<SEC-DOCUMENT>0001856565-25-000007.txt : 20250829
<SEC-HEADER>0001856565-25-000007.hdr.sgml : 20250829
<ACCEPTANCE-DATETIME>20250829160445
ACCESSION NUMBER:		0001856565-25-000007
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250827
FILED AS OF DATE:		20250829
DATE AS OF CHANGE:		20250829

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Oelschlager Kristen M
		CENTRAL INDEX KEY:			0001856565
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38984
		FILM NUMBER:		251280776

	MAIL ADDRESS:	
		STREET 1:		C/O CASTLE BIOSCIENCES
		STREET 2:		505 S. FRIENDSWOOD DRIVE, SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CASTLE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001447362
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				770701774
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
		BUSINESS PHONE:		866-788-9007

	MAIL ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1756497883.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-08-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001447362</issuerCik>
        <issuerName>CASTLE BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>CSTL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001856565</rptOwnerCik>
            <rptOwnerName>Oelschlager Kristen M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CASTLE BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>505 S FRIENDSWOOD DRIVE, SUITE 401</rptOwnerStreet2>
            <rptOwnerCity>FRIENDSWOOD</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77546</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Operating Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-08-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>12677</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>22.019</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>141116</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person, on March 6, 2025</footnote>
        <footnote id="F2">This transaction was executed in multiple trades at prices ranging from $22.000 to 22.145, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby
undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the
transaction was effected.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Frank Stokes, Attorney-in-fact</signatureName>
        <signatureDate>2025-08-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
