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  <xs:element id="mygn_PurchasesOfPropertyPlantAndEquipmentAndCapitalizationOfInternalUseSoftwareInAccountsPayableAndAccruedLiabilities" abstract="false" name="PurchasesOfPropertyPlantAndEquipmentAndCapitalizationOfInternalUseSoftwareInAccountsPayableAndAccruedLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_DebtInstrumentCovenantFixedChargeRatioMinimum" abstract="false" name="DebtInstrumentCovenantFixedChargeRatioMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="mygn_FourthInstallmentMember" abstract="true" name="FourthInstallmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_CashAndCashEquivalentsReclassificationToAssetsHeldForSale" abstract="false" name="CashAndCashEquivalentsReclassificationToAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_StockIssuedDuringPeriodSharesShareBasedPaymentArrangementAndEmployeeStockPurchasePlans" abstract="false" name="StockIssuedDuringPeriodSharesShareBasedPaymentArrangementAndEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="mygn_InvestmentsAndCashAmortizedCostBeforeReclassificationOfAssetsHeldForSale" abstract="false" name="InvestmentsAndCashAmortizedCostBeforeReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_ContingentConsiderationMember" abstract="true" name="ContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_NewYorkFederalReserveBankRateMember" abstract="true" name="NewYorkFederalReserveBankRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_InvestmentsAndCashAmortizedCost" abstract="false" name="InvestmentsAndCashAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_LineOfCreditFacilityDebtDefaultAvailabilityThreshold" abstract="false" name="LineOfCreditFacilityDebtDefaultAvailabilityThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_PharmacogenomicsMember" abstract="true" name="PharmacogenomicsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_OperatingLeaseLiabilityCurrentTerminated" abstract="false" name="OperatingLeaseLiabilityCurrentTerminated" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_VariableRateScenarioTwoMember" abstract="true" name="VariableRateScenarioTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_InvestmentsAndCashBeforeReclassificationOfAssetsHeldForSale" abstract="false" name="InvestmentsAndCashBeforeReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_ABRFloorMember" abstract="true" name="ABRFloorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_LineOfCreditFacilityAccordionFeatureIncreaseLimit" abstract="false" name="LineOfCreditFacilityAccordionFeatureIncreaseLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_DisposalGroupIncludingDiscontinuedOperationAssetsGross" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationAssetsGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_VariableRateScenarioOneMember" abstract="true" name="VariableRateScenarioOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_TumorProfilingMember" abstract="true" name="TumorProfilingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_EmployeeStockPurchasePlanTwentyTwelveMember" abstract="true" name="EmployeeStockPurchasePlanTwentyTwelveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_RashmiKumarMember" abstract="true" name="RashmiKumarMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_LitigationSettlementRemainingAmountAwardedToOtherParty" abstract="false" name="LitigationSettlementRemainingAmountAwardedToOtherParty" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_IncreaseDecreaseInUnrecognizedTaxBenefits" abstract="false" name="IncreaseDecreaseInUnrecognizedTaxBenefits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_SettledLitigationNonContingentPaymentsMember" abstract="true" name="SettledLitigationNonContingentPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingRightsAverageTradingDays" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingRightsAverageTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="mygn_DebtInstrumentDebtDefaultAvailabilityThresholdPercentageOfMaximumCommitmentAmount" abstract="false" name="DebtInstrumentDebtDefaultAvailabilityThresholdPercentageOfMaximumCommitmentAmount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="mygn_ComputerSoftwareInProcessIntangibleAssetMember" abstract="true" name="ComputerSoftwareInProcessIntangibleAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_InvestmentsAndCashAccumulatedGrossUnrealizedLossBeforeTax" abstract="false" name="InvestmentsAndCashAccumulatedGrossUnrealizedLossBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_DebtInstrumentCovenantAvailabilityAmountMinimum" abstract="false" name="DebtInstrumentCovenantAvailabilityAmountMinimum" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_OtherLiabilitiesNoncurrentReclassificationToLiabilitiesHeldForSale" abstract="false" name="OtherLiabilitiesNoncurrentReclassificationToLiabilitiesHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_PropertyPlantAndEquipmentNetReclassificationOfAssetsHeldForSale" abstract="false" name="PropertyPlantAndEquipmentNetReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_FifthInstallmentMember" abstract="true" name="FifthInstallmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_FirstInstallmentMember" abstract="true" name="FirstInstallmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_HereditaryCancerTestingMember" abstract="true" name="HereditaryCancerTestingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_DisposalGroupIncludingDiscontinuedOperationNetAssets" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationNetAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_PrenatalTestingMember" abstract="true" name="PrenatalTestingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_ScheduleOfIntangibleAssetsTable" abstract="true" name="ScheduleOfIntangibleAssetsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="mygn_FiniteLivedIntangibleAssetsNetBeforeReclassificationOfAssetsHeldForSale" abstract="false" name="FiniteLivedIntangibleAssetsNetBeforeReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_LineOfCreditFacilityCommitmentFeeBorrowingBasePeriod" abstract="false" name="LineOfCreditFacilityCommitmentFeeBorrowingBasePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="mygn_ChangeInOperatingLeaseRightOfUseAsset" abstract="false" name="ChangeInOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_PaulDiazMember" abstract="true" name="PaulDiazMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_LegalChargesPendingSettlementNoncurrent" abstract="false" name="LegalChargesPendingSettlementNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_MedicareMember" abstract="true" name="MedicareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_RaygenIncVersusMyriadWomensHealthIncMember" abstract="true" name="RaygenIncVersusMyriadWomensHealthIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_RefundsPayableAndReserveCurrent" abstract="false" name="RefundsPayableAndReserveCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_EndoPredictMember" abstract="true" name="EndoPredictMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_ThirdInstallmentMember" abstract="true" name="ThirdInstallmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_EscrowLiabilityNoncurrent" abstract="false" name="EscrowLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_WestSaltLakeCityMember" abstract="true" name="WestSaltLakeCityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mygn_LeaseTerminationAccrualCurrent" abstract="false" name="LeaseTerminationAccrualCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_IntangibleAssetsLineItems" abstract="true" name="IntangibleAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="mygn_CashAndCashEquivalentsFairValueDisclosureBeforeReclassificationOfAssetsHeldForSale" abstract="false" name="CashAndCashEquivalentsFairValueDisclosureBeforeReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_FiniteLivedIntangibleAssetsAccumulatedAmortizationReclassificationOfAssetsHeldForSale" abstract="false" name="FiniteLivedIntangibleAssetsAccumulatedAmortizationReclassificationOfAssetsHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
