated by reference into the following parts of this Form 10-K: Certain information required in Part III of this Annual Report on Form 10-K is incorporated from the Registrant’s Proxy Statement for the Annual Meeting of Stockholders to be held on December 4, 2014.

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TABLE OF CONTENTS

|  |  |  | Page |
PART I |  |  |  |
Item 1. |  | Business |  |  | 3 |
Item 1A. |  | Risk Factors |  |  | 18 |
Item 1B. |  | Unresolved Staff Comments |  |  | 35 |
Item 2. |  | Properties |  |  | 35 |
Item 3. |  | Legal Proceedings |  |  | 36 |
Item 4. |  | Mine Safety Disclosures |  |  | 37 |
PART II |  |  |  |
Item 5. |  | Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  |  | 38 |
Item 6. |  | Selected Financial Data |  |  | 41 |
Item 7. |  | Management’s Discussion and Analysis of Financial Condition and Results of Operations |  |  | 44 |
Item 7A. |  | Quantitative and Qualitative Disclosures About Market Risk |  |  | 55 |
Item 8. |  | Financial Statements and Supplementary Data |  |  | 55 |
Item 9. |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure |  |  | 56 |
Item 9A. |  | Controls and Procedures |  |  | 56 |
Item 9B. |  | Other Information |  |  | 58 |
PART III |  |  |  |
Item 10. |  | Directors, Executive Officers and Corporate Governance |  |  | 59 |
Item 11. |  | Executive Compensation |  |  | 59 |
Item 12. |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters |  |  | 59 |
Item 13. |  | Certain Relationships and Related Transactions, and Director Independence |  |  | 59 |
Item 14. |  | Principal Accounting Fees and Services |  |  | 59 |
PART IV |  |  |  |
Item 15. |  | Exhibits, Financial Statement Schedules |  |  | 60 |
Signatures |  |  | 61 |

“We,” “us,” “Myriad” and the “Company” as used in this Annual Report on Form 10-K refer to Myriad Genetics, Inc., a Delaware corporation, and its subsidiaries.

“Myriad,” BRACAnalysis, BART, COLARIS, COLARIS AP, MELARIS, myPath, myPlan, myChoice, Myriad myRisk, PANEXIA, PREZEON, Prolaris, HRD, Vectra, Vectraview, TruCulture, DiscoveryMAP and RodentMap are registered trademarks or trademarks of Myriad.

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PART I

Item 1. | BUSINESS

Overview

We are a leading molecular diagnostic company dedicated to making a difference in patients’ lives through the discovery and commercialization of novel, transformative tests across major diseases. We believe in improving healthcare for patients by providing physicians with important information to solve unmet medical needs. Through our proprietary technologies, we believe we are positioned to identify important disease genes, the proteins they produce, and the biological pathways in which they are involved to better understand the genetic basis of human disease and the role that genes and their related proteins may play in the onset and progression of disease. We believe that identifying biomarkers (DNA, RNA and proteins) will enable us to develop novel molecular diagnostic tests.

Our goal is to provide physicians with critical information to guide the healthcare management of their patients by addressing four major questions a patient may have about their healthcare: (1) what is the likelihood of my getting a disease, (2) do I have a disease, (3) how aggressively should my disease be treated, and (4) which therapy will work best to treat my disease. We are developing new molecular diagnostic tests that are designed to assess an individual’s risk for developing disease later in life (predictive medicine), accurately diagnose disease (diagnostic medicine), identify a patient’s likelihood of responding to a particular therapy and assess if a patient will benefit from a particular drug (personalized medicine), and assess a patient’s risk of disease progression and disease recurrence (prognostic medicine).

Our business strategy for future growth is focused on three key initiatives. First, we are working to grow and expand our existing products and markets. Second, we are developing our business internationally with an international direct sales force. Finally, we are launching and intend to continue to launch new potentially transformative products across a diverse set of disease indications, complementing our current businesses in oncology, women’s health, urology, dermatology and rheumatology.

In February 2014, we completed the acquisition of privately-held Crescendo Bioscience, Inc. (“Crescendo”) for $270 million in cash, which was reduced by the repayment of a loan made to Crescendo and other customary adjustments in accordance with the acquisition agreement. We believe that the acquisition of Crescendo facilitates our entry into the high growth autoimmune and inflammatory disease market, diversifies our product revenues and enhances our strength in protein-based diagnostics. The business of Crescendo, including its Vectra®DA blood test for rheumatoid arthritis disease management, is operated as a wholly owned subsidiary.

We offer 13 commercial molecular diagnostic tests, consisting of seven predictive medicine tests, three personalized medicine tests, two prognostic medicine tests and one diagnostic medicine test. We market these tests in the United States through our own sales force of approximately 470. We have also established commercial laboratory operations in Munich, Germany and international headquarters in Zurich, Switzerland. We currently market our products through our own sales force in Europe and Canada and have entered into distributor agreements with organizations in selected Latin American, Middle Eastern, Asian and African countries. We also generate revenue by providing pharmaceutical and clinical services to the pharmaceutical and biotechnology industries and medical research institutions utilizing our multiplexed immunoassay technology. Total revenue was $778.2 million for the year ended June 30, 2014, an increase of 27% over the prior fiscal year.

During the fiscal year ended June 30, 2014, we devoted our resources to supporting (i) our predictive medicine, diagnostic medicine, personalized medicine and prognostic medicine tests, (ii) our pharmaceutical and clinical services business, and (iii) our research and development efforts supporting our existing tests and our future molecular diagnostic candidate tests. For the years ended June 30, 2014, 2013 and 2012, we had research and development expense of $67.5 million, $53.7 million and $42.6 million, respectively. Additional financial information about our three reportable segments is included in Note 10 to our audited financial statements for the fiscal year ended June 30, 2014 included with this Annual Report. For the year ended June 30, 2014, we had net income of $176.2 million, an increase of 20% over the prior fiscal year.

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Our Business Strategy

Our business strategy is to understand the genetics of human disease in order to develop and administer the next generation of molecular diagnostic tests. Through our proprietary technologies in discovering DNA, RNA and protein biomarkers, we believe we are positioned to identify important disease genes, the proteins they produce, and the biological pathways in which they are involved to better understand the underlying molecular basis for the cause of human disease. We believe that identifying these genes, proteins, and pathways has enabled and will continue to enable us to develop novel molecular diagnostic tests. Our business strategy includes the following key elements:

| • |  | Discover important DNA, RNA and protein biomarkers and develop novel molecular diagnostic tests. We plan to continue to use our proprietary DNA sequencing, RNA expression and protein analysis technologies, including our supporting bioinformatics and robotic technologies, in an effort to efficiently discover important genes and their proteins and to understand their role in human disease. Based on these biomarkers we plan to develop highly accurate, informative test that may help physicians better manage their patients’ healthcare. We believe that our technologies provide us with a significant competitive advantage and the potential for numerous product opportunities.

| • |  | Acquire companies, products or promising biomarkers from other organizations. We intend to continue to take advantage of in-licensing or acquisition opportunities to augment our internal research and development programs. For example, in February 2014, we acquired Crescendo, a company that is developing and marketing molecular diagnostic tests for patients suffering from autoimmune disorders, including rheumatoid arthritis. We recognize that we cannot meet all of our research discovery goals internally and can benefit from the research performed by other organizations. We hope to leverage our financial strength, product development expertise, and sales and marketing presence to acquire new product opportunities in molecular diagnostic areas of focus.

| • |  | Independently commercialize new transformative molecular diagnostic tests. Our goal is to commercialize informative molecular diagnostic tests that can save lives and improve the quality of life of patients. We plan to sell these tests through our own direct sales force and marketing efforts in the United States and Europe and employ distributors throughout the rest of the world. In connection with any additional tests that we may launch, we plan to expand our existing oncology, urology, and women’s health sales forces and build new sales forces to address other physician specialty groups.

| • |  | Diversify our molecular diagnostic business across multiple disease indications. We plan to continue to expand our markets and increase the market penetration of our existing molecular diagnostic tests in oncology, women’s health, urology, dermatology, autoimmune and rheumatology. Additionally, we plan to pursue new market opportunities in other adult-onset diseases such as diabetes and the neuroscience diseases to capitalize on our leadership position in the molecular diagnostic industry.

| • |  | Expand our molecular diagnostic business internationally. We believe that the market for our molecular diagnostic products in Europe, Latin America and Asia represents an attractive commercial opportunity. We have established sales offices in Germany, France, United Kingdom, Spain, Switzerland, Italy, Australia and Canada; laboratory operations in Germany; and international headquarters in Switzerland. We believe that our predictive medicine, diagnostic medicine, personalized medicine and prognostic medicine products would benefit patients world-wide by assisting physicians in guiding their health care decisions.

Molecular Diagnostic Testing

Our molecular diagnostic tests are designed to analyze genes, accurately diagnose disease, their expression levels and proteins to assess an individual’s risk for developing disease later in life, determine a patient’s likelihood of responding to a particular drug, and assess a patient’s risk of disease progression and disease recurrence. Armed with this valuable information, physicians may more effectively manage their patient’s healthcare to prevent or delay the onset of disease and ensure that patients receive the most appropriate treatment for their disease.

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We offer 13 primary commercial molecular diagnostic tests. Our current commercial molecular diagnostic tests are:

| • |  | BRACAnalysis ®: predictive medicine test for hereditary breast and ovarian cancer. Our BRACAnalysis test is an analysis of the BRCA1 and BRCA2 genes for assessing a woman’s risk of developing hereditary breast and ovarian cancer. A woman who tests positive for a deleterious mutation with the BRACAnalysis test has up to an 87% risk of developing breast cancer and up to a 44% risk of developing ovarian cancer by age 70. As published in the Journal of the National Cancer Institute, researchers have shown that pre-symptomatic individuals who have a high risk of developing breast or ovarian cancer can reduce their risk by over 50% with appropriate preventive therapies. Additionally, BRACAnalysis may be used to assist patients already diagnosed with breast or ovarian cancer and their physicians in determining the most appropriate therapeutic interventions to address their disease.

According to the American Cancer Society, in 2014 there will be approximately 257,000 women in the United States diagnosed with breast cancer or ovarian cancer. BRACAnalysis accounted for 66.5% of our total revenue during the year ended June 30, 2014.

BART ®: predictive medicine test for hereditary breast and ovarian cancer. Our BART test is based on proprietary technology for detecting large genomic rearrangements in the genes involved in hereditary breast and ovarian cancer patients. As published in the journal Cancer, researchers have shown that up to 10% of hereditary breast and ovarian cancer susceptibility is due to large rearrangement mutations that can’t be detected using conventional sequencing technology. BART may be used to identify these mutation carriers. BART accounted for 11.5% of our total revenue during the year ended June 30, 2014.

| • |  | COLARIS ®: predictive medicine test for hereditary colorectal and uterine cancer. Our COLARIS test is an analysis of the MLH1, MSH2, MSH6, PMS2, EPCAM and MYH genes for assessing a person’s risk of developing colorectal and uterine cancer. Individuals who carry a deleterious mutation in one of the colon cancer genes in the COLARIS test have a greater than 80% lifetime risk of developing colon cancer and women have up to a 71% lifetime chance of developing uterine cancer. Colon cancer is a preventable disease if high-risk individuals diligently have colonoscopies and remove any precancerous polyps.

According to the American Cancer Society, approximately 189,000 new cases of colorectal cancer or uterine cancer will be diagnosed in the United States in 2014. According to the American Society of Clinical Oncologists, familial forms of colorectal cancer are estimated to account for 10% to 30% of all cases.

| • |  | COLARIS AP®: predictive medicine test for hereditary colorectal cancer. Our COLARIS AP test detects mutations in the APC and MYH genes, which cause a colon polyp-forming syndrome such as familial adenomatous polyposis (FAP), a more common variation of the syndrome known as attenuated FAP, and the MYH-associated polyposis signature (MAP). Individuals who carry a deleterious mutation in the APC or MYH gene may have a greater than 90% lifetime risk of developing colon cancer. Effective preventive measures include colonoscopy and the removal of pre-cancerous polyps and prophylactic surgery.

COLARIS and COLARIS AP accounted for 7.6% of our total revenue during the year ended June 30, 2014.

| • |  | EndoPredict: personalized medicine test for breast cancer. Our EndoPredic test is a next generation RNA expression test used to determine which women with breast cancer would benefit from chemotherapy. EndoPredict detects the likelihood of late metastases, metastases occurring after five years, to guide treatment decisions for chemotherapy and extended anti-hormonal therapy. EndoPredict has been shown to accurately predict cancer-specific disease progression and metastases with no confusing intermediate results in 13 published clinical studies with more than 2,200 patients and is CE marked.

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EndoPredict revenues are included in Other Revenue which accounted for 1.8% of our total revenue for the year ended June 30, 2014.

| • |  | MELARIS ®: predictive medicine test for hereditary melanoma. Our MELARIS test analyzes mutations in the p16 gene to determine genetic susceptibility to malignant melanoma. Individuals who test positive with a MELARIS test have a 75-fold increased risk of developing melanoma during their lifetimes as compared to the general population. Melanoma is lethal within five years in 84% of cases where it has spread to another site in the body. However, when melanoma is diagnosed at an early stage, fewer than 10% of patients die within five years. Melanoma may be prevented through appropriate screening and a specific threshold of action for mutation carriers in which pre-cancerous lesions are removed before cancer can develop.

According to the American Cancer Society, approximately 76,000 new cases of melanoma will be diagnosed in the United States in 2014. MELARIS revenues are included in Other Revenue which accounted for 1.8% of our total revenue for the year ended June 30, 2014.

| • |  | myPath™ Melanoma: diagnostic medicine test for melanoma. Our myPath Melanoma test is a gene expression based profile that is performed on biopsy tissue for the purpose of aiding a dermatopathologist in the diagnosis of melanoma. Every year in the United States, there are approximately two million skin biopsies performed specifically for the diagnosis of melanoma. Approximately 14% of these biopsies are classified as indeterminate where a dermatopathologist cannot make a definitive call of whether the biopsy is benign or malignant. Outcomes for patients are poor if melanoma is not caught in early stages with five year survival rates dropping from 98% for stage 1 cancer to less than 20% for stage 4 cancer based upon data from the American Cancer Society. We believe myPath Melanoma may provide an accurate tool to assist physicians in correctly diagnosing indeterminate skin lesions.

There are approximately 280,000 indeterminate diagnosis of melanoma every year in the United States. myPath Melanoma was released through an early access launch which began in November 2013.

| • |  | myPlan™ Lung Cancer: prognostic medicine test for lung cancer. Our myPlan Lung Cancer test is a gene expression based profile that may aid a physician in making a determination as to the aggressiveness of a patient’s lung cancer and based upon this determination more accurately guide patient therapy. Most early stage lung cancer patients do not see added benefit from chemotherapy. In a clinical study presented at the International Association for the Study of Lung Cancer meeting in 2013, 18% of patients with a myPlan Lung Cancer low-risk score died of lung cancer within five years of diagnosis compared to 35% of the patients with a high-risk score. We believe this test may be clinically applicable in the approximately 30,000 new lung cancer diagnoses every year that are early stage lung cancer.

Based on American Lung Association data, approximately 34,000 new early stage cancer cases will be diagnosed in the United States in 2014. myPlan Lung Cancer was released through an early access launch which began in October 2013.

| • |  | myRisk Hereditary Cancer™: predictive medicine test for hereditary cancer. Our myRisk Hereditary Cancer test represents the next generation of our existing hereditary cancer franchisem which we anticipate will eventually replace our current predictive medicine test offerings (BRACAnalysis, Colaris, Colaris AP, Melaris, and Panexia) with a single comprehensive test. myRisk Hereditary Cancer is designed to determine a patient’s hereditary cancer risk for breast cancer, ovarian cancer, colon cancer, uterine cancer, melanoma, pancreatic cancer, prostate cancer and gastric cancer. The test analyzes 25 separate genes to look for deleterious mutations which would put a patient at a substantially higher risk than the general population for developing one or more of the above cancers. All 25 genes in the panel are well documented in clinical literature for the role they play in hereditary cancer and have been shown to have actionable clinical interventions for the patient to lower disease risk or risk of cancer recurrence.

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Based on current American Cancer Society data, in the United States there are over 600,000 new cancer diagnoses in the six cancers covered by myRisk Hereditary Cancer every year. myRisk Hereditary Cancer accounted for 6.9% of our total revenue during the year ended June 30, 2014 . myRisk Hereditary Cancer was initially released through an early access launch which began in September 2013.

| • |  | PANEXIA™: predictive medicine test for pancreatic cancer. Our PANEXIA test is a comprehensive analysis of the PALB2 and BRCA2 genes for assessing a person’s risk of developing pancreatic cancer later in life. Individuals with a mutation detected by the PANEXIA test have up to an 8.6-fold higher risk than the general population of developing pancreatic cancer. If an individual with a family history of pancreatic cancer receives the PANEXIA test and is identified as having a deleterious mutation, increased surveillance and other predictive steps can be taken in an effort to detect the cancer at an early stage where it may be more treatable.

According to the American Cancer Society, pancreatic cancer is estimated to affect approximately 46,000 men and women in the United States in 2014. PANEXIA revenues are included in Other Revenue which accounted for 1.8% of our total revenue for the year ended June 30, 2014.

| • |  | PREZEON®: personalized medicine test for cancer. Our PREZEON test is an immunohistochemistry test that analyzes the PTEN gene and assesses loss of PTEN function in cancerous tumors. The PTEN gene is one of the most important tumor suppressor genes and its loss of function is associated with more aggressive disease progression and poorer survival. The PTEN gene plays a role in the disease progression of all four of the major cancers—breast, prostate, colon, and lung cancer. The PTEN gene also plays a critical role in cell signaling pathways that are the target of a number of cancer drugs such as EGFR, mTOR and PIK3CA inhibitors. Analysis of PTEN function may help oncologists in identifying patients who will likely respond to these classes of cancer drugs.

According to the American Cancer Society, approximately 789,000 new cases of these cancers will be diagnosed this year in the United States. PREZEON revenues are included in Other Revenue which accounted for 1.8% of our total revenue for the year ended June 30, 2014.

| • |  | Prolaris®: prognostic medicine test for prostate cancer. Our Prolaris test is a gene expression assay that assesses whether a patient is likely to have a slow growing, indolent form of prostate cancer that can be safely monitored through active surveillance, or a more aggressive form of the disease that would warrant aggressive intervention such as a radical prostatectomy or radiation therapy. The Prolaris test was developed improve physicians’ ability to predict disease outcome and to thereby optimize patient treatment. As published in the British Journal of Cancer, the Prolaris test was the strongest predictor of prostate cancer death and was highly statistically significant. The Prolaris test outperformed both the Gleason and PSA score in this study.

According to the American Cancer Society, in the United States approximately 233,000 men are expected to be diagnosed with prostate cancer in 2014. Prolaris revenues are included in Other Revenue which accounted for 1.8% of our total revenue for the year ended June 30, 2014.

| • |  | Vectra®DA; personalized medicine test for rheumatoid arthritis. Our Vectra DA test is a quantitative, objective multi-biomaker blood test validated to measure rheumatoid arthritis (RA) disease activity. Vectra DA assesses multiple mechanisms and pathways associated with RA disease activity and integrates the concentrations of 12 serum proteins into a single score reported on a scale of 1 to 100. The test may be used throughout the course of a patient’s disease and provides clinicians with expanded insight on disease severity, risk of radiographic progression, response to therapy and the effect of comorbidities.

According to the Arthritis Foundation, there are over 1.3 million Americans with rheumatoid arthritis. Vectra DA accounted for 1.8% of our total revenue during the year ended June 30, 2014.

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Pharmaceutical and Clinical Services (formerly Companion Diagnostic Services)

In May 2011, we completed the acquisition of the privately-held molecular diagnostic company, Rules-Based Medicine, Inc. of Austin, Texas, for a cash purchase price of approximately $80.0 million. As of June 30, 2014, Rules-Based Medicine is operating as a wholly-owned subsidiary of Myriad under the name of Myriad RBM, Inc. (“Myriad RBM”). The acquisition expanded our test pipeline into new disease states, including neuroscience disorders, infectious diseases and inflammatory diseases. We believe that the tests being developed by Myriad RBM will complement the tests that we are developing using our strength in nucleic acid (DNA and RNA) analysis with proprietary multiplex immunoassay (protein) technology. Myriad RBM has strategic collaborations with approximately 20 major pharmaceutical and biotechnology companies, which we believe, coupled with our industry-leading position in PARP inhibitor and PI3K inhibitor pharmaceutical and clinical services, creates a leading franchise in pharmaceutical and clinical services. In addition, our acquisition of Myriad RBM has provided us with access to samples from additional patient cohorts for new molecular diagnostic test development and clinical validation activities.

Through Myriad RBM, we provide biomarker discovery and pharmaceutical and clinical services to the pharmaceutical, biotechnology, and medical research industries utilizing our multiplexed immunoassay technology. Our technology enables us to efficiently screen large sets of well-characterized clinical samples from both diseased and non-diseased populations against our extensive menu of biomarkers. During the year ended June 30, 2014, Myriad RBM generated $30.0 million in revenue from providing its pharmaceutical and clinical services. In addition to the fees received from analyzing these samples, we also use this information to create and validate potential companion diagnostic test panels.

Our pharmaceutical and clinical services consist of the following:

| • |  | Multi-Analyte Profile (“MAP”): We have compiled a library of over 550 individual human and rodent immunoassays for use in our multi-analyte profile (MAP) testing services and we are continuously adding new assays to this library. We have assembled what we believe are the most clinically relevant human immunoassays from this library into our DiscoveryMAP® assay panel, which we typically employ with pharmaceutical collaborators in human clinical trials. We have also developed RodentMAP®, a proprietary panel for use in pre-clinical animal studies and OncologyMAP®, which measures cancer-related proteins to assist researchers accelerate the pace of discovery, validation and translation of cancer biomarkers for early detection, patient stratification and therapeutic monitoring. Importantly, the data generated through our pharmaceutical and clinical services business can provide new insights into biological systems and enable us to generate potential new companion diagnostic tests. Under the terms of the agreements with many of our collaborators, we retain the rights to the companion diagnostic products. We have licensed rights to the Luminex platform used in our MAP testing services.

| • |  | TruCulture®: TruCulture is a simple, self-contained whole blood culture that can be deployed to clinical sites around the world for acquiring cell culture data without specialized facilities. The TruCulture system may allow pharmaceutical and biotechnology companies to identify drug toxicity prior to human trials, potentially enabling a decision as to whether to continue a drug’s development earlier in the development process and thereby save significant research and development costs.

Multiplexed Immunoassay Kits: Many of our pharmaceutical and biotechnology customers need bioassay kits for complimentary in-house testing. Therefore, we have developed multiplexed immunoassay kits that enable our customers to leverage our technology services with their in-house capabilities.

Patents and Proprietary Rights

We own or have license rights to 252 issued patents as well as numerous patent applications in the United States and foreign countries. These patents and patent applications cover a variety of subject matter including, diagnostic biomarkers, gene expression signatures, antibodies, primers, probes, assays, disease-associated genetic

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mutations, methods for determining genetic predisposition, methods for disease diagnosis, methods for determining disease progression, methods for disease treatment, and general molecular diagnostic techniques. For many of the patents, we hold rights through exclusive or non-exclusive license agreements, which are summarized in the following section under the caption “License Agreements.” We also own additional patent applications and hold other non-exclusive license rights to patents which cover various aspects of our tests or processes.

BRACAnalysis. We own or have exclusive license rights to over 500 claims in 25 issued U.S. patents relating to BRACAnalysis testing. These U.S. patents have terms that are expected to expire commencing in 2014, with the last patent expected to expire in 2029. These patents contain multiple claims, including claims relating to compositions of matter on synthetic BRCA1 and BRCA2 nucleic acids, probes and primers, methods of detecting genetic mutations in the BRCA1 and BRCA2 genes and the use thereof for diagnosing predisposition to breast or ovarian cancer, and general molecular diagnostic technology relating to BRACAnalysis testing.

BART. We own or have exclusive license rights to seven issued U.S. patents relating to BART testing. These U.S. patents have terms that are expected to expire commencing in 2015, with the last patent expected to expire in 2025. These patents contain multiple claims, including but not limited to claims relating to composition of matter on synthetic BRAC1 and BRCA2 nucleic acids, composition of matter on probes and primers, methods of detecting genomic rearrangements and methods of determining BRCA1 and BRCA2 related predisposition to cancer.

COLARIS. We own or have exclusive or non-exclusive license rights to 19 issued U.S. patents relating to COLARIS testing. These U.S. patents have terms that began to expire commencing in 2013, with the last patent expected to expire in 2023. These patents contain multiple claims, including but not limited to claims relating to MLH1, MSH2, PMS2 and MYH compositions of matter on synthetic MLH1, MSH2, PMS2 and MYH nucleic acids, methods of detecting mutations in the MLH1, MSH2 and MYH genes, methods for determining MLH1-, MSH2-, PMS2-, and MYH- related predisposition to cancer, such as Lynch Syndrome cancers, and general molecular diagnostic technology applicable to COLARIS testing.

COLARIS AP. We own or have exclusive license rights to 11 issued U.S. patents relating to COLARIS AP testing. These U.S. patents have terms that are expected to expire commencing in 2017, with the last patent expected to expire in 2026. These patents contain multiple claims, including claims relating to MYH compositions of matter on synthetic MYH nucleic acids, methods of detecting MYH mutations and methods of detecting a predisposition to colorectal cancer using MYH, and general molecular diagnostic technology applicable to COLARIS AP testing.

myRisk Hereditary Cancer. We own or have exclusive license rights to 54 issued U.S. patents and 3 pending U.S. patent applications relating to myRisk Hereditary Cancer TM testing. Subject to applicable extensions, we anticipate that the expiration dates of these patents will commence in 2014, with the last patent, if issued from the currently pending applications, expected to expire in 2029. These patents and patent applications disclose and claim varied subject matter, including claims relating to compositions of matter on synthetic nucleic acids, probes and primers, methods of detecting genetic mutations in the 25 genes that comprise the test (individually and in numerous combinations) and the use thereof for diagnosing predisposition to various cancers, and general molecular diagnostic technology relating to myRisk Hereditary.

We intend to seek patent protection in the United States and major foreign jurisdictions for synthetic nucleic acids, antibodies, biomarker signatures, assays, probes, primers, technologies, methods, processes and other inventions which we believe are patentable and where we believe our interests would be best served by seeking patent protection. However, any patents issued to us or our licensors may not afford meaningful protection for our products or technology or may be subsequently circumvented, invalidated or narrowed or found unenforceable, such as occurred in the U.S. Supreme Court case of Association for Molecular Pathology et al. v. Myriad Genetics, Inc. et al., in which the court ruled that a naturally occurring DNA segment is a product of

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nature and not patent eligible merely because it has been isolated. Any patent applications which we have filed or will file or to which we have licensed or will license rights may not issue, and patents that do issue may not contain commercially valuable claims. In addition, others may obtain patents having claims which cover aspects of our tests or processes which are necessary for or useful to the development, use or performance of our diagnostic products. Should any other group obtain patent protection with respect to our discoveries, our commercialization of our molecular diagnostic tests could be limited or prohibited.

Others may offer clinical diagnostic genomic laboratory testing services which may infringe patents we control. We may seek to negotiate a license to use our patent rights or decide to seek enforcement of our patent rights through litigation. Patent litigation is expensive and the outcome is often uncertain and we may not be able to enforce our patent rights against others. For example, as discussed in Item 3, Legal Proceedings, we have filed complaints against seven companies who are offering laboratory testing services which we believe infringe our patent rights.

Our tests and processes may also conflict with patents which have been or may be granted to competitors, academic institutions or others. In addition, third parties could bring legal actions against us seeking to invalidate our owned or licensed patents, claiming damages, or seeking to enjoin clinical testing, developing and marketing of our tests or processes. If any of these actions are successful, in addition to any potential liability for damages, we could lose patent coverage for our tests, be required to cease the infringing activity or obtain a license in order to continue to develop or market the relevant test or process. We may not prevail in any such action, and any license required under any such patent may not be made available on acceptable terms, if at all. Our failure to maintain patent protection for our test and processes or to obtain a license to any technology that we may require to commercialize our tests and technologies could have a material adverse effect on our business.

We also rely upon unpatented proprietary technology, and in the future may determine in some cases that our interests would be better served by reliance on trade secrets or confidentiality agreements rather than patents or licenses. These include some of our genomic, proteomic, RNA expression, mutation analysis, IHC, robotic and bioinformatic technologies which may be used in discovering and characterizing new genes and proteins and ultimately used in the development or analysis of molecular diagnostic tests. We also maintain a database of gene mutations and their status as either harmful or benign for all of our predictive medicine tests. To further protect our trade secrets and other proprietary information, we require that our employees and consultants enter into confidentiality and invention assignment agreements. However, those confidentiality and invention assignment agreements may not provide us with adequate protection. We may not be able to protect our rights to such unpatented proprietary technology and others may independently develop substantially equivalent technologies. If we are unable to obtain strong proprietary rights to our processes or tests, competitors may be able to market competing processes and tests.

License Agreements

We are a party to multiple license agreements which give us the rights to use certain technologies in the research, development, testing processes, and commercialization of our molecular diagnostic tests and pharmaceutical and clinical services. We may not be able to continue to license these technologies on commercially reasonable terms, if at all. Additionally, patents underlying our license agreements may not afford meaningful protection for our technology or tests or may be subsequently circumvented, invalidated or narrowed, or found unenforceable. Our failure to maintain rights to this technology could have a material adverse effect on our business.

In October 1991, we entered into a license agreement with the University of Utah Research Foundation (the “University”), for the exclusive rights to utilize certain intellectual property rights of the University, including issued patents that relate to the BRCA1 gene, on a world-wide basis. Under this license agreement we pay the University a royalty based on net sales of our BRACAnalysis test. This license agreement ends on the last to expire patent covered by the license agreement which presently is not anticipated to expire until April 2015. The University has the right to terminate the license agreement for the uncured breach of any material term of the license agreement.

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We entered into separate license agreements with the University, Endorecherche, Inc., The Hospital for Sick Children and The Trustees of the University of Pennsylvania (collectively referred to as the “BRCA2 Licensors”) in November 1994, January 1995, March 1995 and March 1996, respectively, for exclusive rights to utilize certain intellectual property rights of the respective BRCA2 Licensors, including issued patents that relate to the BRCA2 gene, on a world-wide basis. Under these license agreements we pay each of the BRCA2 Licensors a royalty based on net sales of our BRACAnalysis test and myRisk Herediatry Cancer test. Each of these license agreements ends on the expiration date of the last to expire patent covered by the respective license agreements which presently is not anticipated to expire until December 2015. The BRCA2 Licensors have the right to terminate the license agreements for the uncured breach of any material term of the license agreements.

In April 2000, we entered into license agreements with Genzyme Corporation and with Dana-Farber Cancer Institute, Inc., Oregon Health Sciences University, University of Vermont and State Agricultural College and Yale University (collectively the “COLARIS Licensors”) for the non-exclusive rights to utilize certain intellectual property rights of the COLARIS Licensors, including issued patents that relate to the MLH1, MSH2 and PMS2 genes, on a world-wide basis. Under these license agreements we pay the COLARIS Licensors a royalty based on net sales of our COLARIS test and our myRisk Hereditary Cancer test. This license agreement ends on the expiration date of the last to expire patent covered by the license agreement, which presently is not anticipated to expire until October 2023. The COLARIS Licensors have the right to terminate the license agreement for the uncured breach of any material term of the license agreement.

Competition

Competition is intense in our existing and potential markets. Our competitors in the United States and abroad are numerous and include, other molecular diagnostic companies, diagnostic reference laboratories, large multi-national healthcare companies, and universities and other research institutions. For instance, some laboratories provide a test intended to predict the cancer’s aggressiveness among patients with prostate cancer and other laboratories provide hereditary cancer testing for melanoma, breast, ovarian, colorectal and uterine cancer. Some of our potential competitors have considerably greater financial, technical, marketing and other resources than we do. We expect competition to intensify in our current fields as technical advances occur and become more widely known. For example, following our Supreme Court case discussed in Item 3, Legal Proceedings, a number of companies commenced offering certain clinical diagnostic testing for hereditary breast and ovarian cancer that compete with our BRACAnalysis testing and future molecular diagnostic testing we plan to launch. We anticipate that others may also launch their own molecular diagnostic tests which may compete with our testing products and services.

