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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (18,592) $ (29,810)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 285 277
Stock-based compensation 7,005 5,716
Accretion/amortization of investments, net 293 61
Amortization of right-of-use assets – operating 751 382
Changes in operating assets and liabilities:    
Receivable from collaborative partners (642) 0
Prepaid expenses and other assets (3,235) (2,860)
Accounts payable and other liabilities 772 (8,068)
Operating lease liabilities (250) (420)
Net cash used in operating activities (13,613) (34,722)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of investments (9,734) (86,947)
Sales and maturities of investments 105,604 173,262
Purchases of property and equipment (1,180) (170)
Net cash provided by investing activities 94,690 86,145
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock, upon the exercise of stock options 721 107
Payments on notes payable 0 (1,375)
Net cash provided by (used in) financing activities 721 (1,268)
Net increase in cash, cash equivalents, and restricted cash 81,798 50,155
Cash, cash equivalents and restricted cash, beginning of period 250,516 171,077
Cash, cash equivalents and restricted cash, end of period 332,314 221,232
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION    
Interest paid 0 4
Non-cash investing and financing activities:    
Leased assets obtained in exchange for operating lease liabilities 20,685 0
Amounts accrued for property and equipment 89 25
Receivable related to issuance of common stock, upon exercise of stock options $ 38 $ 0