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Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Reconciliation of federal statutory income tax to effective income tax
Federal statutory income tax rate	$ (14,795)	$ (13,243)	$ 15,680
State and local income taxes	(4,767)	(1,806)	2,818
Research and development credit	(6,170)	(5,554)	(2,544)
Stock based compensation	444	2,709	733
Effect of the 2017 Tax Cuts and Jobs Act		19,596
Other	414	720	1,008
Net change in valuation allowance	$ 24,874	(2,885)	(16,695)
Income tax provision (benefit)		$ (463)	$ 1,000

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