The technologies for discovering the underlying cause of major diseases, patients’ response to therapies, and disease progression, as well as the approaches for commercializing those discoveries are rapidly evolving. Rapid technological developments could result in our potential tests or processes becoming obsolete before we recover a significant portion of our related research and development costs and associated capital expenditures. If we do not discover biomarkers, develop molecular diagnostic tests and related information services based on such discoveries, obtain regulatory and other approvals, and launch such services before our competitors, we could be adversely affected. Moreover, any molecular diagnostic tests that we may develop could be made obsolete by less expensive or more effective tests or methods that may be developed in the future.

Governmental Regulation

The services that we provide are regulated by federal, state and foreign governmental authorities. Failure to comply with the applicable laws and regulations can subject us to repayment of amounts previously paid to us, significant civil and criminal penalties, loss of licensure, certification, or accreditation, or exclusion from government health care programs. The significant areas of regulation are summarized below.

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Clinical Laboratory Improvement Amendments of 1988 and State Regulation

Each of our clinical laboratories must hold certain federal, state and local licenses, certifications and permits to conduct our business. Laboratories in the United States that perform testing on human specimens for the purpose of providing information for the diagnosis, prevention, or treatment of disease are subject to the Clinical Laboratory Improvement Amendments of 1988, or (“CLIA”). CLIA requires such laboratories to be certified by the federal government and mandates compliance with various operational, personnel, facilities administration, quality and proficiency testing requirements intended to ensure that testing services are accurate, reliable and timely. CLIA certification also is a prerequisite to be eligible to bill state and federal health care programs, as well as many private insurers, for laboratory testing services. Our laboratories in Salt Lake City, Utah, Austin, Texas and South San Francisco, California are CLIA certified to perform high complexity tests.

In addition, CLIA requires our certified laboratories to enroll in an approved proficiency testing program if it performs testing in any category for which proficiency testing is required. Our laboratories periodically test specimens received from an outside proficiency testing organization and then submit the results back to that organization for evaluation. If our laboratories fails to achieve a passing score on a proficiency test they lose their right to perform testing. Further, failure to comply with other proficiency testing regulations, such as the prohibition on referral of a proficiency testing specimen to another laboratory for analysis, can result in revocation of our laboratories’ CLIA certification.

As a condition of CLIA certification, each of our laboratories is subject to survey and inspection every other year, in addition to being subject to additional random inspections. The biennial survey is conducted by the Centers for Medicare & Medicaid Services (“CMS”), a CMS agent (typically a state agency), or, a CMS-approved accreditation organization. Our laboratories are accredited by the College of American Pathologists (“CAP”), which is a CMS-approved accreditation organization.

CLIA provides that a state may adopt laboratory regulations that are more stringent than those under federal law. Our laboratories are licensed by the appropriate state agencies in the states in which they operate, if such licensure is required. In addition, our laboratories hold state licenses from California, Florida, New York, Pennsylvania, Rhode Island and Maryland, to the extent that they accept specimens from one or more of these states, each of which require out-of-state laboratories to obtain licensure. If a laboratory is out of compliance with state laws or regulations governing licensed laboratories, penalties for violation vary from state to state but may include suspension, limitation, revocation or annulment of the license, assessment of financial penalties or fines, or imprisonment. We believe that we are in material compliance with all applicable licensing laws and regulations.

Food and Drug Administration

Although the Food and Drug Administration (FDA) has consistently claimed that it has the authority to regulate laboratory-developed tests (“LDTs”) that are developed, validated and performed only by a CLIA certified laboratory, it has historically exercised enforcement discretion in not otherwise regulating most LDTs. Nevertheless, the FDA recently indicated that it is promulgating draft guidance for FDA regulation of most LDTs in the future.

We are developing companion diagnostic tests for use with drug products in development by pharmaceutical companies, such as our collaborations with pharmaceutical companies on PARP inhibitors for the treatment of ovarian, breast and other cancers. Companion diagnostic tests are subject to regulation by the FDA as medical devices. The FDA issued Guidance on In-Vitro Companion Diagnostic Devices in July 2014, which is intended to assist companies developing in vitro companion diagnostic devices and companies developing therapeutic products that depend on the use of a specific in vitro companion diagnostic for the safe and effective use of the product. The FDA defined an in-vitro companion diagnostic device (“IVD”) Companion Dx, as a device that provides information that is essential for the safe and effective use of a corresponding therapeutic product. The

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FDA expects that the therapeutic sponsor will address the need for an approved or cleared IVD Companion Dx in its therapeutic product development plan and that, in most cases, the therapeutic product and its corresponding companion diagnostic will be developed contemporaneously. We have submitted portions of a premarket approval (“PMA”) for BRACAnalysisCDx to the FDA. The premarket approval process is a complex, costly and time consuming procedure. PMAs must be supported by valid scientific evidence, which typically requires extensive data, including quality technical, preclinical, clinical and manufacturing data to demonstrate to the FDA’s satisfaction the safety and effectiveness of the companion diagnostic.

After a medical device is placed on the market, numerous regulatory requirements apply. These include:

| • |  | compliance with the QSR, which require manufacturers to follow stringent design, testing, control, documentation, record maintenance, including maintenance of complaint and related investigation files, and other quality assurance controls during the manufacturing process;

| • |  | labeling regulations, which prohibit the promotion of products for uncleared, unapproved or “off-label” uses and impose other restrictions on labeling; and

| • |  | medical device reporting obligations, which require that manufacturers investigate and report to the FDA adverse events, including deaths, or serious injuries that may have been or were caused by a medical device and malfunctions in the device that would likely cause or contribute to a death or serious injury if it were to recur.

Failure to comply with applicable regulatory requirements can result in enforcement action by the FDA, which may include sanctions, including but not limited to, warning letters; fines, injunctions, and civil penalties; recall or seizure of the device; operating restrictions, partial suspension or total shutdown of production; refusal to grant 510(k) clearance or PMA approvals of new devices; withdrawal of 510(k) clearance or PMA approvals; and civil or criminal prosecution. To ensure compliance with regulatory requirements, medical device manufacturers are subject to market surveillance and periodic, pre-scheduled and unannounced inspections by the FDA.

HIPAA and other privacy laws

The Health Insurance Portability and Accountability Act of 1996 (“HIPAA”), established comprehensive federal protection for the privacy and security of health information. The HIPAA standards apply to three types of organizations: health plans, healthcare clearing houses, and healthcare providers which conduct certain healthcare transactions electronically (“Covered Entities”). Title II of HIPAA, the Administrative Simplification Act, contains provisions that address the privacy of health data, the security of health data, the standardization of identifying numbers used in the healthcare system and the standardization of certain healthcare transactions. The privacy regulations protect medical records and other protected health information by limiting their use and release, giving patients the right to access their medical records and limiting most disclosures of health information to the minimum amount necessary to accomplish an intended purpose. The HIPAA security standards require the adoption of administrative, physical, and technical safeguards and the adoption of written security policies and procedures.

On February 17, 2009, Congress enacted Subtitle D of the Health Information Technology for Economic and Clinical Health Act, or HITECH, provisions of the American Recovery and Reinvestment Act of 2009. HITECH amends HIPAA and, among other things, expands and strengthens HIPAA, creates new targets for enforcement, imposes new penalties for noncompliance and establishes new breach notification requirements for Covered Entities. Regulations implementing major provisions of HITECH were finalized on January 25, 2013 through publication of the HIPAA Omnibus Rule (the “Omnibus Rule”).

Under HITECH’s new breach notification requirements, Covered Entities must report breaches of protected health information that has not been encrypted or otherwise secured in accordance with guidance from the

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Secretary of the U.S. Department of Health and Human Services (the “Secretary”). Required breach notices must be made as soon as is reasonably practicable, but no later than 60 days following discovery of the breach. Reports must be made to affected individuals and to the Secretary and in some cases, they must be reported through local and national media, depending on the size of the breach. Breach reports can lead to investigation and enforcement.

We are currently subject to the HIPAA regulations and maintain an active compliance program that is designed to identify security incidents and other issues in a timely fashion and enable us to remediate, mitigate harm or report if required by law. We are subject to prosecution and/or administrative enforcement and increased civil and criminal penalties for non-compliance, including a new, four-tiered system of monetary penalties adopted under HITECH. We are also subject to enforcement by state attorneys general who were given authority to enforce HIPAA under HITECH. To avoid penalties under the HITECH breach notification provisions, we must ensure that breaches of protected health information are promptly detected and reported within the company, so that we can make all required notifications on a timely basis. However, even if we make required reports on a timely basis, we may still be subject to penalties for the underlying breach.

In addition to the federal privacy regulations, there are a number of state laws regarding the privacy and security of health information and personal data that are applicable to our clinical laboratories. Many states have also implemented genetic testing and privacy laws imposing specific patient consent requirements and protecting test results by strictly limiting the disclosure of those results. State requirements are particularly stringent regarding predictive genetic tests, due to the risk of genetic discrimination against healthy patients identified through testing as being at a high risk for disease. We believe that we have taken the steps required of us to comply with health information privacy and security statutes and regulations, including genetic testing and genetic information privacy laws in all jurisdictions, both state and federal. However, we may not be able to maintain compliance in all jurisdictions where we do business. Failure to maintain compliance, or changes in state or federal laws regarding privacy or security, could result in civil and/or criminal penalties and could have a material adverse effect on our business.

We are subject to laws and regulations related to the protection of the environment, the health and safety of employees and the handling, transportation and disposal of medical specimens, infectious and hazardous waste and radioactive materials. For example, the U.S. Occupational Safety and Health Administration (“OSHA”), has established extensive requirements relating specifically to workplace safety for healthcare employers in the U.S. This includes requirements to develop and implement multi-faceted programs to protect workers from exposure to blood-borne pathogens, including preventing or minimizing any exposure through needle stick injuries. For purposes of transportation, some biological materials and laboratory supplies are classified as hazardous materials and are subject to regulation by one or more of the following agencies: the U.S. Department of Transportation, the U.S. Public Health Service, the United States Postal Service and the International Air Transport Association. We generally use third-party vendors to dispose of regulated medical waste, hazardous waste and radioactive materials and contractually require them to comply with applicable laws and regulations.

International regulations

We market our tests outside of the United States and are subject to foreign regulatory requirements governing laboratory licensure, human clinical testing, use of tissue, privacy and data security, and marketing approval for our tests. These requirements vary by jurisdiction, differ from those in the United States and may require us to implement additional compliance measures or perform additional pre-clinical or clinical testing. On September 26, 2012, the European Commission released the first drafts of the new European Union (“EU”) regulations for medical devices and IVDs that if finalized will impose additional regulatory requirements on IVDs used in the EU. In many countries outside of the United States, coverage, pricing and reimbursement approvals are also required. We are also required to maintain accurate information and control over sales and distributors’ activities that may fall within the purview of the Foreign Corrupt Practices Act, its books and records provisions and its anti-bribery provisions.

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Reimbursement and Billing

Reimbursement and billing for diagnostic services is generally highly complex. Laboratories must bill various payors, such as private third-party payors, including MCOs and state and federal health care programs, such as Medicare and Medicaid, and each may have different billing requirements. Additionally, the audit requirements we must meet to ensure compliance with applicable laws and regulations, as well as our internal compliance policies and procedures, add further complexity to the billing process. Other factors that complicate billing include:

| • |  | variability in coverage and information requirements among various payors;

| • |  | missing, incomplete or inaccurate billing information provided by ordering physicians;

| • |  | billings to payors with whom we do not have contracts;

| • |  | disputes with payors as to which party is responsible for payment; and

| • |  | disputes with payors as to the appropriate level of reimbursement.

Depending on the reimbursement arrangement and applicable law, the party that reimburses us for our services may be:

| • |  | a third party who provides coverage to the patient, such as an insurance company or MCO;

| • |  | a governmental payor; or

| • |  | the patient.

Presently, approximately 85% of our revenue comes from third party payors.

In February 2011, the American Medical Association CPT Editorial Panel approved 101 new molecular pathology codes to describe molecular diagnostic tests that currently require multiple CPT codes for billing purposes. The new reimbursement rates for the new codes went into effect on January 1, 2013.

Federal and State Fraud and Abuse Laws

A variety of federal laws prohibit fraud and abuse involving state and federal health care programs, such as Medicare and Medicaid. These laws are interpreted broadly and enforced aggressively by various state and federal agencies, including CMS, the Department of Justice, the Office of Inspector General for the Department of Health and Human Services (“OIG”), and various state agencies. In addition, the Medicare and Medicaid programs increasingly use a variety of contractors to review claims data and to identify improper payments as well as fraud and abuse. Any overpayments identified must be repaid to the Medicare program unless a favorable decision is obtained on appeal. In some cases, these overpayments can be used as the basis for an extrapolation, by which the error rate is applied to a larger universe of claims, and which can result in even higher repayments.

Anti-Kickback Laws

The Anti-Kickback Statute prohibits, among other things, knowingly and willfully offering, paying, soliciting, receiving or providing remuneration, directly or indirectly, in exchange for or to induce either the referral of an individual, or the furnishing, arranging for or recommending of an item or service that is reimbursable, in whole or in part, by a federal health care program. “Remuneration” is broadly defined to include anything of value, such as, for example, cash payments, gifts or gift certificates, discounts, or the furnishing of services, supplies or equipment. The Anti-Kickback Statue is broad and prohibits many arrangements and practices that are lawful in businesses outside of the health care industry.

Recognizing the breadth of the Anti-Kickback Statute and the fact that it may technically prohibit many innocuous or beneficial arrangements within the health care industry, the OIG has issued a series of regulations, or safe harbors. Compliance with all requirements of a safe harbor immunizes the parties to the business

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arrangement from prosecution under the Anti-Kickback Statute. The failure of a business arrangement to fit within a safe harbor does not necessarily mean that the arrangement is illegal or that the OIG will pursue prosecution. Still, in the absence of an applicable safe harbor, a violation of the Anti-Kickback Statute may occur even if only one purpose of an arrangement is to induce referrals. The penalties for violating the Anti-Kickback Statute can be severe. These sanctions include criminal and civil penalties, imprisonment and possible exclusion from the federal health care programs. Many states have adopted laws similar to the Anti-Kickback Statute, and some apply to items and services reimbursable by any payor, including private third-party payors.

Physician Self-Referral Bans

The federal ban on physician self-referrals, commonly known as the Stark Law, prohibits, subject to certain exceptions, physician referrals of Medicare patients to an entity providing certain designated health services, which include laboratory services, if the physician or an immediate family member of the physician has any financial relationship with the entity. Several Stark Law exceptions are relevant to arrangements involving clinical laboratories, including: (1) fair market value compensation for the provision of items or services; (2) payments by physicians to a laboratory for clinical laboratory services; (3) certain space and equipment rental arrangements that satisfy certain requirements; and (4) personal services arrangements. Penalties for violating the Stark Law include the return of funds received for all prohibited referrals, fines, civil monetary penalties and possible exclusion from the federal health care programs. In addition to the Stark Law, many states have their own self-referral bans, which may extend to all self-referrals, regardless of the payor.

State and Federal Prohibitions on False Claims

The federal False Claims Act imposes liability on any person or entity that, among other things, knowingly presents, or causes to be presented, a false or fraudulent claim for payment to the federal government. Under the False Claims Act, a person acts knowingly if he has actual knowledge of the information or acts in deliberate ignorance or in reckless disregard of the truth or falsity of the information. Specific intent to defraud is not required. The qui tam provisions of the False Claims Act allow a private individual to bring an action on behalf of the federal government and to share in any amounts paid by the defendant to the government in connection with the action. Penalties include payment of up to three times the actual damages sustained by the government, plus civil penalties of between $5,500 and $11,000 for each false claim, as well as possible exclusion from the federal health care programs. In addition, various states have enacted similar laws modeled after the False Claims Act that apply to items and services reimbursed under Medicaid and other state health care programs, and, in several states, such laws apply to claims submitted to any payor.

Civil Monetary Penalties Law

The federal Civil Monetary Penalties Law, or the CMP Law, prohibits, among other things (1) the offering or transfer of remuneration to a Medicare or state health care program beneficiary if the person knows or should know it is likely to influence the beneficiary’s selection of a particular provider, practitioner, or supplier of services reimbursable by Medicare or a state health care program, unless an exception applies; (2) employing or contracting with an individual or entity that the provider knows or should know is excluded from participation in a federal health care program; (3) billing for services requested by an unlicensed physician or an excluded provider; and (4) billing for medically unnecessary services. The penalties for violating the CMP Law include exclusion, substantial fines, and payment of up to three times the amount billed, depending on the nature of the offense.

Human Resources

As of June 30, 2014, we had 1,649 full-time equivalent employees. Most of our employees are engaged directly in research, development, production, sales and marketing activities. We believe that the success of our business will depend, in part, on our ability to attract and retain qualified personnel. Our employees are not covered by a collective bargaining agreement, and we consider our relations with our employees to be good.

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Available Information

We are a Delaware corporation with our principal executive offices located at 320 Wakara Way, Salt Lake City, Utah 84108. Our telephone number is (801) 584-3600 and our web site address is www.myriad.com. We make available free of charge through the Investor Relations section of our web site our Corporate Code of Conduct and Ethics, our Audit Committee and other committee charters and our other corporate governance policies, as well as our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, current reports on Form 8-K and all amendments to those reports as soon as reasonably practicable after such material is electronically filed with or furnished to the Securities and Exchange Commission. We include our web site address in this Annual Report on Form 10-K only as an inactive textual reference and do not intend it to be an active link to our web site.

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Item 1A. | RISK FACTORS

Risks Related to Our Business and Our Strategy

We may not be successful in transitioning from our existing product portfolio to our new products, such as our myRisk Hereditary Cancer test, which represents the next generation of our existing hereditary cancer franchise. We may not be able to generate sufficient revenue from our existing tests and our new tests or develop new tests to maintain profitability.

Although we have developed and marketed several molecular diagnostic tests to date, we believe our future success is dependent upon our ability to successfully market our existing molecular diagnostic tests to additional patients within the United States, to expand into new markets outside the United States, and to develop and commercialize new molecular diagnostic and companion diagnostic tests. Importantly, in 2014 we launched our myRisk Hereditary Cancer test, which represents the next generation of our existing hereditary cancer franchise. We anticipate that the myRisk Hereditary Cancer test will eventually replace our current predictive medicine test offerings (BRACAnalysis, Colaris, Colaris AP, Melaris, and Panexia) with a single comprehensive test. However, we may not be successful in transitioning from our existing product portfolio to our new tests and in launching and commercializing our new tests. The demand for our existing molecular diagnostic tests may decrease or may not continue to increase at historical rates due to sales of the myRisk Hereditary Cancer test and our other new tests that are replacing our existing product portfolio, or for other reasons. For example, because most of our molecular diagnostic tests are only utilized once per patient, we will need to sell our services through physicians to new patients or develop new molecular diagnostic tests in order to continue to generate revenue. Our pipeline of new molecular diagnostic and companion diagnostic test candidates is in various stages of development and may take several more years to develop and must undergo extensive clinical validation. We may be unable to discover or develop any additional molecular diagnostic or companion diagnostic tests through the utilization of our technologies or technologies we license or acquire from others. Even if we develop tests or services for commercial use, we may not be able to develop tests or services that:

| • |  | meet applicable regulatory standards, in a timely manner or at all;

| • |  | successfully compete with other technologies and tests;

| • |  | avoid infringing the proprietary rights of others;

| • |  | are adequately reimbursed by third-party payors;

| • |  | can be performed at commercial levels or at reasonable cost; or

| • |  | can be successfully marketed.

We must generate significant revenue to maintain profitability. Even if we succeed in marketing myRisk Hereditary Cancer and our existing molecular diagnostic tests to physicians for use in new patients and in developing and commercializing any additional molecular diagnostic tests and companion diagnostic tests, we may not be able to generate sufficient revenue and we may not be able to maintain profitability.

We may not be able to sustain or increase profitability on a quarterly or annual basis.

In order to develop and commercialize our molecular diagnostic and companion diagnostic test candidates, we expect to incur significant expenses over the next several years as we increase our research and development activities, expand clinical validation trials for our molecular diagnostic tests and companion diagnostic tests currently in development, potentially license or acquire additional companies or technologies and engage in commercialization activities in anticipation of the launch of additional molecular diagnostic tests companion diagnostic tests. Because of the numerous risks and uncertainties associated with developing our tests and their potential for commercialization, we are unable to predict the extent of any future profits. If we are unable to sustain or increase profitability, the market value of our common stock will likely decline. Our ability to maintain profitability will depend upon numerous factors, including:

| • |  | our ability to transition from our existing product portfolio to our new products, such as our MyRisk Hereditary Cancer test, and to commercialize these new tests;

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| • |  | our ability to obtain full or partial reimbursement for new products;

| • |  | our ability to sell our other existing molecular diagnostic tests to new patients;

| • |  | our ability to identify biomarkers that may lead to future molecular diagnostic tests and companion diagnostic tests;

| • |  | our ability to develop test candidates and receive any required regulatory approvals;

| • |  | our ability to successfully commercialize our tests in our existing markets and to extend into new markets outside the United States;

| • |  | the approval and introduction of competitive tests;

| • |  | reductions in reimbursement by third-party payors or their willingness to provide full or even partial reimbursement for our tests;

| • |  | our ability to maintain and enforce our intellectual property rights covering our molecular diagnostic tests and companion diagnostic tests;

| • |  | our ability to maintain and grow our sales force and marketing team to market our tests;

| • |  | our ability to successfully integrate, develop and grow products and services and the business of any other companies or technologies that we may license or acquire;

| • |  | our ability to increase commercial acceptance of our current molecular diagnostic tests; and

| • |  | our ability to maintain or grow our current revenues.

If we do not continue to generate sufficient revenue from sales of our molecular diagnostic tests and are unable to secure additional funding, we may have to reduce our operations.

As of June 30, 2014, we had $270.6 million in cash, cash equivalents and marketable securities. For the fiscal year ended June 30, 2014 our consolidated revenues were $778.2 million, and net cash from operating activities was $190.2 million. To develop and bring new molecular diagnostic tests and companion diagnostic tests to market, we must commit substantial resources to costly and time-consuming research, development testing and clinical testing.

While we anticipate that our existing cash, cash equivalents and marketable securities and expected net cash to be generated from sales of our molecular diagnostic tests and pharmaceutical and clinical services will be sufficient to fund our current operations for the foreseeable future, changes could occur that would consume available capital resources more quickly than we currently expect and we may need or want to raise additional financing. If we are unable to secure additional funding, we may be required to reduce research and development projects, limit sales and marketing activities, scale back our expansion efforts outside the United States, reduce headcount or potentially even discontinue operations. Our future capital requirements will depend on many factors that are currently unknown to us, including:

| • |  | our ability to maintain the existing licenses to our molecular diagnostic tests and enter into collaborations, licensing or other arrangements favorable to us;

| • |  | the scope, progress, results and cost of development, clinical testing and pre-market studies of any new molecular diagnostic tests that we may discover or acquire;

| • |  | the progress, results, and costs to develop additional molecular diagnostic tests;

| • |  | the costs by us or our licensors of preparing, filing and prosecuting patent applications, maintaining and enforcing our current issued patents, and defending intellectual property-related claims;

| • |  | the costs of acquiring technologies or businesses, and our ability to successfully integrate and achieve the expected benefits of our business development activities and acquisitions;

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| • |  | the progress, cost and results of our international expansion efforts;

| • |  | the costs of expanding our sales and marketing functions and commercial operation facilities in the United States and in new markets;

| • |  | the costs, timing and outcome of any litigation against us; and

| • |  | the costs to satisfy our current and future obligations.

We may acquire technologies, assets or other businesses that could cause us to incur significant expense and expose us to a number of unanticipated operational and financial risks.

In addition to organic growth, we intend to continue to pursue growth through the acquisition of technology, assets or other businesses that may enable us to enhance our technologies and capabilities, expand our geographic market, add experienced management personnel and increase our test offerings. For example, in May 2011, we completed the acquisition of Rules-Based Medicine, Inc., which we renamed Myriad RBM, and are now offering pharmaceutical and clinical services and developing additional product candidates using the acquired technology. Additionally, in February 2014, we completed the acquisition of Crescendo Bioscience, Inc., and are now offering molecular diagnostic tests for patients suffering from rheumatoid arthritis and developing additional product candidates in the inflammatory and autoimmune disease area. However, these acquisitions may not achieve profitability or generate a positive return on our investment. Additionally, we may be unable to implement our growth strategy if we cannot identify suitable acquisition candidates, reach agreement on potential acquisitions on acceptable terms, successfully integrate personnel or assets that we acquire or for other reasons. Our acquisition efforts may involve certain risks, including:

| • |  | we may have difficulty integrating operations and systems;

| • |  | key personnel and customers of the acquired company may terminate their relationships with the acquired company as a result of the acquisition;

| • |  | we may not be successful in launching new molecular diagnostic tests or companion diagnostic tests, or if those tests are launched they may not prove successful in the market place;

| • |  | we may experience additional financial and accounting challenges and complexities in areas such as tax planning and financial reporting;

| • |  | we may assume or be held liable for risks and liabilities, including for environmental-related costs, as a result of our acquisitions, some of which we may not discover during our due diligence;

| • |  | we may incur significant additional operating expenses;

| • |  | our ongoing business may be disrupted or receive insufficient management attention; and

| • |  | we may not be able to realize synergies, the cost savings or other financial and operational benefits we anticipated, or such synergies, savings or benefits may take longer than we expected.

The process of negotiating acquisitions and integrating acquired tests, services, technologies, personnel or businesses might result in operating difficulties and expenditures and might require significant management attention that would otherwise be available for ongoing development of our business, whether or not any such transaction is ever consummated. Moreover, we might never realize the anticipated benefits of any acquisition. Future acquisitions could result in the use of our available cash and marketable securities, potentially dilutive issuances of equity securities, the incurrence of debt, contingent liabilities, or impairment expenses related to goodwill, and impairment or amortization expenses related to other intangible assets, which could harm our financial condition. In addition, if we are unable to integrate any acquired businesses, tests or technologies effectively, our business, financial condition and results of operations may be materially adversely affected.

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We may not be able to successfully integrate the operations of businesses that we acquire with our own or realize the anticipated benefits of the acquisitions, which could adversely affect our financial condition, results of operations and business prospects.

There can be no assurance that we will be able to successfully integrate our recent acquisitions or develop or commercialize products based on recently acquired technologies, or that we will be able to successfully integrate any other companies, products or technologies that we acquire and may not realize all or any of the expected benefits of any acquisitions as and when planned. Additionally, we may experience increased expenses, distraction of our management, personnel and customer uncertainty.

The difficulties and risks associated with the integration of any other businesses that we may acquire include:

| • |  | possible inconsistencies in the standards, controls, procedures, policies and compensation structures;

| • |  | the increased scope and complexity of the acquired company’s operations;

| • |  | the potential loss of key employees and the costs associated to retain key employees;

| • |  | risks and limitations on our ability to consolidate corporate and administrative infrastructures of the two companies; and

| • |  | the possibility of unanticipated delays, costs or inefficiencies associated with the integration of our operations with the operations of any other companies that we may acquire.

As a result of these difficulties and risks, we may not accomplish the integration of the business of any companies we may acquire smoothly, successfully or within our budgetary expectations and anticipated timetable. Accordingly, we may fail to realize some or all of the anticipated benefits of the acquisition, such as increase in our scale, diversification, cash flows and operational efficiency and meaningful accretion to our diluted earnings per share.

If we were successfully sued for product liability, we could face substantial liabilities that exceed our resources.

Our business exposes us to potential liability risks inherent in the testing, marketing and processing of molecular diagnostic products, including possible misdiagnoses. Although we are insured against such risks in amounts that we believe to be commercially reasonable, our present professional and product liability insurance may be inadequate. A successful product liability claim in excess of our insurance coverage could have a material adverse effect on our business. Any successful product liability claim may prevent us from obtaining adequate product liability insurance in the future on commercially desirable or reasonable terms. An inability to obtain sufficient insurance coverage at an acceptable cost or otherwise to protect against potential product liability claims could prevent or inhibit the commercialization of our products.

We are dependent on our information technology and telecommunications systems, and any failure of these systems could harm our business.

We depend on information technology, or IT, and telecommunications systems for significant aspects of our business. These IT and telecommunications systems support a variety of functions, including sample processing, tracking, quality control, customer service and support, billing, research and development activities, and various general and administrative activities. Failures or significant downtime of our IT or telecommunications systems could prevent us from processing samples, providing test results to physicians, billing payors, addressing patient or physician inquiries, conducting research and development activities and conducting general and administrative elements of our business. Any disruption or loss of IT or telecommunications systems on which critical aspects of our operations depend could have an adverse effect on our business.

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Security breaches, loss of data and other disruptions could compromise sensitive information related to our business, prevent us from accessing critical information or expose us to liability, which could adversely affect our business and our reputation.

In the ordinary course of our business, we collect and store sensitive data, including legally protected patient health information, credit card information, personally identifiable information about our employees, intellectual property, and proprietary business information. We manage and maintain our applications and data utilizing on-site systems. These applications and data encompass a wide variety of business critical information including research and development information, commercial information and business and financial information.

The secure processing, storage, maintenance and transmission of this critical information is vital to our operations and business strategy, and we devote significant resources to protecting such information. Although we take measures to protect sensitive information from unauthorized access or disclosure, our information technology and infrastructure may be vulnerable to attacks by hackers, or viruses, breaches or interruptions due to employee error, malfeasance or other disruptions, or lapses in compliance with privacy and security mandates. Any such virus, breach or interruption could compromise our networks and the information stored there could be accessed by unauthorized parties, publicly disclosed, lost or stolen. We have measures in place that are designed to detect and respond to such security incidents and breaches of privacy and security mandates. Any such access, disclosure or other loss of information could result in legal claims or proceedings, liability under laws that protect the privacy of personal information, such as the Health Insurance Portability and Accountability Act of 1996, government enforcement actions and regulatory penalties. Unauthorized access, loss or dissemination could also disrupt our operations, including our ability to process samples, provide test results, bill payors or patients, provide customer support services, conduct research and development activities, process and prepare company financial information, manage various general and administrative aspects of our business and damage our reputation, any of which could adversely affect our business.

If our current operating plan changes and we find that our existing capital resources will not meet our needs, we may find it necessary to raise additional funding, which may not be available.

We anticipate that our existing capital resources and expected net cash to be generated from sales of our molecular diagnostic tests will enable us to maintain our currently planned operations for the foreseeable future. However, we base this expectation on our current operating plan, which may change. We have incurred, and will continue to incur, significant costs in the discovery, development and marketing of current and prospective molecular diagnostic and companion diagnostic tests. Our ongoing efforts to develop tests and expand our business which may be through internally developed products, in licensing and mergers and acquisitions, will require substantial cash resources. If, due to changes in our current operating plan, adequate funds are not available, we may be required to raise additional funds. Sources of potential additional capital resources may include, but are not limited to, public or private equity financings, establishing a credit facility, or selling convertible debt securities. This additional funding, if necessary, may not be available to us on reasonable terms, or at all. If we issue shares of stock or other securities to acquire new companies or technologies, the ownership interests of our existing stockholders may be significantly diluted.

Because of our potential long-term capital requirements, we may access the public or private equity or debt markets whenever conditions are favorable, even if we do not have an immediate need for additional capital at that time. Under SEC rules, we currently qualify as a well-known seasoned issuer, or WKSI, and can at any time file a registration statement registering securities to be sold to the public which would become effective upon filing. If additional funds are raised by issuing equity securities, existing shareholders may suffer significant dilution. Debt financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring debt, making capital expenditures or declaring dividends. If we raise additional funds through collaborations, strategic alliances and licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies or tests, or grant licenses on terms that are not favorable to us.

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Our business involves environmental risks that may result in liability for us.

In connection with our research and development activities, we are subject to federal, state and local laws, rules, regulations and policies governing the use, generation, manufacture, storage, air emission, effluent discharge, handling and disposal of certain materials, biological specimens, chemicals and wastes. Although we believe that we have complied with the applicable laws, regulations and policies in all material respects and have not been required to correct any material noncompliance, we may be required to incur significant costs to comply with environmental and health and safety regulations in the future. Although we believe that our safety procedures for handling and disposing of controlled materials comply with the standards prescribed by state and federal regulations, accidental contamination or injury from these materials may occur. In the event of such an occurrence, we could be held liable for any damages that result and any such liability could exceed our resources.

