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Summary of Significant Accounting Policies - Concentration Risk (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2015
USD ($)
customer
Dec. 31, 2014
USD ($)
customer
Dec. 31, 2013
USD ($)
Concentrations of risk      
Research and Development Expense | $ $ 34,140 $ 18,516 $ 17,000
Concentrations of Risk      
Amounts on deposit in excess of federally insured limits approximately $12.1 $54.0  
Payables | Service providers      
Concentrations of risk      
Concentration risk percentage 55.00% 47.00%  
Number of service providers 3 1  
Number of critical suppliers 2