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Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Reconciliation of federal statutory income tax to effective income tax |  |  |
Federal statutory income tax rate | $ (14,795) | $ (13,243) | $ 15,680
State and local income taxes | (4,767) | (1,806) | 2,818
Research and development credit | (6,170) | (5,554) | (2,544)
Stock based compensation | 444 | 2,709 | 733
Effect of the 2017 Tax Cuts and Jobs Act |  | 19,596 |
Other | 414 | 720 | 1,008
Net change in valuation allowance | $ 24,874 | (2,885) | (16,695)
Income tax provision (benefit) |  | $ (463) | $ 1,000

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