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Summary of Significant Accounting Policies (Details)
$ in Thousands
 3 Months Ended 12 Months Ended
Jan. 01, 2019
USD ($)
lease
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Dec. 31, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Collaborations, licenses and milestones   $ 11,564 $ 29,039 $ 30,150 $ 12,500 $ 3,500 $ 40,603 $ 46,150 $ 109,020
Increase in assets   576,732   390,202     576,732 390,202  
Increase in liabilities   55,051   73,738     55,051 73,738  
Current portion of deferred revenue   $ 40,079   $ 60,118     $ 40,079 $ 60,118  
ASU 2016-02 | Forecast                  
Number of operating leases | lease 5                
ASU 2016-02 | Maximum | Forecast                  
Right-of-Use Asset $ 12,000                
Lease liability 12,000                
Increase in assets 12,000                
Increase in liabilities 12,000                
ASU 2016-02 | Minimum | Forecast                  
Right-of-Use Asset 10,000                
Lease liability 10,000                
Increase in assets 10,000                
Increase in liabilities $ 10,000