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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Pay vs Performance Disclosure |  |  |  |
Pay vs Performance Disclosure, Table |
| Summary Compensation Table Total for PEO (1) | Compensation Actually Paid to PEO (2) | Average Summary Compensation Table Total for non-PEO NEOs (3) | Average Compensation Actually Paid to non-PEO NEOs | Value of Initial Fixed $100 Investment based on: | Net Income (Loss) (in thousands)
Year | TSR (4) | Peer Group TSR (5)
2023 | $ | 7,965,955 |  | $ | 6,147,081 |  | $ | 3,116,346 |  | $ | 2,116,864 |  | $ | 61.73 |  | $ | 115.42 |  | $ | (126,087) |
2022 | $ | 7,705,953 |  | $ | (770,559) |  | $ | 2,443,329 |  | $ | 38,234 |  | $ | 75.72 |  | $ | 111.27 |  | $ | (55,181) |
2021 | $ | 5,370,295 |  | $ | 317,342 |  | $ | 2,126,860 |  | $ | 668,412 |  | $ | 116.66 |  | $ | 124.89 |  | $ | 82,631 |
2020 | $ | 4,480,925 |  | $ | 6,725,617 |  | $ | 1,263,427 |  | $ | 1,881,821 |  | $ | 126.87 |  | $ | 125.69 |  | $ | (69,333) |
Named Executive Officers, Footnote | For each year our PEO was Bassil Dahiyat.For 2023, our non-PEO NEOs were John Desjarlais, John Kuch, Celia Eckert, Allen Yang, and Nancy Valente. For 2022, 2021 and 2020 our non-PEO NEOs were John Desjarlais, John Kuch, Celia Eckert and Allen Yang. |  |  |
Peer Group Issuers, Footnote | Peer Group TSR is Nasdaq Biotechnology Index ("NBI") TSR. |  |  |
PEO Total Compensation Amount | $ 7,965,955 | $ 7,705,953 | $ 5,370,295 | $ 4,480,925
PEO Actually Paid Compensation Amount | $ 6,147,081 | (770,559) | 317,342 | 6,725,617
Adjustment To PEO Compensation, Footnote | The following is a summary of the adjustments made to PEO compensation as reported in the SCT to determine PEO CAP. Certain numbers in this table may not foot due to rounding.
Adjustment to Determine Compensation Actually Paid to PEO |  |  |
| 2023 |  |  |
Total compensation from SCT | $ | 7,965,955 |  |  |  |
Deduction for amounts reported under stock awards in SCT | (1,650,735) |  |  |  |
Deduction for amounts reported under option awards in SCT | (5,249,673) |  |  |  |
Increase in fair value of awards granted during year that remain outstanding and unvested at year-end | 6,364,696 |  |  |  |
Increase/deduction for change in fair value from prior year-end to current year-end of awards granted in prior year that were outstanding and unvested at year-end | (5,441,290) |  |  |  |
Increase/deduction for change in fair value from prior year-end to vesting date of awards granted in prior year that vested during the year | 4,158,128 |  |  |  |
Compensation actually paid | $ | 6,147,081 |  |  |  |
Non-PEO NEO Average Total Compensation Amount | $ 3,116,346 | 2,443,329 | 2,126,860 | 1,263,427
Non-PEO NEO Average Compensation Actually Paid Amount | $ 2,116,864 | 38,234 | 668,412 | 1,881,821
Adjustment to Non-PEO NEO Compensation Footnote | The following is a summary of the adjustments made to average non-PEO NEO compensation as reported in the SCT to determine average non-PEO NEO CAP. Certain numbers in the following table may not foot due to rounding.
Adjustment to Determine Average Compensation Actually Paid to Non-PEO NEOs |
| 2023 |  |  |
Average total compensation reported in SCT | $ | 3,116,346 |  |  |  |
Deduction for amounts reported under stock awards in SCT | (590,191) |  |  |  |
Deduction for amounts reported under option awards in SCT | (1,903,046) |  |  |  |
Increase in fair value of awards granted during the year that remain outstanding and unvested at year-end | 2,330,632 |  |  |  |
Increase/deduction for change in fair value from prior year-end to current year-end of awards granted prior year that were outstanding and unvested at year-end | (1,904,976) |  |  |  |
Increase/deduction for change in fair value from prior year-end to vesting date of awards granted prior year that vested during the year | 1,068,099 |  |  |  |
Compensation actually paid | $ | 2,116,864 |  |  |  |
Compensation Actually Paid vs. Total Shareholder Return | The following chart sets forth the relationship between Compensation Actually Paid ("CAP") to our PEO, the average CAP to our non-PEO NEOs, and the Company's and the Company's peers' Total Shareholder Return ("TSR") over the four most recently completed fiscal years. |  |  |
Total Shareholder Return Amount | $ 61.73 | 75.72 | 116.66 | 126.87
Peer Group Total Shareholder Return Amount | 115.42 | 111.27 | 124.89 | 125.69
Net Income (Loss) | $ (126,087,000) | $ (55,181,000) | $ 82,631,000 | $ (69,333,000)
PEO Name | Bassil Dahiyat |  |  |
Additional 402(v) Disclosure | Total Shareholder Return ("TSR"). |  |  |
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ 6,364,696 |  |  |
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (5,441,290) |  |  |
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 4,158,128 |  |  |
PEO | Stock Awards Adjustments [Member] |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (1,650,735) |  |  |
PEO | Option Awards Adjustment [Member] |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (5,249,673) |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 2,330,632 |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (1,904,976) |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 1,068,099 |  |  |
Non-PEO NEO | Stock Awards Adjustments [Member] |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (590,191) |  |  |
Non-PEO NEO | Option Awards Adjustment [Member] |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ (1,903,046) |  |  |

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