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Significant Agreements and Contracts - Additional Information (Details)
$ in Thousands
 12 Months Ended
May 03, 2024
USD ($)
performanceObligation
license
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Effect of exchange rate changes on revenue        
Total revenue   $ 114,701 $ 0 $ 0
Deferred revenue, current   17,050 0  
Long-term contract liabilities   38,869 0  
Accounts receivable   5,338 0  
Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.        
Effect of exchange rate changes on revenue        
Number of significant distinct performance obligations | performanceObligation 4      
Number of licenses granted | license 2      
Commercial efforts contribution, percentage 50.00%      
Commercialization activities performance, percentage 50.00%      
Up-front, nonrefundable payment received $ 160,000      
Loyalty term, expiration period 10 years      
Development cost reimbursement payment $ 160,000      
Contract with customer, liability, fair value of equity option $ 500      
Total revenue   114,701    
Contract liability   $ 55,919 $ 0  
Revenue recognition period   4 years    
Accounts receivable   $ 5,300    
Account receivable, payment term   30 days    
Chiesi Farmaceutici S.p.A And Chiesi USA, Inc. | US License        
Effect of exchange rate changes on revenue        
Number of significant distinct performance obligations | performanceObligation 2      
Total revenue   $ 90,700    
Chiesi Farmaceutici S.p.A And Chiesi USA, Inc. | Revenue from PAH research and development service performance obligation satisfied during reporting period        
Effect of exchange rate changes on revenue        
Number of significant distinct performance obligations | performanceObligation 2      
Total revenue   $ 24,100    
Chiesi Farmaceutici S.p.A And Chiesi USA, Inc. | Maximum        
Effect of exchange rate changes on revenue        
Collaboration agreement, regulatory milestones receivable $ 146,000      
Collaboration agreement, sales milestones receivable $ 180,000