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Condensed Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive loss
Beginning balance (in shares) at Dec. 31, 2022   94,423,181      
Beginning balance at Dec. 31, 2022 $ 12,077 $ 10 $ 1,044,864 $ (1,032,223) $ (574)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 8,127   8,127    
Vesting of restricted stock (in shares)   55,225      
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)   249,623      
Issuance of common stock pursuant to Employee Stock Purchase Plan 367   367    
Issuance of common stock for restricted stock units vested (in shares)   716,067      
Net income (loss) (49,165)     (49,165)  
Other comprehensive income (loss) 138       138
Ending balance (in shares) at Mar. 31, 2023   95,444,096      
Ending balance at Mar. 31, 2023 (28,456) $ 10 1,053,358 (1,081,388) (436)
Beginning balance (in shares) at Dec. 31, 2022   94,423,181      
Beginning balance at Dec. 31, 2022 12,077 $ 10 1,044,864 (1,032,223) (574)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net income (loss) (131,669)        
Other comprehensive income (loss) (44)        
Ending balance (in shares) at Sep. 30, 2023   225,409,315      
Ending balance at Sep. 30, 2023 104,617 $ 23 1,269,104 (1,163,892) (618)
Beginning balance (in shares) at Mar. 31, 2023   95,444,096      
Beginning balance at Mar. 31, 2023 (28,456) $ 10 1,053,358 (1,081,388) (436)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 8,197   8,197    
Issuance of common stock for restricted stock units vested (in shares)   8,607      
Net income (loss) (42,496)     (42,496)  
Other comprehensive income (loss) (45)       (45)
Ending balance (in shares) at Jun. 30, 2023   95,452,703      
Ending balance at Jun. 30, 2023 (62,800) $ 10 1,061,555 (1,123,884) (481)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 6,162   6,162    
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)   87,172      
Issuance of common stock pursuant to Employee Stock Purchase Plan 77   77    
Issuance of common stock in connection with a private offering, net of offering costs (in shares)   129,869,440      
Issuance of common stock in connection with a private offering, net of offering costs 201,323 $ 13 201,310    
Net income (loss) (40,008)     (40,008)  
Other comprehensive income (loss) (137)       (137)
Ending balance (in shares) at Sep. 30, 2023   225,409,315      
Ending balance at Sep. 30, 2023 $ 104,617 $ 23 1,269,104 (1,163,892) (618)
Beginning balance (in shares) at Dec. 31, 2023 225,409,315 225,409,315      
Beginning balance at Dec. 31, 2023 $ 62,769 $ 23 1,275,136 (1,212,040) (350)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 5,811   5,811    
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)   390,246      
Issuance of common stock pursuant to Employee Stock Purchase Plan 348   348    
Issuance of common stock for restricted stock units vested (in shares)   419,092      
Net income (loss) (41,928)     (41,928)  
Other comprehensive income (loss) (278)       (278)
Ending balance (in shares) at Mar. 31, 2024   226,218,653      
Ending balance at Mar. 31, 2024 $ 26,722 $ 23 1,281,295 (1,253,968) (628)
Beginning balance (in shares) at Dec. 31, 2023 225,409,315 225,409,315      
Beginning balance at Dec. 31, 2023 $ 62,769 $ 23 1,275,136 (1,212,040) (350)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net income (loss) (23,499)        
Other comprehensive income (loss) $ (1,881)        
Ending balance (in shares) at Sep. 30, 2024 226,604,138 226,604,138      
Ending balance at Sep. 30, 2024 $ 54,136 $ 23 1,291,883 (1,235,539) (2,231)
Beginning balance (in shares) at Mar. 31, 2024   226,218,653      
Beginning balance at Mar. 31, 2024 26,722 $ 23 1,281,295 (1,253,968) (628)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 5,001   5,001    
Issuance of common stock for restricted stock units vested (in shares)   8,606      
Grant of equity option pursuant to Chiesi Collaboration Agreement 464   464    
Net income (loss) 49,232     49,232  
Other comprehensive income (loss) 110       110
Ending balance (in shares) at Jun. 30, 2024   226,227,259      
Ending balance at Jun. 30, 2024 81,529 $ 23 1,286,760 (1,204,736) (518)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation 4,842   4,842    
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)   376,879      
Issuance of common stock pursuant to Employee Stock Purchase Plan 281   281    
Net income (loss) (30,803)     (30,803)  
Other comprehensive income (loss) $ (1,713)       (1,713)
Ending balance (in shares) at Sep. 30, 2024 226,604,138 226,604,138      
Ending balance at Sep. 30, 2024 $ 54,136 $ 23 $ 1,291,883 $ (1,235,539) $ (2,231)