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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities    
Net loss $ (178,756) $ (125,609)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,044 625
Stock-based compensation expense 26,067 13,957
In process research and development expenses 18,080 2,000
Amortization of operating lease right-of-use assets 2,015 1,615
Amortization of debt discount and issuance costs 2,294 148
Amortization of premium on investments, net of accretion of discounts 24 (2,296)
Net realized gain on investments (256) (1)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (3,340) (2,807)
Other assets 698 2,886
Operating lease liabilities (1,294) (1,566)
Accounts payable 10 333
Accrued expenses 2,768 (760)
Accrued research and development expenses (7,019) 8,518
Accrued compensation and benefits (1,959) 2,263
Net cash used in operating activities (139,624) (100,694)
Cash flows from investing activities    
Research and development asset acquisitions, net of cash acquired (18,080) (2,000)
Purchase of marketable securities (108,969) (399,393)
Maturities of marketable securities 199,029 205,750
Sales of marketable securities 83,515 4,004
Purchase of property and equipment (1,253) (2,438)
Net cash provided by (used in) investing activities 154,242 (194,077)
Cash flows from financing activities    
Proceeds from issuance of common stock 117,110 291,311
Proceeds from issuance of convertible debt, net 193,596 0
Proceeds from the issuance of long-term debt, net of issuance costs of $1,778 0 28,222
Proceeds from the exercise of stock options 285 527
Net cash provided by financing activities 312,291 320,060
Effect of exchange rate changes on cash and cash equivalents (42) 0
Net increase in cash and cash equivalents 326,909 25,289
Cash and cash equivalents, at the beginning of the period 135,089 105,419
Cash and cash equivalents, at the end of the period 461,956 130,708
Supplemental disclosure of cash flow information:    
Cash paid for interest 1,911 854
Supplemental disclosure of noncash investing and financing activities:    
Right-of-use assets obtained in exchange for lease liabilities 3,106 12,458
Change in unrealized gain on marketable securities, net of tax 25 510
Unpaid property and equipment 83 127
Conversion of convertible preferred stock to common stock 0 338,367
Employee Stock Purchase Plan    
Cash flows from financing activities    
Proceeds from issuance of common stock $ 1,300 $ 0