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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities |  |  |
Net income (loss) | $ 82,631 | $ (69,333) | $ 26,875
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 7,491 | 5,794 | 4,298
Amortization of premium (accretion of discount) on marketable securities | 3,160 | (272) | (4,321)
Stock-based compensation | 36,975 | 31,619 | 31,851
Abandonment of capitalized intangible assets | 934 | 535 | 221
Loss on disposal of assets | 462 | 4 | 8
Gain on sale of marketable securities available-for-sale |  | (153) |
Equity received in connection with license agreement | (22,379) | (26,660) |
Equity received in connection with sale of financial assets | (3,300) |  |
Cash redemption of equity received in connection with license agreement |  | 5,390 |
Change in fair value of equity securities | (20,988) | (105) |
Equity securities impairment | 762 |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (54,941) | 10,131 | (11,321)
Interest receivable from marketable debt securities | 655 | 1,190 | (387)
Prepaid expenses and other current assets | (13,151) | (4,170) | 3,828
Income tax receivable |  | 895 | 704
Contract asset and deposits | 12,059 | (12,401) |
Accounts payable | 5,047 | (1,235) | 6,392
Accrued expenses | 1,840 | 8,608 | (667)
Deferred rent |  |  | (1,513)
Lease liabilities and right of use (ROU) assets | 1,211 | (325) | 1,354
Deferred revenue | (55,321) | 45,484 | 7,052
Net cash provided by (used in) operating activities | (16,853) | (5,004) | 64,374
Cash flows from investing activities |  |  |
Proceeds from sale and maturities of marketable securities available-for-sale | 485,152 | 757,617 | 456,923
Proceeds from sale of property and equipment | 19 | 1 |
Purchase of marketable securities | (509,597) | (643,658) | (496,855)
Purchase of intangible assets | (2,682) | (3,229) | (3,685)
Purchase of property and equipment | (13,299) | (10,539) | (7,353)
Purchase of convertible note | (5,000) |  |
Exercise of stock options | (842) |  |
Net cash provided by (used in) investing activities | (46,249) | 100,192 | (50,970)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock upon exercise of stock awards | 12,281 | 16,617 | 9,269
Proceeds from issuance of common stock from Employee Stock Purchase Plan | 1,837 | 1,427 | 1,393
Proceeds from issuance of common stock | 28,920 |  |
Net cash provided by financing activities | 43,038 | 18,044 | 10,662
Net (decrease) increase in cash and cash equivalents | (20,064) | 113,232 | 24,066
Cash and cash equivalents, beginning of year | 163,544 | 50,312 | 26,246
Cash and cash equivalents, end of year | 143,480 | 163,544 | 50,312
Cash paid for: |  |  |
Interest | 14 | 15 | 11
Taxes |  |  | 400
Supplemental disclosures of non-cash investing activities |  |  |
Unrealized loss on marketable securities | $ (1,584) | $ (1,087) | $ 2,132

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