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Statements of Comprehensive Income (Loss) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenue                      
Collaborations, licenses and milestones $ 11,564 $ 29,039     $ 30,150   $ 12,500 $ 3,500 $ 40,603 $ 46,150 $ 109,020
Operating expenses                      
Research and development                 97,501 71,772 51,872
General and administrative                 22,472 17,501 13,108
Total operating expenses                 119,973 89,273 64,980
Income (loss) from operations (21,082) 651 $ (28,290) $ (30,649) 5,326 $ (23,580) (8,510) (16,359) (79,370) (43,123) 44,040
Other income (expense)                      
Interest income                 9,102 4,194 2,091
Interest expense                 (16) (13) (21)
Other income (expense)                 (125) (7) 6
Total other income, net                 8,961 4,174 2,076
Income (loss) before income tax                 (70,409) (38,949) 46,116
Income tax expense (benefit)                   (463) 991
Net income (loss) $ (18,197) $ 3,150 $ (25,869) $ (29,493) $ 7,366 $ (22,652) $ (7,725) $ (15,475) (70,409) (38,486) 45,125
Other comprehensive income (loss)                      
Net unrealized gain (loss) on marketable securities available-for-sale                 837 (367) (925)
Comprehensive income (loss)                 $ (69,572) $ (38,853) $ 44,200
Net income (loss) per share attributable to common stockholders:                      
Basic net income (loss) (in dollars per share) $ (0.32) $ 0.06 $ (0.46) $ (0.62) $ 0.16 $ (0.48) $ (0.17) $ (0.33) $ (1.31) $ (0.82) $ 1.09
Diluted net income (loss) (in dollars per share) $ (0.32) $ 0.05 $ (0.46) $ (0.62) $ 0.15 $ (0.48) $ (0.17) $ (0.33) $ (1.31) $ (0.82) $ 1.07
Weighted average shares used to compute net income (loss) per share attributable to common stockholders:                      
Basic (in shares)                 53,942,116 46,817,756 41,267,329
Diluted (in shares)                 53,942,116 46,817,756 42,388,867