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Significant Agreements and Contracts - Schedule of Revenues Disaggregated by Timing of Revenue Recognition (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement $ 114,701 $ 0 $ 0
Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 114,701    
US License | Point in Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 78,947    
ROW License | Point in Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 11,721    
Revenue from PAH research and development service performance obligation satisfied during reporting period | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 9,555    
Revenue from PH-ILD research and development service performance obligation satisfied during reporting period | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 1,291    
Revenue from PAH research and development costs subject to reimbursement | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 10,246    
Revenue from PH-ILD research and development costs subject to reimbursement | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 2,380    
Revenue from PAH commercial costs subject to reimbursement | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 538    
Revenue from PH-ILD commercial costs subject to reimbursement | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement 116    
Effect of exchange rate changes on revenue | Over Time: | Chiesi Farmaceutici S.p.A And Chiesi USA, Inc.      
Effect of exchange rate changes on revenue      
Total revenue from Chiesi Collaboration Agreement $ (93)