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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Pay vs Performance Disclosure        
Pay vs Performance Disclosure, Table
Summary
Compensation
Table Total
for PEO (1)		Compensation
Actually Paid
to PEO (2)		Average Summary
Compensation
Table Total for
non-PEO NEOs (3)		Average
Compensation
Actually Paid
to non-PEO NEOs		Value of Initial Fixed $100
Investment based on:		Net
Income (Loss)
(in thousands)
YearTSR (4)Peer Group
TSR (5)
2023$7,965,955 $6,147,081 $3,116,346 $2,116,864 $61.73 $115.42 $(126,087)
2022$7,705,953 $(770,559)$2,443,329 $38,234 $75.72 $111.27 $(55,181)
2021$5,370,295 $317,342 $2,126,860 $668,412 $116.66 $124.89 $82,631 
2020$4,480,925 $6,725,617 $1,263,427 $1,881,821 $126.87 $125.69 $(69,333)
      
Named Executive Officers, Footnote For each year our PEO was Bassil Dahiyat.For 2023, our non-PEO NEOs were John Desjarlais, John Kuch, Celia Eckert, Allen Yang, and Nancy Valente. For 2022, 2021 and 2020 our non-PEO NEOs were John Desjarlais, John Kuch, Celia Eckert and Allen Yang.      
Peer Group Issuers, Footnote Peer Group TSR is Nasdaq Biotechnology Index ("NBI") TSR.      
PEO Total Compensation Amount $ 7,965,955 $ 7,705,953 $ 5,370,295 $ 4,480,925
PEO Actually Paid Compensation Amount $ 6,147,081 (770,559) 317,342 6,725,617
Adjustment To PEO Compensation, Footnote The following is a summary of the adjustments made to PEO compensation as reported in the SCT to determine PEO CAP. Certain numbers in this table may not foot due to rounding.
Adjustment to Determine Compensation Actually Paid to PEO
2023
Total compensation from SCT$7,965,955 
Deduction for amounts reported under stock awards in SCT(1,650,735)
Deduction for amounts reported under option awards in SCT(5,249,673)
Increase in fair value of awards granted during year that remain outstanding and unvested at year-end6,364,696 
Increase/deduction for change in fair value from prior year-end to current year-end of awards granted in prior year that were outstanding and unvested at year-end(5,441,290)
Increase/deduction for change in fair value from prior year-end to vesting date of awards granted in prior year that vested during the year4,158,128 
Compensation actually paid$6,147,081 
      
Non-PEO NEO Average Total Compensation Amount $ 3,116,346 2,443,329 2,126,860 1,263,427
Non-PEO NEO Average Compensation Actually Paid Amount $ 2,116,864 38,234 668,412 1,881,821
Adjustment to Non-PEO NEO Compensation Footnote
The following is a summary of the adjustments made to average non-PEO NEO compensation as reported in the SCT to determine average non-PEO NEO CAP. Certain numbers in the following table may not foot due to rounding.
Adjustment to Determine Average Compensation Actually Paid to Non-PEO NEOs
2023
Average total compensation reported in SCT$3,116,346 
Deduction for amounts reported under stock awards in SCT(590,191)
Deduction for amounts reported under option awards in SCT(1,903,046)
Increase in fair value of awards granted during the year that remain outstanding and unvested at year-end2,330,632 
Increase/deduction for change in fair value from prior year-end to current year-end of awards granted prior year that were outstanding and unvested at year-end(1,904,976)
Increase/deduction for change in fair value from prior year-end to vesting date of awards granted prior year that vested during the year1,068,099 
Compensation actually paid$2,116,864 
      
Compensation Actually Paid vs. Total Shareholder Return
The following chart sets forth the relationship between Compensation Actually Paid ("CAP") to our PEO, the average CAP to our non-PEO NEOs, and the Company's and the Company's peers' Total Shareholder Return ("TSR") over the four most recently completed fiscal years.

2318
      
Total Shareholder Return Amount $ 61.73 75.72 116.66 126.87
Peer Group Total Shareholder Return Amount 115.42 111.27 124.89 125.69
Net Income (Loss) $ (126,087,000) $ (55,181,000) $ 82,631,000 $ (69,333,000)
PEO Name Bassil Dahiyat      
Additional 402(v) Disclosure Total Shareholder Return ("TSR").      
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ 6,364,696      
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (5,441,290)      
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 4,158,128      
PEO | Stock Awards Adjustments [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (1,650,735)      
PEO | Option Awards Adjustment [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (5,249,673)      
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 2,330,632      
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (1,904,976)      
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 1,068,099      
Non-PEO NEO | Stock Awards Adjustments [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (590,191)      
Non-PEO NEO | Option Awards Adjustment [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ (1,903,046)