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Financial Information By Quarter (Unaudited) (Details) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Quarterly Financial Information [Abstract] |  |  |  |  |  |  |  |  |  |  |
Research and development | $ 1,412,000 | $ 1,390,000 | $ 4,265,000 | $ 5,202,000 | $ 7,159,000 | $ 4,658,000 | $ 1,901,000 | $ 1,270,000 | $ 12,268,960 | $ 14,987,628 | $ 8,175,878
Selling, general and administrative expense | 3,281,000 | 3,094,000 | 3,058,000 | 2,870,000 | 4,464,000 | 2,855,000 | 3,739,000 | 2,656,000 | 12,303,050 | 13,713,635 | 10,582,068
Research and development expense | 2,781,000 | 2,471,000 | 5,068,000 | 6,360,000 | 8,158,000 | 6,069,000 | 2,948,000 | 2,536,000 | 16,679,712 | 19,710,673 | 13,130,529
Patent expenses | 221,000 | 251,000 | 197,000 | 241,000 | 219,000 | 230,000 | 240,000 | 220,000 | 909,946 | 909,376 | 1,009,053
Lease termination | 0 | 1,225,000 | 0 | 0 |  |  |  |  | 1,225,421 | 0 | 0
Interest on PharmAthene liability |  |  |  |  | 927,000 | 3,566,000 | 4,259,000 | 2,917,000 | 0 | 11,668,900 | 0
Operating loss | (4,871,000) | (5,651,000) | (4,059,000) | (4,269,000) | (6,609,000) | (8,062,000) | (9,285,000) | (7,059,000) | (18,849,169) | (31,014,956) | (30,953,266)
Net income (loss) | $ (10,303,000) | $ (9,816,000) | $ (7,501,000) | $ (8,615,000) | $ (10,439,000) | $ (9,244,000) | $ (9,566,000) | $ (10,449,000) | $ (36,235,484) | $ (39,697,960) | $ (39,451,324)
Earnings (loss) per share: basic and diluted (usd per share) | $ (0.13) | $ (0.12) | $ (0.10) | $ (0.11) | $ (0.15) | $ (0.17) | $ (0.18) | $ (0.19) | $ (0.46) | $ (0.69) | $ (0.73)

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 + Details
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