Changes in healthcare policy could increase our costs, decrease our revenues and impact sales of and reimbursement for our tests.

In March 2010, the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Affordability Reconciliation Act, or the ACA became law. This law substantially changes the way health care is financed by both governmental and private insurers, and significantly impacts our industry. The ACA contains a number of provisions that are expected to impact our business and operations, some of which in ways we cannot currently predict, including those governing enrollment in federal healthcare programs, reimbursement changes and fraud and abuse, which will impact existing government healthcare programs and will result in the development of new programs.

In addition to the ACA, there will continue to be proposals by legislators at both the federal and state levels, regulators and third-party payors to reduce costs while expanding individual healthcare benefits. Certain of these changes could impose additional limitations on the prices we will be able to charge for our tests or the amounts of reimbursement available for our tests from governmental agencies or third-party payors.

We face risks associated with currency exchange rate fluctuations, which could adversely affect our operating results.

We receive a portion of our revenues and pay a portion of our expenses in currencies other than the United States dollar, such as the Euro, the Swiss franc, the British pound and the Canadian dollar. As a result, we are at risk for exchange rate fluctuations between such foreign currencies and the United States dollar, which could affect the results of our operations. If the U.S. dollar strengthens against foreign currencies, the translation of these foreign currency denominated transactions will result in decreased revenues, operating expenses and net income. We may not be able to offset adverse foreign currency impact with increased revenues. We do not currently utilize hedging strategies to mitigate foreign currency risk and even if we were to implement hedging strategies to mitigate foreign currency risk, these strategies might not eliminate our exposure to foreign exchange rate fluctuations and would involve costs and risks of their own, such as ongoing management time and expertise, external costs to implement the strategies and potential accounting implications.

Risks Related to Commercialization of Our Tests, Our Services and Test Candidates

We generate most of our revenues from a single product and we may not be able to maintain or increase revenue growth and profitability.

Even though we have experienced double-digit revenue growth in our molecular diagnostic business every year since the initial launch of our first test in 1996; we may not be able to continue this revenue growth or maintain existing revenue levels. Presently, our molecular diagnostic business operates profitably providing a cash contribution to our current funding and operational needs. We may not, however, be able to continue to operate our molecular diagnostic business on a profitable basis. We launched our first molecular diagnostic test, BRACAnalysis, our test for hereditary breast and ovarian cancer, in November 1996. BRACAnalysis test sales

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accounted for approximately two thirds of our revenues for the year ended June 30, 2014, and this percentage has been declining in recent years. An interruption or cessation of BRACAnalysis sample flow would have a material impact on our revenues and future profitability. Moreover, in 2014 we launched our myRisk Hereditary Cancer test, which represents the next generation of our existing hereditary cancer franchise. We may not be successful in transitioning from our existing product portfolio to our new products, such as MyRisk Hereditary Cancer Test, and in commercializing these tests over time. Other potential events or factors that may have a significant impact on our ability to sustain revenue growth and profitability for our molecular diagnostic business include the following:

| • |  | increased costs of reagents and other consumables required for molecular diagnostic testing;

| • |  | increased licensing or royalty costs, and our ability to maintain and enforce the intellectual property rights underlying our tests and services;

| • |  | increased personnel and facility costs;

| • |  | our inability to hire competent, trained staff, including laboratory directors required to review and approve all reports we issue in our molecular diagnostic business, and sales personnel;

| • |  | our inability to obtain necessary equipment or reagents to perform molecular diagnostic testing;

| • |  | our inability to increase production capacity as demand increases;

| • |  | our inability to expand into new markets outside the United States;

| • |  | the efforts of third party payors to limit or decrease the amounts that they are willing to pay for our tests;

| • |  | changes in intellectual propriety law applicable to our patents or enforcement in the United States and foreign countries;

| • |  | potential obsolescence of our tests;

| • |  | our inability to increase commercial acceptance of our molecular diagnostic tests;

| • |  | increased competition and loss of market share; and

| • |  | increased regulatory requirements.

Our international business exposes us to business, regulatory, political, operational, financial and economic risks associated with doing business outside of the United States.

As part of our business strategy, we have expanded into international markets. We have established sales offices in Germany, Switzerland, France, Spain, the United Kingdom, Italy and Canada; laboratory operations in Germany; and international headquarters in Switzerland. We may establish additional operations or acquire additional properties outside the United States in order to advance our international sales Doing business internationally involves a number of risks, including:

| • |  | failure by us to obtain regulatory approvals or adequate reimbursement for the use of our tests in various countries;

| • |  | difficulty in staffing and managing foreign operations;

| • |  | managing multiple payor reimbursement and self-pay systems;

| • |  | logistics and regulations associated with shipping patient samples, including infrastructure conditions and transportation delays;

| • |  | limits in our ability to penetrate international markets if we are not able to process tests locally;

| • |  | financial risks, such as longer payment cycles, difficulty collecting accounts receivable and exposure to foreign currency exchange rate fluctuations;

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| • |  | political and economic instability, including wars, terrorism, and political unrest, outbreak of disease, boycotts, curtailment of trade and other business restrictions;

| • |  | multiple, conflicting and changing laws and regulations such as tax laws, export and import restrictions, employment laws, regulatory requirements and other governmental approvals, permits and licenses; and

| • |  | regulatory and compliance risks that relate to maintaining accurate information and control over sales and distributors’ activities that may fall within the purview of the U.S. Foreign Corrupt Practice Act, anti-boycott and other laws.

Any of these factors could significantly harm our international operations and, consequently, our revenues and results of operations. In addition, any failure to comply with applicable legal and regulatory obligations could impact us in a variety of ways that include, but are not limited to, significant criminal, civil and administrative penalties, including imprisonment of individuals, fines and penalties, denial of export privileges, seizure of shipments, and restrictions on certain business activities. Also, the failure to comply with applicable legal and regulatory obligations could result in the disruption of our distribution and sales activities.

Our international operations could be affected by changes in laws, trade regulations, labor and employment regulations, and procedures and actions affecting approval, production, pricing, reimbursement and marketing of tests, as well as by inter-governmental disputes. Any of these changes could adversely affect our business.

Our success internationally will depend, in part, on our ability to develop and implement policies and strategies that are effective in anticipating and managing these and other risks in the countries in which we do business. Failure to manage these and other risks may have a material adverse effect on our operations in any particular country and on our business as a whole.

Foreign governments may impose reimbursement standards, which may adversely affect our future profitability.

We market our tests in foreign jurisdictions and as such may be subject to rules and regulations in those jurisdictions relating to our testing. In some foreign countries, including countries in the European Union, the reimbursement of diagnostic tests is subject to governmental control. In these countries, reimbursement negotiations with governmental authorities can take considerable time after the receipt of marketing approval for a test candidate. If reimbursement of our future tests is unavailable or limited in scope or amount, or if reimbursement rates are set at unsatisfactory levels, we may be unable to achieve or sustain profitability.

We may experience increased price competition and price erosion, including price decreases from CMS and private payors.

CMS has recently reduced the reimbursement rate for some of our products and as a result we may experience pricing pressures from managed care organizations and other third-party payors. Any declines in average selling prices of our products due to pricing pressures may have an adverse impact on our business, results of operations and financial condition.

Our pharmaceutical testing services customers may reduce the amount of testing they conduct through us.

If there is a change in the regulatory environment or intellectual property law, or our pharmaceutical testing services customers consolidate, our customers may divert resources from testing, resulting in a reduced demand for our laboratory testing services. Alternatively, customers may decide to perform their own laboratory testing services in-house.

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We rely on a single laboratory facility to process each of our molecular diagnostic tests in the United States and Europe and a single laboratory facility to perform our pharmaceutical and clinical services. Failure to maintain the operations of these laboratories in compliance with applicable regulations would seriously harm our business.

We rely on a CLIA-certified laboratory facility in Salt Lake City, Utah to perform most of our molecular diagnostic tests, a CLIA-certified laboratory in South San Francisco, California to perform our VectraDA test, a single laboratory facility in Munich, Germany to perform our international molecular diagnostic tests, and a CLIA-certified laboratory facility in Austin, Texas to perform our pharmaceutical and clinical testing services. These facilities and certain pieces of laboratory equipment would be difficult to replace and may require significant replacement lead-time. In the event our clinical testing facilities were to lose their CLIA certification or other required certifications or licenses or were affected by man-made or natural disasters, we would be unable to continue our molecular diagnostic and pharmaceutical and clinical services business at current levels to meet customer demands for a significant period of time. Although we maintain insurance on these facilities, including business interruption insurance, it may not be adequate to protect us from all potential losses if these facilities were damaged or destroyed. In addition, any interruption in our molecular diagnostic or pharmaceutical and clinical services business would result in a loss of goodwill, including damage to our reputation. If our molecular diagnostic or pharmaceutical and clinical services business were interrupted, it would seriously harm our business.

We depend on a limited number of third parties for some of our supplies of equipment and reagents. If these supplies become unavailable, then we may not be able to successfully perform our research or operate our business on a timely basis or at all.

We currently rely on a small number of suppliers to provide our gene sequencing equipment, content enrichment equipment, multiplex protein analysis equipment, robots, and specialty reagents and laboratory supplies required in connection with our research. We believe that currently there are limited alternative suppliers of these equipment, robots, and reagents. The equipment, robots, or the reagents may not remain available in commercial quantities at acceptable costs. If we are unable to obtain when needed additional or alternative equipment, robots, or an adequate supply of reagents or other ingredients at commercially reasonable rates, our ability to continue to identify genes and perform molecular diagnostic testing and pharmaceutical and clinical services would be adversely affected.

Our molecular diagnostic and companion diagnostic tests in development may never achieve significant commercial market acceptance.

We may not succeed in achieving significant commercial market acceptance of our diagnostic test and clinical service offerings that we have launched in recent years or that we are currently developing. Our ability to successfully develop and commercialize our current molecular diagnostic and companion diagnostic tests, as well as any future molecular diagnostic and companion diagnostic tests that we may develop, will depend on several factors, including:

| • |  | our ability to convince the medical community of the clinical utility of our tests and their potential advantages over existing tests;

| • |  | our ability to collaborate with biotechnology and pharmaceutical companies to develop and commercialize companion diagnostic tests for their therapeutic drugs and drug candidates;

| • |  | the agreement by third-party payors to reimburse our tests, the scope and extent of which will affect patients’ willingness or ability to pay for our tests and will likely heavily influence physicians’ decisions to recommend our tests; and

| • |  | the willingness of physicians to utilize our tests, which can be difficult to interpret. This difficulty is caused by the ability of our tests to predict only as to a probability, not certainty, that a tested individual will develop, have the disease, benefit from a particular therapy or has an aggressive form of the disease that the test is intended to predict.

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These factors present obstacles to commercial acceptance of our tests, which we will have to spend substantial time and money to overcome, if we can do so at all. Our inability to successfully do so will harm our business.

If we do not compete effectively with scientific and commercial competitors, we may not be able to successfully commercialize our tests.

The clinical laboratory and genetics testing fields are intense and highly competitive. Tests that are developed are characterized by rapid technological change. Our competitors in the United States and abroad are numerous and include, among others, major diagnostic companies, reference laboratories, molecular diagnostic firms, universities and other research institutions. Some of our potential competitors have considerably greater financial, technical, marketing and other resources than we do, which may allow these competitors to discover important genes and determine their function before we do. We could be adversely affected if we do not discover genes, proteins or biomarkers and characterize their function, develop molecular diagnostic and pharmaceutical and clinical services based on these discoveries, obtain required regulatory and other approvals and launch these tests and their related services before our competitors. We also expect to encounter significant competition with respect to any molecular diagnostic and companion diagnostic tests that we may develop or commercialize. Those companies that bring to market new molecular diagnostic and companion tests before we do may achieve a significant competitive advantage in marketing and commercializing their tests. We may not be able to develop additional molecular diagnostic tests successfully and we or our licensors may not obtain or enforce patents covering these tests that provide protection against our competitors. Moreover, our competitors may succeed in developing molecular diagnostic and companion diagnostic tests that circumvent our technologies or tests. Furthermore, our competitors may succeed in developing technologies or tests that are more effective or less costly than those developed by us or that would render our technologies or tests less competitive or obsolete. We expect competition to intensify in the fields in which we are involved as technical advances in these fields occur and become more widely known and changes in intellectual property laws generate challenges to our intellectual property position.

If our current research collaborators or scientific advisors terminate their relationships with us or develop relationships with a competitor, our ability to discover genes, proteins, and biomarkers, and to validate and commercialize molecular diagnostic and companion diagnostic tests could be adversely affected.

We have relationships with research collaborators at academic and other institutions who conduct research at our request. These research collaborators are not our employees. As a result, we have limited control over their activities and, except as otherwise required by our collaboration agreements, can expect only limited amounts of their time to be dedicated to our activities. Our ability to discover genes, proteins, and biomarkers involved in human disease and validate and commercialize molecular diagnostic and companion diagnostic tests will depend in part on the continuation of these collaborations. If any of these collaborations are terminated, we may not be able to enter into other acceptable collaborations. In addition, our existing collaborations may not be successful.

Our research collaborators and scientific advisors may have relationships with other commercial entities, some of which could compete with us. Our research collaborators and scientific advisors sign agreements which provide for the confidentiality of our proprietary information and the results of studies conducted at our request. We may not, however, be able to maintain the confidentiality of our technology and other confidential information related to all collaborations. The dissemination of our confidential information could have a material adverse effect on our business.

If we fail to retain our key personnel and hire, train and retain qualified employees and consultants, we may not be able to successfully continue our business.

Because of the specialized scientific nature of our business, we are highly dependent upon our ability to attract and retain qualified management, scientific and technical personnel. We are currently recruiting additional qualified management, scientific and technical personnel. Competition for such personnel is intense. Loss of the

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services of or failure to recruit additional key management, scientific and technical personnel would adversely affect our research and development programs and molecular diagnostic and pharmaceutical and clinical services business and may have a material adverse effect on our business as a whole.

Our agreements with our employees generally provide for employment that can be terminated by either party without cause at any time, subject to specified notice requirements. Further, the non-competition provision to which each employee is subject expires for certain key employees on the applicable date of termination of employment.

As we expand our commercial tests we may be required to incur significant costs and devote significant efforts to expand our existing tests sales and marketing capabilities.

Our sales and marketing experience and capabilities consist primarily of our sales force that markets our cancer-related molecular diagnostic tests to oncologists, Ob/Gyns and urologists in the United States. We are currently expanding our sales efforts outside the United States, which will require us to hire additional personnel and engage in additional sales and marketing efforts. We have limited sales and marketing experience outside the Unites States. As we expand our business operations internationally, we expect to face a number of additional costs and risks, including the need to recruit a large number of additional experienced marketing and sales personnel.

Risks Related to Our Intellectual Property

If we are not able to protect our proprietary technology, others could compete against us more directly, which would harm our business.

As of June 30, 2014, our patent portfolio included 278 issued patents owned or licensed by us and numerous patent applications in the United States and other countries with claims covering our intellectual property rights. Our commercial success will depend, in part, on our ability to obtain additional patents and licenses and protect our existing patent position, both in the United States and in other countries, for synthetic DNA , antibodies and related technologies, processes, methods and other inventions that we believe are patentable. Our ability to preserve our trade secrets and other intellectual property is also important to our long-term success. If we do not adequately protect our intellectual property, competitors may be able to use our technologies and erode or negate any competitive advantage we may have, which could harm our business and ability to maintain profitability. Patents may also issue to third parties which could interfere with our ability to bring our molecular diagnostic tests to market. The laws of some foreign countries do not protect our proprietary rights to the same extent as U.S. laws, and we may encounter significant problems in protecting our proprietary rights in these countries.

The patent positions of diagnostic companies, including our patent position, are generally highly uncertain and involve complex legal and factual questions, and, therefore, any patents issued to us may be challenged, deemed unenforceable, invalidated or circumvented. We will be able to protect our proprietary rights from unauthorized use by third parties only to the extent that our proprietary technologies and any future tests are covered by valid and enforceable patents or are effectively maintained as trade secrets. Our patent applications may never issue as patents, and the claims of any issued patents may not afford meaningful protection for our technology or tests. In addition, any patents issued to us or our licensors may be challenged, and subsequently narrowed, invalidated or circumvented.

Where necessary, we may initiate litigation to enforce our patent or other intellectual property rights, as we have done in the consolidated BRCA1 & BRCA2 Based Hereditary Cancer Test Patent Litigation pending in the U.S. District Court in Utah. Any such litigation may require us to spend a substantial amount of time and money and could distract management from our day-to-day operations. Moreover, there is no assurance that we will be successful in any such litigation.

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The degree of future protection for our proprietary rights is uncertain, and we cannot ensure that:

| • |  | we or our licensors were the first to make the inventions covered by each of our patent applications;

| • |  | we or our licensors were the first to file patent applications for these inventions;

| • |  | others will not independently develop similar or alternative technologies or duplicate any of our technologies;

| • |  | any of our or our licensors’ patent applications will result in issued patents;

| • |  | any of our or our licensors’ patents will be valid or enforceable;

| • |  | any patents issued to us or our licensors and collaborators will provide a basis for commercially viable tests, will provide us with any competitive advantages or will not be challenged by third parties;

| • |  | we will develop additional proprietary technologies or tests that are patentable;

| • |  | the patents of others will not have an adverse effect on our business; or

| • |  | our patents or patents that we license from others will survive legal challenges, and remain valid and enforceable.

If a third party files a patent application with claims to a biomarker we have discovered, the PTO may declare interference between competing patent applications. If an interference is declared, we may not prevail in the interference. If the other party prevails in the interference, we may be precluded from commercializing services or tests based on the biomarker or may be required to seek a license. A license may not be available to us on commercially acceptable terms, if at all.

We also rely upon unpatented proprietary technologies. Although we require employees, consultants and collaborators to sign confidentiality agreements, we may not be able to adequately protect our rights in such unpatented proprietary technologies, which could have a material adverse effect on our business. For example, others may independently develop substantially equivalent proprietary information or techniques or otherwise gain access to our proprietary technologies or disclose our technologies to our competitors.

If we were sued for patent infringement by third parties, we might incur significant costs and delays in test introduction.

Our tests may also conflict with patents that have been or may be granted to others. Our industry includes many organizations that have or are seeking to discern biomarkers and develop genomic, proteomic and other technologies. To the extent any patents are issued or have been issued to those organizations, the risk increases that the sale of our molecular diagnostic and companion diagnostic tests currently being marketed or under development may give rise to claims of patent infringement. Others may have filed and in the future are likely to file patent applications covering biomarkers that are similar or identical to our tests. Any of these patent applications may have priority over our patent applications and these entities or persons could bring legal proceedings against us seeking damages or seeking to enjoin us from testing or marketing our tests. Patent litigation is costly, and even if we prevail, the cost of such litigation could have a material adverse effect on us. If the other parties in any such actions are successful, in addition to any liability for damages, we could be required to cease the infringing activity or obtain a license. Any license required may not be available to us on commercially acceptable terms, if at all. Our failure to obtain a license to any technology that we may require to commercialize our tests could have a material adverse effect on our business. We believe that there may be significant litigation in the industry regarding patent and other intellectual property rights. If we become involved in this litigation, it could consume a substantial portion of our managerial and financial resources.

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We may be unable to adequately prevent disclosure of trade secrets, proprietary databases, and other proprietary information.

We rely on trade secrets to protect our proprietary technologies and databases, especially where we do not believe patent protection is appropriate or obtainable. However, trade secrets are difficult to protect. We rely in part on confidentiality agreements with our employees, consultants, outside scientific collaborators, sponsored researchers and others to protect our trade secrets and other proprietary information. These agreements may not effectively prevent disclosure of confidential information and may not provide an adequate remedy if unauthorized disclosure of confidential information occurs. In addition, others may independently discover our trade secrets and proprietary information. Costly and time-consuming litigation could be necessary to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain trade secret protection could adversely affect our competitive position.

If we fail to comply with our obligations under license or technology agreements with third parties, we could lose license rights that are critical to our business.

We license intellectual property that is critical to our business, including licenses underlying the technology in our molecular diagnostic and pharmaceutical and clinical services, and in the future we may enter into additional agreements that provide us with licenses to valuable intellectual property or technology. These licenses impose various royalty payments, milestones, and other obligations on us. If we fail to comply with any of these obligations, the licensor may have the right to terminate the license. Termination by the licensor would cause us to lose valuable rights, and could prevent us from distributing our current tests, or inhibit our ability to commercialize future test candidates. Our business would suffer if any current or future licenses terminate, if the licensors fail to abide by the terms of the license, if the licensors fail to prevent infringement by third parties, if the licensed patents or other rights are found to be invalid or unenforceable, or if we are unable to enter into necessary licenses on acceptable terms.

We may be subject to claims that we or our employees have wrongfully used or disclosed alleged trade secrets of their former employers.

As is commonplace in our industry, we employ individuals who were previously employed at other biotechnology or pharmaceutical companies, including our potential competitors. Although no claims against us are currently pending, we may be subject to claims that these employees have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims. Even if we are successful in defending against these claims, litigation could result in substantial costs and be a distraction to management.

Risks Related to Government Regulation

If we fail to comply with the complex federal, state, local and foreign laws and regulations that apply to our business, we could suffer severe consequences that could materially and adversely affect our operating results and financial condition.

Our operations are subject to extensive federal, state, local and foreign laws and regulations, all of which are subject to change. These laws and regulations currently include, among other things:

| • |  | CLIA, which requires that laboratories obtain certification from the federal government;

| • |  | FDA laws and regulations;

| • |  | HIPAA, which established comprehensive federal standards with respect to the privacy and security of protected health information and requirements for the use of certain standardized electronic transactions; amendments to HIPAA under the Health Information Technology for Economic and Clinical Health Act, or HITECH, which strengthen and expand HIPAA privacy and security compliance requirements, increase penalties for violators, extend enforcement authority to state attorneys general and impose requirements for breach notification;

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| • |  | state laws regulating genetic testing and protecting the privacy of genetic test results, as well as state laws protecting the privacy and security of health information and personal data and mandating reporting of breaches to affected individuals and state regulators;

| • |  | the federal anti-kickback law, or the Anti-Kickback Statute, which prohibits knowingly and willfully offering, paying, soliciting, receiving, or providing remuneration, directly or indirectly, in exchange for or to induce either the referral of an individual, or the furnishing, arranging for, or recommending of an item or service that is reimbursable, in whole or in part, by a federal health care program;

| • |  | the federal False Claims Act, which imposes liability on any person or entity that, among other things, knowingly presents, or causes to be presented, a false or fraudulent claim for payment to the federal government;

| • |  | the federal Civil Monetary Penalties Law, which prohibits, among other things, the offering or transfer of remuneration to a Medicare or state health care program beneficiary if the person knows or should know it is likely to influence the beneficiary’s selection of a particular provider, practitioner, or supplier of services reimbursable by Medicare or a state health care program, unless an exception applies;

| • |  | other federal and state fraud and abuse laws, such as anti-kickback laws, prohibitions on self-referral, and false claims acts, which may extend to services reimbursable by any third-party payor, including private insurers; and

| • |  | similar foreign laws and regulations that apply to us in the countries in which we operate.

These laws and regulations are complex and are subject to interpretation by the courts and by government agencies. Our failure to comply could lead to civil or criminal penalties, exclusion from participation in government health care programs, or prohibitions or restrictions on our laboratories’ ability to provide services. We believe that we are in material compliance with all statutory and regulatory requirements, but there is a risk that one or more government agencies could take a contrary position, or that a private party could file suit under the qui tam provisions of the federal False Claims Act or a similar state law. Such occurrences, regardless of their outcome, could damage our reputation and adversely affect important business relationships with third parties, including managed care organizations, and other private third-party payors.

Failure to comply with government laws and regulations related to submission of claims for our services could result in significant monetary damages and penalties and exclusion from the Medicare and Medicaid programs and corresponding foreign reimbursement programs.

We are subject to laws and regulations governing the submission of claims for payment for our services, such as those relating to: coverage of our services under Medicare, Medicaid and other state, federal and foreign health care programs; the amounts that we may bill for our services; and the party to which we must submit claims. Our failure to comply with applicable laws and regulations could result in our inability to receive payment for our services or in attempts by government healthcare programs, such as Medicare and Medicaid, to recover payments already made. Submission of claims in violation of these laws and regulations can result in recoupment of payments already received, substantial civil monetary penalties, and exclusion from government health care programs, and can subject us to liability under the federal False Claims Act and similar laws. The failure to report and return an overpayment to the Medicare or Medicaid program within 60 days of identifying its existence can give rise to liability under the False Claims Act. Further, a government agency could attempt to hold us liable for causing the improper submission of claims by another entity for services that we performed if we were found to have knowingly participated in the arrangement at issue.

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Our business could be harmed by the loss, suspension, or other restriction on a license, certification, or accreditation, or by the imposition of a fine or penalties, under CLIA, its implementing regulations, or other state, federal and foreign laws and regulations affecting licensure or certification, or by future changes in these laws or regulations.

The diagnostic testing industry is subject to extensive laws and regulations, many of which have not been interpreted by the courts. CLIA requires virtually all laboratories to be certified by the federal government and mandates compliance with various operational, personnel, facilities administration, quality and proficiency testing requirements intended to ensure that testing services are accurate, reliable and timely. CLIA certification is also a prerequisite to be eligible to bill state and federal health care programs, as well as many private third-party payors, for laboratory testing services. As a condition of CLIA certification, each of our laboratories is subject to survey and inspection every other year, in addition to being subject to additional random inspections. The biennial survey is conducted by CMS; a CMS agent (typically a state agency); or, if the laboratory holds a CLIA certificate of accreditation, a CMS-approved accreditation organization. Sanction for failure to comply with CLIA requirements, including proficiency testing violations, may be suspension, revocation, or limitation of a laboratory’s CLIA certificate, which is necessary to conduct business, as well as the imposition of significant fines or criminal penalties. In addition, we are subject to regulation under state laws and regulations governing laboratory licensure. Some states have enacted state licensure laws that are more stringent than CLIA. We are also subject to laws and regulations governing our reference laboratory in Germany. Changes in state or foreign licensure laws that affect our ability to offer and provide diagnostic services across state or foreign country lines could materially and adversely affect our business. In addition, state and foreign requirements for laboratory certification may be costly or difficult to meet and could affect our ability to receive specimens from certain states or foreign countries.

Any sanction imposed under CLIA, its implementing regulations, or state or foreign laws or regulations governing licensure, or our failure to renew a CLIA certificate, a state or foreign license, or accreditation, could have a material adverse effect on our business. If the CLIA certificate of any one of our laboratories is revoked, CMS could seek revocation of the CLIA certificates of our other laboratories based on their common ownership or operation, even though they are separately certified.

Changes in the way that the FDA regulates tests performed by laboratories like ours could result in delay or additional expense in offering our tests and tests that we may develop in the future.

While the FDA does not currently regulate the activities or tests performed by laboratories like our clinical laboratories, the FDA has stated that it has the right to do so. In July, 2010, the FDA’s office of In-Vitro Diagnostics held a public meeting to discuss oversight of laboratory developed tests. The FDA highlighted the lack of standardized clinical validation at the assay level under current CLIA regulatory guidelines and noted that CLIA does not require post-market surveillance or monitoring of laboratory developed tests. The comment period for providing the FDA with written comments expired on August 15, 2010. On July 31, 2014, the FDA announced its intention to regulate many LDTs and to provide draft guidance in 60 days. If pre-market review is required, our business could be negatively impacted if we are required to stop selling molecular diagnostic tests pending their clearance or approval or the launch of any new tests that we develop could be delayed by new requirements.

Companion diagnostic tests require FDA approval and we may not be able to secure such approval in a timely manner or at all.

Our companion diagnostic products, marketing, sales and development activities and manufacturing processes are subject to extensive and rigorous regulation by the FDA pursuant to the Federal Food, Drug, and Cosmetic Act (FDC Act), by comparable agencies in foreign countries, and by other regulatory agencies and governing bodies. Under the FDC Act, companion diagnostics must receive FDA clearance or approval before they can be commercially marketed in the U.S. The process of obtaining marketing approval or clearance from the FDA or by comparable agencies in foreign countries for new products could:

| • |  | take a significant period of time;

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| • |  | require the expenditure of substantial resources:

| • |  | involve rigorous pre-clinical testing, as well as increased post-market surveillance:

| • |  | require changes to products; and

| • |  | result in limitations on the indicated uses of products.

If the government and third-party payors fail to provide coverage and adequate payment for our tests and future tests, if any, our revenue and prospects for profitability will be harmed.

In both domestic and foreign markets, sales of our molecular diagnostic tests or any future diagnostic tests will depend in large part, upon the availability of reimbursement from third-party payors. Such third-party payors include government healthcare programs such as Medicare, managed care providers, private health insurers and other organizations. These third-party payors are increasingly attempting to contain healthcare costs by demanding price discounts or rebates and limiting both coverage on which diagnostic tests they will pay for and the amounts that they will pay for new molecular diagnostic tests. We have recently experienced price reductions from CMS for some of our products and may experience future price reductions from managed care organizations and other third-party payors. The fact that a diagnostic test has been approved for reimbursement in the past, for any particular indication or in any particular jurisdiction, does not guarantee that such a diagnostic test will remain approved for reimbursement or that similar or additional diagnostic tests will be approved in the future. Moreover, there can be no assurance that any new tests we launch, such as myRisk Hereditary Cancer, myPath Melanoma and myPlan Lung Cancer, will be reimbursed at rates that are comparable to the rates that we historically obtained for our existing product portfolio. As a result, third-party payors may not cover or provide adequate payment for our current or future molecular diagnostic tests. Adequate third-party reimbursement might not be available to enable us to maintain price levels sufficient to realize an appropriate return on investment in product development.

U.S. and foreign governments continue to propose and pass legislation designed to reduce the cost of healthcare. For example, in some foreign markets, the government controls the pricing of many healthcare products. We expect that there will continue to be federal and state proposals to implement governmental controls or impose healthcare requirements. In addition, the Medicare program and increasing emphasis on managed care in the United States will continue to put pressure on product pricing. Cost control initiatives could decrease the price that we would receive for any tests in the future, which would limit our revenue and profitability.

Our business could be adversely impacted by the adoption of the ICD-10-CM Code Set.

CMS has adopted a new coding set for diagnoses, commonly known as ICD-10-CM, which significantly expands the current coding set. ICD-10-CM is currently required to be used on all claims with dates of service on or after October 1, 2014. We may be required to incur significant expense in implementing ICD-10-CM, and, if we do not adequately implement it, our business could be adversely impacted. In addition, if as a result of the new coding set, physicians fail to provide appropriate codes for desired tests, we may not be reimbursed for tests we perform.

Risks Related to Our Common Stock

Our stock price is highly volatile, and our stock may lose all or a significant part of its value.

The market prices for securities of molecular diagnostic companies have been volatile. This volatility has significantly affected the market prices for these securities for reasons frequently unrelated to the operating performance of the specific companies. These broad market fluctuations may adversely affect the market price of our common stock. The market price for our common stock has fluctuated significantly since public trading commenced in October 1995, and it is likely that the market price will continue to fluctuate in the future. Additionally, there is a significant short position in our common stock (over 38 million shares as of June 30,

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2014) and this short position introduces added uncertainty and volatility in our stock price. In the two years ended June 30, 2014, our stock price has ranged from $20.02 per share to $42.50 per share. In addition, the stock market in general has experienced extreme price and volume fluctuations. Events or factors that may have a significant impact on our business and on the market price of our common stock include the following:

| • |  | failure of any of our recently launched tests and any new test candidates to achieve commercial success;

| • |  | failure to sustain revenue growth or margins in our molecular diagnostic business;

| • |  | changes in the structure of healthcare payment systems and changes in the governmental or private insurers reimbursement levels for our molecular diagnostic tests;

| • |  | introduction of new commercial tests or technological innovations by competitors;

| • |  | termination of the licenses underlying our molecular diagnostic and pharmaceutical and clinical services;

| • |  | delays or other problems with operating our laboratory facilities;

| • |  | failure of any of our research and development programs;

| • |  | changes in intellectual property laws of our patents or enforcement in the United States and foreign countries;

| • |  | developments or disputes concerning patents or other proprietary rights involving us directly or otherwise affecting the industry as a whole;

| • |  | missing or changing the financial guidance we provide;

| • |  | changes in estimates or recommendations by securities analysts relating to our common stock or the securities of our competitors;

| • |  | changes in the governmental regulatory approved process for our existing and new tests:

| • |  | failure to meet estimates or recommendations by securities analysts that cover our common stock;

| • |  | public concern over our approved tests and any test candidates;

| • |  | litigation;

| • |  | future sales or anticipated sales of our common stock by us or our stockholders;

| • |  | the timing and amount of repurchases of our common stock;

| • |  | general market conditions;

| • |  | seasonal slowness in sales, particularly in the quarters ending September 30 and March 31, the effects of which may be difficult to understand during periods of growth;

| • |  | economic, healthcare and diagnostic trends, disasters or crises and other external factors; and

| • |  | period-to-period fluctuations in our financial results.

