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Statement of Stockholders’ Equity - USD ($)
$ in Thousands
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Total
Balance at Dec. 31, 2012 $ 1 $ 1,043   $ (167,312) $ (166,268)
Balance (in shares) at Dec. 31, 2012 72,302        
Increase (Decrease) in Stockholders' Equity          
Deemed contribution on exchange of Series A-E Preferred Stock for Series A-1   143,681     143,681
Deemed contribution on exchange of Series A-1 preferred for Series A-2 preferred stock   7,489     7,489
Deemed dividend on sale of Series A-1 preferred   (3,429)     (3,429)
Exchange of Series A-1 and A-2 preferred for common stock $ 166 79,435     79,601
Exchange of Series A-1 and A-2 preferred for common stock (in shares) 16,620,274        
Sale of common stock, net of issuance cost $ 146 72,361     72,507
Sale of common stock, net of issuance cost (in shares) 14,639,500        
Issuance of common stock upon exercise and vesting of stock awards $ 1 12     13
Issuance of common stock upon exercise and vesting of stock awards (in shares) 22,391        
Net loss       (60,259) (60,259)
Comprehensive loss         (60,259)
Stock-based compensation expense   198     198
Balance at Dec. 31, 2013 $ 314 300,790   (227,571) 73,533
Balance (in shares) at Dec. 31, 2013 31,354,467        
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock upon exercise and vesting of stock awards   11     11
Issuance of common stock upon exercise and vesting of stock awards (in shares) 15,941        
Net loss       (16,422) (16,422)
Issuance of common stock under the Employee Stock Purchase Plan   307     307
Issuance of common stock under the Employee Stock Purchase Plan (in shares) 63,864        
Comprehensive loss         (16,422)
Stock-based compensation expense   1,861     1,861
Balance at Dec. 31, 2014 $ 314 302,969   (243,993) 59,290
Balance (in shares) at Dec. 31, 2014 31,434,272        
Increase (Decrease) in Stockholders' Equity          
Sale of common stock, net of issuance cost $ 86 115,118     115,204
Sale of common stock, net of issuance cost (in shares) 8,625,000        
Issuance of common stock upon exercise and vesting of stock awards $ 4 550     554
Issuance of common stock upon exercise and vesting of stock awards (in shares) 379,268        
Net loss         (17,592)
Issuance of common stock under the Employee Stock Purchase Plan $ 1 622     623
Issuance of common stock under the Employee Stock Purchase Plan (in shares) 112,499        
Comprehensive loss     $ (516) (17,592) (18,108)
Stock-based compensation expense   4,869     4,869
Balance at Dec. 31, 2015 $ 405 $ 424,128 $ (516) $ (261,585) $ 162,432
Balance (in shares) at Dec. 31, 2015 40,551,039