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Insider Trading Arrangements | 3 Months Ended
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Mar. 31, 2026
Trading Arrangements, by Individual |
Material Terms of Trading Arrangement | The following table describes, for the first quarter of 2026, each trading arrangement for the sale or purchase of Company securities adopted or terminated by our directors and officers that is either (1) a contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) (a “Rule 10b5-1 trading arrangement”) or (2) a “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K):
Name (Title) |  | Action Taken (Date of Action) |  | Type of Trading Arrangement |  | Nature of Trading Arrangement |  | Duration of Trading Arrangement |  | Aggregate Number of Securities (1)
Randy Teel, Ph.D. (President, Chief Executive Officer, and Director) |  | 2/27/2026 |  | Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all equity awards that were granted on or after February 26, 2026; and all equity awards granted prior to February 26, 2026 that vest after the relevant cooling off period |  | Sale |  | Until final settlement of any restricted stock units, or RSUs |  | Indeterminable
Andrew Saik (Chief Financial Officer and Treasurer) |  | 2/27/2026 |  | Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all equity awards that were granted on or after February 26, 2026; and all equity awards granted prior to February 26, 2026 that vest after the relevant cooling off period |  | Sale |  | Until final settlement of any RSUs |  | Indeterminable
Noah Berkowitz, M.D., Ph.D. (Chief Medical Officer) |  | 2/27/2026 |  | Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all equity awards that were granted on or after February 26, 2026; and all equity awards granted prior to February 26, 2026 that vest after the relevant cooling off period |  | Sale |  | Until final settlement of any RSUs |  | Indeterminable
Angela Cacace, Ph.D. (Chief Scientific Officer) |  | 2/27/2026 |  | Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all equity awards that were granted on or after February 26, 2026; and all equity awards granted prior to February 26, 2026 that vest after the relevant cooling off period |  | Sale |  | Until final settlement of any RSUs |  | Indeterminable
David Loomis (VP, Chief Accounting Officer) |  | 2/27/2026 |  | Durable Rule 10b5-1 trading arrangement for sell-to-cover transactions relating to all equity awards that were granted on or after February 26, 2026; and all equity awards granted prior to February 26, 2026 that vest after the relevant cooling off period |  | Sale |  | Until final settlement of any RSUs |  | Indeterminable
(1) The number of shares subject to RSUs that will be sold to satisfy applicable tax withholding obligations upon vesting is unknown as the number will vary based on the extent to which vesting conditions are satisfied, the market price of the Company’s common stock at the time of settlement and the potential future grant of additional RSUs subject to this arrangement. This trading arrangement, which applies to RSUs whether vesting is based on the passage of time and/or the achievement of performance goals, provides for the automatic sale of shares that would otherwise be issuable on each settlement date of a RSU in an amount sufficient to satisfy the applicable tax withholding obligation, with the proceeds of the sale delivered to the Company in satisfaction of the applicable tax withholding obligation.
Non-Rule 10b5-1 Arrangement Adopted | false
Rule 10b5-1 Arrangement Terminated | false
Non-Rule 10b5-1 Arrangement Terminated | false
Randy Teel [Member] |
Trading Arrangements, by Individual |
Name | Randy Teel
Title | President, Chief Executive Officer, and Director
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 2/27/2026
Andrew Saik [Member] |
Trading Arrangements, by Individual |
Name | Andrew Saik
Title | Chief Financial Officer and Treasurer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 2/27/2026
Noah Berkowitz [Member] |
Trading Arrangements, by Individual |
Name | Noah Berkowitz
Title | Chief Medical Officer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 2/27/2026
Angela Cacace [Member] |
Trading Arrangements, by Individual |
Name | Angela Cacace
Title | Chief Scientific Officer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 2/27/2026
David Loomis [Member] |
Trading Arrangements, by Individual |
Name | David Loomis
Title | VP, Chief Accounting Officer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 2/27/2026

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