These and other external factors may cause the market price and demand for our common stock to fluctuate substantially, which may limit or prevent investors from readily selling their shares of common stock and may otherwise negatively affect the liquidity of our common stock. In addition, securities class action litigation against companies has been on the rise. If any of our stockholders brought a lawsuit against us, we could incur substantial costs defending the lawsuit regardless of the outcome. Such a lawsuit could also divert the time and attention of our management.

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Anti-takeover provisions of Delaware law, provisions in our charter and bylaws and re-adoption of our stockholders’ rights plan, or poison pill, could make a third-party acquisition of us difficult.

Because we are a Delaware corporation, the anti-takeover provisions of Delaware law could make it more difficult for a third party to acquire control of us, even if the change in control would be beneficial to stockholders. We are subject to the provisions of Section 203 of the General Corporation Law of Delaware, which prohibits us from engaging in certain business combinations, unless the business combination is approved in a prescribed manner. In addition, our restated certificate of incorporation and restated bylaws also contain certain provisions that may make a third-party acquisition of us difficult, including:

| • |  | a classified board of directors, with three classes of directors each serving a staggered three-year term;

| • |  | the ability of the board of directors to issue preferred stock;

| • |  | a 70% super-majority shareholder vote to amend our bylaws and certain provisions of our certificate of incorporation; and

| • |  | the inability of our stockholders to call a special meeting or act by written consent.

In the past, we also implemented a stockholders’ rights plan, also called a poison pill, which could make it uneconomical for a third party to acquire our company on a hostile basis. Although the plan expired in July 2011, our Board of Directors could adopt a new plan at any time. The provisions in a stockholders’ rights plan, as well as Section 203, may discourage certain types of transactions in which our stockholders might otherwise receive a premium for their shares over then current market price, and may limit the ability of our stockholders to approve transactions that they think may be in their best interests.

Item 1B. | UNRESOLVED STAFF COMMENTS

None.

Item 2. | PROPERTIES

Our corporate headquarters and facilities are located in Salt Lake City, Utah. We currently lease a total of 307,000 square feet of building space in Salt Lake City dedicated to research and development, administration and our laboratory that has received federal certification under CLIA. Activities related to our oncology, urology, dermatology and women’s health molecular diagnostic business are performed at this location. The leases on our existing Salt Lake City facilities have terms of fifteen years, expiring from 2017 through 2025, and provide for renewal options for up to ten additional years.

We also lease approximately 36,000 square feet in Austin, Texas under a lease that expires in June 2020. This space is dedicated to administration, research and development and the CLIA-certified laboratory. Activities related to our pharmaceutical and clinical services are performed at this location. We also lease approximately 8,300 square feet of laboratory and office space in Saranac Lake, New York under a lease that expires in August 2017 with the right to renew for two additional five-year periods. Our immunoassay development and manufacturing of immunoassay kits are performed at the Saranac Lake facility.

In addition, we lease approximately 54,000 square feet in South San Francisco, California under a lease that expires in February 2017. This space is dedicated to administration, research and development and the CLIA-certified laboratory for our Crescendo subsidiary. Activities related to our autoimmune molecular diagnostic business are performed at this location.

In May 2011, we entered into a lease for approximately 3,600 square feet in Munich, Germany. This space is used as a laboratory for our international molecular diagnostic businesses. The lease on our Munich Germany facility has a term of approximately 5 years expiring in October of 2016.

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In December 2012, we entered into a lease for approximately 5,000 square feet in Zurich, Switzerland. This space is used for the administration of our international operations. We also maintain lease agreements for our administrative offices in Paris, France; Madrid, Spain; Milan, Italy and London, United Kingdom.

We believe that our existing facilities and equipment are well maintained and in good working condition. We believe our current facilities and those planned will provide adequate capacity for at least the next two years. We continue to make investments in capital equipment as needed to meet the anticipated demand for our molecular diagnostic tests and our pharmaceutical and clinical services.

Item 3. | LEGAL PROCEEDINGS

Background

Following the U.S. Supreme Court decision in June 2013 in Association for Molecular Pathology et al. v. Myriad Genetics, Inc. et al., various companies commenced offering clinical diagnostic and genomic laboratory services, including the testing and analysis of the BRCA1, BRCA2 and the MUTYH genes, that purport to compete with our BRACAnalysis, Colaris and Colaris AP and other testing and services. We believe that these tests and services infringe various patent claims that we own or have exclusively licensed from the University of Utah Research Foundation, HSC Research and Development Limited Partnership (an affiliate of Hospital For Sick Children), the Trustees of the University of Pennsylvania, and Endorecherche, Inc. (collectively, the “Patent Owners”). Under our license agreements with the Patent Owners, we are responsible for pursuing these patent infringement litigations, defending any counterclaims and paying related costs.

Multi-District Litigation

We are presently involved in a multi-district litigation matter in the United States District Court for the District of Utah (the “Utah Federal Court”) captioned In re: BRCA1- and BRCA2-Based Hereditary Cancer Test Patent Litigation (2:14 MD 2510 RJS) that consolidates seven lawsuits filed by us and the Patent Owners in the Utah Federal Court seeking to enforce the patent rights described above and three declaratory judgment actions filed in other courts by third parties seeking a determination that they do not infringe various patent claims owned by us and the Patent Owners and that these patent claims are invalid. These consolidated cases are now proceeding forward in the Utah Federal Court for all pretrial matters.

The prior history of the individual cases is set forth below. We are not a party to any other legal proceedings that we believe will have a material impact on our business, financial position or results of operations.

Cases by Myriad and the Patent Owners and Declaratory Judgment Actions in the Utah Federal Court

We filed lawsuits in the Utah Federal Court against Ambry Genetics Corporation on July 9, 2013, GeneDx, Inc. on October 16, 2013, Quest Diagnostics Incorporated and Quest Diagnostics Nichols Institute on October 22, 2013, Invitae Corporation on November 25, 2013, Laboratory Corporation of America Holdings on December 3, 2013, Counsyl, Inc. on June 13, 2014, and Pathway Genomics Corporation on June 16, 2014, alleging that these companies infringe various patent claims owned by Myriad and the Patent Owners and seeking injunctive relief and monetary damages.

Three of these companies (Counsyl, Quest, and Invitae) filed declaratory judgment lawsuits in district courts other than the Utah Federal Court (summarized below), all of which cases have been consolidated for pre-trial purposes with the Utah cases under the multi-district litigation matter described above. The other defendants (Ambry, GeneDx, LabCorp, and Pathway) have filed declaratory judgment counterclaims in the Utah lawsuits seeking a determination that they do not infringe various patent claims owned by Myriad and the Patent Owners and that these patent claims are invalid.

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On March 10, 2014, the Utah Federal Court denied our motion for a preliminary injunction against Ambry Genetics Corporation, Myriad and the Patent Owners appealed the district court’s decision to the United States Court of Appeals for the Federal Circuit. The parties have filed their respective briefs in the matter. A date for oral arguments has not yet been scheduled.

On September 30, 2013 and on November 26, 2013, Counsyl, Inc. and Invitae, Inc., respectively, filed a complaint for declaratory judgment against Myriad in the United States District Court for the Northern District of California and on October 10, 2013 Quest filed a similar complaint in the Central District of California seeking a judgment that they have not infringed and are not infringing various patent claims owned by Myriad and the Patent Owners relating to BRCA testing, and a judgment that various of the patent claims are invalid. These cases are proceeding before the Utah Federal Court as part of the consolidated multi-district litigation.

Other than as set forth above, we are not a party to any legal proceedings that we believe will have a material impact on our business, financial position or results of operations.

Item 4. | MINE SAFETY DISCLOSURES

None.

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PART II

Item 5. | MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES

Market Information

Our common stock is traded on The NASDAQ Global Select Market under the symbol “MYGN.” The following table sets forth the high and low sales prices for our common stock, as reported by The NASDAQ Global Select Market for the last two fiscal years:

|  | High |  |  | Low |
Fiscal Year Ended June 30, 2014: |  |  |  |  |  |  |  |
Fourth Quarter |  | $ | 42.50 |  |  | $ | 32.25 |
Third Quarter |  | $ | 39.15 |  |  | $ | 20.50 |
Second Quarter |  | $ | 30.75 |  |  | $ | 20.02 |
First Quarter |  | $ | 32.05 |  |  | $ | 22.61 |
Fiscal Year Ended June 30, 2013: |  |  |  |  |  |  |  |
Fourth Quarter |  | $ | 38.27 |  |  | $ | 24.12 |
Third Quarter |  | $ | 27.89 |  |  | $ | 24.08 |
Second Quarter |  | $ | 31.80 |  |  | $ | 24.81 |
First Quarter |  | $ | 28.00 |  |  | $ | 23.07 |

Stockholders

As of August 1, 2014, there were approximately 95 stockholders of record of our common stock and, according to our estimates, approximately 40,083 beneficial owners of our common stock.

Equity Compensation Plan Information

We incorporate information regarding the securities authorized for issuance under our equity compensation plans into this section by reference from the section entitled “Equity Compensation—Equity Compensation Plan Information” to be included in the proxy statement for our 2014 Annual Meeting of Stockholders.

Unregistered Sales of Securities

None.

Issuer Purchases of Equity Securities

We have previously announced the following stock repurchase programs for repurchases of our common stock:

Date Authorized |  | Amount Authorized |  |  | Date Completed
May 2010 |  | $ | 100 million |  |  | August 2011
August 2010 |  | $ | 100 million |  |  | February 2011
March 2011 |  | $ | 100 million |  |  | September 2011
August 2011 |  | $ | 200 million |  |  | January 2013
February 2013 |  | $ | 200 million |  |  | November 2013
November 2013 |  | $ | 300 million |  |  | ongoing
Total: |  | $ | 1,000 million |  |  |

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In connection with our most recent stock repurchase authorization, we have been authorized to complete the repurchase through open market transactions or through an accelerated share repurchase program, in each case to be executed at management’s discretion based on market conditions. As of the date of this report, we have not entered into an accelerated share repurchase agreement under our most recent stock repurchase program. The repurchase program may be suspended or discontinued at any time without prior notice. The transactions occurred in open market purchases and pursuant to a trading plan under Rule 10b5-1.

The details of the activity under our stock repurchase programs during the fiscal quarter ended June 30, 2014, were as follows:

Issuer Purchases of Equity Securities

Period |  | (a) Total Number of Shares Purchased |  |  | (b) Average Price Paid per Share |  |  | (c) Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs |  |  | (d) Approximate Dollar Value of Shares that May Yet Be Purchased Under the Plans or Programs |
April 1, 2014 to April 30, 2014 |  |  | 208,955 |  |  | $ | 38.53 |  |  |  | 208,955 |  |  | $ | 223,314,800 |
May 1, 2014 to May 31, 2014 |  |  | 701,421 |  |  | $ | 35.59 |  |  |  | 701,421 |  |  |  | 198,347,967 |
June 1, 2014 to June 30, 2014 |  |  | 917,233 |  |  | $ | 35.62 |  |  |  | 917,233 |  |  |  | 165,677,326 |
Total |  |  | 1,827,609 |  |  |  |  |  |  |  | 1,827,609 |  |  | $ | 165,677,326 |

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Stock Performance Graph

Beginning Fiscal 2014, we included the NADAQ Health Care Providers Index to replace the previously used NASDAQ Health Services Index following the discontinuation of the NASDAQ Health Services Index, effective December 31, 2013. For comparative purposes, the graph below includes both the NASDAQ Health Care Providers Index as well as the NASDAQ Health Services Index through December 31, 2013.

The graph set forth below compares the annual percentage change in our cumulative total stockholder return on our common stock during a period commencing on June 30, 2009 and ending on June 30, 2014 (as measured by dividing (A) the difference between our share price at the end and the beginning of the measurement period; by (B) our share price at the beginning of the measurement period) with the cumulative total return of The NASDAQ Stock Market, Inc. and the NASDAQ Health Care Providers Stock Index during such period. We have not paid any cash dividends on our common stock, and we do not include cash dividends in the representation of our performance. The price of a share of common stock is based upon the closing price per share as quoted on The NASDAQ Global Select Market on the last trading day of the year shown. The graph lines merely connect year-end values and do not reflect fluctuations between those dates. The comparison assumes $100 was invested on June 30, 2009 in our common stock and in each of the foregoing indices. The comparisons shown in the graph below are based upon historical data. We caution that the stock price performance shown in the graph below is not necessarily indicative of, nor is it intended to forecast, the potential future performance of our common stock.

|  | 6/30/2009 |  |  | 6/30/2010 |  |  | 6/30/2011 |  |  | 6/29/2012 |  |  | 6/28/2013 |  |  | 12/31/2013 |  |  | 6/30/2014 |
Myriad Genetics, Inc. |  |  | 100.00 |  |  |  | 44.10 |  |  |  | 66.99 |  |  |  | 70.12 |  |  |  | 79.26 |  |  |  | 61.89 |  |  |  | 114.81 |
NASDAQ Stock Index (U.S.) |  |  | 100.00 |  |  |  | 116.26 |  |  |  | 152.26 |  |  |  | 158.90 |  |  |  | 192.89 |  |  |  | 224.72 |  |  |  | 241.39 |
NASDAQ Health Care Providers Stocks |  |  | 100.00 |  |  |  | 117.72 |  |  |  | 165.81 |  |  |  | 167.20 |  |  |  | 212.07 |  |  |  | 238.37 |  |  |  | 263.04 |
NASDAQ Health Care Services Stocks |  |  | 100.00 |  |  |  | 130.48 |  |  |  | 161.95 |  |  |  | 172.69 |  |  |  | 195.63 |  |  |  | 219.17 |  |  |  | N/A |

Note: Information used on the graph was obtained from the CRSP Total Return Indexes, a source believed to be reliable, but we are not responsible for any errors or omission in such information.

The performance graph shall not be deemed to be incorporated by reference by means of any general statement incorporating by reference this Form 10-K into any filing under the Securities Act of 1933, as amended or the Securities Exchange Act of 1934, as amended, except to the extent that we specifically incorporate such information by reference, and shall not otherwise be deemed filed under such acts.

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Item 6. | SELECTED CONSOLIDATED FINANCIAL DATA

The following table sets forth our selected consolidated financial data and has been derived from our audited consolidated financial statements. Consolidated balance sheets as of June 30, 2014 and 2013, as well as consolidated statements of comprehensive income for the years ended June 30, 2014, 2013 and 2012 and the reports thereon are included elsewhere in this Annual Report on Form 10-K. The information below should be read in conjunction with our audited consolidated financial statements (and notes thereon) and “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” included in Item 7.

In thousands, except per share amounts |  | Years Ended June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |  |  | 2011 |  |  | 2010 |
Consolidated Statement of Comprehensive Income Data: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Molecular diagnostic testing |  | $ | 748,198 |  |  | $ | 582,392 |  |  | $ | 472,390 |  |  | $ | 400,046 |  |  | $ | 362,648 |
Pharmaceutical and clinical services |  |  | 30,018 |  |  |  | 30,773 |  |  |  | 23,615 |  |  |  | 2,038 |  |  |  | — |
Total Revenue |  |  | 778,216 |  |  |  | 613,165 |  |  |  | 496,005 |  |  |  | 402,084 |  |  |  | 362,648 |
Costs and expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of molecular diagnostic testing |  |  | 96,140 |  |  |  | 64,376 |  |  |  | 51,452 |  |  |  | 45,637 |  |  |  | 44,286 |
Cost of pharmaceutical and clinical services |  |  | 13,061 |  |  |  | 15,242 |  |  |  | 13,207 |  |  |  | 1,077 |  |  |  | — |
Research and development expense |  |  | 67,476 |  |  |  | 53,706 |  |  |  | 42,645 |  |  |  | 27,751 |  |  |  | 21,873 |
Selling, general and administrative expense |  |  | 327,097 |  |  |  | 251,839 |  |  |  | 208,383 |  |  |  | 169,841 |  |  |  | 161,414 |
Total costs and expenses |  |  | 503,774 |  |  |  | 385,163 |  |  |  | 315,687 |  |  |  | 244,306 |  |  |  | 227,573 |
Operating income |  |  | 274,442 |  |  |  | 228,002 |  |  |  | 180,318 |  |  |  | 157,778 |  |  |  | 135,075 |
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 5,397 |  |  |  | 5,497 |  |  |  | 4,629 |  |  |  | 2,226 |  |  |  | 5,660 |
Other |  |  | (1,974 | ) |  |  | (223 | ) |  |  | (407 | ) |  |  | (353 | ) |  |  | 99 |
Income before income taxes |  |  | 277,865 |  |  |  | 233,276 |  |  |  | 184,540 |  |  |  | 159,651 |  |  |  | 140,834 |
Income tax provision ( benefit) |  |  | 101,640 |  |  |  | 86,137 |  |  |  | 72,389 |  |  |  | 58,941 |  |  |  | (11,469 | )
Net income |  | $ | 176,225 |  |  | $ | 147,139 |  |  | $ | 112,151 |  |  | $ | 100,710 |  |  | $ | 152,303 |
Earnings per basic share: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | 2.33 |  |  | $ | 1.82 |  |  | $ | 1.33 |  |  | $ | 1.12 |  |  | $ | 1.58 |
Diluted |  | $ | 2.25 |  |  | $ | 1.77 |  |  | $ | 1.30 |  |  | $ | 1.10 |  |  | $ | 1.54 |
Weighted average shares outstanding: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  |  | 75,728 |  |  |  | 80,948 |  |  |  | 84,608 |  |  |  | 89,794 |  |  |  | 96,338 |
Diluted |  |  | 78,182 |  |  |  | 83,327 |  |  |  | 86,465 |  |  |  | 91,704 |  |  |  | 99,152 |
|  | As of June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |  |  | 2011 |  |  | 2010 |
Consolidated Balance Sheet Data: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable investment securities |  | $ | 270,586 |  |  | $ | 531,064 |  |  | $ | 454,224 |  |  | $ | 417,314 |  |  | $ | 488,382 |
Working capital |  |  | 241,845 |  |  |  | 419,483 |  |  |  | 377,525 |  |  |  | 383,874 |  |  |  | 446,510 |
Total assets |  |  | 823,814 |  |  |  | 803,821 |  |  |  | 690,635 |  |  |  | 610,827 |  |  |  | 593,847 |
Stockholders’ equity |  |  | 718,998 |  |  |  | 728,594 |  |  |  | 635,660 |  |  |  | 566,792 |  |  |  | 557,581 |

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Quarterly Financial Data (Unaudited)

In thousands, except per share amounts |  | Quarters Ended |
|  | Jun 30, 2014 |  |  | Mar 31, 2014 |  |  | Dec 31, 2013 |  |  | Sep 30, 2013 |
Consolidated Statement of Comprehensive Income Data: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Molecular diagnostic testing |  | $ | 182,863 |  |  | $ | 176,191 |  |  | $ | 196,158 |  |  | $ | 192,987 |
Pharmaceutical and clinical services |  |  | 5,902 |  |  |  | 6,733 |  |  |  | 7,902 |  |  |  | 9,480 |
Total Revenue |  |  | 188,765 |  |  |  | 182,924 |  |  |  | 204,060 |  |  |  | 202,467 |
Costs and expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of molecular diagnostic testing |  |  | 28,298 |  |  |  | 23,648 |  |  |  | 22,755 |  |  |  | 21,439 |
Cost of pharmaceutical and clinical services |  |  | 2,682 |  |  |  | 2,961 |  |  |  | 3,376 |  |  |  | 4,042 |
Research and development expense |  |  | 20,187 |  |  |  | 13,397 |  |  |  | 17,090 |  |  |  | 16,803 |
Selling, general and administrative expense |  |  | 84,347 |  |  |  | 87,631 |  |  |  | 77,840 |  |  |  | 77,279 |
Total costs and expenses |  |  | 135,514 |  |  |  | 127,637 |  |  |  | 121,061 |  |  |  | 119,563 |
Operating income |  |  | 53,251 |  |  |  | 55,287 |  |  |  | 82,999 |  |  |  | 82,904 |
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 207 |  |  |  | 2,498 |  |  |  | 1,330 |  |  |  | 1,362 |
Other |  |  | (908 | ) |  |  | (442 | ) |  |  | (185 | ) |  |  | (439 | )
Total other income |  |  | (701 | ) |  |  | 2,056 |  |  |  | 1,145 |  |  |  | 923 |
Income before income taxes |  |  | 52,550 |  |  |  | 57,343 |  |  |  | 84,144 |  |  |  | 83,827 |
Income tax provision |  |  | 18,921 |  |  |  | 20,573 |  |  |  | 33,784 |  |  |  | 28,362 |
Net income |  | $ | 33,629 |  |  | $ | 36,770 |  |  | $ | 50,360 |  |  | $ | 55,465 |
Earnings per share: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | 0.45 |  |  | $ | 0.50 |  |  | $ | 0.67 |  |  | $ | 0.70 |
Diluted |  | $ | 0.43 |  |  | $ | 0.48 |  |  | $ | 0.66 |  |  | $ | 0.68 |
Weighted average shares outstanding: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  |  | 74,391 |  |  |  | 73,821 |  |  |  | 75,070 |  |  |  | 79,575 |
Diluted |  |  | 77,678 |  |  |  | 76,374 |  |  |  | 76,825 |  |  |  | 81,798 |

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In thousands, except per share amounts |  | Quarters Ended |
|  | Jun 30, 2013 |  |  | Mar 31, 2013 |  |  | Dec 31, 2012 |  |  | Sep 30, 2012 |
Consolidated Statement of Comprehensive Income Data: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Molecular diagnostic testing |  | $ | 166,089 |  |  | $ | 148,384 |  |  | $ | 140,651 |  |  | $ | 127,268 |
Pharmaceutical and clinical services |  |  | 8,027 |  |  |  | 8,088 |  |  |  | 8,489 |  |  |  | 6,169 |
Total Revenue |  |  | 174,116 |  |  |  | 156,472 |  |  |  | 149,140 |  |  |  | 133,437 |
Costs and expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of molecular diagnostic testing revenue |  |  | 18,416 |  |  |  | 16,462 |  |  |  | 15,566 |  |  |  | 13,932 |
Cost of pharmaceutical and clinical services |  |  | 3,657 |  |  |  | 3,872 |  |  |  | 4,318 |  |  |  | 3,395 |
Research and development expense |  |  | 14,581 |  |  |  | 13,618 |  |  |  | 14,107 |  |  |  | 11,400 |
Selling, general and administrative expense |  |  | 71,546 |  |  |  | 64,602 |  |  |  | 59,563 |  |  |  | 56,128 |
Total costs and expenses |  |  | 108,200 |  |  |  | 98,554 |  |  |  | 93,554 |  |  |  | 84,855 |
Operating income |  |  | 65,916 |  |  |  | 57,918 |  |  |  | 55,586 |  |  |  | 48,582 |
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 1,310 |  |  |  | 1,434 |  |  |  | 1,385 |  |  |  | 1,368 |
Other |  |  | 2 |  |  |  | (111 | ) |  |  | 14 |  |  |  | (128 | )
Total other income |  |  | 1,312 |  |  |  | 1,323 |  |  |  | 1,399 |  |  |  | 1,240 |
Income before income taxes |  |  | 67,228 |  |  |  | 59,241 |  |  |  | 56,985 |  |  |  | 49,822 |
Income tax provision |  |  | 23,153 |  |  |  | 21,349 |  |  |  | 21,949 |  |  |  | 19,686 |
Net income |  | $ | 44,075 |  |  | $ | 37,892 |  |  | $ | 35,036 |  |  | $ | 30,136 |
Earnings per share: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | 0.55 |  |  | $ | 0.47 |  |  | $ | 0.43 |  |  | $ | 0.37 |
Diluted |  | $ | 0.53 |  |  | $ | 0.46 |  |  | $ | 0.42 |  |  | $ | 0.36 |
Weighted average shares outstanding: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic |  |  | 80,166 |  |  |  | 80,375 |  |  |  | 81,692 |  |  |  | 81,572 |
Diluted |  |  | 82,639 |  |  |  | 82,434 |  |  |  | 84,240 |  |  |  | 83,914 |

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Item 7. | MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Overview

We are a leading molecular diagnostic company dedicated to making a difference in patients’ lives through the discovery and commercialization of novel, transformative tests across major diseases. We believe in improving healthcare for patients by providing physicians with important information to solve unmet medical needs. Through our proprietary technologies, we believe we are positioned to identify important disease genes, the proteins they produce, and the biological pathways in which they are involved to better understand the genetic basis of human disease and the role that genes and their related proteins may play in the onset and progression of disease. We believe that identifying biomarkers (DNA, RNA and proteins) will enable us to develop novel molecular diagnostic tests.

Our goal is to provide physicians with critical information to guide the healthcare management of their patients by addressing four major questions a patient may have about their healthcare: (1) what is the likelihood of my getting a disease, (2) do I have a disease, (3) how aggressively should my disease be treated, and (4) which therapy will work best to treat my disease. We are developing new molecular diagnostic tests that are designed to assess an individual’s risk for developing disease later in life (predictive medicine), accurately diagnose disease (diagnostic medicine), identify a patient’s likelihood of responding to a particular therapy and assess if a patient will benefit from a particular drug (personalized medicine), and assess a patient’s risk of disease progression and disease recurrence (prognostic medicine).

Our business strategy for future growth is focused on three key initiatives. First, we are working to grow and expand our existing products and markets. Second, we are developing our business internationally with an international direct sales force. Finally, we are launching and intend to continue to launch new potentially transformative products across a diverse set of disease indications, complementing our current businesses in oncology, women’s health, urology, dermatology and rheumatology.

In February 2014, we completed the acquisition of privately-held Crescendo for $270 million in cash, which was reduced by the repayment of a loan made to Crescendo and other customary adjustments in accordance with the acquisition agreement. We believe that the acquisition of Crescendo facilitates our entry into the high growth autoimmune and inflammatory disease market, diversifies our product revenues and enhances our strength in protein-based diagnostics. The business of Crescendo, including its Vectra®DA blood test for rheumatoid arthritis disease management, is operated as a wholly owned subsidiary.

During the fiscal year ended June 30, 2014, we devoted our resources to supporting and growing our molecular diagnostic testing and pharmaceutical and clinical services businesses, as well as to the research and development of future molecular diagnostic and companion diagnostic candidates. See Note 10 “Segment and Related Information” in the notes to our consolidated financial statements for information regarding our operating segments. We also used $287.7 million of cash generated from operations to repurchase shares of our common stock under our share repurchase program described below. Our consolidated revenues primarily consisted of sales of molecular diagnostic tests through our wholly-owned subsdiaries Myriad Genetic Laboratories, Inc., Myriad Genetics GmbH, and Crescendo Bioscience, Inc. and pharmaceutical and clinical services through our wholly-owned Myriad RBM subsidiary. During the year ended June 30, 2014, we reported total revenues of $778.2 million, net income of $176.2 million and diluted earnings per share of $2.25 that included income tax expense of $101.6 million.

We incurred research and development expenses of $67.5 million, $53.7 million, and $42.6 million for the years ended June 30, 2014, 2013 and 2012, respectively. Our research and development expenses include costs incurred in formulating, improving, validating and creating alternative or modified processes related to and expanding the use of our 13 current molecular diagnostic test offerings and costs incurred for the discovery,

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development and validation of our pipeline of molecular diagnostic and companion diagnostic candidates. Our research and development expense may fluctuate substantially from quarter to quarter depending on the number of clinical studies and the timing of samples supporting those clinical studies.

Our selling, general and administrative expenses include costs associated with building our molecular diagnostic and pharmaceutical and clinical services businesses domestically and internationally. Selling, general and administrative expenses consist primarily of salaries, commissions and related personnel costs for sales, marketing, customer service, billing and collection, legal, finance and accounting, information technology, human resources, and allocated facilities expenses. We expect that our selling, general and administrative expenses will increase from quarter to quarter and that such increases may be substantial, depending on the number and scope of any new molecular diagnostic test launches, our efforts in support of our existing molecular diagnostic tests and pharmaceutical and clinical services and the transition from our existing product portfolio to our new products, as well as our continued international expansion efforts.

Between May 2010 and November 2013, we repurchased $700 million of our outstanding common stock. In November 2013, our board of directors authorized us to repurchase an additional $300 million of our outstanding common stock. In connection with this latest stock repurchase authorization, we have been authorized to repurchase shares at management’s discretion based on market conditions and have repurchased $134.3 million of our outstanding common stock as of June 30, 2014 under this authorization. See also “Part II, Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Repurchases of Equity Securities—Issuer Purchases of Equity Securities.”

Critical Accounting Policies

Critical accounting policies are those policies which are both important to the portrayal of a company’s financial condition and results and require management’s most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Our critical accounting policies are as follows:

| • |  | revenue recognition;

| • |  | allowance for doubtful accounts;

| • |  | goodwill; and

| • |  | income taxes

Revenue Recognition. Revenue includes the sale of molecular diagnostic tests and of our pharmaceutical and clinical services. Revenue is recorded at the invoiced amount net of any discounts or allowances and is recognized when persuasive evidence of an agreement exists, delivery has occurred, the fee is fixed or determinable, and collection is reasonably assured. Revenue is recognized upon completion of the test or service, communication of results, and when collectability is reasonably assured.

Allowance for Doubtful Accounts. The preparation of our financial statements in accordance with U.S. GAAP requires us to make estimates and assumptions that affect the reported amount of assets at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Trade accounts receivable are comprised of amounts due from sales of our molecular diagnostic tests, which are recorded net of any discounts or contractual allowances. We analyze trade accounts receivable and consider historic experience, customer creditworthiness, facts and circumstances specific to outstanding balances, and payment terms when evaluating the adequacy of the allowance for doubtful accounts.

We periodically evaluate and adjust the allowance for doubtful accounts when trends or significant events indicate that a change in estimate is appropriate. Such changes in estimate could materially affect our results of operations or financial position; however, to date these changes have not been material. It is possible that we may need to adjust our estimates in future periods.

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After a review of our allowance for doubtful accounts as of June 30, 2014 and 2013, we have determined that a hypothetical ten percent increase in our allowance for doubtful accounts would result in additional bad debt expense and an increase to our allowance for doubtful accounts of $0.9 million and $0.8 million, respectively.

Goodwill. We test goodwill for impairment on an annual basis and in the interim by reporting unit if events and circumstances indicate that goodwill may be impaired. The events and circumstances that are considered include business climate and market conditions, legal factors, operating performance indicators and competition. Impairment of goodwill is evaluated on a qualitative basis to determine if using a two-step process is necessary. If the qualitative assessment suggests that impairment is more likely than not, a two-step impairment analysis is performed. The first step involves comparison of the fair value of a reporting unit with its carrying amount. The valuation of a reporting unit requires judgment in estimating future cash flows, discount rates and other factors. In making these judgments, we evaluate the financial health of our business, including such factors as industry performance, market saturation and opportunity, changes in technology and operating cash flows. Changes in our forecasts or decreases in the value of our common stock could cause book value of reporting units to exceed their fair values. If the carrying amount of a reporting unit exceeds its fair value, the second step of the process involves a comparison of the fair value and the carrying amount of the goodwill of that reporting unit. If the carrying amount of the goodwill of the reporting unit exceeds the fair value of that goodwill, an impairment loss would be recognized in an amount equal to the excess of carrying value over fair value. If an event occurs that would cause a revision to the estimates and assumptions used in analyzing the value of the goodwill, the revision could result in a non-cash impairment charge that could have a material impact on the financial results.

