<SEC-DOCUMENT>0001958244-25-004545.txt : 20251215
<SEC-HEADER>0001958244-25-004545.hdr.sgml : 20251215
<ACCEPTANCE-DATETIME>20251215182126
ACCESSION NUMBER:		0001958244-25-004545
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251215
DATE AS OF CHANGE:		20251215

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CASTLE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001447362
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				770701774
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38984
		FILM NUMBER:		251572844

	BUSINESS ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
		BUSINESS PHONE:		866-788-9007

	MAIL ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MAETZOLD DEREK J
		CENTRAL INDEX KEY:			0001239501
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		820 S. FRIENDSWOOD DRIVE
		STREET 2:		SUITE 201
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001239501</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001447362</ns2:issuerCik>
            <ns2:issuerName>Castle Biosciences, Inc.</ns2:issuerName>
            <ns2:secFileNumber>001-38984</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>505 S. Friendswood Drive</com:street1>
                <com:street2>Suite 401</com:street2>
                <com:city>Friendswood</com:city>
                <com:stateOrCountry>TX</com:stateOrCountry>
                <com:zipCode>77546</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-866-788-9007</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Derek Maetzold</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>33685</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>1309672.8</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>29188659</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>12/15/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>08/09/2024</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Performance Awards</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>906</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>08/09/2024</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/10/2024</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>3111</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/10/2024</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>12/09/2025</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>20314</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>12/09/2025</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>12/10/2025</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>9354</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>12/10/2025</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/05/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>42462.5</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/05/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>42835.82</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/18/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>45474.45</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
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                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/18/2025</ns2:saleDate>
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            <ns2:grossProceeds>45632.58</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
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                <ns2:address>
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                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>09/17/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>29418.9</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>10/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>30227.66</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
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                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>10/20/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>30046.76</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
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                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
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                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/04/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>6695</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>203782.41</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
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                <ns2:address>
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                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
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            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/25/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>5115</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>204545.78</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>11/26/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>4258</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>170444.33</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>12/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>52449.43</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Maetzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>12/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>52450.77</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Derek Metzold</ns2:name>
                <ns2:address>
                    <com:street1>505 S. Friendswood Drive</com:street1>
                    <com:street2>Suite 401</com:street2>
                    <com:city>Friendswood</com:city>
                    <com:stateOrCountry>TX</com:stateOrCountry>
                    <com:zipCode>77546</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>12/04/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1339</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>53516.35</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 5/8/2025 that is intended to comply with Rule 10b5-1(c).</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>12/15/2025</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>05/08/2025</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Derek Maetzold</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
