<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:61c16ea1-9a3f-4179-9c95-0a2503c7d8af,g:73bba258-d37d-49fa-ba90-64efcb961c10-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="sibn-20250331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_4c174b7c-8462-44a8-9adb-38bd8bef7391" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_02c86754-4873-478d-867f-7914485f7992" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4c174b7c-8462-44a8-9adb-38bd8bef7391" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_02c86754-4873-478d-867f-7914485f7992" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_8c8f2f1b-479d-48c3-a07a-059615281d41" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4c174b7c-8462-44a8-9adb-38bd8bef7391" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_8c8f2f1b-479d-48c3-a07a-059615281d41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d7f779d2-89a4-4744-9759-cff460db0a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4c174b7c-8462-44a8-9adb-38bd8bef7391" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d7f779d2-89a4-4744-9759-cff460db0a8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_2b8f22e1-6903-4d19-933d-4fbd105a90cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4c174b7c-8462-44a8-9adb-38bd8bef7391" xlink:to="loc_us-gaap_LiabilitiesCurrent_2b8f22e1-6903-4d19-933d-4fbd105a90cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_8904c2f3-a30a-4d4e-bbfd-020a99f0548c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_9856c900-9ca1-4bb8-974a-12a73b22d327" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_8904c2f3-a30a-4d4e-bbfd-020a99f0548c" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_9856c900-9ca1-4bb8-974a-12a73b22d327" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_7c035382-9379-4779-8e6f-8f215d5717ee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_8904c2f3-a30a-4d4e-bbfd-020a99f0548c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_7c035382-9379-4779-8e6f-8f215d5717ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_511ddcc3-1081-4666-90ef-15c22f00328b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_8904c2f3-a30a-4d4e-bbfd-020a99f0548c" xlink:to="loc_us-gaap_AccountsPayableCurrent_511ddcc3-1081-4666-90ef-15c22f00328b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_a6a3200c-d19c-4d54-b3c0-c37801d35da7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:to="loc_us-gaap_PreferredStockValue_a6a3200c-d19c-4d54-b3c0-c37801d35da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_19a3f59e-c337-4d19-a042-5d1934e07b21" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:to="loc_us-gaap_CommonStockValue_19a3f59e-c337-4d19-a042-5d1934e07b21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_1ac4ec63-2699-4680-a1e4-ca751f4014b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:to="loc_us-gaap_AdditionalPaidInCapital_1ac4ec63-2699-4680-a1e4-ca751f4014b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_168b2a62-cb0b-43ac-958c-021acce0ade8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_168b2a62-cb0b-43ac-958c-021acce0ade8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0125c4fd-6ef1-4629-8b65-af365ca591f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4a78fa93-2c59-411c-8b23-579bd7ace22f" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0125c4fd-6ef1-4629-8b65-af365ca591f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_7d1527f1-0239-4884-9beb-d4c9beaea14b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8eee1191-0813-4cad-9c5c-a0f94bc17bce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7d1527f1-0239-4884-9beb-d4c9beaea14b" xlink:to="loc_us-gaap_AssetsCurrent_8eee1191-0813-4cad-9c5c-a0f94bc17bce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_05b69294-9868-4981-9a87-75c865ac846c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7d1527f1-0239-4884-9beb-d4c9beaea14b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_05b69294-9868-4981-9a87-75c865ac846c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_7f24a49a-5294-4406-b159-4a470c8a8653" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7d1527f1-0239-4884-9beb-d4c9beaea14b" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_7f24a49a-5294-4406-b159-4a470c8a8653" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_e1a0e940-427a-4486-bfeb-738d13c1c30c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7d1527f1-0239-4884-9beb-d4c9beaea14b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_e1a0e940-427a-4486-bfeb-738d13c1c30c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_2627de81-b81f-4699-982d-03454dd9e18c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_62f20e32-437f-478f-b025-87cb6fc3a088" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_2627de81-b81f-4699-982d-03454dd9e18c" xlink:to="loc_us-gaap_Liabilities_62f20e32-437f-478f-b025-87cb6fc3a088" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_5f1da2aa-beb6-4ebb-8a43-7f409d94c352" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_2627de81-b81f-