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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities |  |  |
Net loss | $ (56,528) | $ (179,817) | $ (229,378)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 833 | 1,607 | 1,832
Stock-based compensation expense | 20,619 | 28,518 | 42,553
In process research and development expenses | 0 | 10,000 | 65
Amortization of operating lease right-of-use assets | 3,318 | 2,778 | 2,597
Amortization of long-term debt discount and issuance costs | 1,086 | 1,321 | 1,163
Amortization of premium on investments, net of accretion of discounts | (13,062) | (9,450) | (1,405)
Loss on disposal of property and equipment | 806 | 726 | 0
Changes in operating assets and liabilities: |  |  |
Receivable from contracts with collaborators | (5,338) | 0 | 0
Prepaid expenses and other current assets | 62 | (3,892) | 296
Other assets | 335 | 62 | 400
Operating lease liabilities | (3,386) | (2,982) | (2,721)
Accounts payable | (1,656) | 3,990 | (1,813)
Accrued expenses | (10,718) | (835) | (1,659)
Accrued research and development expenses | 2,676 | (7,847) | (579)
Accrued compensation and benefits | 1,701 | (3,240) | 1,618
Contract liabilities | 55,919 | 0 | 0
Accrued interest expense | (135) | (97) | (1)
Net cash used in operating activities | (3,468) | (159,158) | (187,032)
Cash flows from investing activities |  |  |
Research and development asset acquisitions, net of cash acquired | 0 | 0 | (65)
Purchase of marketable securities | (494,777) | (441,670) | (238,060)
Maturities of marketable securities | 523,800 | 330,700 | 237,500
Purchase of property and equipment | 0 | 0 | (410)
Net cash provided by (used in) investing activities | 29,023 | (110,970) | (1,035)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock and warrants in a private offering, net of offering costs | 0 | 201,323 | 119,946
Proceeds from issuance of common stock under Employee Stock Purchase Plan | 629 | 444 | 1,214
Proceeds from the exercise of stock options | 0 | 0 | 1,736
Proceeds from issuance of equity option pursuant to stock purchase agreement | 464 | 0 | 0
Principal repayments of long-term debt | (12,581) | (11,613) | (5,806)
Net cash provided by (used in) financing activities | (11,488) | 190,154 | 117,090
Effect of exchange rate changes on cash and cash equivalents | (102) | 110 | (517)
Net increase (decrease) in cash and cash equivalents | 13,965 | (79,864) | (71,494)
Cash and cash equivalents, at the beginning of the period | 32,109 | 111,973 | 183,467
Cash and cash equivalents, at the end of the period | 46,074 | 32,109 | 111,973
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 10,561 | 12,288 | 12,712
Supplemental disclosure of noncash investing and financing activities: |  |  |
Right-of-use assets obtained in exchange for lease liabilities | 5,298 | 0 | 3,029
Change in unrealized gain (loss) on marketable securities, net | 89 | 191 | (75)
Purchases of property and equipment included in accounts payable and accrued expenses and other current liabilities | $ 0 | $ 0 | $ 83

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