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Research Collaboration and License Agreements - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 4 Months Ended | 6 Months Ended | 12 Months Ended | 14 Months Ended | 47 Months Ended | 62 Months Ended |  |  |  |  |  |  |
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Nov. 30, 2017 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2015 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2018 | Jun. 30, 2025 | Jun. 30, 2025 | Aug. 12, 2024 | Dec. 31, 2024 | May 31, 2024 | Apr. 30, 2024 | Dec. 31, 2023 | Jul. 31, 2021 | Jun. 30, 2019 | Dec. 31, 2017
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | $ 4,100,000 | $ 10,700,000 |  | $ 4,100,000 | $ 10,700,000 |  | $ 4,100,000 | $ 4,100,000 |  | $ 7,800,000 |  |  | $ 9,400,000 |  |  |
Collaboration contract asset and other assets |  | 4,400,000 |  |  | 4,400,000 |  |  | 4,400,000 | 4,400,000 |  | 8,100,000 |  |  |  |  |  |
Contract with customer, liability |  | 237,000,000.0 | 599,200,000 |  | 237,000,000.0 | 599,200,000 |  | 237,000,000.0 | 237,000,000.0 |  | $ 448,200,000 |  |  | 549,200,000 |  |  |
Revenue, remaining performance obligation |  | 237,000,000.0 |  |  | 237,000,000.0 |  |  | 237,000,000.0 | 237,000,000.0 |  |  |  |  |  |  |  |
Revenue |  | 22,400,000 | 76,500,000 |  | 211,200,000 | 101,800,000 |  |  |  |  |  |  |  |  |  |  |
Operating expenses |  | (93,900,000) | (125,000,000.0) |  | (211,300,000) | (233,600,000) |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ (61,200,000) | $ (35,200,000) |  | $ 21,700,000 | $ (104,600,000) |  |  |  |  |  |  |  |  |  |  |
Basic (in dollars per share) |  | $ (0.84) | $ (0.49) |  | $ 0.30 | $ (1.46) |  |  |  |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  | $ (0.84) | $ (0.49) |  | $ 0.30 | $ (1.46) |  |  |  |  |  |  |  |  |  |  |
Removal of Combination Trials |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 150,200,000 |  |  |  |  |  |  |  |  |  |  |  |
Operating expenses |  |  |  |  | (2,600,000) |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  | $ 147,600,000 |  |  |  |  |  |  |  |  |  |  |  |
Basic (in dollars per share) |  |  |  |  | $ 2.04 |  |  |  |  |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  |  |  |  | $ 2.03 |  |  |  |  |  |  |  |  |  |  |  |
Updated Research Timelines |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ (2,500,000) |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  | $ (2,500,000) |  |  |  |  |  |  |  |  |  |  |  |
Basic (in dollars per share) |  |  |  |  | $ (0.03) |  |  |  |  |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  |  |  |  | $ (0.03) |  |  |  |  |  |  |  |  |  |  |  |
Pfizer, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  |  |  | $ 28,000,000.0 |  |  |  |  |  |  |  |  |  |
Pfizer, Inc. | Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 650,000,000.0 |  |
Collaboration agreement direct and incremental costs incurred |  |  |  |  | $ 12,900,000 |  |  |  |  |  |  |  |  |  |  |  |
Collaboration contract asset and other assets |  | $ 12,900,000 |  |  | 12,900,000 |  |  | 12,900,000 | 12,900,000 |  |  |  |  |  |  |  |
Pfizer, Inc. | Regulatory and Sales-Based Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,400,000,000 |  |
Pfizer, Inc. | Regulatory Milestone Related to Marketing Approvals |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000,000.0 |  |
Payments received |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |
Pfizer, Inc. | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000,000,000.0 |  |
Pfizer, Inc. | Option Payments To License Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 3,800,000 |  |  | 3,800,000 |  |  | 3,800,000 | 3,800,000 |  |  |  |  |  |  |  |
Pfizer, Inc. | Development Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 225,000,000
Pfizer, Inc. | Sales Based Milestone Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  | 0 |  |  |  | 0 |  |  |  |  |  |  |  |
Pfizer, Inc. | Sales Based Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 550,000,000
Novartis Pharma AG | License |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |
Contract with customer, liability |  |  |  |  |  |  |  |  |  |  |  | $ 150,000,000 |  |  |  |  |
Contingent payments |  |  |  |  |  |  |  |  |  |  |  | $ 1,010,000,000.00 |  |  |  |  |
Revenue recognized |  |  |  |  | 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Revenue, remaining performance obligation |  | 130,000,000 |  |  | 130,000,000 |  |  | 130,000,000 | 130,000,000 |  |  |  |  |  |  |  |
Capitalized costs |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,000,000 |  |  |  |
Bayer Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,500,000 |
Bayer Collaboration Agreement | Development Milestone Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |  |
Bayer Collaboration Agreement | Development Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 197,500,000 |
Bayer Collaboration Agreement | Sales Based Milestone Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |  |
Bayer Collaboration Agreement | Sales Based Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 490,000,000 |
Bayer Collaboration Agreement | Research Funding Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,000,000.0 |  |  |
Genentech |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments received | $ 34,500,000 |  |  | $ 11,000,000.0 | 0 |  |  |  |  |  |  |  |  |  |  |  |
Genentech | Regulatory Milestone Related to Marketing Approvals |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 52,500,000 |  |  | 52,500,000 |  |  | 52,500,000 | 52,500,000 |  |  |  |  |  |  |  |
Genentech | Development Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 44,000,000 |  |  | 44,000,000 |  |  | 44,000,000 | 44,000,000 |  |  |  |  |  |  |  |
Genentech | Commercial Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | $ 60,000,000 |  |  | $ 60,000,000 |  |  | $ 60,000,000 | $ 60,000,000 |  |  |  |  |  |  |  |

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