4699-982d-03454dd9e18c" xlink:to="loc_us-gaap_CommitmentsAndContingencies_5f1da2aa-beb6-4ebb-8a43-7f409d94c352" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f4fc4224-6a89-4bc3-838d-4488842726f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_2627de81-b81f-4699-982d-03454dd9e18c" xlink:to="loc_us-gaap_StockholdersEquity_f4fc4224-6a89-4bc3-838d-4488842726f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1e809f7a-2719-4bf9-b2ac-66e231125951" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1e809f7a-2719-4bf9-b2ac-66e231125951" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_5472ed6b-f1ad-44db-b85d-c9b7a6b0f2dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_5472ed6b-f1ad-44db-b85d-c9b7a6b0f2dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e667e303-32d7-4f87-bc0d-af2a84374340" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_e667e303-32d7-4f87-bc0d-af2a84374340" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_80f6b24a-cd95-4935-951f-cef25de459dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:to="loc_us-gaap_InventoryNet_80f6b24a-cd95-4935-951f-cef25de459dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_bb76b619-fb0d-42b0-ab33-1dabc61ff3f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f107e038-9a61-48a0-b96c-aa3b8fb45355" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_bb76b619-fb0d-42b0-ab33-1dabc61ff3f9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="sibn-20250331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_4c92f022-8a4e-4eb1-a671-457e0f8b5de4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_38428e08-0bcc-4072-a10a-b9d976d0c292" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_4c92f022-8a4e-4eb1-a671-457e0f8b5de4" xlink:to="loc_us-gaap_SellingAndMarketingExpense_38428e08-0bcc-4072-a10a-b9d976d0c292" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_9f71a73f-5145-4fc1-900f-12bab247b322" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_4c92f022-8a4e-4eb1-a671-457e0f8b5de4" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_9f71a73f-5145-4fc1-900f-12bab247b322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_f53f5f39-b26b-49b7-86a6-f3190e867a54" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_4c92f022-8a4e-4eb1-a671-457e0f8b5de4" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_f53f5f39-b26b-49b7-86a6-f3190e867a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_036ffbba-f899-4bf8-8c85-8bb60919dd38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_7b50fb01-dd94-4746-bb8b-e4f166ff2c02" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_036ffbba-f899-4bf8-8c85-8bb60919dd38" xlink:to="loc_us-gaap_GrossProfit_7b50fb01-dd94-4746-bb8b-e4f166ff2c02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_4401eaa1-8047-4756-a613-92690f437174" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_036ffbba-f899-4bf8-8c85-8bb60919dd38" xlink:to="loc_us-gaap_OperatingExpenses_4401eaa1-8047-4756-a613-92690f437174" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_72e5b806-e742-46f4-90fc-d7d58b6e5cea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0d8bc9b5-ed47-4f1b-b004-3c4a9fd65e91" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_72e5b806-e742-46f4-90fc-d7d58b6e5cea" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0d8bc9b5-ed47-4f1b-b004-3c4a9fd65e91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_fe87b348-f7b5-4fdd-8e96-45094550d110" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_72e5b806-e742-46f4-90fc-d7d58b6e5cea" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_fe87b348-f7b5-4fdd-8e96-45094550d110" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_9694a156-04e1-4ff5-8d7f-4c4f5a71c1f4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e0500276-ebf7-4df5-81fe-274ce629c8b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9694a156-04e1-4ff5-8d7f-4c4f5a71c1f4" xlink:to="loc_us-gaap_NetIncomeLoss_e0500276-ebf7-4df5-81fe-274ce629c8b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_90833e64-a8aa-47f2-b715-f8755535d7f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9694a156-04e1-4ff5-8d7f-4c4f5a71c1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_90833e64-a8aa-47f2-b715-f8755535d7f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_008a7bdf-d5dc-4bef-9c02-a79666e8288d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9694a156-04e1-4ff5-8d7f-4c4f5a71c1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_008a7bdf-d5dc-4bef-9c02-a79666e8288d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1521a5b6-d12c-4cc2-b075-b72dcd3e6def" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_be17874d-800a-40e6-8811-3e4ce61689e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_1521a5b6-d12c-4cc2-b075-b72dcd3e6def" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_be17874d-800a-40e6-8811-3e4ce61689e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_0b931a78-1c32-4ae3-81d5-d7eb9c4e9f9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_1521a5b6-d12c-4cc2-b075-b72dcd3e6def