<SEC-DOCUMENT>0001214501-25-000004.txt : 20251028
<SEC-HEADER>0001214501-25-000004.hdr.sgml : 20251028
<ACCEPTANCE-DATETIME>20251028183009
ACCESSION NUMBER:		0001214501-25-000004
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251028
FILED AS OF DATE:		20251028
DATE AS OF CHANGE:		20251028

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MIDDLEKAUFF W BRADFORD
		CENTRAL INDEX KEY:			0001214501
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40384
		FILM NUMBER:		251426186

	MAIL ADDRESS:	
		STREET 1:		200 CONNELL DRIVE
		STREET 2:		SUITE 1600
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Tourmaline Bio, Inc.
		CENTRAL INDEX KEY:			0001827506
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		27 WEST 24TH STREET
		STREET 2:		SUITE 702
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10010
		BUSINESS PHONE:		646-481-9832

	MAIL ADDRESS:	
		STREET 1:		27 WEST 24TH STREET
		STREET 2:		SUITE 702
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Talaris Therapeutics, Inc.
		DATE OF NAME CHANGE:	20201007
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-10282025_061005.xml
<TEXT>
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    <periodOfReport>2025-10-28</periodOfReport>

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    <issuer>
        <issuerCik>0001827506</issuerCik>
        <issuerName>Tourmaline Bio, Inc.</issuerName>
        <issuerTradingSymbol>TRML</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
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            <rptOwnerName>MIDDLEKAUFF W BRADFORD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TOURMALINE BIO, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>27 WEST 24TH STREET, SUITE 702</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>CBO, GC and Secretary</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

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                </transactionShares>
                <transactionPricePerShare>
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        </nonDerivativeTransaction>
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    <derivativeTable>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
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            <transactionDate>
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            </transactionDate>
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                <transactionCode>D</transactionCode>
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                </underlyingSecurityTitle>
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            </underlyingSecurity>
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                </directOrIndirectOwnership>
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                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This Form 4 reports securities disposed pursuant to that certain Agreement and Plan of Merger (the &quot;Merger Agreement&quot;), dated as of September 8, 2025, by and among Issuer, Novartis AG, a company limited by shares (Aktiengesellschaft) incorporated under the laws of Switzerland (&quot;Parent&quot;), and Torino Merger Sub Inc., a Delaware corporation and indirect wholly owned subsidiary of Parent (&quot;Merger Sub&quot;). Pursuant to the Merger Agreement, on October 28, 2025, Merger Sub completed a cash tender offer to acquire all of the shares of common stock of the Issuer, par value $0.0001 (the &quot;Shares&quot;), issued and outstanding immediately prior to the effective time of the merger (the &quot;Effective Time&quot;), in exchange for $48.00 in cash per Share, subject to any applicable withholding of taxes (the &quot;Merger Consideration&quot;).</footnote>
        <footnote id="F2">Pursuant to the terms of the Merger Agreement, each Share was tendered in exchange for $48.00 in cash per Share.</footnote>
        <footnote id="F3">Pursuant to the terms of the Merger Agreement, each restricted Share outstanding and subject to the Issuer's repurchase right as of immediately prior to the Effective Time became fully vested effective as of immediately prior to the Effective Time, and, by virtue of the
merger and net of any applicable withholding taxes, was treated as a Share for all purposes under the terms of the Merger Agreement.</footnote>
        <footnote id="F4">Pursuant to the terms of the Merger Agreement, each stock option that was outstanding and unexercised immediately prior to the Effective Time was automatically canceled and terminated and converted into the right to receive an amount in cash, without interest, equal to the product of (i) the amount by which the Merger Consideration exceeds the applicable exercise price per Share of such option and (ii) the aggregate number of Shares issuable upon exercise of such option or portion thereof, subject to any applicable withholding of taxes.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ W. Bradford Middlekauff</signatureName>
        <signatureDate>2025-10-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
