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Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities      
Net loss $ (17,592) $ (16,422) $ (60,259)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation and amortization 1,113 882 711
Amortization of premium on marketable securities 1,096    
Stock-based compensation 4,869 1,861 198
Abandonment of capitalized intangible assets 296 509 205
Gain on disposal of assets (9) (2) (16)
Gain on sale of marketable securities available-for-sale (5)    
Loss on exchange of notes for preferred stock     48,556
Accrued interest on convertible promissory notes     1,211
Changes in operating assets and liabilities:      
Accounts receivable 2,922 (2,907) 293
Interest receivable (898)    
Prepaid expenses and other current assets (1,068) (73) 115
Other assets (3) 41 (20)
Accounts payable 4,710 (943) 1,319
Accrued expenses 1,425 859 109
Deferred rent 572    
Deferred revenue 29,238 (5,156) 2,125
Net cash provided by (used in) operating activities 26,666 (21,351) (5,453)
Cash flows from investing activities      
Proceeds from sale and maturities of marketable securities available-for-sale 34,358    
Proceeds from sale of property and equipment 9 2 16
Purchase of marketable securities (215,798)    
Purchase of intangible assets (1,745) (1,505) (1,158)
Purchase of property and equipment (1,930) (780) (136)
Net cash used in investing activities (185,106) (2,283) (1,278)
Cash flows from financing activities      
Proceeds from the sale of Series A-1 preferred     10,000
Proceeds from issuance of common stock upon exercise of stock awards 554 9 13
Proceeds from issuance of common stock under the Employee Stock Purchase Plan 623 307  
Proceeds from issuance of common stock 122,906   80,517
Preferred stock issuance cost     (116)
Common stock issuance costs (7,702)   (8,010)
Payments on capital lease obligations   (8) (10)
Net cash provided by financing activities 116,381 308 82,394
Net increase (decrease) in cash and cash equivalents (42,059) (23,326) 75,663
Cash, beginning of period 54,649 77,975 2,312
Cash, end of period 12,590 54,649 77,975
Cash paid for:      
Interest 13 9 1
Taxes 1 $ 1  
Supplemental disclosures of non-cash investing and financing activities      
Capitalization of licensing rights acquired in non-monetary exchange $ 516    
Settlement of notes payable for preferred stock     $ 22,134