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Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Reconciliation of federal statutory income tax to effective income tax
Federal statutory income tax	$ 17,352	$ (14,559)	$ 5,709
State and local income taxes	783	(4,659)	2,549
Research and development credit	(10,492)	(9,669)	(6,747)
Stock based compensation	2,424	529	1,927
State credit			1,725
Other	95	56	(301)
Change in state rate	2,599
Net change in valuation allowance	(12,761)	28,302	(4,550)
Income tax provision	$ 0	$ 0	$ 312

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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