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Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Reconciliation of federal statutory income tax rate to effective income tax rate      
Federal statutory income tax rate $ (5,583,000)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate $ (20,488,000)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate $ (2,922,000)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
Loss on settlement of notes   18,884,000xncr_IncomeTaxReconciliationLossOnSettlementOfNotes  
Non-deductible research and development credit 435,000us-gaap_IncomeTaxReconciliationNondeductibleExpenseResearchAndDevelopment   336,000us-gaap_IncomeTaxReconciliationNondeductibleExpenseResearchAndDevelopment
Stock based compensation 478,000us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost    
Other 2,000us-gaap_IncomeTaxReconciliationOtherAdjustments 4,000us-gaap_IncomeTaxReconciliationOtherAdjustments 12,000us-gaap_IncomeTaxReconciliationOtherAdjustments
Net change in valuation allowance 4,668,000us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance 1,600,000us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance 2,574,000us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
Net effective tax rate         
Deferred income tax assets      
Net operating loss carryforwards 47,401,000us-gaap_DeferredTaxAssetsOperatingLossCarryforwards 58,286,000us-gaap_DeferredTaxAssetsOperatingLossCarryforwards  
Research credits 12,789,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch 24,276,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch  
Depreciation 790,000us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment 849,000us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment  
Stock-based compensation   52,000us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost  
Accrued compensation 373,000us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation 137,000us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation  
Deferred revenue 1,836,000us-gaap_DeferredTaxAssetsDeferredIncome 3,899,000us-gaap_DeferredTaxAssetsDeferredIncome  
Gross deferred income tax assets 63,189,000us-gaap_DeferredTaxAssetsGross 87,499,000us-gaap_DeferredTaxAssetsGross  
Valuation allowance (59,602,000)us-gaap_DeferredTaxAssetsValuationAllowance (84,045,000)us-gaap_DeferredTaxAssetsValuationAllowance  
Net deferred income tax assets 3,587,000us-gaap_DeferredTaxAssetsNet 3,454,000us-gaap_DeferredTaxAssetsNet  
Deferred income tax liabilities      
Patent costs (3,199,000)us-gaap_DeferredTaxLiabilitiesDeferredExpenseCapitalizedPatentCosts (2,929,000)us-gaap_DeferredTaxLiabilitiesDeferredExpenseCapitalizedPatentCosts  
Licensing costs (317,000)xncr_DeferredTaxLiabilitiesLicenseCosts (406,000)xncr_DeferredTaxLiabilitiesLicenseCosts  
Capitalized legal costs (71,000)xncr_DeferredTaxLiabilitiesCapitalizedLegalCosts (119,000)xncr_DeferredTaxLiabilitiesCapitalizedLegalCosts  
Gross deferred income tax liabilities (3,587,000)us-gaap_DeferredIncomeTaxLiabilities (3,454,000)us-gaap_DeferredIncomeTaxLiabilities  
Net deferred income tax asset/(liability)        
Increase (decrease) in deferred tax asset valuation allowance   $ 3,000,000us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount