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Stock-Based Compensation - Employee expense (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Stock-based compensation |  |  |
Total employee, director and non-employee stock-based compensation expense | $ 13,651 | $ 7,848 | $ 4,869
General and administrative |  |  |
Stock-based compensation |  |  |
Total employee, director and non-employee stock-based compensation expense | 5,617 | 3,592 | 2,218
Research and development |  |  |
Stock-based compensation |  |  |
Total employee, director and non-employee stock-based compensation expense | $ 8,034 | $ 4,256 | $ 2,650

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