At June 30, 2014, the Company has recorded goodwill of $169.2 million, $112.3 million recorded in connection with the acquisition of Crescendo in February 2014, which relates to the molecular diagnostics segment, and $56.9 million recorded in connection with the acquisition of Myriad RBM in May 2011, which relates to the pharmaceutical and clinical services segment, formerly our companion diagnostics segment. We have concluded that Crescendo and Myriad RBM represent distinct and separate reporting units. We evaluated the Crescendo reporting unit for impairment noting no indicators of impairment from the date of acquisition. We also measured the fair value of the Myriad RBM reporting unit utilizing income and market approaches. The income approach considered management’s business plans and projections as the basis for expected cash flows for the next twelve years and a 4.0% residual growth rate thereafter. We also used a weighted average discount rate of 30% for the analysis. Other significant estimates used in the analysis include the profitability of the respective reporting unit and working capital effects. The market approach used values for comparable companies and market transactions. We noted the fair value of the Myriad RBM reporting unit exceeded its carrying value by 18% using these assumptions mentioned. A hypothetical increase in the weighted average discount rate of 0.5% would decrease the calculated fair value as a percentage of book value for the Myriad RBM reporting unit by 4%. A hypothetical decrease in the residual growth rate of 0.5% would decrease the calculated fair value as a percent of book value for the Myriad RBM reporting unit by 1%.

Income taxes. Our income tax provision is based on income before taxes and is computed using the liability method in accordance with Accounting Standards Codification (“ASC”) 740—Income Taxes. Deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using tax rates projected to be in effect for the year in which the differences are expected to reverse. Significant estimates are required in determining our provision for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations, or the expected results from any future tax examinations. Various internal and external factors may have favorable or unfavorable effects on our future provision for income taxes. Those factors include, but are not limited to, changes in tax laws, regulations and/or rates, the results of any future tax examinations, changing interpretations of existing tax laws or regulations, changes in estimates of prior years’ items, past levels of research and development spending, acquisitions, changes in our corporate structure, and changes in overall levels of income before taxes all of which may result in periodic revisions to our provision for income taxes.

Developing our provision for income taxes, including our effective tax rate and analysis of potential uncertain tax positions, if any, requires significant judgment and expertise in federal and state income tax laws, regulations and

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strategies, including the determination of deferred tax assets and liabilities and any estimated valuation allowance we deem necessary to offset deferred tax assets. If we do not maintain taxable income from operations in future periods, we may increase the valuation allowance for our deferred tax assets and record material adjustments to our income tax expense. Our judgment and tax strategies are subject to audit by various taxing authorities. While we believe we have provided adequately for our uncertain income tax positions in our consolidated financial statements, adverse determination by these taxing authorities could have a material adverse effect on our consolidated financial condition, results of operations or cash flows. Interest and penalties on income tax items are included as a component of overall income tax expense.

Recent Accounting Pronouncements

In May 2014, the Financial Accounting Standards Board issued ASU No. 2014-09, “Revenue from Contracts with Customers.” Under the new standard, revenue is recognized at the time a good or service is transferred to a customer for the amount of consideration received for that specific good or service. It is effective for annual reporting periods beginning after December 15, 2016, including interim reporting periods, and early adoption is not permitted. Entities may use a full retrospective approach or report the cumulative effect as of the date of adoption. We are currently evaluating the impact, if any, the adoption of this standard will have on our Consolidated Financial Statements.

Results of Operations

Years ended June 30, 2014 and 2013

Revenue is comprised of sales of our molecular diagnostic tests and pharmaceutical and clinical services. Total revenue for the fiscal year ended June 30, 2014 was $778.2 million compared to $613.2 million for the prior fiscal year, an increase of 27%. This 27% increase in revenue is primarily due to increased molecular diagnostic testing volume for all of our tests including the recently launched myRisk Hereditary Cancer test and the recently acquired VectraDA test. Revenues during the year ended June 30, 2014 were negatively impacted by approximately $6 million due to a January 1, 2014 Medicare pricing adjustment that was subsequently reversed in part on April 1, 2014. Sales of our BRACAnalysis test accounted for 66% of our total revenues in fiscal 2014 compared to 75% in the prior year. We believe that our increased sales, marketing, and education efforts resulted in wider acceptance of our molecular diagnostic tests by the medical community and increased patient testing volumes. However, there can be no assurance that our revenue will continue to increase or remain at current levels or that we will be successful in transitioning our existing product portfolio to our new tests, launching other new tests and performing additional pharmaceutical and clinical services, or expanding the sale of our tests outside the United States.

Total revenue of our molecular diagnostic tests and pharmaceutical and clinical services and revenue by product as a percent of total revenue for the year ended June 30, 2014 and 2013 were as follows:

|  | June 30, |  |  |  |  |  | % of Total Revenue |
(In thousands) |  | 2014 |  |  | 2013 |  |  | % Change |  |  | 2014 |  |  | 2013 |
Molecular diagnostic revenues: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
BRACAnalysis |  | $ | 517,902 |  |  | $ | 460,272 |  |  |  | 13 | % |  |  | 66 | % |  |  | 75 | %
BART |  |  | 89,427 |  |  |  | 59,140 |  |  |  | 51 | % |  |  | 11 | % |  |  | 10 | %
COLARIS & COLARIS AP |  |  | 59,109 |  |  |  | 51,938 |  |  |  | 14 | % |  |  | 8 | % |  |  | 8 | %
Myriad myRisk |  |  | 53,680 |  |  |  | — |  |  |  | N/A |  |  |  | 7 | % |  |  | N/A |
VectraDA |  |  | 13,970 |  |  |  | — |  |  |  | N/A |  |  |  | 2 | % |  |  | N/A |
Other |  |  | 14,110 |  |  |  | 11,042 |  |  |  | 28 | % |  |  | 2 | % |  |  | 2 | %
Total molecular diagnostic revenue |  |  | 748,198 |  |  |  | 582,392 |  |  |  | 28 | % |  |  |  |  |  |  |  |
Pharmaceutical and clinical service revenue |  |  | 30,018 |  |  |  | 30,773 |  |  |  | -2 | % |  |  | 4 | % |  |  | 5 | %
Total revenue |  | $ | 778,216 |  |  | $ | 613,165 |  |  |  | 27 | % |  |  | 100 | % |  |  | 100 | %

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Our molecular diagnostic sales force is currently focused on three major market segments, oncology, women’s health, and rheumatology. Oncology, women’s health and rheumatology revenue was 52%, 46% and 2% of total molecular diagnostic testing revenue, respectively, during the year ended June 30, 2014; however, we acquired Crescendo on February 28, 2014, so we had only four months of sales during our fiscal year in the rheumatology market. Sales of molecular diagnostic tests in each major market for the year ended June 30, 2014 and 2013 were as follows:

|  | June 30, |  |  |  |
(In thousands) |  | 2014 |  |  | 2013 |  |  | % Change |
Molecular diagnostic revenues: |  |  |  |  |  |  |  |  |  |  |  |
Oncology |  | $ | 392,461 |  |  | $ | 370,257 |  |  |  | 6 | %
Women’s Health |  |  | 341,767 |  |  |  | 212,135 |  |  |  | 61 | %
Rheumatology |  |  | 13,970 |  |  |  | — |  |  |  | N/A |
Total molecular diagnostic revenues |  | $ | 748,198 |  |  | $ | 582,392 |  |  |  | 28 | %

Certain prior period reclassifications to oncology and women’s health revenue have been made to conform to current period presentation.

Cost of molecular diagnostic testing revenue for the year ended June 30, 2014 was $96.1 million, compared to $64.4 million for the same period ended June 30, 2013. This increase of 49% in molecular diagnostic testing cost of revenue is primarily due to the 28% increase in testing revenue, the additional costs associated with processing samples from our three newly launched tests and our newly acquired Vectra DA test that have yet to receive full reimbursement and are operating at levels that have not yet achieved economies of scale. Cost of pharmaceutical and clinical services for the year ended June 30, 2014 was $13.1 million, compared to $15.2 million for the same period ended June 30, 2013. This 14% decrease in pharmaceutical and clinical services testing cost of revenue is due to technology improvements resulting in increased efficiencies in our pharmaceutical and clinical services laboratory. Gross margins for molecular diagnostics for the year ended June 30, 2014 was 87% compared to 89% for the year ended June 30, 2013. Many of the costs associated with the performance of our pharmaceutical and clinical services are fixed; consequently, gross margins will vary as we experience fluctuations in our pharmaceutical and clinical services service revenue.

Our research and development expenses include costs incurred in formulating, improving and creating alternative or modified processes related to and expanding the use of our 13 current molecular diagnostic tests and costs incurred for the discovery, development and validation of our pipeline of molecular diagnostic and companion diagnostic candidates. Research and development expenses are comprised primarily of salaries and related personnel costs, laboratory supplies, equipment and facility costs. Research and development expenses incurred during the fiscal year ended June 30, 2014 were $67.5 million compared to $53.7 million for the prior fiscal year. This increase of 26% was primarily due to the following:

| • |  | an increase of approximately $6.8 million in internal research and development activities and clinical studies to support creating alternative or modified processes related to, and expanding the use of, our current molecular diagnostic products and to support future molecular diagnostic testing products;

| • |  | an increase of $6.2 million of research and development expenses as a result of the Crescendo acquisition, which includes one-time non-cash expenses of $3.8 million;

| • |  | an increase of $2.0 million due to external research and development activities to develop proprietary technologies;

| • |  | an increase of $1.6 million in share based compensation; and

| • |  | a decrease of approximately $2.8 million in internal development activities to support our pharmaceutical and clinical research services business.

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Our selling, general and administrative expenses include costs associated with growing our molecular diagnostic and pharmaceutical and clinical services businesses domestically and internationally. Selling, general and administrative expenses consist primarily of salaries, commissions and related personnel costs for sales, marketing, customer service, billing and collection, legal, finance and accounting, information technology, human resources, and allocated facilities expenses. Selling, general and administrative expenses for the fiscal year ended June 30, 2014 were $327.1 million compared to $251.8 million for the prior fiscal year. The increase in selling, general and administrative expense of 30% was primarily to support the 27% increase in revenue and include:

| • |  | an increase in sales and marketing expense of approximately $27.8 million to support new marketing initiatives, added sales force headcount and increased sales commissions associated with the increase in revenue;

| • |  | an increase of $23.4 million in selling, general and administrative expenses as a result of the Crescendo acquisition, which includes one-time non-cash expenses of $8.4 million;

| • |  | an increase of approximately $6.7 million in general administrative expenses to support revenue growth;

| • |  | an increase of approximately $6.1 million in international selling and administrative costs to support our international business;

| • |  | an increase of approximately $6.0 million in legal fees associated with legal proceedings to enforce our intellectual property;

| • |  | an increase of approximately $5.9 million in bad debt expense due to increased testing volumes;

| • |  | an increase of approximately $1.1 million in share based compensation; and

| • |  | a decrease of approximately $1.7 million in administrative fees associated with the pharmaceutical and clinical services research services business.

We expect that our selling, general and administrative expenses will continue to increase and that such increases may be substantial, depending on the number and scope of any new molecular diagnostic test launches, our efforts in support of our existing molecular diagnostic tests and pharmaceutical and clinical services as well as our continued international expansion efforts.

Interest income for the fiscal year ended June 30, 2014 was $5.4 million, compared to $5.5 million for the prior fiscal year. Interest income consists primarily of interest income recorded from the note receivable from Crescendo that was extinguished in connection with the closing of the acquisition in February 2014.

Income tax expense for the fiscal year ended June 30, 2014 was $101.6 million, for an effective rate of approximately 37%, compared to income tax expense of $86.1 million and an effective rate of approximately 37% in the 2013 period. Our tax rate is a product of a U.S. federal effective rate of 35% and a blended state income tax rate of 2%. Certain significant or unusual items are separately recognized during the period in which they occur and can be a source of variability in the effective tax rates from period to period. For the year ended June 30, 2014 we realized $11.1 million of excess tax benefits from share-based compensation as a reduction of taxes payable. Excess tax benefits from share-based compensation are credited directly to additional paid-in-capital and are not included in income tax expense. Accordingly, they do not impact our effective income tax rate. (See Note 8 in the fiscal 2014 Notes to Consolidated Financial Statements.)

Net income for the fiscal year ended June 30, 2014 was $176.2 million compared to $147.1 million in the prior fiscal year, an increase of 20% over the prior fiscal year. This 20% increase was primarily due to an increase in revenues partially offset by cost of revenue expenses and selling, general and administrative expenses. Earnings per diluted share was $2.25 for the fiscal year ended June 30, 2014 as compared to $1.77 for the prior fiscal year, an increase of 28%. This increase was due to increased net income and a reduced number of weighted shares outstanding during the 2014 fiscal year due to our share repurchase program.

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Years ended June 30, 2013 and 2012

Revenue was comprised of sales of our molecular diagnostic tests and pharmaceutical and clinical services. Total revenue for the fiscal year ended June 30, 2013 was $613.2 million compared to $496.0 million for the prior fiscal year, an increase of 24%. This 24% increase in revenue was primarily due to increased molecular diagnostic testing volume for our BRACAnalysis, Colaris and Colaris AP, a significant increase in BART testing volume as a result of revised medical guidelines, and a significant increase in pharmaceutical and clinical services due to increased research collaborations, as disclosed in the table below. Sales of our BRAC Analysis test accounted for 75.1% of our total revenues in fiscal 2013 compared to 81.7% in the prior year. We believe that our increased sales, marketing, and education efforts resulted in wider acceptance of our molecular diagnostic tests by the medical community and increased patient testing volumes.

Total revenue of our molecular diagnostic tests and pharmaceutical and clinical services and revenue by product as a percent of total revenue for the year ended June 30, 2013 and 2012 were as follows:

|  | June 30, |  |  |  |  |  | % of Total Revenue |
(In thousands) |  | 2013 |  |  | 2012 |  |  | % Change |  |  | 2013 |  |  | 2012 |
Molecular diagnostic revenues: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
BRACAnalysis |  | $ | 460,272 |  |  | $ | 405,478 |  |  |  | 14 | % |  |  | 75 | % |  |  | 82 | %
COLARIS & COLARIS AP |  |  | 51,938 |  |  |  | 43,277 |  |  |  | 20 | % |  |  | 8 | % |  |  | 8 | %
BART |  |  | 59,140 |  |  |  | 13,587 |  |  |  | 335 | % |  |  | 10 | % |  |  | 3 | %
Other |  |  | 11,042 |  |  |  | 10,048 |  |  |  | 10 | % |  |  | 2 | % |  |  | 2 | %
Total molecular diagnostic revenues |  |  | 582,392 |  |  |  | 472,390 |  |  |  | 23 | % |  |  |  |  |  |  |  |
Pharmaceutical and clincal service revenues |  |  | 30,773 |  |  |  | 23,615 |  |  |  | 30 | % |  |  | 5 | % |  |  | 5 | %
Total revenues |  | $ | 613,165 |  |  | $ | 496,005 |  |  |  | 24 | % |  |  | 100 | % |  |  | 100 | %

Our molecular diagnostic sales force during fiscal 2013 and 2012 was focused on two major markets, oncology and women’s health. Sales of molecular diagnostic tests in each market for the fiscal years ended June 30, 2013 and 2012 were as follows:

|  | June 30, |  |  |  |
(In thousands) |  | 2013 |  |  | 2012 |  |  | % Change |
Molecular diagnostic revenues: |  |  |  |  |  |  |  |  |  |  |  |
Oncology |  | $ | 370,257 |  |  | $ | 320,106 |  |  |  | 16 | %
Women’s Health |  |  | 212,135 |  |  |  | 152,284 |  |  |  | 39 | %
Total molecular diagnostic revenues |  | $ | 582,392 |  |  | $ | 472,390 |  |  |  | 23 | %

Cost of revenue was comprised primarily of salaries and related personnel costs, laboratory supplies, royalty payments, equipment costs and facilities expense. Cost of molecular diagnostic testing revenue for the fiscal year ended June 30, 2013 was $64.4 million compared to $51.5 million for the prior fiscal year. This increase of 25% in molecular diagnostic cost of revenue was primarily due to the increase in molecular diagnostic testing volumes. Cost of pharmaceutical and clinical services service revenue for the fiscal year ended June 30, 2013 was $15.2 million compared to $13.2 million for the prior fiscal year. Many of these costs associated with the performance of our pharmaceutical and clinical services are fixed; consequently, gross margins will vary as we experience fluctuations in our pharmaceutical and clinical services service revenue.

Our research and development expenses include costs incurred in formulating, improving and creating alternative or modified processes related to and expanding the use of our nine molecular diagnostic test offerings and costs incurred for the discovery, development and validation of our pipeline of molecular diagnostic and pharmaceutical and clinical services test candidates. Research and development expenses are comprised

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primarily of salaries and related personnel costs, laboratory supplies, molecular and pharmaceutical and clinical services development, equipment and facility costs. Research and development expenses incurred during the fiscal year ended June 30, 2013 were $53.7 million compared to $42.6 million for the prior fiscal year. This increase of 26% was primarily due to the following:

| • |  | an increase of approximately $5.0 million due to the internal development of future molecular diagnostic product candidates;

| • |  | an increase of approximately $3.0 million in internal development to support our pharmaceutical and clinical services business;

| • |  | an increase of approximately $1.9 million in internal development activities and clinical studies to support creating alternative or modified processes related to and expanding the use of our current molecular diagnostic products and to support future molecular diagnostic testing products; and

| • |  | an increase of approximately $0.8 million in costs associated with the in-license of new molecular diagnostic product candidates.

Our selling, general and administrative expenses included costs associated with growing our molecular diagnostic and pharmaceutical and clinical services businesses domestically and internationally. Selling, general and administrative expenses consisted primarily of salaries, commissions and related personnel costs for sales, marketing, customer service, billing and collection, executive, legal, finance and accounting, information technology, human resources, and allocated facilities expenses. Selling, general and administrative expenses for the fiscal year ended June 30, 2013 were $251.8 million compared to $208.4 million for the prior fiscal year. The increase in selling, general and administrative expense of 21% was primarily to support the 24% increase in revenue and include:

| • |  | an increase in sales and marketing expense of approximately $29.3 million due to various marketing programs and initiatives, added headcount and increased sales commissions;

| • |  | an increase of approximately $8.5 million in bad debt expense, a portion of which was associated with the 24% increase in revenues; and

| • |  | an increase of approximately $5.2 million in costs from our international operations.

Interest income for the fiscal year ended June 30, 2013 was $5.5 million, compared to $4.6 million for the prior fiscal year. Interest income consisted primarily of interest income recorded from our note receivable from Crescendo.

Income tax expense for the fiscal year ended June 30, 2013 was $86.1 million, for an effective rate of approximately 37%, compared to income tax expense of $72.4 million and an effective rate of approximately 39% in the 2012 period. Our tax rate is a product of a U.S. federal effective rate of 35% and a blended state income tax rate of 2%. Certain significant or unusual items are separately recognized during the period in which they occur and can be a source of variability in the effective tax rates from period to period. For the year ended June 30, 2013 we realized $7.9 million of excess tax benefits from stock-based compensation as a reduction of taxes payable. Excess tax benefits from stock-based compensation were credited directly to additional paid-in-capital and were not included in income tax expense. Accordingly, they did not impact our effective income tax rate. Due to the realization of these excess tax benefits that offset our taxes payable, our current income tax expense in fiscal 2013 was higher than our actual cash paid. (See Note 8 in the fiscal 2013 Notes to Consolidated Financial Statements.)

Net income for the fiscal year ended June 30, 2013 was $147.1 million compared to $112.2 million in the prior fiscal year. This 31% increase was primarily due to an increase in revenues partially offset by higher research and development expenses and selling, general and administrative expenses. Earnings per diluted share were $1.77 for the fiscal year ended June 30, 2013 compared to $1.30 for the prior fiscal year, an increase of 36%. This increase was due to increased net income and a reduced number of weighted shares outstanding during the 2013 fiscal year due to our share repurchase program.

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Liquidity and Capital Resources

Cash, cash equivalents, and marketable investment securities decreased $260.5 million, or 49%, from $531.1 million at June 30, 2013 to $270.6 million at June 30, 2014. This decrease was attributable to the repurchase of $287.7 million of our common stock under our share repurchase programs, the use of $223.5 million for the acquisition of Crescendo, payments of $108.2 million in estimated income tax obligations, and operating expenditures during fiscal 2014; partially offset by increased sales of $165.1 million and $64.8 million in proceeds from issuance of common stock under share-based compensation plans.

Net cash provided by operating activities was $190.2 million, $173.9 million and $141.8 million during the fiscal years ended June 30, 2014, 2013 and 2012, respectively. During the year ended June 30, 2014, our net income was reduced by non-cash charges in the form of share-based compensation and depreciation and amortization, which totaled $27.1 million and $13.8 million, respectively. Net cash provided by operating activities for year ended June 30, 2014 was also impacted by changes in bad debt expense, trade accounts receivable, prepaid taxes, accounts payable, inventory, and accrued liabilities.

Our investing activities used cash of $17.7 million, $75.6 million and $38.9 million during the fiscal years ended June 30, 2014, 2013 and 2012, respectively. Cash used in investing activities for the fiscal year ended June 30, 2014 was primarily comprised of the use of $223.5 million for the acquisition of Crescendo and $161.8 million for the purchase of marketable investment securities offset by $381.9 million in proceeds from maturities and sales of marketable investment securities. Capital expenditures for equipment and facilities for the year ended June 30, 2014 were $14.3 million. Cash used in investing activities from the prior fiscal years ended June 30, 2013 and 2012 was primarily due to the purchase of marketable investment securities and issuance of a $25 million note payable to Crescendo offset by proceeds from maturities and sales of marketable investment securities as well as capital expenditures for research and laboratory equipment.

Financing activities used cash of $211.8 million, $80.6 million, and $69.2 million during the fiscal years ended June 30, 2014, 2013 and 2012. Cash utilized from financing activities in these years was primarily due to the purchase of $287.7 million, $146.3 million and $128.5 million respectively, of our common stock through our share repurchase program. The cash used in the share purchase was partially offset by cash provided by the exercise of stock options and sales of our shares under our share-based compensation plans.

We believe that with our existing capital resources and expected net cash to be generated from sales of our molecular diagnostic tests and pharmaceutical and clinical services, we will have adequate funds to maintain our current and planned operations for the foreseeable future, although no assurance can be given that changes will not occur that would consume available capital resources more quickly than we currently expect and that we may need or want to raise financing. Our future capital requirements, cash flows, and results of operations could be affected by and will depend on many factors that are currently unknown to us, including:

| • |  | failure to sustain revenue growth or margins in our molecular diagnostic testing and pharmaceutical and clinical services businesses;

| • |  | termination of the licenses underlying our molecular diagnostic tests and pharmaceutical and clinical services or failure to enter into product or technology licensing or other arrangements favorable to us;

| • |  | delays or other problems with operating our laboratory facilities;

| • |  | the costs and expenses incurred in supporting our existing molecular diagnostic tests and pharmaceutical and clinical services;

| • |  | the progress, results and cost of transitioning from our current product portfolio to our new molecular diagnostic tests, as well as developing and launching additional molecular diagnostic tests and offering additional pharmaceutical and clinical services;

| • |  | potential business development activities, in-licensing agreements and acquisitions, such as our acquisition of Crescendo;

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| • |  | our ability to successfully integrate and achieve the expected benefits of our business development activities, in-licensing agreements and acquisitions;

| • |  | changes in the government regulatory approval process for our tests;

| • |  | the progress, costs and results of our international expansion efforts;

| • |  | the timing and amount of repurchases of our common stock;

| • |  | the costs, timing, outcome, and enforcement of any regulatory review of our existing or future molecular diagnostic tests and pharmaceutical and clinical services;

| • |  | the costs of preparing, filing and prosecuting patent applications, maintaining and enforcing our issued patents and pursuing or defending intellectual property-related claims;

| • |  | the costs, timing and outcome of any litigation against us or that we pursue;

| • |  | the introduction of technological innovations or new commercial tests by our competitors;

| • |  | changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries;

| • |  | changes in the governmental or private insurers reimbursement levels for our tests; and

| • |  | changes in structure of the healthcare system or healthcare payment systems.

Off-Balance Sheet Arrangements

None.

Contractual Obligations

The following table represents our consolidated contractual obligations as of June 30, 2014 (in thousands):

|  | Total |  |  | Less than one year |  |  | 1-3 Years |  |  | 4-5 Years |  |  | More than 5 years |
Operating leases |  | $ | 72,253 |  |  | $ | 11,235 |  |  | $ | 22,328 |  |  | $ | 12,499 |  |  | $ | 26,191 |
Purchase obligations |  |  | 48,410 |  |  |  | 15,006 |  |  |  | 33,404 |  |  |  | — |  |  |  | — |
Total |  | $ | 120,663 |  |  | $ | 26,241 |  |  | $ | 55,732 |  |  | $ | 12,499 |  |  | $ | 26,191 |

As of June 30, 2014, Crescendo has approximately three years remaining under an unconditional purchase obligation with a vendor to purchase goods and services used in the Company’s diagnostic processes. The agreement specifies certain minimum quantities and pricing terms.

The expected timing of payment for the obligations listed above is estimated based on current information. Actual payment timing and amounts may differ depending on the timing of goods or services received or other changes. The table above only includes payment obligations that are fixed or determinable. The table excludes royalties to third parties based on future sales of any of our product candidates that are approved for sale, as the amounts, timing, and likelihood of any such payments are based on the level of future sales of tests and are unknown.

Effects of Inflation

We do not believe that inflation has had a material impact on our business, revenues, or operating results during the periods presented.

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Certain Factors That May Affect Future Results of Operations

The Securities and Exchange Commission encourages companies to disclose forward-looking information so that investors can better understand a company’s future prospects and make informed investment decisions. This Annual Report on Form 10-K contains such “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995.

Words such as “may,” “anticipate,” “estimate,” “expects,” “projects,” “intends,” “plans,” “believes” and words and terms of similar substance used in connection with any discussion of future operating or financial performance, identify forward-looking statements. All forward-looking statements are management’s present expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; and other factors discussed under the heading “Risk Factors” contained in Item 1A of this Annual Report.

In light of these assumptions, risks and uncertainties, the results and events discussed in the forward-looking statements contained in this Annual Report or in any document incorporated by reference might not occur. Stockholders are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date of this Annual Report. We are not under any obligation, and we expressly disclaim any obligation, to update or alter any forward-looking statements, whether as a result of new information, future events or otherwise. All subsequent forward-looking statements attributable to us or to any person acting on our behalf are expressly qualified in their entirety by the cautionary statements contained or referred to in this section.

Market, Industry and Other Data

This Annual Report on Form 10-K contains estimates, projections and other information concerning our industry, our business and relevant molecular diagnostics markets, including data regarding the estimated size of relevant molecular diagnostic markets, patient populations, and the perceptions and preferences of patients and physicians regarding certain therapies, as well as data regarding market research and estimates. Information that is based on estimates, forecasts, projections, market research or similar methodologies is inherently subject to uncertainties

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and actual events or circumstances may differ materially from events and circumstances that are assumed in this information. Unless otherwise expressly stated, we obtained this industry, business, market and other data from reports, research surveys, studies and similar data prepared by market research firms and other third parties, industry, medical and general publications, government data and similar sources that we believe to be reliable. In some cases, we do not expressly refer to the sources from which this data is derived. In that regard, when we refer to one or more sources of this type of data in any paragraph, you should assume that other data of this type appearing in the same paragraph is derived from the same sources, unless otherwise expressly stated or the context otherwise requires.

Item 7A. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We maintain an investment portfolio in accordance with our written investment policy. The primary objectives of our investment policy are to preserve principal, maintain proper liquidity to meet operating needs and maximize yields. Our investment policy specifies credit quality standards for our investments and limits the amount of credit exposure to any single issue, issuer or type of investment.

Our investments consist of securities of various types and maturities of five years or less, with a maximum average maturity of three years. These securities are classified as available for sale. Available-for-sale securities are recorded on the balance sheet at fair market value with unrealized gains or losses reported as part of accumulated other comprehensive income/loss. Realized gains and losses on investment security transactions are reported on the specific-identification method. Dividend and interest income are recognized when earned. A decline in the market value of any available-for-sale security below cost that is deemed other-than-temporary results in a charge to earnings and establishes a new cost basis for the security.

Although our investment policy guidelines are intended to ensure the preservation of principal, current market conditions have resulted in high levels of uncertainty. Our ability to trade or redeem the marketable investment securities in which we invest, including certain corporate bonds, has become difficult. Valuation and pricing of these securities has also become variable and subject to uncertainty.

As of June 30, 2014 we have net unrealized gains of $0.4 million in our investment portfolio. For the year ended June 30, 2014 we have experienced fluctuations in our portfolio value primarily from our investments in bonds of various municipalities. If interest rates rise, the market value of our investments may decline, which could result in a realized loss if we are forced to sell an investment before its scheduled maturity. A hypothetical increase in interest rates by 25 basis points would have resulted in a decrease in the fair value of our net investment position of approximately $0.7 million and $1.3 million as of June 30, 2014 and 2013, respectively. We do not utilize derivative financial instruments to manage our interest rate risks.

Item 8. | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

MYRIAD GENETICS, INC.

Index to Financial Statements |  | Number |
Report of Independent Registered Public Accounting Firm |  |  | F-1 |
Consolidated Balance Sheets as of June 30, 2014 and 2013 |  |  | F-2 |
Consolidated Statements of Comprehensive Income for the Years Ended June 30, 2014, 2013 and 2012 |  |  | F-3 |
Consolidated Statements of Stockholders’ Equity for the Years Ended June 30, 2014, 2013 and 2012 |  |  | F-4 |
Consolidated Statements of Cash Flows for the Years Ended June 30, 2014, 2013 and 2012 |  |  | F-5 |
Notes to Consolidated Financial Statements |  |  | F-6 |

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Item 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

Not applicable.

Item 9A. | CONTROLS AND PROCEDURES

1. Disclosure Controls and Procedures

We maintain disclosure controls and procedures (Disclosure Controls) within the meaning of Rules 13a-15(e) and 15d-15(e) of the Securities Exchange Act of 1934, as amended, or the Exchange Act. Our Disclosure Controls are designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act, such as this Annual Report on Form 10-K, is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms. Our Disclosure Controls are also designed to ensure that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating our Disclosure Controls, management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management necessarily applied its judgment in evaluating and implementing possible controls and procedures.

As of the end of the period covered by this Annual Report on Form 10-K, we evaluated the effectiveness of the design and operation of the Company’s Disclosure Controls, which was done under the supervision and with the participation of our management, including our Chief Executive Officer and our Chief Financial Officer. Based on the evaluation of our Disclosure Controls, our Chief Executive Officer and Chief Financial Officer have concluded that, as of June 30, 2014, our Disclosure Controls were effective to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms and is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosure.

2. Internal Control Over Financial Reporting

| a. | Management’s Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting. Internal control over financial reporting is defined in Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act as a process designed by, or under the supervision of, a company’s principal executive and principal financial officers and effected by the company’s board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with U.S. generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that:

| • |  | pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company;

| • |  | provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and

| • |  | provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation.

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Our management assessed the effectiveness of our internal control over financial reporting as of June 30, 2014. In making this assessment, management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (1992 framework) (COSO) in Internal Control—Integrated Framework. Based on our assessment, management believes that, as of June 30, 2014, our internal control over financial reporting is effective based on those criteria.

Management has excluded Crescendo from its assessment of internal control over financial reporting as of June 30, 2014 because we acquired Crescendo in a business combination on February 28, 2014. Crescendo is a wholly-owned subsidiary of Myriad Genetics, Inc. whose total assets and total revenues represented 40% and 2%, respectively, of the related consolidated financial statement amounts as of and for the year ended June 30, 2014.

The effectiveness of Myriad Genetics, Inc.’s internal control over financial reporting as of June 30, 2014, has been audited by Ernst & Young LLP, an independent registered public accounting firm, as stated in their report as follows:

| b. | Report of the Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Myriad Genetics, Inc.

We have audited Myriad Genetics, Inc. and subsidiaries’ internal control over financial reporting as of June 30, 2014, based on criteria established in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (1992 framework) (the COSO criteria). Myriad Genetics Inc. and subsidiaries’ management is responsible for maintaining effective internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying Management’s Report on Internal Control over Financial Reporting. Our responsibility is to express an opinion on the company’s internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

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As indicated in the accompanying Management’s Report on Internal Control over Financial Reporting, management’s assessment of and conclusion on the effectiveness of internal control over financial reporting did not include the internal controls of Crescendo Bioscience, Inc., which is included in the June 30, 2014, consolidated financial statements of Myriad Genetics, Inc. and subsidiaries and constituted approximately 40 percent and 38 percent of total and net assets, respectively, as of June 30, 2014, and 2 percent of revenues for the year then ended. Our audit of internal control over financial reporting of Myriad Genetics, Inc. and subsidiaries also did not include an evaluation of the internal control over financial reporting of Crescendo Bioscience, Inc.

