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Prior-Period Financial Statements - Comprehensive Income (Loss) (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenue                      
Collaborations, licenses and milestones $ 11,564 $ 29,039     $ 30,150   $ 12,500 $ 3,500 $ 40,603 $ 46,150 $ 109,020
Operating expenses                      
Research and development                 97,501 71,772 51,872
General and administrative                 22,472 17,501 13,108
Total operating expenses                 119,973 89,273 64,980
Income (loss) from operations (21,082) 651 $ (28,290) $ (30,649) 5,326 $ (23,580) (8,510) (16,359) (79,370) (43,123) 44,040
Other income (expense)                      
Interest income                 9,102 4,194 2,091
Interest expense                 (16) (13) (21)
Other income (expense)                 (125) (7) 6
Total other income, net                 8,961 4,174 2,076
Income (loss) before income tax                 (70,409) (38,949) 46,116
Income tax expense                   (463) 991
Net income (loss) $ (18,197) $ 3,150 $ (25,869) $ (29,493) $ 7,366 $ (22,652) $ (7,725) $ (15,475) (70,409) (38,486) 45,125
Other comprehensive income                      
Net unrealized gain (loss) on marketable securities available-for-sale                 837 (367) (925)
Comprehensive income (loss)                 $ (69,572) $ (38,853) $ 44,200
Basic and diluted net loss (in dollars per share)                   $ (0.82)  
Basic net income (loss) (in dollars per share) $ (0.32) $ 0.06 $ (0.46) $ (0.62) $ 0.16 $ (0.48) $ (0.17) $ (0.33) $ (1.31) (0.82) $ 1.09
Diluted net income (loss) (in dollars per share) $ (0.32) $ 0.05 $ (0.46) $ (0.62) $ 0.15 $ (0.48) $ (0.17) $ (0.33) $ (1.31) $ (0.82) $ 1.07
As Reported Before ASC Topic 606                      
Other comprehensive income                      
Comprehensive income (loss)                   $ (49,292) $ 22,700
ASU 2014-09 | As Reported Before ASC Topic 606                      
Revenue                      
Collaborations, licenses and milestones                   35,711 87,520
Operating expenses                      
Research and development                   71,772 51,872
General and administrative                   17,501 13,108
Total operating expenses                   89,273 64,980
Income (loss) from operations                   (53,562) 22,540
Other income (expense)                      
Interest income                   4,194 2,091
Interest expense                   (13) (21)
Other income (expense)                   (7) 6
Total other income, net                   4,174 2,076
Income (loss) before income tax                   (49,388) 24,616
Income tax expense                   (463) 991
Net income (loss)                   (48,925) 23,625
Other comprehensive income                      
Net unrealized gain (loss) on marketable securities available-for-sale                   (367) (925)
Comprehensive income (loss)                   $ (49,292) $ 22,700
Basic and diluted net loss (in dollars per share)                   $ (1.05)  
Basic net income (loss) (in dollars per share)                     $ 0.57
Diluted net income (loss) (in dollars per share)                     $ 0.56
ASU 2014-09 | Effect of Adoption of ASC Topic 606                      
Revenue                      
Collaborations, licenses and milestones                   $ 10,439 $ 21,500
Operating expenses                      
Income (loss) from operations                   10,439 21,500
Other income (expense)                      
Income (loss) before income tax                   10,439 21,500
Net income (loss)                   10,439 21,500
Other comprehensive income                      
Comprehensive income (loss)                   $ 10,439 $ 21,500
Basic and diluted net loss (in dollars per share)                   $ 0.23  
Basic net income (loss) (in dollars per share)                     $ 0.52
Diluted net income (loss) (in dollars per share)                     $ 0.51