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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (163,619) | $ (128,724) | $ (57,796)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 652 | 675 | 619
Stock-based compensation | 33,205 | 27,356 | 15,347
Accretion/amortization of investments, net | (10,521) | (2,507) | 493
Amortization of right-of-use assets – operating | 1,724 | 1,660 | 1,471
Non-cash interest expense | 18,083 | 21,108 | 1,450
Gain on disposal of property and equipment | 0 | 0 | (15)
Changes in operating assets and liabilities: |  |  |
Receivables from collaborative partners | (5,432) | (543) | (876)
Prepaid expenses and other assets | (4,194) | (813) | (1,801)
Accounts payable and other liabilities | 10,938 | 9,700 | (4,740)
Operating lease liabilities | (1,636) | (1,505) | (72)
Net cash used in operating activities | (120,800) | (73,593) | (45,920)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of investments | (303,919) | (802,503) | (118,662)
Sales and maturities of investments | 449,480 | 408,016 | 158,848
Proceeds from the sale of property and equipment | 0 | 0 | 15
Purchases of property and equipment | (807) | (358) | (1,366)
Net cash provided by (used in) investing activities | 144,754 | (394,845) | 38,835
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from issuance of common stock | 2,472 | 11,827 | 2,553
Proceeds from the sale of future royalties | 0 | 35,000 | 250,000
Repayment of liability for sale of future royalties | (11,726) | (2,474) | 0
Payments for repurchase of common stock | (50,000) | 0 | 0
Payments for issuance costs related to the sale of future royalties | (43) | (336) | (255)
Net cash (used in) provided by financing activities | (59,297) | 44,017 | 252,298
Net (decrease) increase in cash, cash equivalents, and restricted cash | (35,343) | (424,421) | 245,213
Cash, cash equivalents and restricted cash, beginning of period | 71,308 | 495,729 | 250,516
Cash, cash equivalents and restricted cash, end of period | 35,965 | 71,308 | 495,729
Non-cash investing and financing activities: |  |  |
Leased assets obtained in exchange for operating lease liabilities | 0 | 0 | 20,685
Amounts accrued for property and equipment | 8 | 154 | 31
Amounts accrued for issuance costs related to the sale of future royalties | 0 | 80 | 102
Amounts accrued for repurchase of common stock | 456 | 0 | 0
Receivable related to issuance of common stock, upon exercise of stock options | $ (51) | $ 40 | $ 11

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