In our opinion, Myriad Genetics, Inc. and subsidiaries maintained, in all material respects, effective internal control over financial reporting as of June 30, 2014, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of Myriad Genetics, Inc. and subsidiaries as of June 30, 2014 and 2013, and the related consolidated statements of comprehensive income, stockholders’ equity and cash flows for each of the three years in the period ended June 30, 2014 of Myriad Genetics, Inc. and subsidiaries’ and our report dated August 13, 2014 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP
Salt Lake City, Utah
August 13, 2014

| c. | Change in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting, identified in connection with the evaluation of such internal control that occurred during the fourth quarter of our last fiscal year that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Item 9B. | OTHER INFORMATION

None.

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PART III

Item 10. | DIRECTORS AND EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

The response to this item is incorporated by reference from the discussion responsive thereto under the captions “Management and Corporate Governance,” “Section 16(a) Beneficial Ownership Reporting Compliance” and “Corporate Code of Conduct and Ethics” in our Proxy Statement for the 2014 Annual Meeting of Stockholders to be held on December 4, 2014.

Item 11. | EXECUTIVE COMPENSATION

The response to this item is incorporated by reference from the discussion responsive thereto under the captions “Executive Compensation,” “Management and Corporate Governance—Committees of the Board of Directors and Meetings—Compensation Committee Interlocks and Insider Participation,” “Compensation Committee Report” and “Management and Corporate Governance—Board’s Role in the Oversight of Risk Management” in our Proxy Statement for the 2014 Annual Meeting of Stockholders to be held on December 4, 2014.

Item 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

The response to this item is incorporated by reference from the discussion responsive thereto under the captions “Security Ownership of Certain Beneficial Owners and Management” and “Executive Compensation—Equity Compensation Plan Information” in our Proxy Statement for the 2014 Annual Meeting of Stockholders to be held on December 4, 2014.

Item 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

The response to this item is incorporated by reference from the discussion responsive thereto under the caption “Certain Relationships and Related Person Transactions” and “Management and Corporate Governance—Director Independence” in our Proxy Statement for the 2014 Annual Meeting of Stockholders to be held on December 4, 2014.

Item 14. | PRINCIPAL ACCOUNTANT FEES AND SERVICES

The response to this item is incorporated by reference from the discussion responsive thereto in the proposal entitled “Independent Public Accountants” in our Proxy Statement for the 2014 Annual Meeting of the Stockholders to be held on December 4, 2014.

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PART IV

Item 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

(a) The following documents are included as part of this Annual Report on Form 10-K.

| 1. | Financial Statements

See “Index to Consolidated Financial Statements” at Item 8 to this Annual Report on Form 10-K.

| 2. | Financial Statement Schedule

The following schedule is filed as part of this Annual Report on Form 10-K:

Schedule II—Schedule of Valuation and Qualifying Accounts for the Years Ended June 30, 2014, 2013 and 2012.

Other financial statement schedules have not been included because they are not applicable or the information is included in the financial statements or notes thereto.

| 3. | Exhibits

The exhibits which are filed with or incorporated by reference into this Annual Report on Form 10-K are set forth in the Exhibit Index beginning on page A-1, which is incorporated herein by reference.

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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, on August 13, 2014.

MYRIAD GENETICS, INC.
By: |  | /s/ PETER D. MELDRUM
|  | Peter D. Meldrum
|  | President and Chief Executive Officer

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities indicated below and on the dates indicated.

|  | Signatures |  | Title |  | Date
By: |  | /s/ PETER D. MELDRUM Peter D. Meldrum |  | President, Chief Executive Officer and Director (principal executive officer) |  | August 13, 2014
By: |  | /s/ JAMES S. EVANS James S. Evans |  | Chief Financial Officer (principal financial and accounting officer) |  | August 13, 2014
By: |  | /s/ JOHN T. HENDERSON John T. Henderson, M.D. |  | Chairman of the Board |  | August 13, 2014
By: |  | /s/ WALTER GILBERT Walter Gilbert, Ph.D. |  | Vice Chairman of the Board |  | August 13, 2014
By: |  | /s/ LAWRENCE C. BEST Lawrence C. Best |  | Director |  | August 13, 2014
By: |  | /s/ HEINER DREISMANN Heiner Dreismann, Ph.D. |  | Director |  | August 13, 2014
By: |  | /s/ DENNIS LANGER Dennis Langer, M.D., J.D. |  | Director |  | August 13, 2014
By: |  | /s/ S. LOUISE PHANSTIEL S. Louise Phanstiel |  | Director |  | August 13, 2014

61

##### Table of Contents

Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Myriad Genetics, Inc.

We have audited the accompanying consolidated balance sheets of Myriad Genetics, Inc. and subsidiaries as of June 30, 2014 and 2013, and the related consolidated statements of comprehensive income, stockholders’ equity, and cash flows for each of the three years in the period ended June 30, 2014. Our audits also included the financial statement schedule listed in the Index at Item 15(a). These financial statements and schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements and schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Myriad Genetics, Inc. and subsidiaries at June 30, 2014 and 2013, and the consolidated results of their operations and their cash flows for each of the three years in the period ended June 30, 2014, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole, presents fairly in all material respects the information set forth therein.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), Myriad Genetics, Inc. and subsidiaries’ internal control over financial reporting as of June 30, 2014, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (1992 framework) and our report dated August 13, 2014 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Salt Lake City, Utah

August 13, 2014

F-1

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Consolidated Balance Sheets

June 30, 2014 and 2013

(In thousands, except per share amounts)

|  | 2014 |  |  | 2013 |
Assets |  |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |  |
Cash and cash equivalents |  | $ | 64,821 |  |  | $ | 104,073 |
Marketable investment securities |  |  | 121,641 |  |  |  | 268,243 |
Prepaid expenses |  |  | 6,921 |  |  |  | 956 |
Inventory |  |  | 23,919 |  |  |  | 5,007 |
Trade accounts receivable, less allowance for doubtful accounts of $8,968 in 2014 and $7,500 in 2013 |  |  | 81,297 |  |  |  | 94,333 |
Deferred taxes |  |  | 6,445 |  |  |  | 8,007 |
Prepaid taxes |  |  | 13,609 |  |  |  | 728 |
Other receivables |  |  | 3,770 |  |  |  | 2,645 |
Total current assets |  |  | 322,423 |  |  |  | 483,992 |
Equipment and leasehold improvements: |  |  |  |  |  |  |  |
Equipment |  |  | 80,685 |  |  |  | 65,903 |
Leasehold improvements |  |  | 18,922 |  |  |  | 18,294 |
|  |  | 99,607 |  |  |  | 84,197 |
Less accumulated depreciation |  |  | 65,013 |  |  |  | 56,595 |
Net equipment and leasehold improvements |  |  | 34,594 |  |  |  | 27,602 |
Long-term marketable investment securities |  |  | 84,124 |  |  |  | 158,748 |
Long-term deferred taxes |  |  | 3,180 |  |  |  | 28,632 |
Note receivable |  |  | — |  |  |  | 21,667 |
Other assets |  |  | 5,000 |  |  |  | 13,000 |
Intangibles, net |  |  | 205,312 |  |  |  | 13,330 |
Goodwill |  |  | 169,181 |  |  |  | 56,850 |
Total assets |  | $ | 823,814 |  |  | $ | 803,821 |
Liabilities and Stockholders’ Equity |  |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |  |
Accounts payable |  | $ | 23,078 |  |  | $ | 18,132 |
Accrued liabilities |  |  | 56,410 |  |  |  | 44,334 |
Deferred revenue |  |  | 1,090 |  |  |  | 2,043 |
Total current liabilities |  |  | 80,578 |  |  |  | 64,509 |
Unrecognized tax benefits |  |  | 24,238 |  |  |  | 10,718 |
Total liabilities |  |  | 104,816 |  |  |  | 75,227 |
Commitments and contingencies |  |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |  |
Preferred stock, $0.01 par value, authorized 5,000 shares; no shares issued and outstanding |  |  | — |  |  |  | — |
Common stock, $0.01 par value, authorized 150,000 shares; issued and outstanding 73,497 shares in 2014 and 80,577 shares in 2013 |  |  | 735 |  |  |  | 806 |
Additional paid-in capital |  |  | 717,774 |  |  |  | 697,346 |
Accumulated other comprehensive loss |  |  | (1,515 | ) |  |  | (424 | )
Retained earnings |  |  | 2,004 |  |  |  | 30,866 |
Total stockholders’ equity |  |  | 718,998 |  |  |  | 728,594 |
Total liabilities and stockholders’ equity |  | $ | 823,814 |  |  | $ | 803,821 |

See accompanying notes to consolidated financial statements.

F-2

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Consolidated Statements of Comprehensive Income

Years ended June 30, 2014, 2013 and 2012

(In thousands, except per share amounts)

|  | 2014 |  |  | 2013 |  |  | 2012 |
Molecular diagnostic testing |  | $ | 748,198 |  |  | $ | 582,392 |  |  | $ | 472,390 |
Pharmaceutical and clinical services |  |  | 30,018 |  |  |  | 30,773 |  |  |  | 23,615 |
Total revenue |  |  | 778,216 |  |  |  | 613,165 |  |  |  | 496,005 |
Costs and expenses: |  |  |  |  |  |  |  |  |  |  |  |
Cost of molecular diagnostic testing |  |  | 96,140 |  |  |  | 64,376 |  |  |  | 51,452 |
Cost of pharmaceutical and clinical services |  |  | 13,061 |  |  |  | 15,242 |  |  |  | 13,207 |
Research and development expense |  |  | 67,476 |  |  |  | 53,706 |  |  |  | 42,645 |
Selling, general, and administrative expense |  |  | 327,097 |  |  |  | 251,839 |  |  |  | 208,383 |
Total costs and expenses |  |  | 503,774 |  |  |  | 385,163 |  |  |  | 315,687 |
Operating income |  |  | 274,442 |  |  |  | 228,002 |  |  |  | 180,318 |
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 5,397 |  |  |  | 5,497 |  |  |  | 4,629 |
Other |  |  | (1,974 | ) |  |  | (223 | ) |  |  | (407 | )
Total other income (expense): |  |  | 3,423 |  |  |  | 5,274 |  |  |  | 4,222 |
Income before income taxes |  |  | 277,865 |  |  |  | 233,276 |  |  |  | 184,540 |
Income tax provision |  |  | 101,640 |  |  |  | 86,137 |  |  |  | 72,389 |
Net income |  | $ | 176,225 |  |  | $ | 147,139 |  |  | $ | 112,151 |
Earnings per share: |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | 2.33 |  |  | $ | 1.82 |  |  | $ | 1.33 |
Diluted |  |  | 2.25 |  |  |  | 1.77 |  |  |  | 1.30 |
Weighted average shares outstanding: |  |  |  |  |  |  |  |  |  |  |  |
Basic |  |  | 75,728 |  |  |  | 80,948 |  |  |  | 84,608 |
Diluted |  |  | 78,182 |  |  |  | 83,327 |  |  |  | 86,465 |
Net income |  | $ | 176,225 |  |  | $ | 147,139 |  |  | $ | 112,151 |
Comprehensive income: |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on available-for-sale securities, net of tax |  |  | 610 |  |  |  | (257 | ) |  |  | (135 | )
Change in foreign currency translation adjustment, net of tax |  |  | (1,701 | ) |  |  | (5 | ) |  |  | (178 | )
Comprehensive income |  | $ | 175,134 |  |  | $ | 146,877 |  |  | $ | 111,838 |

See accompanying notes to consolidated financial statements.

F-3

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Consolidated Statements of Stockholders’ Equity

Years ended June 30, 2014, 2013 and 2012

(In thousands)

|  | Common stock |  |  | Additional paid-in capital |  |  | Accumulated other comprehensive income (loss) |  |  | Retained Earnings (accumulated deficit) |  |  | Stockholders’ equity |
|  | Shares |  |  | Amount |  |  |  |  |
Balances at June 30, 2011 |  |  | 86,244 |  |  | $ | 862 |  |  | $ | 604,409 |  |  | $ | 151 |  |  | $ | (38,630 | ) |  | $ | 566,792 |
Issuance of common stock for cash upon exercise of options and employee stock purchase plan |  |  | 2,013 |  |  |  | 21 |  |  |  | 25,008 |  |  |  | — |  |  |  | — |  |  |  | 25,029 |
Share-based payment expense |  |  | — |  |  |  | — |  |  |  | 26,275 |  |  |  | — |  |  |  | — |  |  |  | 26,275 |
Stock-based compensation tax benefits |  |  | — |  |  |  | — |  |  |  | 34,193 |  |  |  |  |  |  |  |  |  |  |  | 34,193 |
Repurchase and retirement of common stock |  |  | (5,688 | ) |  |  | (57 | ) |  |  | (42,205 | ) |  |  | — |  |  |  | (86,205 | ) |  |  | (128,467 | )
Net income |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 112,151 |  |  |  | 112,151 |
Other comprehensive income, net of tax |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (313 | ) |  |  | — |  |  |  | (313 | )
Balances at June 30, 2012 |  |  | 82,569 |  |  | $ | 826 |  |  | $ | 647,680 |  |  | $ | (162 | ) |  | $ | (12,684 | ) |  | $ | 635,660 |
Issuance of common stock for cash upon exercise of options and employee stock purchase plan |  |  | 3,640 |  |  |  | 36 |  |  |  | 57,789 |  |  |  | — |  |  |  | — |  |  |  | 57,825 |
Share-based payment expense |  |  | — |  |  |  | — |  |  |  | 26,612 |  |  |  | — |  |  |  | — |  |  |  | 26,612 |
Stock-based compensation tax benefits |  |  | — |  |  |  | — |  |  |  | 7,888 |  |  |  |  |  |  |  |  |  |  |  | 7,888 |
Repurchase and retirement of common stock |  |  | (5,632 | ) |  |  | (56 | ) |  |  | (42,623 | ) |  |  | — |  |  |  | (103,589 | ) |  |  | (146,268 | )
Net income |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 147,139 |  |  |  | 147,139 |
Other comprehensive income, net of tax |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (262 | ) |  |  | — |  |  |  | (262 | )
Balances at June 30, 2013 |  |  | 80,577 |  |  | $ | 806 |  |  | $ | 697,346 |  |  | $ | (424 | ) |  | $ | 30,866 |  |  | $ | 728,594 |
Issuance of common stock for cash upon exercise of options and employee stock purchase plan |  |  | 3,292 |  |  |  | 33 |  |  |  | 64,729 |  |  |  | — |  |  |  | — |  |  |  | 64,762 |
Share-based payment expense |  |  | — |  |  |  | — |  |  |  | 27,068 |  |  |  | — |  |  |  | — |  |  |  | 27,068 |
Stock-based compensation tax benefits |  |  | — |  |  |  | — |  |  |  | 11,143 |  |  |  |  |  |  |  |  |  |  |  | 11,143 |
Repurchase and retirement of common stock |  |  | (10,373 | ) |  |  | (104 | ) |  |  | (82,512 | ) |  |  | — |  |  |  | (205,087 | ) |  |  | (287,703 | )
Net income |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 176,225 |  |  |  | 176,225 |
Other comprehensive income, net of tax |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (1,091 | ) |  |  | — |  |  |  | (1,091 | )
Balances at June 30, 2014 |  |  | 73,496 |  |  | $ | 735 |  |  | $ | 717,774 |  |  | $ | (1,515 | ) |  | $ | 2,004 |  |  | $ | 718,998 |

See accompanying notes to consolidated financial statements.

F-4

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Consolidated Statements of Cash Flows

Years ended June 30, 2014, 2013 and 2012

(In thousands)

|  | 2014 |  |  | 2013 |  |  | 2012 |
Cash flows from operating activities: |  |  |  |  |  |  |  |  |  |  |  |
Net income |  | $ | 176,225 |  |  | $ | 147,139 |  |  | $ | 112,151 |
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |  |  |  |  |  |  |  |  |  |
Depreciation and amortization |  |  | 13,819 |  |  |  | 8,889 |  |  |  | 9,069 |
Loss on disposition of assets |  |  | 855 |  |  |  | 8 |  |  |  | 194 |
Share-based compensation expense |  |  | 27,068 |  |  |  | 26,612 |  |  |  | 26,275 |
Bad debt expense |  |  | 39,235 |  |  |  | 33,294 |  |  |  | 24,742 |
Non-cash expense related to in-process research and development technology |  |  | — |  |  |  | — |  |  |  | 750 |
Impairment of intangible assets |  |  | — |  |  |  | 1,490 |  |  |  | — |
Deferred income taxes |  |  | 8,124 |  |  |  | 7,469 |  |  |  | 33,625 |
Unrecognized tax benefits |  |  | (660 | ) |  |  | 710 |  |  |  | 560 |
Accreted interest on note receivable |  |  | (3,337 | ) |  |  | (2,667 | ) |  |  | (2,000 | )
Excess tax benefit from share-based compensation |  |  | (11,143 | ) |  |  | (7,888 | ) |  |  | (34,193 | )
Gain on sale of marketable investment securities |  |  | — |  |  |  | (165 | ) |  |  | (566 | )
Changes in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |  |
Prepaid expenses |  |  | (5,486 | ) |  |  | 757 |  |  |  | 1,204 |
Trade accounts receivable |  |  | (24,372 | ) |  |  | (67,185 | ) |  |  | (34,986 | )
Other receivables |  |  | (1,870 | ) |  |  | (706 | ) |  |  | (2,312 | )
Inventory |  |  | (15,794 | ) |  |  | 6,567 |  |  |  | (3,426 | )
Prepaid taxes |  |  | (12,881 | ) |  |  |  |  |  |  |  |
Accounts payable |  |  | (1,492 | ) |  |  | 7,991 |  |  |  | (1,249 | )
Accrued liabilities |  |  | 3,077 |  |  |  | 11,562 |  |  |  | 11,218 |
Deferred revenue |  |  | (1,155 | ) |  |  | (11 | ) |  |  | 748 |
Net cash provided by operating activities |  |  | 190,213 |  |  |  | 173,866 |  |  |  | 141,804 |
Cash flows from investing activities: |  |  |  |  |  |  |  |  |  |  |  |
Capital expenditures for equipment and leasehold improvements |  |  | (14,271 | ) |  |  | (11,373 | ) |  |  | (9,408 | )
Acquisition of Crescendo Biosciences, Inc. (see Note 12), net of cash acquired |  |  | (223,531 | ) |  |  | — |  |  |  | — |
Acquisition of Rules-Based Medicine, Inc., net of cash acquired |  |  | — |  |  |  | — |  |  |  | (799 | )
Purchase of in-process research and development technology |  |  | — |  |  |  | — |  |  |  | (750 | )
Purchase of other assets |  |  | — |  |  |  | — |  |  |  | (100 | )
Purchase of an acquisition option |  |  | — |  |  |  | — |  |  |  | (8,000 | )
Issuance of note receivable (Crescendo) |  |  | — |  |  |  | — |  |  |  | (17,000 | )
Equity investment (RainDance) |  |  | — |  |  |  | (5,000 | ) |  |  |  |
Purchases of marketable investment securities |  |  | (161,764 | ) |  |  | (443,777 | ) |  |  | (388,067 | )
Proceeds from maturities and sales marketable investment securities |  |  | 381,899 |  |  |  | 384,560 |  |  |  | 385,236 |
Net cash used in investing activities |  |  | (17,667 | ) |  |  | (75,590 | ) |  |  | (38,888 | )
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from common stock issued under share-based compensation plans |  |  | 64,762 |  |  |  | 57,825 |  |  |  | 25,029 |
Excess tax benefit from share-based compensation |  |  | 11,143 |  |  |  | 7,888 |  |  |  | 34,193 |
Repurchase and retirement of common stock |  |  | (287,703 | ) |  |  | (146,268 | ) |  |  | (128,467 | )
Net cash used in financing activities |  |  | (211,798 | ) |  |  | (80,555 | ) |  |  | (69,245 | )
Net increase (decrease) in cash and cash equivalents |  |  | (39,252 | ) |  |  | 17,721 |  |  |  | 33,671 |
Cash and cash equivalents at beginning of year |  |  | 104,073 |  |  |  | 86,352 |  |  |  | 52,681 |
Cash and cash equivalents at end of year |  | $ | 64,821 |  |  | $ | 104,073 |  |  | $ | 86,352 |
Supplemental cash flow information: |  |  |  |  |  |  |  |  |  |  |  |
Cash paid during the year for income taxes |  | $ | 108,207 |  |  | $ | 80,317 |  |  | $ | 33,382 |
Non-cash investing and financing activities: |  |  |  |  |  |  |  |  |  |  |  |
Fair value adjustment on marketable investment securities recorded to stockholders’ equity |  | $ | (362 | ) |  | $ | 433 |  |  | $ | (14 | )

See accompanying notes to consolidated financial statements.

F-5

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

(1) | Organization and Summary of Significant Accounting Policies

| (a) | Business Description and Basis of Presentation

Myriad Genetics, Inc. and subsidiaries (collectively, the Company) is a leading molecular diagnostic company focused on developing and marketing novel predictive medicine, personalized medicine and prognostic medicine tests. The Company employs a number of proprietary technologies, including DNA, RNA and protein analysis, that help it to understand the genetic basis of human disease and the role that genes and their related proteins may play in the onset and progression of disease. The Company uses this information to guide the development of new molecular diagnostic and companion diagnostic tests that are designed to assess an individual’s risk for developing disease later in life (predictive medicine), identify a patient’s likelihood of responding to drug therapy and guide a patient’s dosing to ensure optimal treatment (personalized medicine), or assess a patient’s risk of disease progression and disease recurrence (prognostic medicine). The Company currently offers thirteen commercial molecular diagnostic tests, including seven predictive medicine tests, three personalized medicine tests, two prognostic medicine tests and one diagnostic medicine test. The Company also generates revenue by providing pharmaceutical and clinical services to the pharmaceutical and biotechnology industries and medical research institutions utilizing its multiplexed immunoassay technology. The Company’s corporate headquarters is located in Salt Lake City, Utah.

The consolidated financial statements of the Company are prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) and include the accounts of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions have been eliminated in consolidation. In the opinion of management, the accompanying financial statements contain all adjustments (consisting of normal and recurring accruals) necessary to present fairly all financial statements in accordance with U.S. GAAP. Certain reclassifications have been made to prior period amounts to conform to the current period presentation.

| (b) | Marketable Investment Securities

The Company has classified its marketable investment securities as available-for-sale. Available-for-sale investment securities with remaining maturities of greater than one year are classified as long-term. Available-for-sale investment securities with remaining maturities of less than one year are classified as short-term. Available-for-sale investment securities with remaining maturities of less than three months at the time of purchase are classified as cash equivalents. Marketable securities are carried at estimated fair value with unrealized holding gains and losses, net of the related tax effect, included in accumulated other comprehensive (loss) in stockholders’ equity until realized. Gains and losses on investment security transactions are reported on the specific-identification method. Dividend and interest income are recognized when earned.

A decline in the market value of any available-for-sale security below cost that is deemed other than temporary results in a charge to earnings and establishes a new cost basis for the security. Losses are charged against “Other income” when a decline in fair value is determined to be other than temporary. We review several factors to determine whether a loss is other than temporary. These factors include but are not limited to: (i) the extent to which the fair value is less than cost and the cause for the fair value decline, (ii) the financial condition and near term prospects of the issuer, (iii) the length of time a security is in an unrealized loss position and (iv) our ability to hold the security for a period of time sufficient to allow for any anticipated recovery in fair value. There were no other-than-temporary impairments recognized during the years ended June 30, 2014, 2013 and 2012.

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

| (c) | Trade Accounts Receivable and Allowance for Doubtful Accounts

Trade accounts receivable are comprised of amounts due from sales of the Company’s molecular diagnostic tests and pharmaceutical and clinical services and are recorded at the invoiced amount, net of discounts and contractual allowances. The allowance for doubtful accounts is based on the Company’s best estimate of the amount of probable losses in the Company’s existing accounts receivable, which is based on historical write-off experience, customer creditworthiness, facts and circumstances specific to outstanding balances, and payment terms. Account balances are charged against the allowance after all means of collection have been exhausted and the potential for recovery is considered remote. The Company does not have any off-balance-sheet credit exposure related to its customers and does not require collateral.

| (d) | Equipment and Leasehold Improvements

Equipment and leasehold improvements are stated at cost less accumulated depreciation. Depreciation and amortization are computed using the straight-line method based on the lesser of estimated useful lives of the related assets or lease terms. Equipment items have depreciable lives of five to seven years. Leasehold improvements are depreciated over the shorter of the estimated useful lives or the associated lease terms, which range from three to fifteen years. Repairs and maintenance costs are charged to expense as incurred. For the years ended June 30, 2014, 2013 and 2012, the Company recorded the depreciation expense as follows:

|  | Years Ended June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
(In thousands) |  |  |  |  |  |  |  |  |
Depreciation expense |  | $ | 9,186 |  |  | $ | 7,994 |  |  | $ | 7,969 |

| (e) | Inventory

Inventories consist of reagents, plates and testing kits. Inventories are stated at the lower of cost or market on a first-in, first-out basis. In order to assess the ultimate realization of inventories, the Company is required to make judgments as to future demand requirements compared to current or committed inventory levels.

The Company evaluates its inventories for excess quantities and obsolescence. Inventories that are considered obsolete are expensed. The valuation of inventories requires the use of estimates as to the amounts of current inventories that will be sold. These estimates are dependent on management’s assessment of current and expected orders from the Company’s customers.

| (f) | Intangible Assets and Other Long-Lived Assets

Intangible and other assets as of June 30, 2014 and 2013 are comprised of acquired patents and intellectual property and purchased in-process research and development. Acquired intangible assets are recorded at fair value and amortized over the shorter of the contractual life or the estimated useful life.

The Company continually reviews and monitors long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If the carrying amount of an asset exceeds its estimated future undiscounted cash flows, an impairment charge is

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

recognized in the amount by which the carrying amount of the asset exceeds the fair value of the asset. Assets to be disposed of are reported at the lower of the carrying amount or fair value less costs to sell. In December 2012, the Company notified the licensor of the Company’s OnDose product of the Company’s intent to terminate the license agreement, and as a result, recorded an impairment charge of approximately $1.5 million associated with the purchased license agreement. Other than this $1.5 million impairment charge, the Company concluded there was no impairment of long-lived assets for the years ended June 30, 2014, 2013 and 2012.

| (g) | Goodwill

The Company has recorded goodwill of $169.2 million from the acquisition of Crescendo Bioscience, Inc. that was completed on February 28, 2014 (see Note 12) and Rules-Based Medicine, Inc. that was completed on May 31, 2011. Of this goodwill, $112.3 million relates to the Company’s molecular diagnostic segment and $56.9 million related to the Company’s pharmaceutical and clinical services segment. Goodwill is tested for impairment on an annual basis as of April 1 and in the interim by reporting unit if events and circumstances indicate that goodwill may be impaired. The events and circumstances that are considered include business climate and market conditions, legal factors, operating performance indicators and competition. Impairment of goodwill was evaluated using a two-step process. The first step involves a comparison of the fair value of the reporting unit with its carrying amount. If the carrying amount of the reporting unit exceeds its fair value, the second step of the process involves a comparison of the fair value and the carrying amount of the goodwill of that reporting unit. If the carrying amount of the goodwill of the reporting unit exceeds the fair value of that goodwill, an impairment loss would be recognized in an amount equal to the excess of carrying value over fair value. If an event occurs that would cause a revision to the estimates and assumptions used in analyzing the value of the goodwill, the revision could result in a non-cash impairment charge that could have a material impact on the financial results.

| (h) | Revenue Recognition

Molecular diagnostic testing revenue is recognized when persuasive evidence of an agreement exists, results have been communicated to the patient, the fee is fixed or determinable, and collection is reasonably assured. Revenue from the sale of molecular diagnostic tests and related marketing agreements is recorded at the invoiced amount net of any discounts or contractual allowances.

Pharmaceutical and clinical service revenue is recognized when persuasive evidence of an agreement exists, the fee is fixed and or determinable, when the testing service has been completed and the results of the tests are transferred to the customer, and collectability is reasonably assured. In addition, the Company’s wholly owned subsidiary, Myriad RBM, has received national, state, foreign government and private foundation grants and contracts. Revenue associated with these grants and contracts is recognized in the period in which qualifying costs for the services by the grants and contracts are incurred and the related grant or contract fee is earned.

| (i) | Income Taxes

The Company recognizes income taxes under the asset and liability method. This approach requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the carrying amounts and the tax bases of assets and liabilities.

The provision for income taxes, including the effective tax rate and analysis of potential tax exposure items, if any, requires significant judgment and expertise in federal and state income tax laws,

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MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

regulations and strategies, including the determination of deferred tax assets and liabilities and any estimated valuation allowances deemed necessary to recognize deferred tax assets at an amount that is more likely than not to be realized. The Company’s filings, including the positions taken therein, are subject to audit by various taxing authorities. While the Company believes it has provided adequately for its income tax liabilities in the consolidated financial statements, adverse determinations by these taxing authorities could have a material adverse effect on the consolidated financial condition, results of operations or cash flows.

| (j) | Earnings Per Share

Basic earnings per share is computed based on the weighted-average number of shares of common stock outstanding. Diluted earnings per share is computed based on the weighted-average number of shares of common stock, including the dilutive effect of common stock equivalents outstanding.

The following is a reconciliation of the denominators of the basic and diluted earnings per share computations:

(In thousands) |  | Years Ended June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Denominator: |  |  |  |  |  |  |  |  |  |  |  |
Weighted-average shares outstanding used to compute basic EPS |  |  | 75,728 |  |  |  | 80,948 |  |  |  | 84,608 |
Effect of dilutive stock options |  |  | 2,454 |  |  |  | 2,379 |  |  |  | 1,857 |
Weighted-average shares outstanding and dilutive securities used to compute diluted EPS |  |  | 78,182 |  |  |  | 83,327 |  |  |  | 86,465 |

Certain outstanding stock options were excluded from the computation of diluted earnings per share because the effect would have been anti-dilutive. These potential dilutive common shares, which may be dilutive to future diluted earnings per share, are as follows:

(In thousands) |  | Years Ended June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Anti-dilutive options excluded from EPS computation |  |  | 5,273 |  |  |  | 5,136 |  |  |  | 8,585 |

| (k) | Use of Estimates

The preparation of the consolidated financial statements in accordance with U.S. GAAP requires Company management to make estimates and assumptions relating to the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the period. Significant items subject to such estimates and assumptions include the carrying amount of fixed assets, valuation allowances for receivables and deferred income tax assets, certain accrued liabilities, share-based compensation and impairment analysis of goodwill and intangible assets. Actual results could differ from those estimates.

| (l) | Recent Accounting Pronouncements

In May 2014, the Financial Accounting Standards Board issued ASU No. 2014-09, “Revenue from Contracts with Customers.” Under the new standard, revenue is recognized at the time a good or service is transferred to a customer for the amount of consideration received for that specific good or

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

service. It is effective for annual reporting periods beginning after December 15, 2016, including interim reporting periods, and early adoption is not permitted. Entities may use a full retrospective approach or report the cumulative effect as of the date of adoption. We are currently evaluating the impact, if any, the adoption of this standard will have on our Consolidated Financial Statements.