" xlink:to="loc_us-gaap_OperatingIncomeLoss_0b931a78-1c32-4ae3-81d5-d7eb9c4e9f9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_563793a5-1423-4f75-8e37-276d3db6aa0d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_1521a5b6-d12c-4cc2-b075-b72dcd3e6def" xlink:to="loc_us-gaap_InterestExpenseNonoperating_563793a5-1423-4f75-8e37-276d3db6aa0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_1f55e385-e328-4809-b7d9-8a94d87831ee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_1521a5b6-d12c-4cc2-b075-b72dcd3e6def" xlink:to="loc_us-gaap_InvestmentIncomeInterest_1f55e385-e328-4809-b7d9-8a94d87831ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="sibn-20250331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_407de7cd-19f0-4abc-8414-c4def0396a50" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_9d2bf408-35a3-489d-a863-01eed4d15913" xlink:href="sibn-20250331.xsd#sibn_ProceedsFromMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_407de7cd-19f0-4abc-8414-c4def0396a50" xlink:to="loc_sibn_ProceedsFromMaturityOfMarketableSecurities_9d2bf408-35a3-489d-a863-01eed4d15913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8fef1003-a2ef-4b1d-b647-e4fadd491f0a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_407de7cd-19f0-4abc-8414-c4def0396a50" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8fef1003-a2ef-4b1d-b647-e4fadd491f0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fe735fa5-850a-40bc-a251-275e7c34f3b8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_407de7cd-19f0-4abc-8414-c4def0396a50" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fe735fa5-850a-40bc-a251-275e7c34f3b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d1a0a656-5b0a-43e0-952a-5fe64a12f100" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_62106ba8-a712-4561-9063-14b9e3cd72f6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d1a0a656-5b0a-43e0-952a-5fe64a12f100" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_62106ba8-a712-4561-9063-14b9e3cd72f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_83bd1676-0622-4cc7-a460-6f1b1e5eba2b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d1a0a656-5b0a-43e0-952a-5fe64a12f100" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_83bd1676-0622-4cc7-a460-6f1b1e5eba2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01ed5d73-d00c-4ef5-b29a-5f5d7a0b043b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d1a0a656-5b0a-43e0-952a-5fe64a12f100" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01ed5d73-d00c-4ef5-b29a-5f5d7a0b043b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_352b8f72-d279-4fbb-900f-32d0e6d532a9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d1a0a656-5b0a-43e0-952a-5fe64a12f100" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_352b8f72-d279-4fbb-900f-32d0e6d532a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_7f9fa9c6-e2c1-48e3-a013-8db5e474ed3c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_NetIncomeLoss_7f9fa9c6-e2c1-48e3-a013-8db5e474ed3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_f1ee2392-c609-44a1-95cd-67aa94eef175" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_ShareBasedCompensation_f1ee2392-c609-44a1-95cd-67aa94eef175" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_6e2cb796-08f8-4e8e-ae8c-9f02c70bb15b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_6e2cb796-08f8-4e8e-ae8c-9f02c70bb15b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_302d62fa-4500-46fc-a7f3-3332b3231b46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_302d62fa-4500-46fc-a7f3-3332b3231b46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_b3610b1e-f081-4cff-952e-17c600934b67" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_b3610b1e-f081-4cff-952e-17c600934b67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_8f414c7e-71c4-4cf5-b556-97aeedb75604" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_8f414c7e-71c4-4cf5-b556-97aeedb75604" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_17ce5e3b-6592-45e0-b716-5ed9008907cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_17ce5e3b-6592-45e0-b716-5ed9008907cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_0dfc6b25-80ce-4f5f-b454-662e5e24ce3a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_0dfc6b25-80ce-4f5f-b454-662e5e24ce3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ad9d854d-e219-4cee-b890-4fe9205474b5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ad9d854d-e219-4cee-b890-4fe9205474b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_65dd6a52-3750-479f-a1ab-98927df0cc71" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_65dd6a52-3750-479f-a1ab-98927df0cc71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_69bdf383-0c5d-4fde-8581-3a710211cec8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_69bdf383-0c5d-4fde-8581-3a710211cec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_29c9a0f7-221b-421b-8a0b-803c2556f77d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_29c9a0f7-221b-421b-8a0b-803c2556f77d