<SEC-DOCUMENT>0001950047-25-008673.txt : 20251112
<SEC-HEADER>0001950047-25-008673.hdr.sgml : 20251112
<ACCEPTANCE-DATETIME>20251112065841
ACCESSION NUMBER:		0001950047-25-008673
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251112
DATE AS OF CHANGE:		20251112

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CASTLE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001447362
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				770701774
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38984
		FILM NUMBER:		251468605

	BUSINESS ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
		BUSINESS PHONE:		866-788-9007

	MAIL ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Stokes Frank
		CENTRAL INDEX KEY:			0001782815
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O CASTLE BIOSCIENCES
		STREET 2:		820 S. FRIENDSWOOD DRIVE, SUITE 201
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001782815</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001447362</issuerCik>
            <issuerName>CASTLE BIOSCIENCES INC</issuerName>
            <secFileNumber>001-38984</secFileNumber>
            <issuerAddress>
                <ns2:street1>505 S. Friendswood Drive, Suite 401</ns2:street1>
                <ns2:city>Friendstown</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>77546</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8667889007</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FRANKLIN STOKES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5388</noOfUnitsSold>
            <aggregateMarketValue>187179.12</aggregateMarketValue>
            <noOfUnitsOutstanding>29188659</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/08/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5388</amountOfSecuritiesAcquired>
            <paymentDate>08/08/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday.</remarks>
        <noticeSignature>
            <noticeDate>11/11/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/12/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Franklin Stokes</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
