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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income Taxes

Reconciliation of the federal statutory income tax rate to our effective income tax rate

		Year Ended
		December 31,
		2015			2014			2013
Federal statutory income tax rate		$	(6,157)		$	(5,583)		$	(20,488)
Loss on settlement of notes			—			—			18,884
Non-deductible research and development credit			708			435			—
Stock based compensation			651			478			—
Other			14			2			4
Net change in valuation allowance			4,784			4,668			1,600
Net effective tax rate		$	—		$	—		$	—

Schedule of tax effect of temporary differences that give rise to a significant portion of the deferred tax assets and liabilities

		2015			2014
Deferred income tax assets
Net operating loss carryforwards		$	69,348		$	47,401
Research credits			8,096			12,789
Depreciation			735			790
Unrealized loss on securities			206			—
Accrued compensation			511			373
Deferred revenue			1,032			1,836
Gross deferred income tax assets			79,928			63,189
Valuation allowance			(76,036)			(59,602)
Net deferred income tax assets			3,892			3,587
Deferred income tax liabilities
Patent costs			(3,489)			(3,199)
Licensing costs			(339)			(317)
Capitalized legal costs			(64)			(71)
Gross deferred income tax liabilities			(3,892)			(3,587)
Net deferred income tax asset/(liability)		$	—		$	—

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- References

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319

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