(2) | Marketable Investment Securities

The amortized cost, gross unrealized holding gains, gross unrealized holding losses, and fair value for available-for-sale securities by major security type and class of security at June 30, 2014 and 2013 were as follows:

(In thousands) |  | Amortized cost |  |  | Gross unrealized holding gains |  |  | Gross unrealized holding losses |  |  | Estimated fair value |
At June 30, 2014: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash |  | $ | 45,181 |  |  | $ | — |  |  | $ | — |  |  | $ | 45,181 |
Cash equivalents |  |  | 19,639 |  |  |  | 1 |  |  |  | — |  |  |  | 19,640 |
Total cash and cash equivalents |  |  | 64,820 |  |  |  | 1 |  |  |  | — |  |  |  | 64,821 |
Available-for-sale: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate bonds and notes |  |  | 44,449 |  |  |  | 36 |  |  |  | (11 | ) |  |  | 44,474 |
Municipal bonds |  |  | 137,821 |  |  |  | 334 |  |  |  | (3 | ) |  |  | 138,152 |
Federal agency issues |  |  | 23,134 |  |  |  | 12 |  |  |  | (7 | ) |  |  | 23,139 |
Total |  | $ | 270,224 |  |  | $ | 383 |  |  | $ | (21 | ) |  | $ | 270,586 |

(In thousands) |  | Amortized cost |  |  | Gross unrealized holding gains |  |  | Gross unrealized holding losses |  |  | Estimated fair value |
At June 30, 2013: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash |  | $ | 40,412 |  |  | $ | — |  |  | $ | — |  |  | $ | 40,412 |
Cash equivalents |  |  | 63,653 |  |  |  | 8 |  |  |  | — |  |  |  | 63,661 |
Total cash and cash equivalents |  |  | 104,065 |  |  |  | 8 |  |  |  | — |  |  |  | 104,073 |
Available-for-sale: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate bonds and notes |  |  | 71,626 |  |  |  | 13 |  |  |  | (15 | ) |  |  | 71,624 |
Municipal bonds |  |  | 251,513 |  |  |  | 109 |  |  |  | (537 | ) |  |  | 251,085 |
Federal agency issues |  |  | 104,293 |  |  |  | 24 |  |  |  | (35 | ) |  |  | 104,282 |
Total |  | $ | 531,497 |  |  | $ | 154 |  |  | $ | (587 | ) |  | $ | 531,064 |

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

Cash, cash equivalents, and maturities of debt securities classified as available-for-sale are as follows at June 30, 2014:

(In thousands) |  | Amortized cost |  |  | Estimated fair value |
Cash |  | $ | 45,181 |  |  | $ | 45,181 |
Cash equivalents |  |  | 19,639 |  |  |  | 19,640 |
Available-for-sale: |  |  |  |  |  |  |  |
Due within one year |  |  | 121,505 |  |  |  | 121,641 |
Due after one year through five years |  |  | 83,899 |  |  |  | 84,124 |
Due after five years |  |  | — |  |  |  | — |
Total |  | $ | 270,224 |  |  | $ | 270,586 |

Debt securities in an unrealized loss position as of June 30, 2014 were not impaired at acquisition and the declines in fair value are not attributed to declines in credit quality. Management believes that it is more likely than not that the securities will be held until a recovery of par value. All securities in an unrealized loss position as of June 30, 2014 and 2013 are debt securities. Debt securities available-for-sale in a gross unrealized loss position as of June 30, 2014 and 2013 are summarized as follows:

|  | Less than 12 months |  |  | More than 12 months |  |  | Total |
(In thousands) |  | Fair value |  |  | Unrealized losses |  |  | Fair value |  |  | Unrealized losses |  |  | Fair value |  |  | Unrealized losses |
At June 30, 2014: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt securities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate bonds and notes |  |  | 15,961 |  |  |  | (11 | ) |  |  | — |  |  |  | — |  |  |  | 15,961 |  |  |  | (11 | )
Municipal bonds |  |  | 8,651 |  |  |  | (3 | ) |  |  | — |  |  |  | — |  |  |  | 8,651 |  |  |  | (3 | )
Federal agency issues |  |  | 4,993 |  |  |  | (7 | ) |  |  | — |  |  |  | — |  |  |  | 4,993 |  |  |  | (7 | )
|  | $ | 29,605 |  |  | $ | (21 | ) |  | $ | — |  |  | $ | — |  |  | $ | 29,605 |  |  | $ | (21 | )
|  | Less than 12 months |  |  | More than 12 months |  |  | Total |
(In thousands) |  | Fair value |  |  | Unrealized losses |  |  | Fair value |  |  | Unrealized losses |  |  | Fair value |  |  | Unrealized losses |
At June 30, 2013: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt securities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate bonds and notes |  |  | 30,309 |  |  |  | (15 | ) |  |  | — |  |  |  | — |  |  |  | 30,309 |  |  |  | (15 | )
Municipal bonds |  |  | 93,992 |  |  |  | (538 | ) |  |  | — |  |  |  | — |  |  |  | 93,992 |  |  |  | (538 | )
Federal agency issues |  |  | 45,528 |  |  |  | (34 | ) |  |  | — |  |  |  | — |  |  |  | 45,528 |  |  |  | (34 | )
|  | $ | 169,829 |  |  | $ | (587 | ) |  | $ | — |  |  | $ | — |  |  | $ | 169,829 |  |  | $ | (587 | )

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

(3) | Fair Value Measurements

The fair value of the Company’s financial instruments reflects the amounts that the Company estimates to receive in connection with the sale of an asset or paid in connection with the transfer of a liability in an orderly transaction between market participants at the measurement date (exit price). The fair value hierarchy prioritizes the use of inputs used in valuation techniques into the following three levels:

Level 1—quoted prices in active markets for identical assets and liabilities.

Level 2— observable inputs other than quoted prices in active markets for identical assets and liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Some of the Company’s marketable securities primarily utilize broker quotes in a non-active market for valuation of these securities.

Level 3—unobservable inputs.

The substantial majority of the Company’s financial instruments are valued using quoted prices in active markets or based on other observable inputs. The following table sets forth the fair value of the Company’s financial assets that are re-measured on a regular basis:

(In thousands) |  | Level 1 |  |  | Level 2 |  |  | Level 3 |  |  | Total |
at June 30, 2014 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Money market funds (a) |  | $ | 13,634 |  |  | $ | — |  |  | $ | — |  |  | $ | 13,634 |
Corporate bonds and notes |  |  | — |  |  |  | 44,474 |  |  |  | — |  |  |  | 44,474 |
Municipal bonds |  |  | — |  |  |  | 144,158 |  |  |  | — |  |  |  | 144,158 |
Federal agency issues |  |  | — |  |  |  | 23,139 |  |  |  | — |  |  |  | 23,139 |
Total |  | $ | 13,634 |  |  | $ | 211,771 |  |  | $ | — |  |  | $ | 225,405 |

(In thousands) |  | Level 1 |  |  | Level 2 |  |  | Level 3 |  |  | Total |
at June 30, 2013 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Money market funds (a) |  | $ | 12,691 |  |  | $ | — |  |  | $ | — |  |  | $ | 12,691 |
Corporate bonds and notes |  |  | — |  |  |  | 71,624 |  |  |  | — |  |  |  | 71,624 |
Municipal bonds |  |  | — |  |  |  | 302,055 |  |  |  | — |  |  |  | 302,055 |
Federal agency issues |  |  | — |  |  |  | 104,282 |  |  |  | — |  |  |  | 104,282 |
Total |  | $ | 12,691 |  |  | $ | 477,961 |  |  | $ | — |  |  | $ | 490,652 |

| (a) | Money market funds are primarily comprised of exchange traded funds and accrued interest

The Company’s Level 1 assets include money market instruments. Level 2 assets consist of marketable investment securities that include federal agency issues, commercial paper, corporate bonds, and municipal bonds. Level 2 securities are valued based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers and reference data including market research publications. As of June 30, 2014 and 2013, the Company had no investments which were measured using unobservable (Level 3) inputs.

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

(4) | Goodwill and Other Intangible Assets

Goodwill

At June 30, 2014, the Company had goodwill of $169.2 million recorded as a result of the acquisition of Crescendo Bioscience, Inc. (“Crescendo”) on February 28, 2014 (see Note 12) and Rules-Based Medicine, Inc. (“Myriad RBM”) on May 31, 2011. The Company assessed goodwill for impairment in accordance with the appropriate guidance (see Note 1(g)) and recorded no impairment of goodwill for the period ended June 30, 2014. The following summarizes changes to the goodwill balance for the years ended June 30, 2014 and 2013:

|  | Year Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |
Balance at beginning of period |  | $ | 56,850 |  |  | $ | 56,850 |
Current period acquisitions |  |  | 112,331 |  |  |  | — |
Balance at end of period |  | $ | 169,181 |  |  | $ | 56,850 |

Intangible Assets

Intangible assets primarily consist of amortizable assets of purchased licenses and technologies, developed technology, a laboratory database, trademarks, and customer relationships as well as non-amortizable intangible assets of in-process technologies, research and development. Certain of these intangible assets were recorded as part of the Company’s purchase of Crescendo on February 28, 2014 (see Note 12) and Myriad RBM on May 31, 2011. The Company’s developed technology and database acquired in conjunction with the purchase of Crescendo have estimated remaining useful lives of 18 years. Trademarks acquired in conjunction with the purchase of Myriad RBM have an estimated remaining useful life of approximately 14 years and customer relationships have an estimated remaining useful life of approximately 7 years. The estimated useful life of acquired in-process research and development was also evaluated in conjunction with the annual impairment analysis of intangible assets and the classification of the acquired in-process research and development as an indefinite lived asset was deemed appropriate as the related research and development was not yet complete nor had it been abandoned.

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

In December 2012, the Company notified the licensor of the Company’s OnDose product of the Company’s intent to terminate the license agreement, and as a result, recorded an impairment charge of approximately $1.5 million associated with the purchased license agreement. The fair value was estimated for the license agreement using the undiscounted future cash flows method, under which the Company determined that the fair value was less than the carrying value. The impairment is included in research and development in the condensed consolidated statement of comprehensive income and is part of the molecular diagnostic segment. The following summarizes the amounts reported as intangible assets:

(In thousands) |  | Gross Carrying Amount |  |  | Accumulated Amortization |  |  | Net |
at June 30, 2014 |  |  |  |  |  |  |  |  |  |  |  |
Purchased licenses and technologies |  | $ | 201,100 |  |  | $ | (6,597 | ) |  | $ | 194,503 |
Customer relationships |  |  | 4,650 |  |  |  | (1,441 | ) |  |  | 3,209 |
Trademarks |  |  | 3,000 |  |  |  | (200 | ) |  |  | 2,800 |
Total amortized intangible assets |  |  | 208,750 |  |  |  | (8,238 | ) |  |  | 200,512 |
In-process research and development |  |  | 4,800 |  |  |  | — |  |  |  | 4,800 |
Total unamortized intangible assets |  |  | 4,800 |  |  |  | — |  |  |  | 4,800 |
Total intangible assets |  | $ | 213,550 |  |  | $ | (8,238 | ) |  | $ | 205,312 |
(In thousands) |  | Gross Carrying Amount |  |  | Accumulated Amortization |  |  | Net |
at June 30, 2013 |  |  |  |  |  |  |  |  |  |  |  |
Purchased licenses and technologies |  | $ | 4,500 |  |  | $ | (2,644 | ) |  | $ | 1,856 |
Customer relationships |  |  | 4,650 |  |  |  | (976 | ) |  |  | 3,674 |
Trademarks |  |  | 3,000 |  |  |  | — |  |  |  | 3,000 |
Total amortized intangible assets |  |  | 12,150 |  |  |  | (3,620 | ) |  |  | 8,530 |
In-process research and development |  |  | 4,800 |  |  |  | — |  |  |  | 4,800 |
Total unamortized intangible assets |  |  | 4,800 |  |  |  | — |  |  |  | 4,800 |
Total intangible assets |  | $ | 16,950 |  |  | $ | (3,620 | ) |  | $ | 13,330 |

As of June 30, 2014 the weighted average remaining amortization period for purchased licenses and technologies, trademarks, and customer relationships is approximately 17 years.

The Company recorded amortization during the respective periods for these intangible assets as follows:

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Amortization on intangible assets |  | $ | 4,633 |  |  | $ | 895 |  |  | $ | 1,100 |

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

Future estimated amortization expense as of June 30, 2014 for the five succeeding fiscal years is as follows:

(In thousands) |  |  |
Fiscal year ending: |  |  |  |
2015 |  | $ | 11,900 |
2016 |  |  | 11,900 |
2017 |  |  | 11,900 |
2018 |  |  | 11,881 |
2019 |  |  | 11,587 |
|  | $ | 59,168 |

(5) | Leases

The Company leases office and laboratory space under five non-cancelable operating leases, with terms that expire between 2017 and 2025 in Salt Lake City, Utah, one cancelable lease for office and laboratory space with a term of five years in Munich, Germany, and two non-cancelable operating leases for Myriad RBM for office and laboratory space that expire between 2017 and 2020 in Austin, Texas and Saranac Lake, New York. The Company also leases office and laboratory space under one non-cancellable operating lease that expires in 2017 in South San Francisco, California for Crescendo. In addition, the Company maintains lease agreements that expire between 2013 and 2018 for administrative offices in Zurich, Switzerland; Paris, France; Madrid, Spain; and Milan, Italy. Furthermore, the Company leases information technology equipment under two non-cancelable leases, with terms that expire in 2016.

The following is a summary of the Company’s rental expense for the fiscal years reported:

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Rental expense |  | $ | 11,266 |  |  | $ | 8,155 |  |  | $ | 6,819 |

Future minimum lease payments under the Company’s current leases as of June 30, 2014 are as follows:

(In thousands) |  |  |
Fiscal year ending: |  |  |  |
2015 |  | $ | 11,235 |
2016 |  |  | 11,500 |
2017 |  |  | 10,828 |
2018 |  |  | 6,489 |
2019 |  |  | 6,009 |
Thereafter |  |  | 26,191 |
|  | $ | 72,252 |

(6) | Share-Based Compensation

The Company maintains a share-based compensation plan, the 2010 Employee, Director and Consultant Equity Incentive Plan, as amended (the “2010 Plan”), that has been approved by the Company’s shareholders. The 2010 Plan allows the Company, under the direction of the Compensation Committee of

F-15

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

the Board of Directors, to make grants of stock options, restricted and unrestricted stock awards and other stock-based awards to employees, consultants and directors. On December 5, 2013, the shareholders approved an amendment to the 2010 Plan to set the number of shares available for grant to 3,500,000. As of June 30, 2014, a total of 3,757,381 shares of common stock are reserved for issuance under the 2010 Plan. In addition, as of June 30, 2014, the Company may grant up to 5,005,532 additional shares under the 2010 Plan if options previously granted under the Company’s terminated 2003 Employee, Director and Consultant Option Plan are cancelled or expire in the future without the issuance of shares of common stock by the Company. The exercise price of options granted in 2014, 2013 and 2012 was equivalent to the fair market value of the stock at the date of grant. The number of shares, terms, and vesting periods are determined by the Company’s board of directors or a committee thereof on an option-by-option basis. Options generally vest ratably over service periods of four years. Options granted after December 5, 2012 expire eight years from the date of grant, and options granted prior to that date generally expire ten years from the date of grant.

The fair value of each option grant is estimated on the date of the grant using the Black-Scholes option-pricing model with the following weighted-average assumptions used for grants for the fiscal year ended June 30:

|  | 2014 |  | 2013 |  | 2012
Risk-free interest rate |  | 1.6% |  | 0.8% |  | 1.0%
Expected dividend yield |  | 0% |  | 0% |  | 0%
Expected lives (in years) |  | 4.1 - 4.7 |  | 4.2 - 4.7 |  | 4.2 - 4.6
Expected volatility |  | 40% |  | 44% |  | 44%

Expected option lives and volatilities are based on historical data of the Company and other factors.

A summary of activity is as follows:

|  | 2014 |  |  | 2013 |  |  | 2012 |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Number of shares |  |  | Weighted average exercise price |  |  | Number of shares |  |  | Weighted average exercise price |
Options outstanding at beginning of year |  |  | 14,434,970 |  |  |  | 21.75 |  |  |  | 15,233,281 |  |  | $ | 19.32 |  |  |  | 14,453,913 |  |  | $ | 18.22 |
Options granted |  |  | 3,320,553 |  |  |  | 26.52 |  |  |  | 2,957,623 |  |  |  | 27.09 |  |  |  | 3,188,160 |  |  |  | 20.42 |
Less: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options exercised |  |  | (3,122,427 | ) |  |  | 19.44 |  |  |  | (3,490,495 | ) |  |  | 15.65 |  |  |  | (1,852,245 | ) |  |  | 11.94 |
Options canceled or expired |  |  | (394,913 | ) |  |  | 24.30 |  |  |  | (265,439 | ) |  |  | 22.26 |  |  |  | (556,547 | ) |  |  | 21.48 |
Options outstanding at end of year |  |  | 14,238,183 |  |  |  | 23.30 |  |  |  | 14,434,970 |  |  |  | 21.75 |  |  |  | 15,233,281 |  |  |  | 19.32 |
Options exercisable at end of year |  |  | 7,149,155 |  |  |  | 21.90 |  |  |  | 7,480,472 |  |  |  | 20.51 |  |  |  | 8,397,678 |  |  |  | 18.01 |
Options vested and expected to vest |  |  | 13,374,736 |  |  |  | 23.12 |  |  |  | 13,543,852 |  |  |  | 21.58 |  |  |  | 14,514,637 |  |  |  | 19.28 |
Weighted average fair value of options granted during the year |  |  |  |  |  |  | 10.04 |  |  |  |  |  |  |  | 9.87 |  |  |  |  |  |  |  | 7.47 |

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

The following table summarizes information about stock options outstanding at June 30, 2014:

|  | Options outstanding |  |  | Options exercisable |
Range of exercise prices |  | Number outstanding at June 30, 2014 |  |  | Weighted average remaining contractual life (years) |  |  | Weighted average exercise price |  |  | Number exercisable at June 30, 2014 |  |  | Weighted average exercise price |
$5.89 - 19.47 |  |  | 4,750,203 |  |  |  | 5.85 |  |  | $ | 17.20 |  |  |  | 3,103,525 |  |  | $ | 16.44 |
20.01 - 26.49 |  |  | 5,531,296 |  |  |  | 6.55 |  |  |  | 25.03 |  |  |  | 2,064,390 |  |  |  | 23.14 |
26.84 - 30.34 |  |  | 3,929,684 |  |  |  | 7.09 |  |  |  | 28.16 |  |  |  | 1,975,740 |  |  |  | 29.17 |
30.53 - 37.73 |  |  | 27,000 |  |  |  | 7.18 |  |  |  | 34.05 |  |  |  | 5,500 |  |  |  | 31.11 |
|  |  | 14,238,183 |  |  |  | 6.47 |  |  |  |  |  |  |  | 7,149,155 |  |  |  | 21.90 |

Options exercisable at June 30, 2014 had a weighted average remaining contractual life of 5.56 years.

Share-based compensation expense recognized and included in the consolidated statements of comprehensive income for the fiscal years ended June 30, 2014, 2013 and 2012 was as follows:

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Cost of molecular diagnostic testing |  | $ | 833 |  |  | $ | 1,030 |  |  | $ | 1,158 |
Cost of pharmaceutical and clinical services |  |  | 317 |  |  |  | 219 |  |  |  | 85 |
Research and development expense |  |  | 5,429 |  |  |  | 3,246 |  |  |  | 3,350 |
Selling, general, and administrative expense |  |  | 27,418 |  |  |  | 22,117 |  |  |  | 21,682 |
Total share-based compensation expense |  | $ | 33,997 |  |  | $ | 26,612 |  |  | $ | 26,275 |

Total stock-based compensation for the year ended June 30, 2014 included $0.2 million, $2.0 million and $4.7 million in cost of molecular diagnostic testing, research and development and selling, general and administrative expenses, respectively, related to the acceleration of unvested stock options in connection with the acquisition of Crescendo which closed in February 2014 (see Note 12).

The Company has unrecognized share-based compensation cost related to share-based compensation granted under its current plans. The estimated unrecognized share-based compensation cost and related weighted average recognition period, aggregate intrinsic value of options outstanding, and aggregate intrinsic value of options that are fully vested is as follows:

(In thousands) |  | As of June 30, 2014 |
Unrecognized share-based compensation cost |  | $ | 41,728 |
Aggregate intrinsic value of options outstanding |  | $ | 222,451 |
Aggregate intrinsic value of options fully vested |  | $ | 121,659 |

The estimated unrecognized share-based compensation cost will be recognized over a weighted-average period of 2.3 years.

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

The total intrinsic value of options exercised during 2014, 2013 and 2012 was as follows:

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Total intrinsic value of options exercised |  | $ | 49,379 |  |  | $ | 51,785 |  |  | $ | 21,575 |

The Company had an Employee Stock Purchase Plan that was approved by shareholders in 1995 (the “1995 Purchase Plan”), and subsequently amended, under which 2,000,000 shares of common stock had been authorized. As of December 5, 2012, a total of 1,990,000 shares of common stock had been issued under the 1995 Purchase Plan when it was terminated. On December 5, 2012, following shareholder approval, the Company adopted the 2012 Employee Stock Purchase Plan (the “2012 Purchase Plan”), under which 2,000,000 shares of common stock have been authorized. Shares are issued under the 2012 Purchase Plan twice yearly at the end of each offering period. At June 30, 2014, a total of 169,000 shares of common stock had been purchased under the 2012 Plan. Shares purchased under and compensation expense associated with the 1995 and 2012 Plans for the years reported are as follows:

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Shares purchased under the Plans |  |  | 169 |  |  |  | 149 |  |  |  | 161 |
Plan compensation expense |  | $ | 1,317 |  |  | $ | 885 |  |  | $ | 892 |

The fair value of shares issued under the Plan that was in effect for each period reported was calculated using the Black-Scholes option-pricing model using the following weighted-average assumptions:

|  | 2014 |  |  | 2013 |  |  | 2012 |
Risk-free interest rate |  |  | 0.1 | % |  |  | 0.1 | % |  |  | 0.1 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected lives (in years) |  |  | 0.5 |  |  |  | 0.5 |  |  |  | 0.5 |
Expected volatility |  |  | 56 | % |  |  | 37 | % |  |  | 30 | %

(7) | Stockholders’ Equity

Stock Repurchase Program

The Company previously announced the following stock repurchase programs for its common stock:

Date Authorized |  | Amount Authorized |  |  | Date Completed
May 2010 |  | $ | 100,000,000 |  |  | August 2010
August 2010 |  | $ | 100,000,000 |  |  | February 2011
March 2011 |  | $ | 100,000,000 |  |  | September 2011
August 2011 |  | $ | 200,000,000 |  |  | January 2013
February 2013 |  | $ | 200,000,000 |  |  | November 2013
November 2013 |  | $ | 300,000,000 |  |  | ongoing
Total: |  | $ | 1,000,000,000 |  |  |

F-18

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

In November 2013, the Company completed its fifth share repurchase program, which authorized the repurchase of up to $200 million of the Company’s common stock. From July 2013 through November 2013, the Company repurchased $153 million worth of shares under this program. In November 2013, the Company’s Board of Directors authorized a sixth share repurchase program of $300 million of the Company’s outstanding common stock. The Company plans to repurchase the $300 million of its common stock from time to time or on an accelerated basis through open market transactions or privately negotiated transactions as determined by the Company’s management. The amount and timing of stock repurchases under the program will depend on business and market conditions, stock price, trading restrictions, acquisition activity and other factors. As of June 30, 2014, the Company has repurchased $134 million of shares under the current $300 million share repurchase authorization.

The Company uses the par value method of accounting for its stock repurchases. As a result of the stock repurchases, the Company reduced common stock and additional paid-in capital and recorded charges to accumulated deficit. The shares retired, aggregate common stock and additional paid-in capital reductions, and related charges to accumulated deficit for the repurchases for periods ended June 30, 2014, 2013 and 2012 were as follows:

|  | Year ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Shares purchased and retired |  |  | 10,373 |  |  |  | 5,632 |  |  |  | 5,688 |
Common stock and additional paid-in-capital reductions |  | $ | 82,617 |  |  | $ | 42,679 |  |  | $ | 42,262 |
Charges to retained earnings |  | $ | 205,086 |  |  | $ | 103,589 |  |  | $ | 86,205 |

(8) | Income Taxes

Income tax expense consists of the following:

|  | Year ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Current: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  | $ | 97,442 |  |  | $ | 80,333 |  |  | $ | 67,492 |
State |  |  | 3,541 |  |  |  | 6,021 |  |  |  | 4,647 |
Total Current |  |  | 100,983 |  |  |  | 86,354 |  |  |  | 72,139 |
Deferred: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  |  | (666 | ) |  |  | 660 |  |  |  | (2,192 | )
State |  |  | 746 |  |  |  | (431 | ) |  |  | 2,326 |
Foreign |  |  | (2,865 | ) |  |  | (2,051 | ) |  |  | (1,735 | )
Change in valuation allowance |  |  | 3,442 |  |  |  | 1,605 |  |  |  | 1,851 |
Total Deferred |  |  | 657 |  |  |  | (217 | ) |  |  | 250 |
Total income tax expense |  | $ | 101,640 |  |  | $ | 86,137 |  |  | $ | 72,389 |

F-19

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

Income (loss) before income taxes consists of the following:

|  | Year ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
United States |  | $ | 292,081 |  |  | $ | 243,556 |  |  | $ | 189,702 |
Foreign |  |  | (14,216 | ) |  |  | (10,280 | ) |  |  | (5,162 | )
|  |  | 277,865 |  |  |  | 233,276 |  |  |  | 184,540 |

The differences between income taxes at the statutory federal income tax rate and income taxes reported in the consolidated statements of comprehensive income were as follows:

|  | Year ended June 30, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Federal income tax expense at the statutory rate |  |  | 35.0 | % |  |  | 35.0 | % |  |  | 35.0 | %
State income taxes, net of federal benefit |  |  | 1.6 |  |  |  | 1.7 |  |  |  | 2.7 |
Research and development credits, net of the federal tax on state credits |  |  | (0.2 | ) |  |  | (1.0 | ) |  |  | (1.3 | )
Uncertain tax positions, net of federal benefit on state positions |  |  | (0.1 | ) |  |  | 0.2 |  |  |  | 0.2 |
Incentive stock option and employee stock purchase plan expense |  |  | (0.3 | ) |  |  | (0.5 | ) |  |  | 1.0 |
Change in valuation allowance |  |  | 1.2 |  |  |  | 0.7 |  |  |  | 1.0 |
Basis difference, disposition of foreign subsidiary |  |  | (1.9 | ) |  |  | 0.0 |  |  |  | 0.0 |
Other, net |  |  | 1.3 |  |  |  | 0.8 |  |  |  | 0.6 |
|  |  | 36.6 | % |  |  | 36.9 | % |  |  | 39.2 | %

F-20

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

The significant components of the Company’s deferred tax assets and liabilities were comprised of the following at June 30, 2014 and 2013:

|  | Year ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 76,986 |  |  | $ | 8,336 |
Property, plant and equipment |  |  | 2,947 |  |  |  | 3,103 |
Accrued vacation |  |  | 1,551 |  |  |  | 1,269 |
Allowance for doubtful accounts |  |  | 3,285 |  |  |  | 2,771 |
Stock compensation expense |  |  | 25,952 |  |  |  | 21,135 |
Capital loss carryover |  |  | 0 |  |  |  | 1,424 |
Research and development credits |  |  | 11,207 |  |  |  | 5,367 |
Uncertain state tax positions |  |  | 555 |  |  |  | 1,247 |
Other, net |  |  | 312 |  |  |  | 643 |
Total gross deferred tax assets |  |  | 122,795 |  |  |  | 45,295 |
Less valuation allowance |  |  | (41,420 | ) |  |  | (8,218 | )
Total deferred tax assets |  |  | 81,375 |  |  |  | 37,077 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Intangible assets |  |  | 71,750 |  |  |  | 438 |
Total deferred tax liabilities |  |  | 71,750 |  |  |  | 438 |
Net deferred tax assets |  |  | 9,625 |  |  |  | 36,639 |
Current net deferred tax asset |  |  | 6,386 |  |  |  | 8,007 |
Long term net deferred tax asset |  |  | 3,239 |  |  |  | 28,632 |
Net deferred tax asset |  | $ | 9,625 |  |  | $ | 36,639 |

F-21

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

On February 28, 2104, the Company completed the acquisition of privately-held Crescendo Bioscience, Inc. See Note 12. The Company’s allocation of the purchase consideration included deferred tax assets and liabilities to reflect the difference between financial statement and tax basis of assets and liabilities. Due to the limitations of Internal Revenue Code Sections 382 and 383 related to ownership changes, a significant portion of Crescendo’s deferred tax assets related to net operating losses and research credits are estimated to expire un-utilized. A valuation allowance was established to reflect the estimated expiration of those deferred tax assets. In addition, ASC guidance requires that the impact of a tax position be recognized in the financial statements if that position is more likely than not of being sustained on audit, based on the technical merits of the position. In accordance with those guidelines, the Company established a liability for unrecognized tax benefits. The components of deferred tax assets, deferred tax liabilities, and the liability for unrecognized tax benefits that were included in the allocation of Crescendo’s purchase consideration are as follows:

(In thousands) |  |  |
Deferred tax assets: |  |  |  |
Net operating loss carryforwards |  | $ | 70,048 |
Research and development credits |  |  | 5,815 |
Other, net |  |  | 312 |
Total gross deferred tax assets |  |  | 76,175 |
Less valuation allowance |  |  | (29,760 | )
Total deferred tax assets |  |  | 46,415 |
Deferred tax liabilities: |  |  |  |
Intangible assets |  |  | 72,005 |
Stock compensation expense |  |  | 4,443 |
Total deferred tax liabilities |  |  | 76,448 |
Net deferred tax liability |  |  | 30,033 |
Liability for unrecognized tax benefits |  | $ | 14,180 |

Due to sustained positive operating performance and the availability of expected future taxable income, the Company concluded that it is more likely than not that the benefits of the majority of its deferred income tax assets will be realized. However, for certain deferred tax assets, a valuation allowance has been established. For the years ended June 30, 2014 and 2013, the Company’s valuation allowance increased by $33,202,000 and $1,605,000, respectively. The increase for the year ended June 30, 2014 consisted of $29,760,000 related to the acquisition of Crescendo and $3,442,000 primarily due to foreign net operating losses, for which the Company concluded it was more likely than not that the benefits of the losses will not be realized. The increase in the year ended June 30, 2013 was primarily due to foreign net operating losses, for which the Company concluded it was more likely than not that the benefits of the losses will not be realized.

For the years ended June 30, 2014 and 2013, the Company realized $7,122,000 and $7,888,000, respectively, of excess tax benefits from stock-based compensation as a reduction of taxes payable. Excess tax benefits from stock based compensation are credited directly to additional paid-in-capital. The Company has adopted the with-and-without tax allocation approach for excess tax benefits, which results in the windfall tax benefits being utilized last after considering all other tax attributes available to the Company.

F-22

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

At June 30, 2014, the Company had the following net operating loss and research credit carryforwards, with their respective expiration periods. Certain carryforwards are subject to the limitations of Section 382 and 383 of the Internal Revenue Code as indicated.

(In thousands) |  | Amount |  |  | Subject to sections 382, 383 |  |  | Expires beginning in year |  |  | through |
Carryforwards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Federal net operating loss |  | $ | 164,504 |  |  |  | Yes |  |  |  | 2027 |  |  |  | 2033 |
Utah net operating loss |  |  | 229,900 |  |  |  | No |  |  |  | 2015 |  |  |  | 2024 |
California net operating loss |  |  | 155,834 |  |  |  | Yes |  |  |  | 2016 |  |  |  | 2033 |
Oklahoma net operating loss |  |  | 14,142 |  |  |  | Yes |  |  |  | 2023 |  |  |  | 2033 |
Foreign net operating losses (various jurisdictions) |  |  | 27,183 |  |  |  | No |  |  |  | Various |  |  |  | Various |
Federal research credit |  |  | 3,250 |  |  |  | Yes |  |  |  | 2025 |  |  |  | 2032 |
Utah research credit |  |  | 8,296 |  |  |  | No |  |  |  | 2021 |  |  |  | 2028 |
California research credit |  |  | 2,565 |  |  |  | Yes |  |  |  | n/a |  |  |  | n/a |

All of the Utah net operating loss carryforwards are ‘excess tax benefits’ as defined by ASC guidance and, if realized in future years, will be recognized as a credit to additional paid-in capital. Approximately $92,557,000 of the Utah net operating loss ‘excess tax benefits’ are attributable to periods prior to adoption of guidance limiting recognition of the deferred tax asset and are included in deferred tax assets (prior to any offset by valuation allowance.) The remaining $137,343,000 of Utah net operating loss ‘excess tax benefits’ are not included in deferred tax assets and will be recognized only upon realization of the tax benefit.

