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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Cash flows from operating activities:    
Net loss $ (95,907) $ (69,883)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 277 289
Non-cash lease expense 863 973
Non-cash interest income on marketable securities (6,547) (3,253)
Loss on sale of equipment   111
Stock-based compensation expense, including employee stock purchase plan expense 16,259 12,905
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,475 293
Other assets and long-term deposits (2,589) (5,328)
Accounts payable (13) 1,833
Other current liabilities 8,972 (2,223)
Operating lease liabilities (857) (968)
Net cash used in operating activities (78,067) (65,251)
Cash flows from investing activities:    
Purchase of equipment (159)  
Disposal of fixed assets   14
Maturities of marketable securities 226,786 196,760
Purchases of marketable securities (205,729) (170,710)
Net cash provided by investing activities 20,898 26,064
Cash flows from financing activities:    
Issuance of shares under at-the-market offering, net of issuance costs of $166 22,787  
Proceeds from equity private placement, net of issuance costs of $240   129,760
Proceeds from exercise of stock options 1,081 2,421
Proceeds from issuance of common stock under the ESPP plan 650 711
Net cash provided by financing activities 24,518 132,892
Net (decrease) increase in cash and cash equivalents (32,651) 93,705
Cash and cash equivalents at beginning of period 68,539 23,702
Cash and cash equivalents at end of period $ 35,888 $ 117,407