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Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Schedule of Fair Value of Stock Option Award Granted

The following assumptions were used to estimate the fair value of stock option awards granted to employees under the Company’s equity incentive plans and the shares purchasable under the ESPP during the periods presented:

			Year Ended December 31,
			2024						2023						2022
Employee Stock Options
Expected term (in years)			4.6 - 6.1						1.0 - 7.0						4.4 - 6.1
Risk-free interest rate			3.59% - 4.50%						3.36% - 4.73%						1.31% - 4.35%
Volatility			100.72% - 104.51%						70.01% - 170.69%						71.10% - 89.87%
Dividend yield			—						—						—
Employee Stock Purchase Plan
Expected term (in years)			0.5 - 2.0						0.5 - 2.0						0.5 - 2.0
Risk-free interest rate			3.88% -5.27%						4.87% - 5.47%						0.60% - 3.51%
Volatility			83.96% - 151.54%						115.19% - 216.45%						64.98% - 121.43%
Dividend yield			—						—						—

Schedule of Stock Option Activity

The following table summarizes stock option activity for the years ended December 31, 2024, 2023 and 2022:

			Shares Subject to Options Outstanding												Weighted- Average Remaining Contractual Life (Years)						Aggregate Intrinsic Value
			Shares						Weighted- Average Exercise Price
																					(in thousands)
Outstanding as of December 31, 2021			9,434,660						$	12.24					7.4						$	15,822
Options granted			9,271,272						$	6.75
Options exercised			(270,707)						$	6.41
Options forfeited/cancelled			(948,060)						$	15.69
Outstanding as of December 31, 2022			17,487,165						$	9.24					8.1						$	47
Options granted			17,159,617						$	1.16
Options exercised			—						$	—
Options forfeited/cancelled			(11,020,667)						$	11.07
Outstanding as of December 31, 2023			23,626,115						$	2.52					7.9						$	369
Options granted			13,006,228						$	0.96
Options exercised			—						$	—
Options forfeited/cancelled			(2,216,006)						$	2.25
Outstanding as of December 31, 2024			34,416,337						$	1.95					7.5						$	598
Options vested and expected to vest as of December 31, 2024			34,416,337						$	1.95					7.5						$	598
Options exercisable as of December 31, 2024			14,126,062						$	3.20					6.1						$	100

Schedule of Restricted Stock Activity

The summary of the Company’s restricted stock activity during the years ended December 31, 2024, 2023 and 2022 is as follows: 

			Number of Restricted Stock Units Outstanding						Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2021			2,561,219						$	8.67
Granted			572,901						11.94
Vested			(1,592,588)						7.78
Forfeited / cancelled			(191,497)						10.68
Nonvested at December 31, 2022			1,350,035						$	10.83
Granted			—						—
Vested			(779,900)						10.67
Forfeited / cancelled			(142,437)						11.39
Nonvested at December 31, 2023			427,698						$	10.92
Granted			—						—
Vested			(427,698)						10.92
Forfeited / cancelled			—						—
Nonvested at December 31, 2024			—						$	—

Schedule of Stock-Based Compensation Expense Reported in Condensed Consolidated Statements of Operations

Stock-based compensation expense has been reported in the Company’s consolidated statements of operations and comprehensive loss as follows (in thousands):

			Year Ended December 31,
			2024						2023						2022
Research and development			$	10,172					$	15,871					$	24,415
General and administrative			10,447						12,647						18,138
Total stock-based compensation expense			$	20,619					$	28,518					$	42,553

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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