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Research Collaboration and License Agreements - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Nov. 30, 2017 | Mar. 31, 2026 | Mar. 31, 2025 | Dec. 31, 2015 | Dec. 31, 2018 | Dec. 31, 2025 | Dec. 31, 2024 | Jun. 18, 2024 | May 31, 2024 | Jul. 31, 2021 | Dec. 31, 2017
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | $ 3.2 | $ 4.5 |  |  | $ 3.5 | $ 7.8 |  |  |  |
Collaboration contract asset and other assets |  | 3.5 |  |  |  | 3.8 |  |  |  |  |
Contract with customer, liability |  | 190.0 | 259.4 |  |  | $ 205.6 | $ 448.2 |  |  |  |
Revenue |  | 15.6 | 188.8 |  |  |  |  |  |  |  |
Operating expenses |  | (79.4) | (117.4) |  |  |  |  |  |  |  |
Net loss |  | $ (57.6) | $ 82.9 |  |  |  |  |  |  |  |
Basic (in dollars per share) |  | $ (0.90) | $ 1.14 |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  | $ (0.90) | $ 1.14 |  |  |  |  |  |  |  |
Removal of Combination Trials |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  | $ 150.2 |  |  |  |  |  |  |  |
Operating expenses |  |  | (2.6) |  |  |  |  |  |  |  |
Net loss |  |  | $ (147.6) |  |  |  |  |  |  |  |
Basic (in dollars per share) |  |  | $ 2.04 |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  |  | $ 2.03 |  |  |  |  |  |  |  |
Updated Research Timelines |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  | $ (2.5) |  |  |  |  |  |  |  |
Net loss |  |  | $ (2.5) |  |  |  |  |  |  |  |
Basic (in dollars per share) |  |  | $ 0.03 |  |  |  |  |  |  |  |
Diluted (in dollars per share) |  |  | $ 0.03 |  |  |  |  |  |  |  |
Pfizer, Inc. |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payments received |  |  |  |  | $ 28.0 |  |  |  |  |  |
Revenue |  | $ 1.2 | $ (1.1) |  |  |  |  |  |  |  |
Pfizer, Inc. | Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  | $ 650.0 |
Collaboration agreement direct and incremental costs incurred |  | 12.9 |  |  |  |  |  |  |  |  |
Collaboration contract asset and other assets |  | 12.9 |  |  |  |  |  |  |  |  |
Pfizer, Inc. | Regulatory and Sales-Based Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  | 1,400.0 |
Pfizer, Inc. | Regulatory Milestone Related to Marketing Approvals |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  | 400.0 |
Pfizer, Inc. | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  | $ 1,000.0 |
Pfizer, Inc. | Option Payments To License Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 3.8 |  |  |  |  |  |  |  |  |
Pfizer, Inc. | Development Milestone Payments |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  | $ 50.0 |  |  |
Pfizer, Inc. | Development Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  | $ 225.0
Pfizer, Inc. | Sales Based Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  |  |  |  |  |  |  |  |  |  | $ 550.0
Novartis Pharma AG | License |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract with customer, liability |  |  |  |  |  |  |  |  | $ 150.0 |  |
Contingent payments |  |  |  |  |  |  |  |  | $ 1,010.0 |  |
Genentech |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payments received | $ 34.5 |  |  | $ 11.0 |  |  |  |  |  |  |
Genentech | Regulatory Milestone Related to Marketing Approvals |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 52.5 |  |  |  |  |  |  |  |  |
Genentech | Development Milestone Payments | Maximum |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | 44.0 |  |  |  |  |  |  |  |  |
Genentech | Commercial Milestones |  |  |  |  |  |  |  |  |  |  |
Research Collaboration And License Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract revenue receivable if milestones achieved |  | $ 60.0 |  |  |  |  |  |  |  |  |

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