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Summary of Significant Accounting Policies (Details) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jan. 01, 2019 USD ($) lease | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Collaborations, licenses and milestones |  | $ 11,564 | $ 29,039 | $ 30,150 | $ 12,500 | $ 3,500 | $ 40,603 | $ 46,150 | $ 109,020
Increase in assets |  | 576,732 |  | 390,202 |  |  | 576,732 | 390,202 |
Increase in liabilities |  | 55,051 |  | 73,738 |  |  | 55,051 | 73,738 |
Current portion of deferred revenue |  | $ 40,079 |  | $ 60,118 |  |  | $ 40,079 | $ 60,118 |
ASU 2016-02 | Forecast |  |  |  |  |  |  |  |  |
Number of operating leases | lease | 5 |  |  |  |  |  |  |  |
ASU 2016-02 | Maximum | Forecast |  |  |  |  |  |  |  |  |
Right-of-Use Asset | $ 12,000 |  |  |  |  |  |  |  |
Lease liability | 12,000 |  |  |  |  |  |  |  |
Increase in assets | 12,000 |  |  |  |  |  |  |  |
Increase in liabilities | 12,000 |  |  |  |  |  |  |  |
ASU 2016-02 | Minimum | Forecast |  |  |  |  |  |  |  |  |
Right-of-Use Asset | 10,000 |  |  |  |  |  |  |  |
Lease liability | 10,000 |  |  |  |  |  |  |  |
Increase in assets | 10,000 |  |  |  |  |  |  |  |
Increase in liabilities | $ 10,000 |  |  |  |  |  |  |  |

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