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Income Taxes - Temporary Differences and Carryforwards and Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | --- | ---
Deferred Tax Assets |  |  |
Net operating loss carryforwards | $ 35,067 | $ 32,210 |
Research and development credits | 2,255 | 2,070 |
Depreciation and amortization | 132 | 179 |
Accruals and reserves | 2,958 | 1,376 |
Deferred tax asset, gross | 40,412 | 35,835 |
Less: Valuation allowance | (40,412) | (35,835) | $ (43,348)
Total deferred tax asset | $ 0 | $ 0 |

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