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Stock-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of Total Employee, Director and Non-Employee Stock-Based Compensation Expense Recognized
Total employee, director and non-employee stock-based compensation expense recognized for the three and six months ended June 30, 2024 and 2023 are as follows (in thousands):
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
General and administrative $8,469 $4,471 $13,168 $8,747 
Research and development 8,721 9,092 15,443 17,415 
$17,190 $13,563 $28,611 $26,162 
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
Stock options$10,945 $6,842 $17,818 $13,825 
ESPP211 341 417 663 
RSUs6,034 6,380 10,376 11,674 
$17,190 $13,563 $28,611 $26,162 
Summary of Stock Option Activity
The following table summarizes option activity under our stock plans and related information:
Number of
Shares Subject
to Outstanding
Options		Weighted
Average
Exercise
Price
(Per
Share)		Weighted
Average
Remaining
Contractual
Term
(in years)		Aggregate
Intrinsic
Value
(in thousands)
Balance at December 31, 202311,142,986$29.60 6.03$9,977 
Options granted2,167,253$22.43 
Options forfeited(485,918)$32.84 
Options exercised(162,895)$11.83 
Balance at June 30, 202412,661,426$28.48 6.18$5,813 
Exercisable8,295,121$29.38 4.76$5,745 
Schedule of Weighted Average Assumptions Used for Estimation of Fair Value of Stock Options We estimated the fair value of each equity award, including stock options and shares issued under our ESPP, using the Black-Scholes option-pricing model based on the date of grant of such stock option or ESPP share
issuance date, with the following weighted average assumptions for the three and six months ended June 30, 2024 and 2023:
OptionsOptions
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
Expected term (years)6.46.56.46.1
Expected volatility50.4 %51.2 %50.1 %50.5 %
Risk-free interest rate4.42 %3.69 %4.18 %4.17 %
Expected dividend yield— %— %— %— %
Schedule of Weighted Average Assumptions Used for Estimation of Fair Value of ESPP
ESPPESPP
Three Months Ended
June 30,		Six Months Ended
June 30,
2024202320242023
Expected term (years)
0.5 - 2.0
0.5 - 2.0
0.5 - 2.0
0.5 -2.0
Expected volatility
43.0% - 44.6%
38.2% - 55.7%
43.0% - 44.6%
38.2% - 55.7%
Risk-free interest rate
4.71% - 5.40%
0.13% - 5.39%
4.71% - 5.40%
0.13% - 5.39%
Expected dividend yield— %— %— %— %
Summary of Restricted Stock Unit Activity
The following table summarizes the RSU activity for the six-month period ended June 30, 2024:
Restricted
Stock
Units		Weighted
Average Grant
Date Fair Value
(Per unit)
Unvested RSUs at December 31, 20231,490,040$30.66 
Granted959,07122.58 
Vested(550,972)31.72 
Forfeited(119,483)29.80 
Unvested RSUs at June 30, 20241,778,656$26.02