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_cb2925f9-f5e4-463a-8692-852da3198fbf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6a110ab3-957c-4e6e-bb83-e8d8030afa08" xlink:to="loc_us-gaap_InventoryWriteDown_cb2925f9-f5e4-463a-8692-852da3198fbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_5c4bb931-6e85-482f-9377-5965982f1186" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_442a325c-9376-46a6-89ac-3ce19cd0d438" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_5c4bb931-6e85-482f-9377-5965982f1186" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_442a325c-9376-46a6-89ac-3ce19cd0d438" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/MarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#MarketableSecuritiesScheduleofMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/MarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_e44cd927-7075-42d2-a8dc-f0fe6b2e7867" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_01f484e6-d5b5-4f12-93a4-5f7a66fa8194" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_e44cd927-7075-42d2-a8dc-f0fe6b2e7867" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_01f484e6-d5b5-4f12-93a4-5f7a66fa8194" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_31623df1-a850-4b3c-b3b5-b2334b4677c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_e44cd927-7075-42d2-a8dc-f0fe6b2e7867" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_31623df1-a850-4b3c-b3b5-b2334b4677c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_22a86a20-e04c-47f8-818d-7fa509b52d55" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_e44cd927-7075-42d2-a8dc-f0fe6b2e7867" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_22a86a20-e04c-47f8-818d-7fa509b52d55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_a77d2256-6292-48fd-86f3-3ac598546519" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_0ddddb1b-108c-4963-8685-69b9b7a4f30a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_a77d2256-6292-48fd-86f3-3ac598546519" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_0ddddb1b-108c-4963-8685-69b9b7a4f30a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_5d44b94f-4c1e-47be-b706-a987378062cd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_a77d2256-6292-48fd-86f3-3ac598546519" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_5d44b94f-4c1e-47be-b706-a987378062cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_MarketableSecuritiesAmortizedCost_8244fdad-5965-4ef0-89b3-70258ccfce13" xlink:href="sibn-20250331.xsd#sibn_MarketableSecuritiesAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_bc7d6698-3f35-462c-b8a2-800e00a9e950" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_8244fdad-5965-4ef0-89b3-70258ccfce13" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_bc7d6698-3f35-462c-b8a2-800e00a9e950" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_24514dd9-e11c-459f-a2f8-7742cbd6a4db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_sibn_MarketableSecuritiesAmortizedCost_8244fdad-5965-4ef0-89b3-70258ccfce13" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_24514dd9-e11c-459f-a2f8-7742cbd6a4db" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#BalanceSheetComponentsPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_4a4d7b38-6e9f-4a00-b8dc-0a6bc4e11f72" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_a008b687-5831-4c5c-803c-aa0b4f55307a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4a4d7b38-6e9f-4a00-b8dc-0a6bc4e11f72" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_a008b687-5831-4c5c-803c-aa0b4f55307a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01768107-60e8-469b-8457-f67fc0eec218" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4a4d7b38-6e9f-4a00-b8dc-0a6bc4e11f72" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01768107-60e8-469b-8457-f67fc0eec218" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#BalanceSheetComponentsAccruedLiabilitiesandOtherDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BalanceSheetComponentsAccruedLiabilitiesandOtherDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_9e90e3c6-7233-46a4-8315-f3c30e4c19ef" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_9e90e3c6-7233-46a4-8315-f3c30e4c19ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_127b1369-a4f6-454b-9d17-ee27e99d70fe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_127b1369-a4f6-454b-9d17-ee27e99d70fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_6f25701b-fac8-4e4f-b847-029dca19b012" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_6f25701b-fac8-4e4f-b847-029dca19b012" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_6d62307e-9c3e-416e-9eec-704ede5cb85a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_6d62307e-9c3e-416e-9eec-704ede5cb85a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_AccruedRebatesCurrent_f4ff3a6a-291a-49a8-98e4-599955ee32e5" xlink:href="sibn-20250331.xsd#sibn_AccruedRebatesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_dd9e0549-df15-470c-baad-450