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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities:    
Net loss $ (81.9) $ (63.4)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1.2 1.5
Net accretion of bond discounts/premiums (3.4) 3.3
Loss on sale of marketable securities 0.9 0.0
Amortization of right-of-use assets 0.5 0.6
Amortization of collaboration contract asset 0.6 0.3
Stock-based compensation 19.9 16.6
Changes in operating assets and liabilities:    
Accounts receivable 1.0 15.0
Other receivables 2.3 4.1
Prepaid expenses and other current assets 6.9 2.3
Accounts payable and accrued liabilities (8.8) (15.6)
Operating lease liability (0.5) (0.6)
Deferred revenue (29.9) (21.2)
Net cash used in operating activities (91.2) (57.1)
Cash flows from investing activities:    
Purchases of marketable securities (175.7) (263.2)
Maturities of marketable securities 280.3 273.9
Sales of marketable securities 35.1 0.0
Purchases of property, equipment and leasehold improvements (1.1) (2.1)
Net cash provided by investing activities 138.6 8.6
Cash flows from financing activities:    
Proceeds from exercise of stock options and issuance of ESPP shares 1.5 2.5
Net cash provided by financing activities 1.5 2.5
Net increase (decrease) in cash, cash equivalents and restricted cash 48.9 (46.0)
Cash, cash equivalents and restricted cash, beginning of the period 86.8 112.8
Cash, cash equivalents and restricted cash, end of the period 135.7 66.8
Supplemental disclosure of cash flow information:    
Purchases of property, equipment and leasehold improvements unpaid at period end $ 0.1 $ 0.1