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Stock-Based Compensation - Employee expense (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense $ 20,548 $ 13,651 $ 7,848
Employee stock options      
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense 19,537 13,153 7,470
ESPP      
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense 744 498 378
Restricted stock units      
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense 267    
General and administrative      
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense 7,699 5,617 3,592
Research and development      
Stock-based compensation      
Total employee, director and non-employee stock-based compensation expense $ 12,849 $ 8,034 $ 4,256