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Statements of Comprehensive Income (Loss) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenue      
Collaborations, licenses and milestones $ 35,711 $ 87,520 $ 27,762
Operating expenses      
Research and development 71,772 51,872 34,140
General and administrative 17,501 13,108 11,960
Total operating expenses 89,273 64,980 46,100
Income (loss) from operations (53,562) 22,540 (18,338)
Other income (expense)      
Interest income 4,194 2,091 744
Interest expense (13) (21) (13)
Other income (7) 6 15
Total other income, net 4,174 2,076 746
Income (loss) before income taxes (49,388) 24,616 (17,592)
Income tax expense (benefit) (463) 991  
Net income (loss) (48,925) 23,625 (17,592)
Other comprehensive income (loss)      
Net unrealized loss on marketable securities available-for-sale (367) (925) (516)
Comprehensive income (loss) $ (49,292) $ 22,700 $ (18,108)
Net income (loss) per share attributable to common shareholders:      
Basic net income (loss) (in dollars per share) $ (1.05) $ 0.57 $ (0.45)
Diluted net income (loss) (in dollars per share) $ (1.05) $ 0.56 $ (0.45)
Weighted average shares used to compute net income (loss) per share attributable to common stockholders:      
Basic (in shares) 46,817,756 41,267,329 39,015,131
Diluted (in shares) 46,817,756 42,388,867 39,015,131