<SEC-DOCUMENT>0001085146-25-002201.txt : 20250418
<SEC-HEADER>0001085146-25-002201.hdr.sgml : 20250418
<ACCEPTANCE-DATETIME>20250418172402
ACCESSION NUMBER:		0001085146-25-002201
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250418
DATE AS OF CHANGE:		20250418

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SI-BONE, Inc.
		CENTRAL INDEX KEY:			0001459839
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				262216351
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90888
		FILM NUMBER:		25851052

	BUSINESS ADDRESS:	
		STREET 1:		471 EL CAMINO REAL, SUITE 101
		CITY:			SANTA CLARA
		STATE:			CA
		ZIP:			95050
		BUSINESS PHONE:		4082070700

	MAIL ADDRESS:	
		STREET 1:		471 EL CAMINO REAL, SUITE 101
		CITY:			SANTA CLARA
		STATE:			CA
		ZIP:			95050

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SI-Bone Inc.
		DATE OF NAME CHANGE:	20090326

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BROWN ADVISORY INC
		CENTRAL INDEX KEY:			0001345929
		ORGANIZATION NAME:           	
		EIN:				522112409
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		901 SOUTH BOND STREET
		STREET 2:		SUITE #400
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21231
		BUSINESS PHONE:		410-537-5400

	MAIL ADDRESS:	
		STREET 1:		901 SOUTH BOND STREET
		STREET 2:		SUITE #400
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21231

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BROWN ADVISORY HOLDINGS INC
		DATE OF NAME CHANGE:	20051202
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns1="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001085146-22-000567</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001345929</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001459839</issuerCik>
        <issuerName>SI-BONE, Inc.</issuerName>
        <issuerCusip>825704109</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <ns1:street1>471 El Camino Real</ns1:street1>
          <ns1:street2>Suite 101</ns1:street2>
          <ns1:city>Santa Clara</ns1:city>
          <ns1:stateOrCountry>CA</ns1:stateOrCountry>
          <ns1:zipCode>95050</ns1:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN ADVISORY INC</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2669868</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>3219079</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3219079</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.6</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN INVESTMENT ADVISORY &amp; TRUST CO</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>18203</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>18203</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18203</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0</classPercent>
      <typeOfReportingPerson>BK</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN ADVISORY LLC</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2650771</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>3198548</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3198548</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.5</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>SIGNATURE FINANCIAL MANAGEMENT, INC.</reportingPersonName>
      <citizenshipOrOrganization>VA</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>894</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>2328</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2328</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>SI-BONE, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>471 El Camino Real
Suite 101
Santa Clara, CALIFORNIA
95050</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>BROWN ADVISORY INC

BROWN INVESTMENT ADVISORY &amp; TRUST CO

BROWN ADVISORY LLC

SIGNATURE FINANCIAL MANAGEMENT, INC.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>901 SOUTH BOND STREET
SUITE #400
Baltimore, Maryland
21231</principalBusinessOfficeOrResidenceAddress>
        <citizenship>BROWN ADVISORY INC - MARYLAND

BROWN INVESTMENT ADVISORY &amp; TRUST CO - MARYLAND

BROWN ADVISORY LLC - MARYLAND

SIGNATURE FINANCIAL MANAGEMENT, INC. - VIRGINIA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>BK</typeOfPersonFiling>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>3,219,079</amountBeneficiallyOwned>
        <classPercent>7.6</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>BROWN ADVISORY INC - 2,669,868

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 18,203

BROWN ADVISORY LLC - 2,650,771

SIGNATURE FINANCIAL MANAGEMENT, INC. - 894</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>BROWN ADVISORY INC - 0

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 0

BROWN ADVISORY LLC - 0

SIGNATURE FINANCIAL MANAGEMENT, INC. - 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>BROWN ADVISORY INC - 0

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 0

BROWN ADVISORY LLC - 0

SIGNATURE FINANCIAL MANAGEMENT, INC. - 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>BROWN ADVISORY INC - 3,219,079

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 18,203

BROWN ADVISORY LLC - 3,198,548

SIGNATURE FINANCIAL MANAGEMENT, INC. - 2,328</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>The total securities being reported are beneficially owned by investment companies and other managed accounts of direct/indirect subsidiaries of BROWN ADVISORY INC (listed above). These subsidiaries may be deemed to be beneficial owners of the reported securities because applicable investment advisory contracts provide voting and/or investment power over securities.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>N</notApplicableFlag>
        <subsidiaryIdentificationAndClassification>BROWN ADVISORY INC is a parent holding company filing this schedule on behalf of the following subsidiaries pursuant to Rule 13d-1(b)(1)(ii)(G) under the Securities Exchange Act of 1934:
BROWN INVESTMENT ADVISORY &amp; TRUST CO - BK (Bank)
BROWN ADVISORY LLC - IA (Investment Adviser)
SIGNATURE FINANCIAL MANAGEMENT, INC. - IA (Investment Adviser)</subsidiaryIdentificationAndClassification>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>BROWN ADVISORY INC</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>BROWN INVESTMENT ADVISORY &amp; TRUST CO</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>BROWN ADVISORY LLC</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>SIGNATURE FINANCIAL MANAGEMENT, INC.</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
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</DOCUMENT>
</SEC-DOCUMENT>
