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Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Reconciliation of federal statutory income tax to effective income tax |  |  |
Federal statutory income tax | $ 17,352 | $ (14,559) | $ 5,709
State and local income taxes | 783 | (4,659) | 2,549
Research and development credit | (10,492) | (9,669) | (6,747)
Stock based compensation | 2,424 | 529 | 1,927
State credit |  |  | 1,725
Other | 95 | 56 | (301)
Change in state rate | 2,599 |  |
Net change in valuation allowance | (12,761) | 28,302 | (4,550)
Income tax provision | $ 0 | $ 0 | $ 312

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