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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2021
Stock-Based Compensation  
Schedule of total employee, director and non-employee stock-based compensation expense recognized

Three Months Ended

 

March 31, 

 

    

2021

    

2020

 

General and administrative

$

2,737

$

2,291

Research and development

 

5,556

 

4,221

$

8,293

$

6,512

Three Months Ended

March 31, 

2021

    

2020

Stock options

$

6,530

$

5,882

ESPP

248

194

RSUs

1,515

436

$

8,293

$

6,512

Summary of stock option activity

    

    

    

Weighted

 

Weighted

Average

 

Average

Number of

Exercise

 

Remaining

Aggregate

Shares Subject

Price

 

Contractual

Intrinsic

to Outstanding

(Per

 

Term

Value

Options

Share)

 

(in years)

(in thousands)

Balance at December 31, 2020

 

7,751,789

$

26.23

7.00

$

134,941

Options granted

 

1,321,917

$

43.24

Options forfeited

 

(64,824)

$

33.00

Options exercised

 

(230,701)

$

23.14

Balance at March 31, 2021

 

8,778,181

$

28.82

7.25

$

125,395

Exercisable

4,963,607

$

22.73

5.95

$

100,938

Schedule of weighted average assumptions used for estimation of fair value of stock options

Options

Three Months Ended

March 31, 

    

2021

    

2020

    

Expected term (years)

6.2

 

6.3

Expected volatility

55.6

%

53.9

%

Risk-free interest rate

1.02

%

1.71

%

Expected dividend yield

%  

%  

Schedule of weighted average assumptions used for estimation of fair value of ESPP

ESPP

Three Months Ended

March 31, 

    

2021

    

2020

    

Expected term (years)

 

0.5 - 2.0

 

0.5 - 2.0

Expected volatility

50.8 - 66.4

%

50.8

%

Risk-free interest rate

 

0.09 - 1.65

%

1.56 - 1.65

%

Expected dividend yield

%

%

Summary of restricted stock unity activity

Weighted

Restricted

Average Grant

Stock

Date Fair Value

Units

(Per unit)

Unvested RSUs at December 31, 2020

 

358,825

$

33.04

Granted

 

247,050

43.11

Vested

 

(117,808)

31.75

Forfeited

 

(9,071)

32.36

Unvested RSUs at March 31, 2021

 

478,996

$

38.56