<SEC-DOCUMENT>0001968582-25-001257.txt : 20251217
<SEC-HEADER>0001968582-25-001257.hdr.sgml : 20251217
<ACCEPTANCE-DATETIME>20251217164904
ACCESSION NUMBER:		0001968582-25-001257
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251217
DATE AS OF CHANGE:		20251217

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CASTLE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001447362
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				770701774
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38984
		FILM NUMBER:		251579940

	BUSINESS ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
		BUSINESS PHONE:		866-788-9007

	MAIL ADDRESS:	
		STREET 1:		505 S FRIENDSWOOD DRIVE
		STREET 2:		SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Oelschlager Kristen M
		CENTRAL INDEX KEY:			0001856565
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O CASTLE BIOSCIENCES
		STREET 2:		505 S. FRIENDSWOOD DRIVE, SUITE 401
		CITY:			FRIENDSWOOD
		STATE:			TX
		ZIP:			77546
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001856565</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001447362</issuerCik>
      <issuerName>Castle Biosciences, Inc.</issuerName>
      <secFileNumber>001-38984</secFileNumber>
      <issuerAddress>
        <com:street1>505 S. Friendswood Drive, Suite 401</com:street1>
        <com:city>Friendswood</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>77546</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>866-788-9007</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kristen M. Oelschlager</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>14888</noOfUnitsSold>
      <aggregateMarketValue>581376</aggregateMarketValue>
      <noOfUnitsOutstanding>29188659</noOfUnitsOutstanding>
      <approxSaleDate>12/17/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>12/09/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11270</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>12/10/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3618</amountOfSecuritiesAcquired>
      <paymentDate>12/10/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kristen M. Oelschlager</name>
        <address>
          <com:street1>C/o Castle Biosciences, Inc.</com:street1>
          <com:street2>505 S. Friendswood Drive, Suite 401</com:street2>
          <com:city>Friendswood</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77546</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>10/31/2025</saleDate>
      <amountOfSecuritiesSold>12678</amountOfSecuritiesSold>
      <grossProceeds>317503</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kristen M. Oelschlager</name>
        <address>
          <com:street1>C/o Castle Biosciences, Inc.</com:street1>
          <com:street2>505 S. Friendswood Drive, Suite 401</com:street2>
          <com:city>Friendswood</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77546</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>11/11/2025</saleDate>
      <amountOfSecuritiesSold>18932</amountOfSecuritiesSold>
      <grossProceeds>664511</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/17/2025</noticeDate>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kristen M. Oelschlager.</signature>
    </noticeSignature>
  </formData>
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