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Collaborative and Licensing Agreements - Revenue Recognition (Details) - USD ($)	1 Months Ended	3 Months Ended					12 Months Ended
	Jun. 30, 2017	Dec. 31, 2018	Sep. 30, 2018	Dec. 31, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue recognized		$ 11,564,000	$ 29,039,000	$ 30,150,000	$ 12,500,000	$ 3,500,000	$ 40,603,000	$ 46,150,000	$ 109,020,000
Research collaboration
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue recognized							20,100,000	20,100,000	34,200,000
Milestone
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue recognized							20,500,000	26,000,000	5,000,000
Licensing
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue recognized								100,000	69,800,000
United States
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned							40,600,000	30,200,000	106,300,000
Non - United States
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned								16,000,000	2,700,000
Alexion Pharmaceuticals, Inc.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned							20,000,000		5,000,000
Amgen, Inc.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned							600,000	10,000,000	31,200,000
CSL Limited
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned								3,500,000
MorphoSys
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned								12,500,000
Novo Nordisk A/S
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned									2,700,000
Novartis
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned							20,000,000	20,100,000	69,900,000
Other
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue earned								100,000	$ 200,000
2009 Research License and Commercialization Agreement | CSL Limited
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue		0					0
Collaboration And License Agreement | MorphoSys
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payment	$ 12,500,000
Deferred revenue		0					0
Collaboration And License Agreement | Novo Nordisk A/S
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue		0					0
Collaboration And License Agreement | Novartis
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue		$ 40,100,000		$ 60,100,000			$ 40,100,000	$ 60,100,000

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