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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($)
$ in Millions
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities:    
Net loss $ (133.4) $ (91.3)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3.0 2.3
Net accretion of bond discounts/premiums 5.8 2.7
Forgiveness of debt income 0.0 (1.0)
Loss on sale of marketable securities 0.1 0.0
Amortization of right-of-use assets 1.0 0.6
Amortization of collaboration contract asset 0.8 0.0
Stock-based compensation 36.6 24.9
Changes in operating assets and liabilities:    
Accounts receivable 13.6 1.0
Other receivables 4.0 0.0
Prepaid expenses and other current assets (1.0) (9.1)
Accounts payable and accrued liabilities (12.7) (7.8)
Operating lease liability (1.0) (0.6)
Deferred revenue (52.5) (8.1)
Net cash used in operating activities (135.7) (86.4)
Cash flows from investing activities:    
Purchases of marketable securities (469.1) (538.0)
Maturities of marketable securities 555.9 82.6
Sales of marketable securities 34.3 0.0
Purchases of property, equipment and leasehold improvements (3.5) (1.5)
Net cash provided by (used in) investing activities 117.6 (456.9)
Cash flows from financing activities:    
Proceeds from exercise of stock options 3.0 8.1
Net cash provided by financing activities 3.0 8.1
Net decrease in cash, cash equivalents and restricted cash (15.1) (535.2)
Cash, cash equivalents and restricted cash, beginning of the period 112.8 588.4
Cash, cash equivalents and restricted cash, end of the period 97.7 53.2
Supplemental disclosure of cash flow information:    
Purchases of property, equipment and leasehold improvements unpaid at period end $ 0.5 $ 0.3