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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (23,030) $ (15,339)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 84 9
Non-cash lease expense 323  
Premium amortization and discount accretion on marketable securities, net 6 64
Stock-based compensation expense, including employee stock purchase plan expense 4,965 3,208
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 172 291
Other assets (240)  
Accounts payable 245 (327)
Other current liabilities (113) 1,010
Operating lease liabilities (315)  
Net cash used in operating activities (17,903) (11,084)
Cash flows from investing activities:    
Purchase of equipment (30) (420)
Maturities of marketable securities 148,750 1,000
Purchases of marketable securities (123,153) (280,164)
Net cash provided by (used in) investing activities 25,567 (279,584)
Cash flows from financing activities:    
Proceeds from exercise of stock options 33  
Net cash provided by financing activities 33  
Net increase (decrease) in cash and cash equivalents 7,697 (290,668)
Cash and cash equivalents at beginning of period 13,812 338,549
Cash and cash equivalents at end of period 21,509 47,881
Supplemental disclosure of non-cash investing and financing activities:    
Reclassification of prepaid expenses and other current liabilities into other assets 2,014  
Vesting of early exercised stock options $ 31 31
Purchases of property and equipment included in accounts payable   $ 39