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Stock-Based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2015
Stock-Based Compensation |
Schedule of total employee, director and non-employee stock-based compensation expense recognized | Total employee, director and non-employee stock-based compensation expense recognized for the three months and nine months ended September 30, 2015 and 2014 are as follows (in thousands):
|  | Three Months Ended |  | Nine Months Ended
|  | September 30, |  | September 30,
|  | 2015 |  | 2014 |  | 2015 |  | 2014
General and administrative |  | $ | 593 |  | $ | 276 |  | $ | 1,628 |  | $ | 575
Research and development |  |  | 493 |  |  | 215 |  |  | 1,758 |  |  | 535
|  | $ | 1,086 |  | $ | 491 |  | $ | 3,386 |  | $ | 1,110
Summary of stock option activity |
|  |  |  | Weighted |  | Weighted |  |
|  |  |  | Average |  | Average |  |
|  | Number of |  | Exercise |  | Remaining |  | Aggregate
|  | Shares subject |  | Price |  | Contractual |  | Intrinsic
|  | to outstanding |  | (Per |  | Term |  | Value
|  | options |  | Share) |  | (in years) |  | (in thousands)
Balances at December 31, 2014 |  | 2,826,794 |  | $ | 5.12 |  |  |  |  |  |
Options granted |  | 930,250 |  | $ | 15.96 |  |  |  |  |  |
Options forfeited |  | (9,375) |  | $ | 18.75 |  |  |  |  |  |
Options exercised |  | (369,743) |  | $ | 1.47 |  |  |  |  |  |
Balance at September 30, 2015 |  | 3,377,926 |  | $ | 8.47 |  |  | 7.21 |  | $ | 16,173
Exercisable |  | 1,515,353 |  | $ | 3.69 |  |  | 5.15 |  | $ | 12,965
Schedule of weighted average assumptions used for estimation of fair value of stock options |
|  | Options |  | Options |
|  | Three Months Ended |  | Nine Months Ended |
|  | September 30, |  | September 30, |
|  | 2015 |  | 2014 |  | 2015 |  | 2014 |
Expected term (years) |  | 6.4 |  | 6.0 |  | 6.1 |  | 6.0 |
Expected volatility |  | 86.5 | % | 77.4 | % | 76.6 | % | 77.4 | %
Risk-free interest rate |  | 1.95 | % | 2.02 | % | 1.62 | % | 2.02 | %
Expected dividend yield |  | — | % | — | % | — | % | — | %
Schedule of weighted average assumptions used for estimation of fair value of ESPP |
|  | ESPP |  | ESPP |
|  | Three Months Ended |  | Nine Months Ended |
|  | September 30, |  | September 30, |
|  | 2015 |  | 2014 |  | 2015 |  | 2014 |
Expected term (years) |  | 0.5 - 2.0 |  | 0.5 - 2.0 |  | 0.5 - 2.0 |  | 0.5 - 2.0 |
Expected volatility |  | 70.6 - 82.9 | % | 70.6 | % | 70.6 - 82.9 | % | 70.6 | %
Risk-free interest rate |  | .06% - .46 | % | .06% - .46 | % | .06% - .46 | % | .06% - .46 | %
Expected dividend yield |  | — | % | — | % | — | % | — | %

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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of employee stock purchase plans, including, but not limited to: (a) expected term, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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