The Company’s deferred tax asset for the Utah net operating loss ‘excess tax benefits’ attributable to periods prior to the adoption of the standard is approximately $3,008,000 and is offset by a full valuation allowance at June 30, 2014. If the ‘excess tax benefits’ are recognized as additional paid-in-capital in future years, the corresponding valuation allowance will be reversed. At June 30, 2014, the Company also has a valuation allowance of $3,786,000 offsetting its foreign net operating loss carryforwards.

The Company incurred a taxable loss of $15,200,000 on the disposition of Psynova, a U.K. corporation, during the fiscal year. The Company’s tax basis in the stock of this subsidiary exceeded its accounting basis. According to ASC guidance, no deferred tax asset is recorded on outside basis differences in a foreign subsidiary when the tax basis exceeds the book basis. Due to the fact that a deferred tax asset had not been previously recorded, the loss on disposition reduces the Company’s effective tax rate and, accordingly, is reflected in the effective rate reconciliation.

Consistent with the indefinite reversal criteria of ASC 740-30-25-17, the Company intends to invest undistributed earnings of its foreign subsidiaries indefinitely. However, due to the cumulative losses that have been incurred to date in its foreign operations, the amount of unrecorded deferred liability due to the indefinite reversal criteria at June 30, 2014 is $0.

F-23

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

In July 2006, the FASB issued ASC Topic 740 Subtopic 10 Section 05, which clarifies the accounting for uncertainty in tax positions. ASC guidance requires that the impact of a tax position be recognized in the financial statements if that position is more likely than not of being sustained on audit, based on the technical merits of the position. The Company adopted the guidance on July 1, 2007 and recorded $0 cumulative effect. A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:

|  | Year ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Unrecognized tax benefits at the beginning of year |  | $ | 10,918 |  |  | $ | 10,208 |  |  | $ | 9,648 |
Gross increases—current year tax positions |  |  | 1,785 |  |  |  | 710 |  |  |  | 560 |
Gross increases—prior year tax positions |  |  | 350 |  |  |  | — |  |  |  | — |
Gross increases—acquisitions |  |  | 14,180 |  |  |  |  |  |  |  |  |
Gross decreases—prior year tax positions |  |  | (2,995 | ) |  |  |  |  |  |  |  |
Unrecognized tax benefits at end of year |  | $ | 24,238 |  |  | $ | 10,918 |  |  | $ | 10,208 |
Interest and penalties in year-end balance |  | $ | 620 |  |  | $ | 270 |  |  | $ | — |

Interest and penalties related to uncertain tax positions are included as a component of income tax expense.

The Company files U.S., foreign and state income tax returns in jurisdictions with various statutes of limitations. The years ended June 30, 2011 through June 30, 2014 remain subject to examination at June 30, 2014. The Company’s New York State income tax returns for the years ended June 30, 2011, 2012 and 2013 were under examination by the New York State Department of Taxation and Finance. The audit was settled during the year ended June 30, 2014. All amounts due resulting from the New York audit have been paid and are reflected in the current income tax provision. The Company’s New Jersey State income tax returns for the years ended June 30, 2007 through 2013 are currently under examination by the New Jersey State Department of Taxation and Finance. Annual tax provisions include amounts considered necessary to pay assessments that may result from examination of prior year tax returns; however, the amount ultimately paid upon resolution of issues may differ materially from the amount accrued. The Company’s U.S. federal tax return, U.K. income tax return and all other state tax returns are not currently under examination.

(9) | Employee Deferred Savings Plan

The Company has a deferred savings plan which qualifies under Section 401(k) of the Internal Revenue Code. Substantially all of the Company’s U.S. employees are covered by the plan. The Company makes matching contributions of 50% of each employee’s contribution with the employer’s contribution not to exceed 4% of the employee’s compensation. The Company’s recorded contributions to the plan as follows:

|  | Years ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Deferred savings plan Company contributions |  | $ | 4,430 |  |  | $ | 3,450 |  |  | $ | 2,955 |

F-24

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

(10) | Segment and Related Information

The Company’s business units have been aggregated into three reportable segments: (i) research, (ii) molecular diagnostics and (iii) pharmaceutical and clinical services, formerly called companion diagnostics. The research segment is focused on the discovery of genes, biomarkers and proteins related to major common diseases and includes corporate services such as finance, human resources, legal, and information technology. The molecular diagnostics segment provides testing that is designed to assess an individual’s risk for developing disease later in life, identify a patient’s likelihood of responding to drug therapy and guide a patient’s dosing to ensure optimal treatment, or assess a patient’s risk of disease progression and disease recurrence. The business of Crescendo acquired in February 2014 is included as part of the molecular diagnostic segment. The pharmaceutical and clinical services segment provides testing products and services to the pharmaceutical, biotechnology and medical research industries.

The accounting policies of the segments are the same as those described in the summary of significant accounting policies (Note 1). The Company evaluates segment performance based on income (loss) before interest income and other income and expense.

(In thousands) |  | Research |  |  | Molecular diagnostics |  |  | Pharmaceutical & clinical services |  |  | Total |
Year ended June 30, 2014: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  | $ | — |  |  | $ | 748,198 |  |  | $ | 30,018 |  |  | $ | 778,216 |
Depreciation and amortization |  |  | 2,001 |  |  |  | 9,887 |  |  |  | 1,931 |  |  |  | 13,819 |
Segment operating income (loss) |  |  | (64,981 | ) |  |  | 338,020 |  |  |  | 1,403 |  |  |  | 274,442 |
Year ended June 30, 2013: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  | $ | — |  |  | $ | 582,392 |  |  | $ | 30,773 |  |  | $ | 613,165 |
Depreciation and amortization |  |  | 2,182 |  |  |  | 4,974 |  |  |  | 1,733 |  |  |  | 8,889 |
Segment operating income (loss) |  |  | (56,428 | ) |  |  | 291,509 |  |  |  | (7,079 | ) |  |  | 228,002 |
Year ended June 30, 2012: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  | $ | — |  |  | $ | 472,390 |  |  | $ | 23,615 |  |  | $ | 496,005 |
Depreciation and amortization |  |  | 2,021 |  |  |  | 5,395 |  |  |  | 1,653 |  |  |  | 9,069 |
Segment operating income (loss) |  |  | (49,231 | ) |  |  | 237,737 |  |  |  | (8,188 | ) |  |  | 180,318 |

|  | Years Ended June 30, |
(In thousands) |  | 2014 |  |  | 2013 |  |  | 2012 |
Total operating income for reportable segments |  | $ | 274,442 |  |  | $ | 228,002 |  |  | $ | 180,318 |
Unallocated amounts: |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 5,397 |  |  |  | 5,497 |  |  |  | 4,629 |
Other |  |  | (1,974 | ) |  |  | (223 | ) |  |  | (407 | )
Income from operations before income taxes |  |  | 277,865 |  |  |  | 233,276 |  |  |  | 184,540 |
Income tax provision |  |  | 101,640 |  |  |  | 86,137 |  |  |  | 72,389 |
Net income |  | $ | 176,225 |  |  | $ | 147,139 |  |  | $ | 112,151 |

F-25

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

The following table sets forth a comparison of balance sheet assets by operating segment:

(In thousands) |  | June 30, |
|  | 2014 |  |  | 2013 |
Net equipment and leasehold improvements: |  |  |  |  |  |  |  |
Research |  | $ | 8,199 |  |  | $ | 8,590 |
Molecular diagnostics |  |  | 24,316 |  |  |  | 15,769 |
Pharmaceutical and clinical services |  |  | 2,079 |  |  |  | 3,243 |
Total |  | $ | 34,594 |  |  | $ | 27,602 |
Total Assets: |  |  |  |  |  |  |  |
Research |  | $ | 67,999 |  |  | $ | 82,517 |
Molecular diagnostics |  |  | 409,795 |  |  |  | 110,329 |
Pharmaceutical and clinical services |  |  | 75,434 |  |  |  | 79,911 |
Total |  | $ | 553,228 |  |  | $ | 272,757 |

The following table reconciles assets by operating segment to total assets:

|  | June 30, |
(In thousands) |  | 2014 |  |  | 2013 |
Total assets by segment |  | $ | 553,228 |  |  | $ | 272,757 |
Cash, cash equivalents, and marketable investment securities (1) |  |  | 270,586 |  |  |  | 531,064 |
Total |  | $ | 823,814 |  |  | $ | 803,821 |

| (1) | The Company manages cash, cash equivalents, and marketable investment securities at the consolidated level for all segments

The majority of the Company’s revenues were derived from the sale of molecular diagnostic tests in the United States. There were no customers that accounted for greater than 10% of revenue in the years ended June 30, 2014, 2013 and 2012.

Of the Company’s $169.2 million goodwill balance at June 30, 2014, $112.3 million related to Crescendo which is included in the molecular diagnostics segment and $56.9 million related to Myriad RBM which is included in the pharmaceutical and clinical services segment. Additionally, the majority of the Company’s long-lived assets are located in the United States.

(11) | Commitments and Contingencies

The Company is subject to various claims and legal proceedings covering matters that arise in the ordinary course of its business activities. As of June 30, 2014, management of the Company believes any liability that may ultimately result from the resolution of these matters will not have a material adverse effect on the Company’s consolidated financial position, operating results, or cash flows.

As of June 30, 2014, Crescendo Bioscience, Inc. has approximately three years remaining under an unconditional purchase obligation with a vendor to purchase goods and services used in the Company’s diagnostic processes. The agreement specifies certain minimum quantities and pricing terms.

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

In addition to the minimum quantities and pricing terms, the Company may also make additional purchase commitments of anticipated purchases based upon forecasted needs which are not included in the unconditional purchase obligation amounts below.

As of June 30, 2014, the remaining obligations under this agreement were as follows (in thousands):

|  | Amount |
Fiscal year ending: |  |  |  |
2015 |  | $ | 10,863 |
2016 |  |  | 21,262 |
2017 |  |  | 12,142 |
Total unconditional purchase obligation |  | $ | 44,267 |

(12) | Acquisitions

Crescendo Bioscience, Inc.

On February 28, 2014, the Company completed the acquisition of privately-held Crescendo Bioscience, Inc. (“Crescendo”), pursuant to an Amended and Restated Agreement and Plan of Merger, dated February 2, 2014 (the “Merger Agreement”). Pursuant to the terms of the Merger Agreement, Myriad acquired Crescendo for total consideration of $259 million as detailed below, by means of a reverse triangular merger in which Crescendo survived the merger as the surviving corporation and a wholly-owned subsidiary of Myriad. The surviving corporation operates under the name Crescendo Bioscience, Inc.

The following table reconciles consideration transferred to the total cash paid to acquire Crescendo:

(In thousands) |  |  |
Total consideration transferred |  | $ | 258,950 |
Share-based compensation to Crescendo employees |  |  | 6,929 |
Change of control payments to Crescendo employees |  |  | 5,695 |
Offset: Non-cash fair value purchase option |  |  | (8,000 | )
Total cash paid |  | $ | 263,574 |

The total consideration of $259 million consisted of (i) $225.1 million in cash, (ii) $25.9 million in elimination of intercompany balances related to accrued interest and the term loan the Company issued to Crescendo on September 8, 2011, and (iii) $8 million related to the fair value of the purchase option granted to the Company on September 8, 2011 by Crescendo through a definitive merger agreement (“Option Agreement”) entered into in association with the term note. Of the cash consideration, $20 million was deposited into an escrow account to fund (i) any post-closing adjustments payable to Myriad based upon differences between the estimated working capital and the actual working capital of Crescendo at closing, and (ii) any indemnification claims made by Myriad against Crescendo, for a period of time, based upon the completion of an audit of Crescendo’s financial statements, of no fewer than twelve nor more than fifteen months following closing.

Of the total cash paid, $6.9 million was accounted for as share-based compensation expense resulting from the accelerated vesting of employee options immediately prior to the acquisition and $5.7 million was

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##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

accounted for as change of control bonuses paid to Crescendo employees and directors. The Company recognized the share-based compensation expense and change of control bonuses in post-acquisition Condensed Consolidated Statements of Income for the year ended June 30, 2014.

Total consideration transferred was allocated to tangible and identifiable intangible assets acquired and liabilities assumed based on their fair values at the acquisition date as set forth below. The Company believes that the acquisition of Crescendo facilitates the Company’s entry into the high growth autoimmune market, diversifies its product revenue and enhances its strength in protein-based diagnostics. These factors contributed to consideration transferred in excess of the fair value of Crescendo’s net tangible and intangible assets acquired, resulting in the Company recording goodwill in connection with the transaction. Management estimated the fair values of tangible and intangible asset and liabilities in accordance with the applicable accounting guidance for business combinations and utilized the services of third-party valuation consultants.

The Company’s allocation of consideration transferred for Crescendo is as follows (in thousands):

(In thousands) |  | Estimated Fair Value |
Other assets acquired |  | $ | 15,826 |
Intangible assets |  |  | 196,600 |
Goodwill |  |  | 112,331 |
Total assets acquired |  |  | 324,757 |
Deferred tax liability |  |  | 44,213 |
Other liabilities assumed |  |  | 21,594 |
Total net assets acquired |  | $ | 258,950 |

Identifiable Intangible Assets

The Company acquired intangible assets that consisted of developed technology which had an estimated fair value of $165.4 million and a laboratory database with an estimated fair value of $31.2 million. The fair values of the assets were determined using a probability-weighted income approach that discounts expected future cash flows to present value. The estimated net cash flows were discounted using a discount rate of 19% which is based on the estimated internal rate of return for the acquisition and represents the rate that market participants might use to value the intangible assets. The projected cash flows were based on key assumptions such as: estimates of revenues and operating profits; the time and resources need to recreate databases and product and commercial development and approval; the life of the commercialized product; and associated risks related to viability and product alternatives. The Company will amortize the intangible assets on a straight-line basis over their estimated useful lives of 18 years. This amortization is not deductible for income tax purposes.

Goodwill

The $112.3 million of goodwill represents the excess of consideration transferred over the fair value of assets acquired and liabilities assumed and is attributable to the benefits expected from combining the Company’s research and commercial operations with Crescendo’s. This goodwill is not deductible for income tax purposes.

F-28

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

Subsequent to the acquisition date, the Company completed a study on net operating loss tax limitations resulting in a reduction of deferred tax assets of $2.4 million that were previously recorded in conjunction with the acquisition of Crescendo. The Company determined that the adjustment related to facts and circumstances that existed at the acquisition date. As a result of this new information, the acquisition date net deferred tax liability was retrospectively increased by $2.4 million with a corresponding increase to goodwill. The adjustment did not impact the Company’s results from operations and is reflected above in the Company’s allocation of consideration transferred.

Share-Based Compensation

The share-based compensation expense recognized for the accelerated vesting of employee options immediately prior to the acquisition was reported in the Company’s Consolidated Statements of Comprehensive Income for the year ended June 30, 2014 as follows:

(In thousands) |  |  |
Cost of molecular diagnostic testing |  | $ | 185 |
Research and development expense |  |  | 2,075 |
Selling, general, and administrative expense |  |  | 4,669 |
Total share-based compensation |  | $ | 6,929 |

Change of Control

The change of control expense recognized for bonuses paid to Crescendo employees and directors for completion of the acquisition with Myriad was reported in the Company’s Consolidated Statements of Comprehensive Income for the year ended June 30, 2014 as follows:

(In thousands) |  |  |
Cost of molecular diagnostic testing |  | $ | 238 |
Research and development expense |  |  | 1,710 |
Selling, general, and administrative expense |  |  | 3,747 |
Total change of control bonuses |  | $ | 5,695 |

Both the share-based compensation and change of control expenses are one-time items and will not impact future reporting periods.

Other

The Company also recorded interest income related to accretion of the note receivable that was settled at the acquisition date, for the year ended June 30, 2014 of $4.5 million, respectively, in the Consolidated Statements of Comprehensive Income. From the date of acquisition through June 30, 2014, the Company recorded Crescendo revenue of approximately $14.0 million and a net loss from Crescendo of approximately $26.0 million that included non-recurring acquisition related charges of $12.6 million.

F-29

##### Table of Contents

MYRIAD GENETICS, INC.

AND SUBSIDIARIES

Notes to Consolidated Financial Statements

June 30, 2014, 2013 and 2012

Pro Forma Information

The unaudited pro-forma results presented below include the effects of the Crescendo acquisition as if it had been consummated as of July 1, 2012, with adjustments to give effect to pro forma events that are directly attributable to the acquisition which includes adjustments related to the amortization of acquired intangible assets, interest income and expense, stock-based compensation expense, and depreciation. The unaudited pro forma results do not reflect any operating efficiency or potential cost savings which may result from the consolidation of Crescendo. Accordingly, these unaudited pro forma results are presented for informational purposes only and are not necessarily indicative of what the actual results of operations of the combined company would have been if the acquisition had occurred at the beginning of the period presented nor are they indicative of future results of operations and are not necessarily indicative of either future results of operations or results that might have been achieved had the acquisition been consummated as of July 1, 2012.

(In thousands) |  |  |  |  |  |
|  | June 30, |
|  | 2014 |  |  | 2013 |
Revenue |  | $ | 807,509 |  |  | $ | 619,835 |
Income from operations |  |  | 252,634 |  |  |  | 177,998 |
Net income |  | $ | 155,924 |  |  | $ | 108,024 |
Net income per share, basic |  | $ | 2.06 |  |  | $ | 1.33 |
Net income per share, diluted |  | $ | 1.99 |  |  | $ | 1.30 |

(13) | Term Loan

On September 8, 2011, the Company issued a $25 million term loan to Crescendo. Under the Loan Agreement, the Company loaned Crescendo $25 million for a term of six years, with the principal due upon maturity. Interest accrued at 6% per year and is due annually. During the fiscal quarter ended September 30, 2012, the Loan Agreement was amended to increase the stated interest rate from 6% to 7% per year. On February 28, 2014, $25.9 million that represented the loan and interest outstanding was settled as an offset against the cash paid for the Crescendo acquisition.

(14) | Cost Basis Investment

In April 2013, the Company acquired approximately 28 million shares of Series E preferred stock of RainDance Technologies, Inc. (“RainDance”) of Lexington, Massachusetts, for $5 million. RainDance provides high-throughput picodroplet-based technology that can encapsulate a single molecule, cell or reaction and be digitally analyzed and sorted one at a time. The Series E shares purchased by the Company represented less than 5% of the total shares outstanding of RainDance’s capital stock. Subsequent to the investment the Company evaluated its relationship with RainDance and determined it did not have significant influence over the operations of RainDance. The Company’s investment in RainDance has been recorded under the cost method as an “Other Asset” on the Company’s consolidated balance sheet. The Company will periodically evaluate the investment for impairment. No impairment indicators were noted at June 30, 2014.

F-30

##### Table of Contents

Schedule II

MYRIAD GENETICS, INC.

Schedule of Valuation and Qualifying Accounts

Years Ended June 30, 2014, 2013, and 2012

(In thousands)

|  | Balance at Beginning of Period |  |  | Addition Charged to Cost and Expenses |  |  | Addition due to acquisition of Crescendo |  |  | Deductions (1) |  |  | Balance at End of Period |
Allowance for doubtful accounts: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Year ended June 30, 2014 |  | $ | 7,500 |  |  | $ | 39,235 |  |  |  | 868 |  |  | ($ | 38,635 | ) |  | $ | 8,968 |
Year ended June 30, 2013 |  | $ | 4,600 |  |  | $ | 33,294 |  |  |  | — |  |  | ($ | 30,394 | ) |  | $ | 7,500 |
Year ended June 30, 2012 |  | $ | 3,700 |  |  | $ | 24,742 |  |  |  | — |  |  | ($ | 23,842 | ) |  | $ | 4,600 |

(1) | Represents amounts written off against the allowance.

See report of independent registered public accounting firm.

##### Table of Contents

EXHIBIT INDEX

Exhibit Number |  |  |  | Exhibit Description |  | Filed with this Report |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/ Registration Number
2.1 |  |  |  | Amended and Restated Agreement and Plan of Merger dated as of February 2, 2014, by and among the Registrant, Myriad Crescendo, Inc., Crescendo Bioscience, Inc. and MDV IX, L.P.** |  |  |  | 8-K (Exhibit 2.1) |  | 02/04/14 |  | 000-26642
3.1 |  |  |  | Restated Certificate of Incorporation, as amended |  |  |  | 10-K (Exhibit 3.1) |  | 08/15/11 |  | 000-26642
3.2 |  |  |  | Restated By-Laws |  |  |  | 8-K (Exhibit 3.1) |  | 02/28/11 |  | 000-26642
4.1 |  |  |  | Specimen common stock certificate |  |  |  | 10-K (Exhibit 4.1) |  | 08/15/11 |  | 000-26642
Lease Agreements |  |  |  |  |  |
10.1 |  |  |  | Lease Agreement, dated October 12, 1995, between the Registrant and Boyer Research Park Associates V, by its general partner, the Boyer Company |  |  |  | 10-Q (Exhibit 10.2) |  | 11/08/96 |  | 000-26642
10.2 |  |  |  | Amendment to Lease Agreement, dated March 29, 1996 between the Registrant and Boyer Research Park Associates V, by its general partner, the Boyer Company |  |  |  | 10-Q (Exhibit 10.3) |  | 11/08/96 |  | 000-26642
10.3 |  |  |  | Lease Agreement-Research Park Building Phase II, dated March 6, 1998, between the Registrant and Research Park Associated VI, by its general partner, the Boyer Company, L.C. |  |  |  | 10-K (Exhibit 10.44) |  | 09/24/98 |  | 000-26642
10.4 |  |  |  | Memorandum of Lease, dated August 24, 1998, between the Registrant and Boyer Foothill Associates, Ltd. |  |  |  | 10-Q (Exhibit 10.1) |  | 11/12/98 |  | 000-26642
10.5 |  |  |  | Memorandum of Lease, dated August 24, 1998, between the Registrant and Boyer Research Park Associates VI, L.C. |  |  |  | 10-Q (Exhibit 10.2) |  | 11/12/98 |  | 000-26642
10.6 |  |  |  | Subordination Agreement and Estoppel, Attornment and Non-Disturbance Agreement (Lease to Deed of Trust), dated June 24, 1998, between the Registrant and Wells Fargo Bank, National Association |  |  |  | 10-Q (Exhibit 10.3) |  | 11/12/98 |  | 000-26642
10.7 |  |  |  | Lease Agreement, dated March 31, 2001, between the Registrant and Boyer Research Park Associates VI, by its general partner, The Boyer Company, L.C. |  |  |  | 10-Q (Exhibit 10.1) |  | 05/15/01 |  | 000-26642

##### Table of Contents

Exhibit Number |  |  |  | Exhibit Description |  | Filed with this Report |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/ Registration Number
10.8 |  |  |  | Agreement, dated March 31, 2001, between the Registrant and Boyer Research Park Associates VI, by its general partner, The Boyer Company, L.C. |  |  |  | 10-Q (Exhibit 10.2) |  | 05/15/01 |  | 000-26642
10.9 |  |  |  | Lease Agreement, dated June 29, 2005, between the Registrant and Boyer Research Park Associates VIII, by its general partner, The Boyer Company, L.C. |  |  |  | 8-K (Exhibit 99.1) |  | 07/05/05 |  | 000-26642
10.10 |  |  |  | Letter of Understanding regarding Lease Agreement, dated June 29, 2005, between the Registrant and Boyer Research Park Associates VIII, by its general partner, The Boyer Company, L.C. |  |  |  | 8-K (Exhibit 99.2) |  | 07/05/05 |  | 000-26642
10.11 |  | .1 |  | Lease Agreement, dated March 11, 2008, between the Registrant and Boyer Research Park Associates IX, by its general partner, The Boyer Company, L.C. |  |  |  | 10-K (Exhibit 10.32) |  | 08/28/08 |  | 000-26642
|  | .2 |  | Amendment to Lease Agreement, dated February 12, 2010 between the Registrant and Boyer Research Park Associates IX, L.C.. |  |  |  | 10-Q (Exhibit 10.4) |  | 05/05/10 |  | 000-26642
10.12 |  | .1 |  | Sublease Agreement, dated June 30, 2009, between the Registrant and Myriad Pharmaceuticals, Inc. |  |  |  | 8-K (Exhibit 10.2) |  | 07/07/09 |  | 000-26642
|  | .2 |  | Amendment No. 1, dated November 11, 2009, to Sublease Agreement, dated June 30, 2009, between the Registrant and Myriad Pharmaceuticals, Inc. |  |  |  | 10-K (Exhibit 10.12.2) |  | 08/12/10 |  | 000-26642
|  | .3 |  | Amendment No. 2, dated February 19, 2010, to Sublease Agreement, dated June 30, 2009, between the Registrant and Myriad Pharmaceuticals, Inc. |  |  |  | 10-K (Exhibit 10.12.3) |  | 08/12/10 |  | 000-26642
Agreements with Respect to Collaborations, Licenses, Research and Development |  |  |  |
10.13 |  |  |  | Exclusive License Agreement, dated October 8, 1991, between the Registrant and the University of Utah Research Foundation, as amended (Breast Cancer—BRCA1)* |  |  |  | S-1 (Exhibit 10.13) |  | 10/05/95 |  | 33-95970
10.14 |  |  |  | Exclusive License Agreement, dated November 23, 1994, between the Registrant and the University of Utah Research Foundation (Breast Cancer—BRCA2)* |  |  |  | S-1 (Exhibit 10.17) |  | 10/05/95 |  | 33-95970

##### Table of Contents

Exhibit Number |  |  |  | Exhibit Description |  | Filed with this Report |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/ Registration Number
10.15 |  |  |  | Exclusive License Agreement, dated March 15, 1995, between the Registrant and the Hospital for Sick Children* |  |  |  | 10-Q (Exhibit 10.1) |  | 11/01/07 |  | 000-26642
10.16 |  |  |  | Exclusive License Agreement, dated January 6, 1995, between the Registrant and Endorecherche* |  |  |  | 10-Q (Exhibit 10.2) |  | 11/01/07 |  | 000-26642
10.17 |  |  |  | Exclusive License Agreement, dated March 13, 1996, between the Registrant and The Trustees of the University of Pennsylvania* |  |  |  | 10-Q (Exhibit 10.3) |  | 11/01/07 |  | 000-26642
Agreements with Executive Officers and Directors |  |  |  |
10.18 |  |  |  | Employment Agreement, dated May 15, 1993, between the Registrant, Myriad Genetic Laboratories, Inc. and Peter D. Meldrum+ |  |  |  | S-1 (Exhibit 10.3) |  | 10/05/95 |  | 33-95970
10.19 |  |  |  | Employment Agreement between Myriad Genetics, Inc., Myriad Genetic Laboratories, Inc. and James S. Evans dated March 3,1995+ |  |  |  | 8-K (Exhibit 10.1) |  | 11/06/07 |  | 000-26642
10.20 |  |  |  | Employment Agreement, dated November 5, 2002, between the Registrant, Myriad Genetic Laboratories, Inc. and Richard M. Marsh+ |  |  |  | 10-K (Exhibit 10.27) |  | 08/25/09 |  | 000-26642
10.21 |  |  |  | Employment Agreement, dated October 1, 2002, between the Registrant, Myriad Genetic Laboratories, Inc. and Mark. C. Capone+ |  |  |  | 10-K (Exhibit 10.28) |  | 08/25/09 |  | 000-26642
10.22 |  |  |  | Employment Agreement, dated September 2, 2002, between the Registrant, Myriad Genetic Laboratories, Inc. and Jerry S. Lanchbury, Ph.D.+ |  |  |  | 10-K (Exhibit 10.22) |  | 08/15/2011 |  | 000-26642
10.23 |  | .1 |  | Form of Executive Retention Agreement+@ |  |  |  | 10-Q (Exhibit 10.1) |  | 05/05/10 |  | 000-26642
|  | .2 |  | Form of Amendment to Form of Executive Retention Agreement+@ |  |  |  | 10-Q (Exhibit 10.2) |  | 05/05/10 |  | 000-26642
10.24 |  |  |  | Executive Retention Agreement, dated November 17, 2006, between the Registrant and Mark. C. Capone+ |  |  |  | 10-Q (Exhibit 10.1) |  | 02/06/07 |  | 000-26642
10.25 |  |  |  | Non-Employee Director Compensation Policy+ |  |  |  | 10-Q (Exhibit 10.1) |  | 11/02/11 |  | 000-26642
10.26 |  |  |  | Form of director and executive officer indemnification agreement |  |  |  | 10-K (Exhibit 10.34) |  | 08/25/09 |  | 000-26642

##### Table of Contents

Exhibit Number |  |  |  | Exhibit Description |  | Filed with this Report |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/ Registration Number
Equity Compensation Plans |  |  |  |
10.27 |  | .1 |  | 2002 Amended and Restated Employee, Director and Consultant Stock Option Plan (the “2002 Plan”)+ |  |  |  | 10-K (Exhibit 10.1) |  | 09/27/02 |  | 000-26642
|  | .2 |  | Form of Incentive Stock Option Agreement under the 2002 Plan+ |  |  |  | 10-Q (Exhibit 10.9) |  | 11/01/07 |  | 000-26642
|  | .3 |  | Form of Non-Qualified Stock Option Agreement under the 2002 Plan+ |  |  |  | 10-Q (Exhibit 10.10) |  | 11/01/07 |  | 000-26642
10.28 |  | .1 |  | 2003 Employee, Director and Consultant Stock Option Plan, as amended (the “2003 Plan”)+ |  |  |  | 10-Q (Exhibit 10.1) |  | 02/3/10 |  | 000-26642
|  | .2 |  | Form of Incentive Stock Option Agreement under the 2003 Plan+ |  |  |  | 10-Q (Exhibit 10.7) |  | 11/01/07 |  | 000-26642
|  | .3 |  | Form of Non-Qualified Stock Option Agreement under the 2003 Plan+ |  |  |  | 10-Q (Exhibit 10.8) |  | 11/01/07 |  | 000-26642
10.29 |  | .1 |  | Myriad Genetics, Inc. 2010 Employee, Director and Consultant Equity Incentive Plan, as amended (the “2010 Plan”)+ |  |  |  | 8-K (Exhibit 10.1) |  | 12/06/13 |  | 000-26642
|  | .2 |  | Form of Stock Option Agreement under the 2010 Equity Incentive Plan+ |  |  |  | 10-Q (Exhibit 10.3) |  | 02/01/11 |  | 000-26642
|  | .3 |  | Form of Director Stock Option Agreement under the 2010 Equity Incentive Plan+ |  |  |  | 10-Q (Exhibit 10.4) |  | 02/01/11 |  | 000-26642
10.30 |  |  |  | 2012 Employee Stock Purchase Plan+ |  |  |  | 8-K (Exhibit 10.2) |  | 12/07/12 |  | 000-26642
10.31 |  |  |  | 2013 Executive Incentive Plan+ |  |  |  | 8-K (Exhibit 10.3) |  | 12/07/12 |  | 000-26642
Other |  |  |  |
21.1 |  |  |  | List of Subsidiaries of the Registrant |  | X |  |  |  |  |  |
23.1 |  |  |  | Consent of Independent Registered Public Accounting Firm (Ernst & Young LLP) |  | X |  |  |  |  |  |
31.1 |  |  |  | Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |  | X |  |  |  |  |  |
31.2 |  |  |  | Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |  | X |  |  |  |  |  |
32 |  |  |  | Certification pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |  | X |  |  |  |  |  |

##### Table of Contents

Exhibit Number |  |  |  | Exhibit Description |  | Filed with this Report |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/ Registration Number
101 |  |  |  | The following materials from Myriad Genetics, Inc.’s Annual Report on Form 10-K for the fiscal year ended June 30, 2013, formatted in XBRL (Xtensible Business Reporting Language): (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Comprehensive Income, (iii) Consolidated Statements of Stockholders’ Equity, (iv) Consolidated Statements of Cash Flows, and (v) Notes to Consolidated Financial Statements. |  | X |  |  |  |  |  |

(+) | Management contract or compensatory plan arrangement.

(@) | The agreements with all executives are identical except for the executive who is a party to the agreement and the date of execution, which are listed at the end of the exhibit

(*) | Confidential treatment has been granted by the Securities and Exchange Commission as to certain portions.

(**) | The schedules and exhibits to the Agreement and Plan of Merger have been omitted from this filing pursuant to Item 601(b)(2) of Regulation S-K. The Company will furnish supplemental copies of any such schedules or exhibits to the U.S. Securities and Exchange Commission upon request.