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Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2025

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Schedule of Share Option Activity

​

​	​	​	​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​	​	Weighted-	​
​	​		​		Weighted-			​	Average	​
​	​	​	​	​	Average		​	​	Remaining	​
​	​	​	Number of	​	Exercise		​	​	Contractual	​
​	​	​	Options	​	Price		​	​	Term (years)	​
Outstanding at December 31, 2024	​		8,232,587	​	$	12.57		​	5.35	years
Granted	​		—	​	$	—		​	​	​
Exercised	​		(638)	​	$	5.73		​	​	​
Forfeited	​		(208,960)	​	$	16.39		​	​	​
Outstanding at March 31, 2025	​		8,022,989	​	$	12.48	​	​	5.18	years
Options exercisable at March 31, 2025	​		6,956,612	​	$	12.85	​		4.79	years
Options vested and expected to vest at March 31, 2025	​	​	8,022,989	​	$	12.48	​	​	5.18	years
Aggregate intrinsic value of options outstanding as of March 31, 2025	​	$	2,228	​			​			​
Aggregate intrinsic value of options exercisable as of March 31, 2025	​	$	2,079	​			​			​

Schedule of Inputs Used in Determining Fair Value of Share Options

​

​	​	​	​	​
​		2025		2024
Risk-free interest rate		-		4.04 - 4.17%
Expected volatility		-		67%
Expected dividend yield		-		0%
Expected term (in years)		-		3.6 - 6.1

Schedule of Restricted Share Unit (RSU) Activity

​

​	​	​	​	​	​	​
​	​		​		Weighted-
​	​	Number of		​	Average
​	​	Restricted		​	Grant Date
​	​	Share Units		​	Fair Value
Outstanding at December 31, 2024	​		4,252,250	​	$	8.91
Granted	​		—	​	$	—
Vested	​	​	(862,500)	​	$	13.70
Forfeited	​	​	—	​	$	—
Outstanding at March 31, 2025	​		3,389,750	​	$	7.69

Schedule of Share-Based Compensation Expense

​

​	​	​	​	​	​	​
​	​	Three-Month Periods Ended March 31,
​		2025			2024
Research and development	​	$	2,046	​	$	2,875
General and administrative	​		2,841	​	​	4,085
Total share-based compensation	​	$	4,887	​	$	6,960

Employee Stock Option

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Schedule of Share-Based Compensation Expense

​

​	​	​	​	​	​	​
​	​	Three-Month Periods Ended March 31,
​		2025			2024
Research and development	​	$	939	​	$	1,635
General and administrative	​	​	597	​	​	1,053
Total share-based compensation	​	$	1,536	​	$	2,688

Restricted Share Units

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Schedule of Share-Based Compensation Expense

​

​	​	​	​	​	​	​
​	​	Three-Month Periods Ended March 31,
​		2025			2024
Research and development	​	$	1,107	​	$	1,240
General and administrative	​	​	2,244	​	​	3,032
Total share-based compensation	​	$	3,351	​	$	4,272

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