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Stock-Based Compensation - Options by exercise price (Details)	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Stock options outstanding and exercisable by exercise price
Stock Options Outstanding, Number of Shares | shares	8,676,329
Stock Options Outstanding, Remaining Contractual Term	6 years 7 months 24 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 29.11
Stock Options Exercisable, Number of Shares | shares	5,576,430
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 24.15
$4.25 - $10.28
Stock options outstanding and exercisable by exercise price
Range of Exercise Prices, lower limit (in dollars per share)	4.25
Range of Exercise Prices, upper limit (in dollars per share)	$ 10.28
Stock Options Outstanding, Number of Shares | shares	151,488
Stock Options Outstanding, Remaining Contractual Term	1 year 8 months 4 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 4.29
Stock Options Exercisable, Number of Shares | shares	151,488
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 4.29
$10.52 - $15.78
Stock options outstanding and exercisable by exercise price
Range of Exercise Prices, lower limit (in dollars per share)	10.52
Range of Exercise Prices, upper limit (in dollars per share)	$ 15.78
Stock Options Outstanding, Number of Shares | shares	1,508,709
Stock Options Outstanding, Remaining Contractual Term	3 years 3 months 29 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 13.15
Stock Options Exercisable, Number of Shares | shares	1,507,724
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 13.15
$15.91 - $23.87
Stock options outstanding and exercisable by exercise price
Range of Exercise Prices, lower limit (in dollars per share)	15.91
Range of Exercise Prices, upper limit (in dollars per share)	$ 23.87
Stock Options Outstanding, Number of Shares | shares	1,777,216
Stock Options Outstanding, Remaining Contractual Term	5 years 6 months 7 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 22.77
Stock Options Exercisable, Number of Shares | shares	1,756,016
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 22.76
$23.96 - $35.94
Stock options outstanding and exercisable by exercise price
Range of Exercise Prices, lower limit (in dollars per share)	23.96
Range of Exercise Prices, upper limit (in dollars per share)	$ 35.94
Stock Options Outstanding, Number of Shares | shares	2,312,270
Stock Options Outstanding, Remaining Contractual Term	7 years 10 months 28 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 32.08
Stock Options Exercisable, Number of Shares | shares	1,168,530
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 31.65
$35.99 - $53.99
Stock options outstanding and exercisable by exercise price
Range of Exercise Prices, lower limit (in dollars per share)	35.99
Range of Exercise Prices, upper limit (in dollars per share)	$ 53.99
Stock Options Outstanding, Number of Shares | shares	2,926,646
Stock Options Outstanding, Remaining Contractual Term	8 years 3 months 21 days
Stock Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 40.12
Stock Options Exercisable, Number of Shares | shares	992,672
Stock Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 37.52

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The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

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The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.

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The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

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Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.

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The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.

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Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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