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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2024

Accounting Policies [Abstract]

Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share

The table below provides potentially dilutive securities not included in the calculation of the diluted net loss per share because to do so would be anti-dilutive (in common stock equivalent shares):

			December 31,
			2024						2023						2022
2027 Notes			12,321,900						12,321,900						12,321,900
Shares issuable upon exercise of stock options			34,416,337						23,626,115						17,487,165
Shares issuable upon exercise of Chiesi Equity Option			22,433,809						—						—
Shares issuable upon exercise of warrants			32,467,360						32,467,360						—
Non-vested shares under restricted stock grants			—						427,698						1,350,035
Total potentially dilutive securities			101,639,406						68,843,073						31,159,100

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- Definition

Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482662/260-10-50-1

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