d005665fb" xlink:to="loc_sibn_AccruedRebatesCurrent_f4ff3a6a-291a-49a8-98e4-599955ee32e5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#CommitmentandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentandContingenciesSupplementalInformationRelatedtoLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_b6b30ef5-8db7-41a8-9898-9d02fb11ac0e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_8f4a4357-ee11-441b-988e-3ba670edd62e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_b6b30ef5-8db7-41a8-9898-9d02fb11ac0e" xlink:to="loc_us-gaap_OperatingLeaseCost_8f4a4357-ee11-441b-988e-3ba670edd62e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_67f05c76-5981-49d8-8590-f86c84afd4cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_b6b30ef5-8db7-41a8-9898-9d02fb11ac0e" xlink:to="loc_us-gaap_VariableLeaseCost_67f05c76-5981-49d8-8590-f86c84afd4cb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_58a9459f-46e7-4dc3-b977-d12ba4dc6311" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_9a3e3a07-cae4-46f7-86f5-11fbb4fbfa6c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_58a9459f-46e7-4dc3-b977-d12ba4dc6311" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_9a3e3a07-cae4-46f7-86f5-11fbb4fbfa6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_b349c1c3-ec2c-4015-a711-2b29646328a0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_58a9459f-46e7-4dc3-b977-d12ba4dc6311" xlink:to="loc_us-gaap_OperatingLeaseLiability_b349c1c3-ec2c-4015-a711-2b29646328a0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="sibn-20250331.xsd#CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/CommitmentsandContingenciesAggregateFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_96dcdf94-1a90-4313-9ec4-260f69874a82" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_96dcdf94-1a90-4313-9ec4-260f69874a82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_94f2099a-05cf-4883-88cc-0c9c4bee3bc8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_94f2099a-05cf-4883-88cc-0c9c4bee3bc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_05b5b5c3-a7bc-4f49-ba1d-c0f93c218966" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_05b5b5c3-a7bc-4f49-ba1d-c0f93c218966" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_0fb41801-f91f-4d96-9790-63b6696a8550" xlink:href="sibn-20250331.xsd#sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_sibn_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_0fb41801-f91f-4d96-9790-63b6696a8550" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_3aefa2dd-d499-4e90-a416-dea03503c0cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_3aefa2dd-d499-4e90-a416-dea03503c0cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_cee73b09-6f35-4d5b-b987-bcfed7e0e8a1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b817d3ed-40d8-4284-b4e9-c417bd86c5e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_cee73b09-6f35-4d5b-b987-bcfed7e0e8a1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#BorrowingsSummaryofBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsSummaryofBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_63f7f558-6827-4ef5-8220-eb91438eba13" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_185b55d6-59d3-45e3-a909-a009f339c851" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_63f7f558-6827-4ef5-8220-eb91438eba13" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_185b55d6-59d3-45e3-a909-a009f339c851" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_89aa4fa0-8dca-485b-8568-51a3be3c7dce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_63f7f558-6827-4ef5-8220-eb91438eba13" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_89aa4fa0-8dca-485b-8568-51a3be3c7dce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://si-bone.com/role/BorrowingsDebtMaturityDetails" xlink:type="simple" xlink:href="sibn-20250331.xsd#BorrowingsDebtMaturityDetails"/>
  <link:calculationLink xlink:role="http://si-bone.com/role/BorrowingsDebtMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_ddbc2366-a51f-4abb-8b7b-8776f10db55f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_ddbc2366-a51f-4abb-8b7b-8776f10db55f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_44ca7540-1664-4b8b-9503-1a4189a9c9e7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_44ca7540-1664-4b8b-9503-1a4189a9c9e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_74ca2cf2-d5aa-4b27-8e12-9cd8aa90b0a1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_74ca2cf2-d5aa-4b27-8e12-9cd8aa90b0a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_87473b48-f8ab-4b11-a8a5-607b7c24b3e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_87473b48-f8ab-4b11-a8a5-607b7c24b3e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_507bd1e6-8e3a-4998-9865-fd65a3c86678" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_81437a97-b87f-475e-9f05-f141eb363e41" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_507bd1e6-8e3a-4998-9865-fd65a3c86678" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
